KEGG ORTHOLOGY: K04415

ORTHOLOGY: K04415

Entry

K04415                      KO

Symbol

MAP3K8, COT

Name

mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04620

Toll-like receptor signaling pathway

map04660

T cell receptor signaling pathway

map04668

TNF signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
   04668 TNF signaling pathway
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
   04660 T cell receptor signaling pathway
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  Other
   K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8

Other DBs

GO:

0004709

Genes

HSA:	1326(MAP3K8)

PTR:	450384(MAP3K8)

PPS:	100978161(MAP3K8)

GGO:	101133328(MAP3K8)

PON:	103889401(MAP3K8)

NLE:	100579516(MAP3K8)

HMH:	116462065(MAP3K8)

MCC:	696936(MAP3K8)

MCF:	102132599(MAP3K8)

MTHB:

126963358

MNI:	105479953(MAP3K8)

CSAB:

103247459(MAP3K8)

CATY:

105596958(MAP3K8)

PANU:

101024944(MAP3K8)

TGE:	112632119(MAP3K8)

MLEU:

105537669(MAP3K8)

RRO:	104657273(MAP3K8)

RBB:	108528065(MAP3K8)

TFN:	117082018(MAP3K8)

PTEH:

111546640(MAP3K8)

CANG:

105521962(MAP3K8)

CJC:	100385107(MAP3K8)

SBQ:	101046566(MAP3K8)

CIMI:

108309141(MAP3K8)

CSYR:

103276430(MAP3K8)

MMUR:

105884788(MAP3K8)

LCAT:

123624815(MAP3K8)

PCOQ:

105818749 105818750

OGA:	100953651(MAP3K8)

MMU:	26410(Map3k8)

MCAL:

110284809(Map3k8)

MPAH:

110333248(Map3k8)

RNO:	116596(Map3k8)

MCOC:

116086796(Map3k8)

ANU:	117714402(Map3k8)

MUN:	110558401(Map3k8)

CGE:	100759538(Map3k8)

MAUA:

101833636(Map3k8)

PROB:

127237406(Map3k8)

MORG:

121440744(Map3k8)

MFOT:

126507798

AAMP:

119817321(Map3k8)

NGI:	103747991(Map3k8)

HGL:	101710286(Map3k8)

CPOC:

100725834(Map3k8)

CCAN:

109695913(Map3k8)

DORD:

105984525(Map3k8)

DSP:	122113201(Map3k8)

PLOP:

125367139(Map3k8)

NCAR:

124961556

OCU:

100355566

OPI:	101520715(MAP3K8)

TUP:	102493021(MAP3K8)

GVR:	103601711(MAP3K8)

CFA:	487085(MAP3K8)

CLUD:

112670385(MAP3K8)

VVP:	112921580(MAP3K8)

VLG:	121498006(MAP3K8)

NPO:	129515595(MAP3K8)

AML:	100480593(MAP3K8)

UMR:	103656496(MAP3K8)

UAH:	113244248(MAP3K8)

UAR:	123802264(MAP3K8)

ELK:

111158620

LLV:

125107123

MPUF:

101671137(MAP3K8)

NVS:	122891627(MAP3K8)

ORO:	101385184(MAP3K8)

EJU:	114222423(MAP3K8)

ZCA:	113922054(MAP3K8)

MLX:	117998440(MAP3K8)

NSU:	110577249(MAP3K8)

LWW:	102739290(MAP3K8)

FCA:	101090624(MAP3K8)

PYU:	121014663(MAP3K8)

PCOO:

112867639(MAP3K8)

PBG:	122473980(MAP3K8)

LRUF:

124501424

PTG:	102961042(MAP3K8)

PPAD:

109276338(MAP3K8)

PUC:

125918661

AJU:

106977317

HHV:	120221616(MAP3K8)

BTA:	535622(MAP3K8)

BOM:	102278856(MAP3K8)

BIU:	109568007(MAP3K8)

