KEGG   ORTHOLOGY: K04437
Entry
K04437                      KO                                     
Symbol
FLNA
Name
filamin
Pathway
map04010  MAPK signaling pathway
map04510  Focal adhesion
map05132  Salmonella infection
map05205  Proteoglycans in cancer
Disease
H00270  Periventricular nodular heterotopia
H00292  Hypertrophic cardiomyopathy
H00456  Fronto-otopalatodigital syndromes
H00499  Spondylocarpotarsal synostosis syndrome
H00594  Distal myopathy
H00595  Myofibrillar myopathies
H00894  FG syndrome
H01219  Restrictive cardiomyopathy
H01276  Chronic idiopathic intestinal pseudo-obstruction
H01740  Macrothrombocytopenia
H02048  Larsen syndrome
H02064  Atelosteogenesis type I and III
H02067  Boomerang dysplasia
H02227  Frontometaphyseal dysplasia
H02229  Terminal osseous dysplasia
H02230  X-linked cardiac valvular dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04437  FLNA; filamin
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04437  FLNA; filamin
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K04437  FLNA; filamin
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04437  FLNA; filamin
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K04437  FLNA; filamin
   04147 Exosome
    K04437  FLNA; filamin
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Cross-linking proteins
     K04437  FLNA; filamin
  Intermediate filaments
   Intermediate filament-binding proteins
    K04437  FLNA; filamin
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04437  FLNA; filamin
Genes
HSA: 2316(FLNA) 2317(FLNB) 2318(FLNC)
PTR: 460476(FLNB) 463711(FLNC) 465940(FLNA)
PPS: 100980320(FLNA) 100991254 100992733(FLNB)
GGO: 101130344(FLNB) 101134853(FLNA) 101142657(FLNC)
PON: 100436976(FLNB) 100446579(FLNA) 100447210(FLNC)
NLE: 100584689(FLNC) 100597513(FLNA) 100603369(FLNB)
MCC: 699524(FLNA) 700223(FLNC) 702732(FLNB)
MCF: 102114837(FLNC) 102134285(FLNB) 102138509(FLNA)
CSAB: 103226867(FLNC) 103227804(FLNB) 103232822(FLNA)
CATY: 105585619(FLNB) 105598551(FLNC) 105598710(FLNA)
PANU: 100137263(FLNA) 101014475(FLNB) 101023700
TGE: 112615064(FLNA) 112617214(FLNB) 112620505(FLNC)
RRO: 104660189(FLNB) 104663540(FLNA) 104674436(FLNC)
RBB: 108518765 108518766(FLNA) 108543601(FLNB) 108544858(FLNC)
TFN: 117064366(FLNA) 117073460(FLNC) 117083051(FLNB)
PTEH: 111534210(FLNB) 111550210(FLNC)
CJC: 100385221(FLNA) 100394911(FLNB) 100397531(FLNC)
SBQ: 101030782(FLNC) 101033199(FLNB) 101038946(FLNA)
CSYR: 103260885(FLNB) 103263100(FLNA) 103265960(FLNC)
MMUR: 105867801(FLNA) 105884847(FLNC) 105884913(FLNB)
OGA: 100953848(FLNA) 100958068(FLNC) 100961817(FLNB)
MMU: 192176(Flna) 286940(Flnb) 68794(Flnc)
