KEGG   ORTHOLOGY: K04438
Entry
K04438                      KO                                     
Symbol
CRK, CRKII
Name
C-crk adapter molecule crk
Pathway
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04015  Rap1 signaling pathway
map04062  Chemokine signaling pathway
map04510  Focal adhesion
map04666  Fc gamma R-mediated phagocytosis
map04722  Neurotrophin signaling pathway
map04810  Regulation of actin cytoskeleton
map04910  Insulin signaling pathway
map04935  Growth hormone synthesis, secretion and action
map05100  Bacterial invasion of epithelial cells
map05131  Shigellosis
map05135  Yersinia infection
map05163  Human cytomegalovirus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05206  MicroRNAs in cancer
map05211  Renal cell carcinoma
map05220  Chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04438  CRK, CRKII; C-crk adapter molecule crk
   04012 ErbB signaling pathway
    K04438  CRK, CRKII; C-crk adapter molecule crk
   04015 Rap1 signaling pathway
    K04438  CRK, CRKII; C-crk adapter molecule crk
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04438  CRK, CRKII; C-crk adapter molecule crk
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04438  CRK, CRKII; C-crk adapter molecule crk
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K04438  CRK, CRKII; C-crk adapter molecule crk
   04062 Chemokine signaling pathway
    K04438  CRK, CRKII; C-crk adapter molecule crk
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04438  CRK, CRKII; C-crk adapter molecule crk
   04935 Growth hormone synthesis, secretion and action
    K04438  CRK, CRKII; C-crk adapter molecule crk
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04438  CRK, CRKII; C-crk adapter molecule crk
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04438  CRK, CRKII; C-crk adapter molecule crk
   05206 MicroRNAs in cancer
    K04438  CRK, CRKII; C-crk adapter molecule crk
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    K04438  CRK, CRKII; C-crk adapter molecule crk
   05211 Renal cell carcinoma
    K04438  CRK, CRKII; C-crk adapter molecule crk
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04438  CRK, CRKII; C-crk adapter molecule crk
   05163 Human cytomegalovirus infection
    K04438  CRK, CRKII; C-crk adapter molecule crk
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K04438  CRK, CRKII; C-crk adapter molecule crk
   05135 Yersinia infection
    K04438  CRK, CRKII; C-crk adapter molecule crk
   05100 Bacterial invasion of epithelial cells
    K04438  CRK, CRKII; C-crk adapter molecule crk
Other DBs
GO: 0005070
Genes
HSA: 1398(CRK) 1399(CRKL)
PTR: 107970369(CRKL) 747142(CRK)
PPS: 100973798(CRKL) 100976587(CRK)
GGO: 101127403(CRKL)
PON: 100443298(CRKL) 100452410(CRK)
NLE: 100595820(CRKL) 100601245(CRK)
MCC: 696584(CRKL) 701185(CRK)
MCF: 101865065(CRK) 102122623(CRKL)
CSAB: 103222955(CRKL) 103242119(CRK)
CATY: 105584307(CRK) 105598246(CRKL)
PANU: 101007122(CRKL) 101011160(CRK)
TGE: 112609430(CRK) 112632798(CRKL)
RRO: 104666852(CRKL) 104670311(CRK)
RBB: 108524318(CRK) 108536084(CRKL)
TFN: 117067958(CRK) 117096632(CRKL)
PTEH: 111530638(CRK) 111530661(CRKL)
CJC: 100390206(CRKL) 100399916(CRK)
SBQ: 101029260(CRK) 101051048(CRKL)
CSYR: 103271341(CRKL) 103275951(CRK)
