K04415                      KO                                     

mitogen-activated protein kinase kinase kinase 8 [EC:]
ko04010  MAPK signaling pathway
ko04620  Toll-like receptor signaling pathway
ko04660  T cell receptor signaling pathway
ko04668  TNF signaling pathway
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
   04668 TNF signaling pathway
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
   04660 T cell receptor signaling pathway
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases  mitogen-activated protein kinase kinase kinase
     K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
   K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8
Other DBs
GO: 0004709
HSA: 1326(MAP3K8)
PTR: 450384(MAP3K8)
PPS: 100978161(MAP3K8)
GGO: 101133328(MAP3K8)
PON: 103889401(MAP3K8)
NLE: 100579516(MAP3K8)
MCC: 696936(MAP3K8)
MCF: 102132599(MAP3K8)
CSAB: 103247459(MAP3K8)
RRO: 104657273(MAP3K8)
RBB: 108528065(MAP3K8)
CJC: 100385107(MAP3K8)
SBQ: 101046566(MAP3K8)
MMU: 26410(Map3k8)
MCAL: 110284809(Map3k8)
MPAH: 110333248(Map3k8)
RNO: 116596(Map3k8)
MUN: 110558401(Map3k8)
CGE: 100759538(Map3k8)
NGI: 103747991(Map3k8)
HGL: 101710286(Map3k8)
CCAN: 109695913(Map3k8)
OCU: 100355566(MAP3K8)
TUP: 102493021(MAP3K8)
CFA: 487085(MAP3K8)
VVP: 112921580(MAP3K8)
AML: 100480593(MAP3K8)
UMR: 103656496(MAP3K8)
UAH: 113244248(MAP3K8)
ORO: 101385184(MAP3K8)
ELK: 111158620
FCA: 101090624(MAP3K8)
PTG: 102961042(MAP3K8)
PPAD: 109276338(MAP3K8)
AJU: 106977317(MAP3K8)
BTA: 535622(MAP3K8)
BOM: 102278856(MAP3K8)
BIU: 109568007(MAP3K8)
BBUB: 102399287(MAP3K8)
CHX: 102188512(MAP3K8)
OAS: 101117094(MAP3K8)
SSC: 100622217(MAP3K8)
CFR: 102518335(MAP3K8)
CDK: 105096296(MAP3K8)
BACU: 103010611(MAP3K8)
LVE: 103070441(MAP3K8)
OOR: 101269575(MAP3K8)
DLE: 111178133(MAP3K8)
PCAD: 102988471(MAP3K8)
ECB: 100063602(MAP3K8)
EPZ: 103541518(MAP3K8)
EAI: 106837968(MAP3K8)
MYB: 102248363(MAP3K8)
MYD: 102775461(MAP3K8)
MMYO: 118677055(MAP3K8)
MNA: 107524427(MAP3K8)
HAI: 109389111(MAP3K8)
DRO: 112316842(MAP3K8)
MMF: 118639002(MAP3K8)
PALE: 102896654(MAP3K8)
RAY: 107518939(MAP3K8)
MJV: 108392181(MAP3K8)
LAV: 100662383(MAP3K8)
TMU: 101343130
MDO: 100018684(MAP3K8)
SHR: 100925633(MAP3K8)
PCW: 110211269(MAP3K8)
OAA: 100076215(MAP3K8)
GGA: 420479(MAP3K8)
MGP: 100541097(MAP3K8)
CJO: 107308936(MAP3K8)
NMEL: 110393429(MAP3K8)
APLA: 101791769(MAP3K8)
ACYG: 106042681(MAP3K8)
TGU: 100230596(MAP3K8)
LSR: 110477339(MAP3K8)
SCAN: 103812752(MAP3K8)
GFR: 102035976(MAP3K8)
FAB: 101819414(MAP3K8)
PHI: 102114163(MAP3K8)
PMAJ: 107200816(MAP3K8)
CCAE: 111924099(MAP3K8)
CCW: 104686470(MAP3K8)
ETL: 114060299(MAP3K8)
FPG: 101921040(MAP3K8)
FCH: 102055830(MAP3K8)
CLV: 102087091(MAP3K8)
EGZ: 104133587(MAP3K8)
NNI: 104022250(MAP3K8)
ACUN: 113476643(MAP3K8)
PADL: 103918240(MAP3K8)
AAM: 106489958(MAP3K8)
ASN: 102387437(MAP3K8)
AMJ: 102566471(MAP3K8)
PSS: 102449623(MAP3K8)
CMY: 102936511(MAP3K8)
CPIC: 101941097(MAP3K8)
ACS: 100562883(map3k8)
PVT: 110082918(MAP3K8)
PBI: 103064348(MAP3K8)
PMUR: 107282828(MAP3K8)
TSR: 106548362(MAP3K8)
PMUA: 114607849(MAP3K8)
GJA: 107107910(MAP3K8)
XLA: 108718772(map3k8.L) 108719849(map3k8.S)
XTR: 100493069(map3k8)
NPR: 108788845(MAP3K8)
DRE: 563727(map3k8)
IPU: 108274187(map3k8)
PHYP: 113527715(map3k8)
AMEX: 103031259(map3k8)
EEE: 113588627(map3k8)
TRU: 101069247(map3k8)
LCO: 104928818(map3k8)
NCC: 104953904(map3k8)
MZE: 101484222(map3k8)
ONL: 100710682(map3k8)
OLA: 101159779(map3k8)
XMA: 102235260(map3k8)
XCO: 114137073(map3k8)
PRET: 103482391(map3k8)
CVG: 107085276(map3k8)
NFU: 107377426(map3k8)
KMR: 108247128(map3k8)
ALIM: 106524835(map3k8)
AOCE: 111571049(map3k8)
CSEM: 103376862(map3k8)
POV: 109629507(map3k8)
LCF: 108894681 108898340(map3k8)
SDU: 111228231(map3k8)
SLAL: 111669238(map3k8)
HCQ: 109514181(map3k8)
MALB: 109974520(map3k8)
SASA: 100380500(m3k8) 106578553
ELS: 105019416(map3k8)
SFM: 108927787(map3k8) 108937580
PKI: 111840193 111850109(map3k8)
LCM: 102367513(MAP3K8)
CMK: 103186428(map3k8)
RTP: 109916936(map3k8)
 » show all
Patriotis C, Makris A, Bear SE, Tsichlis PN
Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation.
Proc Natl Acad Sci U S A 90:2251-5 (1993)
Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD
MAP3Ks as central regulators of cell fate during development.
Dev Dyn 237:3102-14 (2008)

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