BBUB:

102399287(MAP3K8)

BBIS:

105003067(MAP3K8)

CHX:	102188512(MAP3K8)

OAS:	101117094(MAP3K8)

BTAX:

128058726(MAP3K8)

ODA:	120869009(MAP3K8)

CCAD:

122448564(MAP3K8)

MBEZ:

129558685(MAP3K8)

SSC:	100622217(MAP3K8)

CFR:	102518335(MAP3K8)

CBAI:

105071706(MAP3K8)

CDK:	105096296(MAP3K8)

VPC:	102533792(MAP3K8)

BACU:

103010611(MAP3K8)

LVE:	103070441(MAP3K8)

OOR:	101269575(MAP3K8)

DLE:	111178133(MAP3K8)

PCAD:

102988471(MAP3K8)

PSIU:

116748892(MAP3K8)

NASI:

112402871(MAP3K8)

ECB:	100063602(MAP3K8)

EPZ:	103541518(MAP3K8)

EAI:	106837968(MAP3K8)

MYB:	102248363(MAP3K8)

MYD:	102775461(MAP3K8)

MMYO:

118677055(MAP3K8)

MLF:	102428565(MAP3K8)

MNA:	107524427(MAP3K8)

PKL:	118727591(MAP3K8)

EFUS:

103294008(MAP3K8)

HAI:	109389111(MAP3K8)

DRO:	112316842(MAP3K8)

SHON:

118995176(MAP3K8)

AJM:

119063905

PDIC:

114491904(MAP3K8)

PHAS:

123831179(MAP3K8)

MMF:	118639002(MAP3K8)

RFQ:	117022645(MAP3K8)

PALE:

102896654(MAP3K8)

PGIG:

120584101(MAP3K8)

PVP:	105298317(MAP3K8)

RAY:	107518939(MAP3K8)

MJV:	108392181(MAP3K8)

TOD:	119244638(MAP3K8)

SARA:

101550491(MAP3K8)

LAV:	100662383(MAP3K8)

TMU:

101343130

ETF:	101649071(MAP3K8)

DNM:	101422236(MAP3K8)

MDO:	100018684(MAP3K8)

GAS:	123249099(MAP3K8)

SHR:	100925633(MAP3K8)

AFZ:

127564555

PCW:	110211269(MAP3K8)

OAA:	100076215(MAP3K8)

GGA:	420479(MAP3K8)

PCOC:

116244402(MAP3K8)

MGP:	100541097(MAP3K8)

CJO:	107308936(MAP3K8)

TPAI:

128086352(MAP3K8)

LMUT:

125696289(MAP3K8)

NMEL:

110393429(MAP3K8)

APLA:

101791769(MAP3K8)

ACYG:

106042681(MAP3K8)

CATA:

118247484(MAP3K8)

AFUL:

116486568(MAP3K8)

TGU:	100230596(MAP3K8)

LSR:	110477339(MAP3K8)

SCAN:

103812752(MAP3K8)

PMOA:

120503915(MAP3K8)

OTC:	121338045(MAP3K8)

PRUF:

121364572(MAP3K8)

GFR:	102035976(MAP3K8)

FAB:	101819414(MAP3K8)

OMA:	130249884(MAP3K8)

PHI:	102114163(MAP3K8)

PMAJ:

107200816(MAP3K8)

CCAE:

111924099(MAP3K8)

CCW:	104686470(MAP3K8)

CBRC:

103620627(MAP3K8)

ETL:	114060299(MAP3K8)

ZAB:	102070099(MAP3K8)

ACHL:

103804394(MAP3K8)

SVG:	106855578(MAP3K8)

MMEA:

130578235(MAP3K8)

HRT:	120754335(MAP3K8)

FPG:	101921040(MAP3K8)

FCH:	102055830(MAP3K8)

CLV:	102087091(MAP3K8)

EGZ:	104133587(MAP3K8)