MCAL: 110287345(Flna) 110297122(Flnc) 110308932(Flnb)
MPAH: 110314123(Flna) 110316290(Flnc) 110325251(Flnb)
RNO: 293860(Flna) 306204(Flnb) 362332(Flnc)
MCOC: 116072674(Flnb) 116086142(Flna) 116098662(Flnc)
MUN: 110554614(Flnb) 110562530(Flna) 110564415(Flnc)
CGE: 100751994(Flnc) 100760050(Flna) 100769967(Flnb)
PLEU: 114680721(Flnb) 114691085(Flnc) 114706253(Flna)
HGL: 101702004(Flna) 101714131(Flnb) 101714775(Flnc)
CPOC: 100722132(Flnb) 100725162(Flna) 100730013(Flnc)
CCAN: 109679690 109684086(Flnc) 109696859(Flna)
DORD: 105981360(Flnb) 105988337(Flnc) 106000147(Flna)
DSP: 122097049(Flna) 122107847(Flnb) 122121776(Flnc)
OCU: 100008760(FLNB) 100328754(FLNA) 100328756(RA_M006_JSM7BED4F) 100353671(FLNC)
OPI: 101524600(FLNA) 101528456(FLNB) 101529389(FLNC)
TUP: 102493536(FLNA) 102497970(FLNB) 102498440(FLNC)
CFA: 481084(FLNA) 482266(FLNC) 484713(FLNB)
VVP: 112909750(FLNB) 112911473(FLNA) 112928910(FLNC)
VLG: 121474725(FLNC) 121482823(FLNA) 121494350(FLNB)
AML: 100467791(FLNA) 100475857(FLNC) 100481308(FLNB)
UMR: 103674200(FLNB) 103676641(FLNC) 103679686(FLNA)
UAH: 113247826(FLNA) 113257012(FLNB) 113263925(FLNC)
UAR: 123787808(FLNA) 123788968(FLNC) 123798792(FLNB)
MPUF: 101681544(FLNB) 101689515(FLNA) 101692958(FLNC)
ORO: 101380560(FLNA) 101382948(FLNB) 101383660(FLNC)
EJU: 114201601(FLNA) 114210621(FLNC) 114214590(FLNB)
ZCA: 113911761(FLNC) 113916413(FLNB) 113930660(FLNA)
MLX: 118005192(FLNB) 118014658(FLNA) 118021061(FLNC)
FCA: 101081210(FLNC) 101082637(FLNA) 101098612(FLNB)
PYU: 121016805(FLNB) 121025062(FLNA) 121028360(FLNC)
PBG: 122476821(FLNA) 122487364(FLNB) 122488235(FLNC)
PTG: 102951673(FLNB) 102958609(FLNC) 102969406(FLNA)
PPAD: 109259850(FLNA) 109268963(FLNC) 109279138(FLNB)
AJU: 106968844(FLNB) 106973900(FLNC) 106989714(FLNA)
HHV: 120227474(FLNA) 120238632(FLNB) 120238724(FLNC)
BTA: 281165(FLNA) 528415(FLNC) 613533(FLNB)
BOM: 102265714(FLNB) 102281567(FLNA) 102287936(FLNC)
BIU: 109555118(FLNA) 109557606(FLNC) 109576011(FLNB)
BBUB: 102398881(FLNC) 102403050(FLNA) 102411216(FLNB)
CHX: 102170485(FLNC) 102176601(FLNA) 102187630(FLNB)
OAS: 101104655(FLNC) 101120390(FLNA) 101123330(FLNB)
ODA: 120867967(FLNB) 120877330(FLNC) 120881795(FLNA)
CCAD: 122424824(FLNB) 122434434(FLNA) 122438618(FLNC)
SSC: 100514491(FLNB) 100518997(FLNC) 733585(FLNA)
CFR: 102514709(FLNA) 102515088(FLNB) 102522311(FLNC)
CBAI: 105063098(FLNC) 105076064(FLNA) 105079567(FLNB)
CDK: 105085371(FLNC) 105089800(FLNB) 105098720(FLNA)
VPC: 102539882(FLNC) 102543963(FLNA) 102545489(FLNB)
BACU: 103000025(FLNA) 103001285(FLNC) 103018177(FLNB)
LVE: 103070633(FLNA) 103082555(FLNB) 103085481(FLNC)