MMUR: 105857910(CRK) 105877776(CRKL)
OGA: 100951208(CRKL) 100958636(CRK)
MMU: 12928(Crk) 12929(Crkl)
MCAL: 110305233(Crk) 110311596(Crkl)
MPAH: 110329586(Crkl) 110331717(Crk)
RNO: 287942(Crkl) 54245(Crk)
MCOC: 116078814(Crk) 116085656(Crkl)
MUN: 110547367(Crk) 110559213(Crkl)
CGE: 100752014(Crkl) 100762827(Crk)
PLEU: 114682714(Crkl) 114691441(Crk) 119088838
NGI: 103730505(Crk) 103741458(Crkl)
HGL: 101705695(Crkl) 101717585(Crk)
CPOC: 100718486(Crk) 100723968(Crkl)
CCAN: 109682600(Crk) 109684371(Crkl)
DORD: 105985676(Crk) 105997164(Crkl)
DSP: 122095902(Crkl) 122102190(Crk)
OCU: 100342327(CRKL) 100358552(CRK)
OPI: 101519209(CRKL) 101527001(CRK)
TUP: 102482865(CRKL) 102486599(CRK)
CFA: 100684309(CRK) 608125(CRKL)
VVP: 112907448(CRKL) 112933059(CRK)
VLG: 121473371(CRK) 121475542(CRKL)
AML: 100466609(CRKL) 100467322(CRK)
UMR: 103667390(CRK) 103669230(CRKL)
UAH: 113247057(CRKL) 113269112(CRK)
UAR: 123776898(CRK) 123795650(CRKL)
MPUF: 101678913(CRKL) 101683736(CRK)
ORO: 101369015(CRKL) 101384062(CRK)
EJU: 114201951(CRKL) 114213901(CRK)
ZCA: 113912750(CRKL) 113939500(CRK)
MLX: 117999812(CRKL) 118025226(CRK)
FCA: 101084908(CRKL) 101086100(CRK)
PYU: 121017297(CRK) 121023034(CRKL)
PBG: 122470502(CRKL) 122485124(CRK)
PTG: 102956621(CRK) 102957241(CRKL)
PPAD: 109255155(CRK) 109259695(CRKL)
AJU: 106983188(CRK) 106989988(CRKL)
HHV: 120238810(CRKL) 120245519(CRK)
BTA: 512841(CRK) 518180(CRKL)
BOM: 102277025(CRKL)
BIU: 109570977(CRKL) 109573847(CRK)
BBUB: 102389483(CRKL) 102397411(CRK)
CHX: 102174330(CRK) 102175206(CRKL)
OAS: 101115380(CRK) 101117537(CRKL)
ODA: 120866233(CRK) 120871323(CRKL)
CCAD: 122447839(CRK) 122455174(CRKL)
SSC: 100192444(CRK) 100525363(CRKL)
CFR: 102511476(CRK) 102516584(CRKL)
CBAI: 105070566(CRKL) 105071519(CRK)
CDK: 105088123(CRK) 105095221(CRKL)
VPC: 102533491(CRKL) 102539935(CRK)
BACU: 103001411(CRK) 103020871(CRKL)
LVE: 103087905(CRK) 103090463(CRKL)
OOR: 101270546(CRKL) 101284062(CRK)
DLE: 111162913(CRKL) 111185687(CRK)
PCAD: 102990100(CRKL) 102994214(CRK)
PSIU: 116738862(CRKL) 116745432(CRK)
ECB: 100050855(CRKL) 100072356(CRK)
EPZ: 103543614(CRKL) 103547531(CRK)
EAI: 106822010(CRK) 106848274(CRKL)
MYB: 102248665(CRKL) 102252934(CRK) 102253195
MYD: 102758195(CRK) 102761799(CRKL)
MMYO: 118671896(CRK) 118678200(CRKL)
MLF: 102420269(CRKL) 102440736(CRK)
MNA: 107530545(CRKL) 107535608(CRK)
PKL: 118702581(CRK) 118725386(CRKL)
HAI: 109376239(CRKL) 109386906(CRK)
DRO: 112301790(CRKL) 112308445(CRK)
SHON: 119001789(CRKL) 119003414(CRK)
AJM: 119038902(CRKL) 119040664(CRK)
PDIC: 114502362(CRK) 114509191(CRKL)
PHAS: 123806597(CRKL) 123817321(CRK)
MMF: 118633933(CRK) 118639914(CRKL)
RFQ: 117012945(CRK) 117017506(CRKL)
PALE: 102885553(CRK) 102898080(CRKL)
PVP: 105289311(CRKL) 105291866(CRK)
RAY: 107497859(CRKL) 107507729(CRK)
MJV: 108394533(CRK) 108408988(CRKL)
TOD: 119230819(CRK) 119234869(CRKL)
SARA: 101543637(CRK) 101547306(CRKL)
LAV: 100659273(CRK) 100662046(CRKL)
DNM: 101424990(CRK) 101434926(CRKL)
MDO: 100012317(CRK) 100015312(CRKL)
GAS: 123232459(CRKL) 123246812(CRK)
SHR: 100923581(CRKL) 116423462(CRK)
PCW: 110215191(CRKL) 110222129(CRK)
OAA: 100076081(CRKL) 100092854(CRK)
GGA: 107054794(CRK) 416939(CRKL)
PCOC: 116228099(CRK) 116228476(CRKL)
MGP: 100538907(CRKL) 100550512(CRK)
CJO: 107321452(CRKL) 107322427(CRK)