NNI:	104022250(MAP3K8)

PCRI:

104028584(MAP3K8)

PLET:

104621251(MAP3K8)

EHS:	104504620(MAP3K8)

PCAO:

104052481(MAP3K8)

ACUN:

113476643(MAP3K8)

TALA:

104366750(MAP3K8)

PADL:

103918240(MAP3K8)

AFOR:

103895567(MAP3K8)

ACHC:

115339876(MAP3K8)

HALD:

104314762(MAP3K8)

HLE:	104842599(MAP3K8)

AGEN:

126037792

GCL:

127013069

CCRI:

104156094(MAP3K8)

CSTI:

104556476(MAP3K8)

CMAC:

104478361(MAP3K8)

MUI:	104537994(MAP3K8)

BREG:

104639876(MAP3K8)

FGA:	104083296(MAP3K8)

GSTE:

104261364(MAP3K8)

LDI:	104344174(MAP3K8)

MNB:	103772670(MAP3K8)

OHA:	104339011(MAP3K8)

NNT:	104407006(MAP3K8)

SHAB:

115609510(MAP3K8)

DPUB:

104298496(MAP3K8)

PGUU:

104466443(MAP3K8)

ACAR:

104525613(MAP3K8)

CPEA:

104397055(MAP3K8)

AVIT:

104275816(MAP3K8)

CVF:	104295358(MAP3K8)

CUCA:

104066653(MAP3K8)

TEO:	104375373(MAP3K8)

BRHI:

104501562(MAP3K8)

AAM:	106489958(MAP3K8)

AROW:

112963216(MAP3K8)

NPD:	112955469(MAP3K8)

TGT:	104570213(MAP3K8)

DNE:	112984070(MAP3K8)

SCAM:

104147176(MAP3K8)

ASN:	102387437(MAP3K8)

AMJ:	102566471(MAP3K8)

CPOO:

109307420(MAP3K8)

GGN:	109291286(MAP3K8)

PSS:	102449623(MAP3K8)

CMY:	102936511(MAP3K8)

CCAY:

125631303(MAP3K8)

DCC:	119852255(MAP3K8)

CPIC:

101941097(MAP3K8)

TST:	117872092(MAP3K8)

CABI:

116815634(MAP3K8)

MRV:	120397005(MAP3K8)

ACS:	100562883(map3k8)

PVT:	110082918(MAP3K8)

SUND:

121935259(MAP3K8)

PBI:	103064348(MAP3K8)

PMUR:

107282828(MAP3K8)

CTIG:

120317307(MAP3K8)

TSR:	106548362(MAP3K8)

PGUT:

117654976(MAP3K8)

APRI:

131198334(MAP3K8)

PTEX:

113442468(MAP3K8)

NSS:	113415002(MAP3K8)

VKO:	123020769(MAP3K8)

PMUA:

114607849(MAP3K8)

PRAF:

128424340(MAP3K8)

ZVI:	118091971(MAP3K8)

HCG:	128328763(MAP3K8)

GJA:	107107910(MAP3K8)

STOW:

125440990(MAP3K8)

EMC:	129337658(MAP3K8)

XLA:	108718772(map3k8.L) 108719849(map3k8.S)

XTR:	100493069(map3k8)

NPR:	108788845(MAP3K8)

RTEM:

120940043(MAP3K8)

BBUF:

121002791(MAP3K8)

BGAR:

122938804(MAP3K8)

MUO:	115467485(MAP3K8)

GSH:	117354262(MAP3K8)

DRE:	563727(map3k8)

SRX:	107738976 107749374

SANH:

107665890 107686375

SGH:	107549410 107584407

CCAR:

109096626 109099537

CAUA:

113056113 113111840

CGIB:

127969125 128025254

PTET:

122332144(map3k8)

LROH:

127174075(map3k8)

OMC:	131550508(map3k8)

PPRM:

120471533 120471534

MAMB:

125255242(map3k8)