OOR: 101275748(FLNA) 101277589(FLNC) 101285072(FLNB)
DLE: 111170584(FLNA) 111174250(FLNB) 111178654(FLNC)
PCAD: 102987028(FLNB) 102988864(FLNA) 102994181(FLNC)
PSIU: 116747906(FLNA) 116759097(FLNC) 116761657(FLNB)
ECB: 100057963(FLNB) 100058256(FLNA) 100071760(FLNC)
EAI: 106825616(FLNA) 106839532(FLNC) 106848649(FLNB)
MYB: 102246018(FLNC) 102255293(FLNB) 102257802(FLNA)
MYD: 102756703(FLNC) 102761579(FLNB) 102764268(FLNA)
MMYO: 118653342(FLNA) 118666430(FLNC) 118667944(FLNB)
MLF: 102423871(FLNA) 102430780(FLNB) 102437988(FLNC)
MNA: 107531471(FLNB) 107537382(FLNC) 107545550(FLNA)
PKL: 118706399(FLNA) 118712554(FLNC) 118715079(FLNB)
HAI: 109377338(FLNA) 109384635(FLNC) 109388247(FLNB)
DRO: 112296269(FLNA) 112299880(FLNC) 112301177(FLNB)
SHON: 118983379(FLNB) 118989170(FLNC)
AJM: 119043387(FLNB) 119051411(FLNA) 119065637(FLNC)
PDIC: 114501505(FLNB) 114504617(FLNA) 114507257(FLNC)
PHAS: 123814585(FLNB) 123823135(FLNA) 123829664(FLNC)
MMF: 118619908(FLNC) 118633021(FLNB) 118636593(FLNA)
RFQ: 117018159(FLNC) 117020697(FLNA) 117037093(FLNB)
PALE: 102887099(FLNB) 102889996(FLNA) 102894137(FLNC)
PGIG: 120599490(FLNB) 120601221(FLNC)
PVP: 105290185(FLNC) 105299870(FLNB) 105302494(FLNA)
RAY: 107499467(FLNA) 107503384(FLNB) 107512795(FLNC)
MJV: 108387997(FLNA) 108392169(FLNC) 108394917(FLNB)
TOD: 119230427(FLNB) 119245792(FLNA) 119246559(FLNC)
SARA: 101536966(FLNB) 101542229(FLNC) 101546274(FLNA)
LAV: 100655159(FLNB) 100666153(FLNC) 100674763(FLNA)
DNM: 101415610(FLNA) 101425135(FLNB) 101428317(FLNC)
MDO: 100014156(FLNB) 100014995(FLNC) 100617907(FLNA)
SHR: 100923582(FLNB) 100924343(FLNA) 100932639(FLNC)
PCW: 110195967(FLNB) 110200343(FLNA) 110219227(FLNC)
OAA: 100077046(FLNA) 100078338(FLNC) 100084462(FLNB)
GGA: 378913(FLNB) 395260(FLNC) 395261(FLNA)
PCOC: 116238340(FLNB)
MGP: 100549125(FLNB)
NMEL: 110404616(FLNB)
APLA: 101796074(FLNB)
ACYG: 106037975(FLNB) 106048920(FLNC)
AFUL: 116493195(FLNB)
TGU: 100224625(FLNC) 100230709(FLNB)
LSR: 110471636(FLNB) 110479584(FLNC) 110482785
SCAN: 103817009(FLNB) 103822494(FLNC)
PMOA: 120500092(FLNC) 120509322 120514040(FLNB)
OTC: 121337180(FLNC) 121347123(FLNB)
PRUF: 121349476(FLNB) 121355073(FLNC)
GFR: 102038057(FLNB) 102039906(FLNC)
FAB: 101807613(FLNC) 101815478(FLNB)
PHI: 102102293(FLNA) 102109930(FLNC) 102113738(FLNB)
PMAJ: 107198769(FLNC) 107210334(FLNB)
CCAE: 111923226 111935101(FLNB)
CCW: 104683467(FLNB) 120411918(FLNC)
ZAB: 102065396(FLNB)
FPG: 101914782(FLNB) 101921248(FLNC)
FCH: 102048385(FLNC) 102055640(FLNB)
CLV: 102090285 102090492(FLNB)
EGZ: 104126644(FLNB)
ACUN: 113484731(FLNB)
TALA: 104366606(FLNB)
PADL: 103915476(FLNB)