NMEL: 110406265(CRKL) 110407619(CRK)
APLA: 101793961(CRK) 101804570(CRKL)
ACYG: 106031307(CRKL) 106041393(CRK)
AFUL: 116496037(CRKL) 116497176(CRK)
TGU: 100222846(CRKL) 100230536(CRK)
LSR: 110481320(CRKL) 110481994(CRK)
SCAN: 103818004(CRKL) 103820104(CRK)
PMOA: 120507678(CRK) 120510250(CRKL)
OTC: 121344397(CRKL) 121345696(CRK)
PRUF: 121361767(CRK) 121364856(CRKL)
GFR: 102039553(CRKL) 102040219(CRK)
FAB: 101807715(CRK) 101808629(CRKL)
PHI: 102102139(CRK) 102102631(CRKL)
PMAJ: 107211597(CRKL) 107212927(CRK)
CCAE: 111936642(CRKL) 111937736(CRK)
CCW: 104688581(CRKL) 104691074(CRK)
ETL: 114060458(CRK) 114061504(CRKL)
ZAB: 102069426(CRKL) 102075146(CRK)
FPG: 101911148(CRKL)
FCH: 102048492(CRK) 102051164(CRKL)
CLV: 102091247(CRK) 102092831(CRKL)
EGZ: 104130098(CRKL) 104131823(CRK)
NNI: 104011434(CRKL) 104016008(CRK)
ACUN: 113486127(CRKL) 113487332(CRK)
TALA: 104356823(CRK) 104359857(CRKL)
PADL: 103922609(CRKL) 103924846(CRK)
ACHC: 115346006(CRKL) 115346773(CRK)
AAM: 106486247(CRKL) 106487715(CRK)
AROW: 112960674(CRK) 112970583(CRKL)
NPD: 112945911(CRKL) 112954570(CRK)
DNE: 112986346(CRK) 112994640(CRKL)
ASN: 102371723(CRKL) 102377791(CRK)
AMJ: 102557881(CRKL) 102559298(CRK)
CPOO: 109312825(CRKL) 109317278(CRK)
GGN: 109290396(CRKL) 109293430(CRK)
PSS: 102445892(CRKL) 102456320 102457830(CRK)
CMY: 102932780 102942619(CRKL) 102944956(CRK)
CPIC: 101935800(CRK) 101936589(CRKL) 101939540
TST: 117867301(CRK) 117888021(CRKL)
CABI: 116829437(CRK) 116837099(CRKL)
MRV: 120385987(CRKL) 120387321(CRK) 120402850
PVT: 110081775 110081994(CRKL) 110084280(CRK)
SUND: 121917039(CRK) 121917981(CRKL) 121932763
TSR: 106543399(CRK) 106546560 106554137(CRKL)
PGUT: 117666753 117669767(CRK) 117677953(CRKL)
VKO: 123023691(CRK) 123030292(CRKL) 123032314
PMUA: 114581979 114585132(CRK) 114586239(CRKL)
ZVI: 118076480(CRKL) 118094387 118096728(CRK)
GJA: 107108519(CRKL) 107117460 107119408(CRK)
STOW: 125442799(CRKL) 125444678 125445863(CRK)
XLA: 108709342(crk.S) 398951(crk.L) 414569(crkl.S) 447419(crkl.L)
XTR: 394657(crkl) 448023(crk)
NPR: 108801710(CRK) 108802369(CRKL)
RTEM: 120927613(CRK) 120936703(CRKL)
BBUF: 120988744(CRKL) 120994747(CRK)
BGAR: 122922790(CRK) 122934259(CRKL)
DRE: 445234(crk) 556443(crkl)
PPRM: 120478646(crk) 120490723(crkl)
MAMB: 125248369(crk) 125252400(crkl)
IPU: 108260055 108278187(crk) 108278795(crkl)
PHYP: 113531504 113532494(crk) 113543132(crkl)
SMEO: 124379546 124394717(crk) 124398023(crkl)
TFD: 113634145 113638642(crkl) 113643500(crk)
AMEX: 103035530(crk) 103038949 103044277(crkl)
TRU: 101065989 101078357(crkl) 101079298(crk)
NCC: 104945371(crkl)
ELY: 117247387 117260317(crk) 117269677(crkl)
SLUC: 116038939(crk) 116048914(crkl) 116056025
ECRA: 117941715(crk) 117955511 117959323(crkl)
GAT: 120821629 120826481(crk) 120831943(crkl)
PPUG: 119209207(crk) 119215623 119226598(crkl)
MSAM: 119883403(crk) 119895044 119914247(crkl)
CUD: 121518573(crk) 121525084(crkl)
OAU: 116323713(crk) 116326373 116335173(crkl)
OLA: 101157634(crk) 101164077(crkl) 110016423
OML: 112143053 112149634(crk) 112163343(crkl)
XMA: 102218757 102219651(crkl) 102236416(crk)
XCO: 114133190(crk) 114149532(crkl) 114152956
XHE: 116724304(crkl) 116728498 116737332(crk)
PRET: 103473580(crkl) 103474879(crk) 103476349
PMEI: 106911536 106914368(crk) 106918296(crkl)