CIDE:

127523392

MASI:

127422763 127427465

TROS:

130569227(map3k8)

IPU:

108274187

PHYP:

113527715(map3k8)

SMEO:

124388915(map3k8)

TFD:	113662603(map3k8)

AMEX:

103031259(map3k8)

CMAO:

118809321(map3k8)

EEE:	113588627(map3k8)

CHAR:

105897242(map3k8)

TRU:	101069247(map3k8)

TFS:	130514185(map3k8)

TNG:	GSTEN00016563G001

LCO:	104928818(map3k8)

NCC:	104953904(map3k8)

CGOB:

115025450(map3k8)

ELY:	117264380(map3k8)

EFO:	125881579(map3k8)

PLEP:

121960813(map3k8)

SLUC:

116048931(map3k8)

ECRA:

117937733(map3k8)

ESP:	116671912(map3k8)

PFLV:

114549165(map3k8)

GAT:	120811623(map3k8)

PPUG:

119198773(map3k8)

AFB:	129110714(map3k8)

MSAM:

119906521(map3k8)

SCHU:

122866695(map3k8)

CUD:	121527631(map3k8)

ALAT:

119008523(map3k8)

MZE:	101484222(map3k8)

ONL:	100710682(map3k8)

OAU:	116327470(map3k8)

OLA:	101159779(map3k8)

OML:	112151368(map3k8)

XMA:	102235260(map3k8)

XCO:	114137073(map3k8)

XHE:	116711854(map3k8)

PRET:

103482391(map3k8)

GAF:	122824156(map3k8)

CVG:	107085276(map3k8)

CTUL:

119793560(map3k8)

GMU:	124857687(map3k8)

NFU:	107377426(map3k8)

KMR:	108247128(map3k8)

ALIM:

106524835(map3k8)

AOCE:

111571049(map3k8)

MCEP:

124996063(map3k8)

CSEM:

103376862(map3k8)

POV:	109629507(map3k8)

SSEN:

122778030(map3k8)

HHIP:

117753979(map3k8)

HSP:	118098891(map3k8)

LCF:	108894681 108898340

SDU:	111228231(map3k8)

SLAL:

111669238(map3k8)

XGL:	120790247(map3k8)

HCQ:	109514181(map3k8)

SSCV:

125985669

MALB:

109974520(map3k8)

BSPL:

114854157(map3k8)

SASA:

100380500(m3k8) 106578553

STRU:

115153850 115195881

OTW:	112215597(map3k8) 112228040

OMY:	110490026 110535550

OGO:	124016988 124039846

ONE:	115105104 115130447

OKI:	109899545 109908729

SALP:

111953230 111973334

SNH:	120027948 120050434

CCLU:

121549952 121569803

ELS:	105019416(map3k8)

SFM:	108927787(map3k8) 108937580

PKI:	111840193 111850109(map3k8)

AANG:

118226179(map3k8)

LOC:	102695077(map3k8)

PSPA:

121311604 121314104

ARUT:

117399861 117435608

PSEX:

120529757(map3k8)

LCM:	102367513(MAP3K8)

CMK:	103186428(map3k8)

RTP:	109916936(map3k8)

CPLA:

122550070

LERI:

129715114(map3k8)

PTRU:

123498178

HRJ:

124270401

» show all

Reference

PMID:7681591

Authors

Patriotis C, Makris A, Bear SE, Tsichlis PN

Title

Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation.

Journal

Proc Natl Acad Sci U S A 90:2251-5 (1993)
DOI:10.1073/pnas.90.6.2251

Sequence

[rno:116596]

Reference

PMID:18855897

Authors

Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD

Title

MAP3Ks as central regulators of cell fate during development.

Journal

Dev Dyn 237:3102-14 (2008)
DOI:10.1002/dvdy.21750

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (649)   
   KEGG GENES (380)   
   KEGG MGENES (124)   
   RefGene (144)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (664)   

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