ACHC: 115341642(FLNC) 115353823(FLNB)
AROW: 112963265 112972407(FLNB)
NPD: 112956756 112958782(FLNB)
DNE: 112981008(FLNB)
ASN: 102367807(FLNC) 102368306(FLNB) 102370975(FLNA)
AMJ: 102570042(FLNB) 102572603(FLNC) 102573539(FLNA)
CPOO: 109311301(FLNB)
GGN: 109289080(FLNB)
PSS: 102454001(FLNB)
CMY: 102942474(FLNC) 102947590(FLNB)
CPIC: 101935574(FLNA) 101948714(FLNC) 101953493(FLNB)
TST: 117873501(FLNC) 117881056(FLNB)
CABI: 116833534 116837161(FLNB) 116837626(FLNC)
MRV: 120388642(FLNA) 120395515(FLNC) 120409129(FLNB)
ACS: 100555896(flnc) 100557416(flnb) 100559302 100562207(flna)
PVT: 110078614(FLNA) 110082409(FLNB) 110089402(FLNC)
SUND: 121921240(FLNA) 121923878(FLNB) 121930858(FLNC)
PBI: 103050411(FLNC) 103063627(FLNA) 103064197(FLNB)
PMUR: 107286711(FLNA) 107287783(FLNB) 107298381
PGUT: 117656232 117675501(FLNA) 117676694(FLNB)
VKO: 123023084(FLNC) 123030057(FLNA) 123034194(FLNB)
PMUA: 114587359(FLNA) 114591708(FLNB) 114606020(FLNC)
ZVI: 118075210(FLNA) 118080725(FLNB) 118091488(FLNC)
XTR: 100329116(flnc) 100485165(flnb) 779840(flna)
NPR: 108790450(FLNA) 108791862(FLNB) 108794883(FLNC)
RTEM: 120913186(FLNA) 120931618(FLNC) 120945226(FLNB)
BBUF: 120977309(FLNA) 120978600(FLNB) 120985258(FLNC)
BGAR: 122919600(FLNA) 122927771(FLNC) 122943041 122944052(FLNB)
DRE: 100048921(flnca) 100534866(flnb) 562529(flna) 563023(flnb) 570288(flncb)
PPRM: 120463492(flnb) 120468057(flnca) 120473355(flna) 120476795(flncb) 120480447
SMEO: 124386424(flnca) 124400844(flncb) 124402516
ELS: 105013504 105013563(flnb) 105021804(flnc)
LOC: 102692617(flnc) 102693550(flnb) 102695708(flna)
LCM: 102345455(FLNA) 102352444(FLNC) 102360310(FLNB)
CMK: 103190015(flncb) 103190036
DME: Dmel_CG30092(jbug) Dmel_CG3937(cher) Dmel_CG5984(CG5984)
DSE: 6616793
DSI: Dsimw501_GD15083(Dsim_GD15083) Dsimw501_GD20251(Dsim_GD20251) Dsimw501_GD25106(Dsim_GD25106)
DVI: 6632599
BOD: 106614759
CNS: 116338879
BBIF: 117209458
MGEN: 117223320
SOY: 115876898
PRAP: 111000535
DCI: 103516441
CLEC: 106661376
HHAL: 106677963
PCHN: 125034176
CEL: CELE_C23F12.1(fln-2) CELE_Y66H1B.2(fln-1)
CBR: CBG_10541 CBG_16142(Cbr-fln-2.1)
BMY: BM_BM2319(Bma-fln-2) BM_BM6989(Bma-fln-1.2)
DDI: DDB_G0269100(abpC)
DFA: DFA_01474(abpC)
EHI: EHI_104630(3.t00014)
NGR: NAEGRDRAFT_80016(AM3)
 » show all
Reference
  Authors
Adams M, Simms RJ, Abdelhamed Z, Dawe HR, Szymanska K, Logan CV, Wheway G, Pitt E, Gull K, Knowles MA, Blair E, Cross SH, Sayer JA, Johnson CA
  Title
A meckelin-filamin A interaction mediates ciliogenesis.
  Journal
Hum Mol Genet 21:1272-86 (2012)
DOI:10.1093/hmg/ddr557
  Sequence
[hsa:2316] [mmu:192176]

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