GAF: 122819530(crkl) 122832221(crk) 122845411
CVG: 107081852 107090966(crkl) 107094348(crk)
CTUL: 119775452(crk) 119776625(crkl) 119795566
GMU: 124872914(crkl) 124876940 124884098(crk)
KMR: 108232740(crkl) 108246548(crk) 108248149
SSEN: 122758420(crkl) 122773063(crk) 122780034
HHIP: 117771643(crkl) 117772555(crk) 117774549
LCF: 108879264(crkl) 108888177(crk) 108891917
XGL: 120791860(crk) 120803007 120806310(crkl)
BPEC: 110160359(crk) 110166352(crkl)
LOC: 102683891 102695616(crkl)
CMK: 103174463(crk)
RTP: 109916685(crk) 109923915(crkl)
SCLV: 120343516
APLC: 110984023
SKO: 102803663
DME: Dmel_CG1587(Crk)
DER: 6555868
DSE: 6620290
DSI: Dsimw501_GD14194(Dsim_GD14194)
DAN: 6506057
DSR: 110185430
DPE: 6602021
DMN: 108164427
DWI: 6650793
DGR: 6570259
DAZ: 108617855
DNV: 108658044
DHE: 111598393
DVI: 6636188
CCAT: 101453442
BOD: 106621829
MDE: 101900499
SCAC: 106084308
ACOZ: 120959958
AARA: 120900086
AAG: 5568068
CPII: 120427095
CNS: 116344096
AME: 409578
ACER: 108002260
ALAB: 122719456
BIM: 100744152
BBIF: 117217268
BVK: 117243019
BVAN: 117155226
BTER: 100651298
BPYO: 122575019
CCAL: 108629748
OBB: 114873468
MGEN: 117226334
NMEA: 116427129
CGIG: 122396105
SOC: 105201164
MPHA: 105839206
AEC: 105146358
ACEP: 105627820
PBAR: 105426254
VEM: 105561554
HST: 105190213
DQU: 106747621
CFO: 105252989
FEX: 115243939
LHU: 105671279
PGC: 109855779
OBO: 105274618
PCF: 106789445
PFUC: 122522609
VPS: 122637773
NVI: 100119269
CSOL: 105361327
TPRE: 106649776
MDL: 103576624
FAS: 105263809
DAM: 107039881
AGIF: 122852675
CCIN: 107271161
TCA: 658768
DPA: 109532920
SOY: 115876850
ATD: 109609462
CSET: 123322095
AGB: 108916486
LDC: 111503082
APLN: 108739298
PPYR: 116165982
OTU: 111425164
BMOR: 101745959
BMAN: 114251694
MSEX: 115449639
BANY: 112056202
PMAC: 106711277
PPOT: 106111361
PXU: 106123183
PRAP: 111001145
ZCE: 119837563
HAW: 110372661
TNL: 113497932
SLIU: 111364411
OFU: 114362204
PXY: 105386226
API: 100164632
AGS: 114128960
RMD: 113559781
CLEC: 106672731
HHAL: 106685333
NLU: 120354314
FOC: 113209363
ZNE: 110834965
CSEC: 111864465
DMK: 116921290
PVM: 113817105
PJA: 122256598
PCHN: 125029799
HAME: 121859259
PCLA: 123768966
PTRU: 123502906
HAZT: 108679068
EAF: 111707844
LSM: 121128555
DSV: 119433087
RSAN: 119403999
RMP: 119181100
VDE: 111250459
VJA: 111270105
TUT: 107360227
DPTE: 113794118
DFR: 124490131
PTEP: 107447848
SDM: 118190052
CEL: CELE_Y41D4B.13(ced-2)
CBR: CBG_13568(Cbr-ced-2)
BMY: BM_BM6517(Bma-ced-2)
TSP: Tsp_06038
PCAN: 112559020
BGT: 106073261
GAE: 121382161
HRF: 124116844
HRJ: 124267677
CRG: 105330355
MYI: 110450258
PMAX: 117336014
OBI: 106869162
OSN: 115211886
LAK: 106154936
EGL: EGR_02997
NVE: 5510062
ADF: 107340353
AMIL: 114955073
PDAM: 113664999
SPIS: 111328511
XEN: 124453046
AQU: 100636612
 » show all
Reference
  Authors
Feller SM
  Title
Crk family adaptors-signalling complex formation and biological roles.
  Journal
Oncogene 20:6348-71 (2001)
DOI:10.1038/sj.onc.1204779
Reference
PMID:1630456
  Authors
Matsuda M, Tanaka S, Nagata S, Kojima A, Kurata T, Shibuya M
  Title
Two species of human CRK cDNA encode proteins with distinct biological activities.
  Journal
Mol Cell Biol 12:3482-9 (1992)
DOI:10.1128/MCB.12.8.3482
  Sequence
[hsa:1398]

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