KEGG   ORTHOLOGY: K04398Help
Entry
K04398                      KO                                     

Name
CASP8
Definition
caspase 8 [EC:3.4.22.61]
Pathway
ko01524  Platinum drug resistance
ko04115  p53 signaling pathway
ko04210  Apoptosis
ko04214  Apoptosis - fly
ko04215  Apoptosis - multiple species
ko04217  Necroptosis
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05010  Alzheimer's disease
ko05016  Huntington's disease
ko05134  Legionellosis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05165  Human papillomavirus infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05416  Viral myocarditis
Disease
H00108  Autoimmune lymphoproliferative syndromes (ALPS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04668 TNF signaling pathway
    K04398  CASP8; caspase 8
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04398  CASP8; caspase 8
   04214 Apoptosis - fly
    K04398  CASP8; caspase 8
   04215 Apoptosis - multiple species
    K04398  CASP8; caspase 8
   04217 Necroptosis
    K04398  CASP8; caspase 8
   04115 p53 signaling pathway
    K04398  CASP8; caspase 8
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04624 Toll and Imd signaling pathway
    K04398  CASP8; caspase 8
   04621 NOD-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04622 RIG-I-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04625 C-type lectin receptor signaling pathway
    K04398  CASP8; caspase 8
   04657 IL-17 signaling pathway
    K04398  CASP8; caspase 8
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04398  CASP8; caspase 8
   05203 Viral carcinogenesis
    K04398  CASP8; caspase 8
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K04398  CASP8; caspase 8
   05016 Huntington's disease
    K04398  CASP8; caspase 8
  Cardiovascular diseases
   05416 Viral myocarditis
    K04398  CASP8; caspase 8
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04398  CASP8; caspase 8
  Infectious diseases
   05134 Legionellosis
    K04398  CASP8; caspase 8
   05152 Tuberculosis
    K04398  CASP8; caspase 8
   05161 Hepatitis B
    K04398  CASP8; caspase 8
   05168 Herpes simplex infection
    K04398  CASP8; caspase 8
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04398  CASP8; caspase 8
   05165 Human papillomavirus infection
    K04398  CASP8; caspase 8
   05145 Toxoplasmosis
    K04398  CASP8; caspase 8
   05142 Chagas disease (American trypanosomiasis)
    K04398  CASP8; caspase 8
  Drug resistance
   01524 Platinum drug resistance
    K04398  CASP8; caspase 8
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     K04398  CASP8; caspase 8
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C14: caspase family
   K04398  CASP8; caspase 8
BRITE hierarchy
Other DBs
GO: 0097199
Genes
HSA: 841(CASP8)
PTR: 746477(CASP8)
PPS: 100978497(CASP8)
GGO: 101138898(CASP8)
PON: 100172115(CASP8)
NLE: 100586183(CASP8)
MCC: 702781(CASP8)
MCF: 101865354(CASP8)
CSAB: 103217637(CASP8)
RRO: 104671864(CASP8)
RBB: 108532002(CASP8)
CJC: 100395220(CASP8)
SBQ: 101053601(CASP8)
MMU: 12370(Casp8)
RNO: 64044(Casp8)
CGE: 100689369(Casp8)
NGI: 103738672(Casp8)
HGL: 101702773(Casp8)
CCAN: 109689613(Casp8)
OCU: 100348477(CASP8)
TUP: 102498355(CASP8)
CFA: 488473(CASP8)
AML: 100472842(CASP8)
UMR: 103659742(CASP8)
ORO: 101365855(CASP8)
FCA: 100142684(CASP8)
PTG: 102962460(CASP8)
AJU: 106987995(CASP8)
BTA: 507481(CASP8)
BOM: 102272602(CASP8)
BIU: 109569521(CASP8)
PHD: 102326267(CASP8)
CHX: 102169919(CASP8)
OAS: 101107334(CASP8)
SSC: 595105(CASP8)
CFR: 102508224(CASP8)
CDK: 105099181(CASP8)
BACU: 103004642(CASP8)
LVE: 103077054(CASP8)
OOR: 101281780(CASP8)
ECB: 100066502(CASP8)
EPZ: 103565685(CASP8)
EAI: 106823493(CASP8)
MYB: 102246377(CASP8)
MYD: 102761550(CASP8)
HAI: 109379228(CASP8)
RSS: 109444985(CASP8)
PALE: 102878181(CASP8)
LAV: 100660542(CASP8) 100663575
TMU: 101344302
MDO: 100017025(CASP18) 100617599(CASP8)
SHR: 100931580
OAA: 100082949(CASP8) 100087835
GGA: 395284(CASP8)
MGP: 100541513(CASP8) 100541666
APLA: 101803161(CASP8) 106014283
TGU: 100222284
PHI: 102110759
PMAJ: 107207226
CCW: 104693779
FPG: 101916968(CASP8) 106113022
FCH: 102056597(CASP8) 106630990
EGZ: 104130511(CASP8)
AAM: 106492412 106492473(CASP8)
AMJ: 102573591(CASP8) 102575862(CASP18)
PSS: 102446244(CASP8) 102447455
CPIC: 101934006(CASP8) 101934828
XLA: 373559(casp8.L)
XTR: 100495471(casp8)
NPR: 108795080
DRE: 557302(casp8l2) 58022(casp8)
TRU: 101075191 101075631(casp8)
OLA: 100049400(casp8) 100125536
XMA: 111608841
LCF: 108883888
BPEC: 110173494(casp8) 110173519
SASA: 106569473
CMK: 103171902(casp8)
CIN: 100183123(casp8)
SPU: 585496
APLC: 110986601
DME: Dmel_CG7486(Dredd)
DSI: Dsimw501_GD16467(Dsim_Dredd)
DYA: Dyak_GE16575(Dyak_Dredd)
MDE: 101900122
AGA: AgaP_AGAP011693(CASPL1)
AAG: 5563818
AME: 724930
BIM: 100741190
BTER: 100652115
SOC: 105205440
AEC: 105147270
ACEP: 105625685
PBAR: 105429159
HST: 105181776
CFO: 105248277
LHU: 105678455
PGC: 109856665
NVI: 100680000
TCA: 661095(Dredd)
DPA: 109534720
NVL: 108556913
BMOR: 100141428(Dredd)
PMAC: 106720189
PRAP: 110996855
PXY: 105390324
ZNE: 110835030
EPA: 110231936
HMG: 100207763 100579132(casp8)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9931493
  Authors
Grenet J, Teitz T, Wei T, Valentine V, Kidd VJ
  Title
Structure and chromosome localization of the human CASP8 gene.
  Journal
Gene 226:225-32 (1999)
DOI:10.1016/S0378-1119(98)00565-4
  Sequence
[hsa:841]

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