KEGG ORTHOLOGY: K04446

ORTHOLOGY: K04446

Entry

K04446                      KO

Symbol

NFATC1, NFAT2, NFATC

Name

nuclear factor of activated T-cells, cytoplasmic 1

Pathway

map04010

MAPK signaling pathway

map04020

Calcium signaling pathway

map04022

cGMP-PKG signaling pathway

map04024

cAMP signaling pathway

map04148

Efferocytosis

map04218

Cellular senescence

map04310

Wnt signaling pathway

map04380

Osteoclast differentiation

map04625

C-type lectin receptor signaling pathway

map04650

Natural killer cell mediated cytotoxicity

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map04662

B cell receptor signaling pathway

map04921

Oxytocin signaling pathway

map04933

AGE-RAGE signaling pathway in diabetic complications

map05135

Yersinia infection

map05161

Hepatitis B

map05163

Human cytomegalovirus infection

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05170

Human immunodeficiency virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05321

Inflammatory bowel disease

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   04310 Wnt signaling pathway
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   04020 Calcium signaling pathway
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   04024 cAMP signaling pathway
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   04022 cGMP-PKG signaling pathway
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
  09143 Cell growth and death
   04218 Cellular senescence
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   04650 Natural killer cell mediated cytotoxicity
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   04660 T cell receptor signaling pathway
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   04658 Th1 and Th2 cell differentiation
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   04659 Th17 cell differentiation
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   04662 B cell receptor signaling pathway
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   05170 Human immunodeficiency virus 1 infection
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   05161 Hepatitis B
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   05163 Human cytomegalovirus infection
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
  09163 Immune disease
   05321 Inflammatory bowel disease
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
Transcription factors [BR:ko03000]
Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) NF-AT
    K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1

Genes

HSA:	4772(NFATC1)

PTR:	455485(NFATC1)

PPS:	100974281(NFATC1)

GGO:	101147593(NFATC1)

PON:	100436209(NFATC1)

PPYG:

129018951(NFATC1)

NLE:	100598995(NFATC1)

HMH:	116468452(NFATC1)

SSYN:

129491438(NFATC1)

MCC:	698089(NFATC1)

MCF:	102133233(NFATC1)

MTHB:

126941512

MNI:	105489353(NFATC1)

CSAB:

103244028(NFATC1)

CATY:

105596502(NFATC1)

PANU:

100997330(NFATC1)

MLEU:

105536518(NFATC1)

RRO:	104667797(NFATC1)

RBB:	108525049(NFATC1)

TFN:	117064215(NFATC1)

PTEH:

111551042(NFATC1)

CANG:

105506313(NFATC1)

CJC:	100405187(NFATC1)

CIMI:

108286599(NFATC1)

ANAN:

105731635(NFATC1)

CSYR:

103266669(NFATC1)

MMUR:

105884723(NFATC1)

LCAT:

123621580(NFATC1)

PCOQ:

105821171(NFATC1)

OGA:	100940498(NFATC1)

MMU:	18018(Nfatc1)

MCAL:

110284760(Nfatc1)

MPAH:

110333017(Nfatc1)

RNO:	100361818(Nfatc1)

MCOC:

116087416(Nfatc1)

ANU:	117719854(Nfatc1)

MUN:	110550273(Nfatc1)

CGE:	100764851(Nfatc1)

MAUA:

101844781(Nfatc1)

PROB:

127235061(Nfatc1)

PLEU:

114694913(Nfatc1)

MORG:

121440145(Nfatc1)

MFOT:

126515387

AAMP:

119814795(Nfatc1)

NGI:	103748128(Nfatc1)

HGL:	101697946(Nfatc1)

CPOC:

100730044(Nfatc1)

CCAN:

109686431(Nfatc1)

DORD:

105992999(Nfatc1)

DSP:	122097750(Nfatc1)

PLOP:

125363835(Nfatc1)

NCAR:

124965416

MMMA:

107153998(Nfatc1)

OCU:

100352378

OPI:	101518851(NFATC1)

TUP:	102481120(NFATC1)

GVR:	103585050(NFATC1)

CFA:	483925(NFATC1)

CLUD:

112643925(NFATC1)

VVP:	112919341(NFATC1)

VLG:	121481950(NFATC1)

NPO:	129495445(NFATC1) 129514485

AML:	100470861(NFATC1)

UMR:	103658473(NFATC1)

UAH:	113253544(NFATC1)

UAR:	123787495(NFATC1)

ELK:

111154209

MPUF:

101673044(NFATC1)

MNP:	132023704(NFATC1)

MLK:	131810821(NFATC1)

NVS:	122902796(NFATC1)

ORO:	101385449(NFATC1)

EJU:	114202451(NFATC1)

ZCA:	113926172(NFATC1)

MLX:	118004651(NFATC1)

NSU:	110576910(NFATC1)

FCA:	101101259(NFATC1)

PYU:	121033234(NFATC1)

PBG:	122470886(NFATC1)

PVIV:

125148866(NFATC1)

LRUF:

124516980

PPAD:

109251747(NFATC1)

PUC:

125914768

AJU:

106977679

HHV:	120240942(NFATC1)

BTA:	511224(NFATC1)

BOM:	102285474 102286049

BIU:	109577750(NFATC1)

BBUB:

102413480(NFATC1)

BBIS:

104999550(NFATC1)

CHX:	102188180(NFATC1)

OAS:	101108097(NFATC1)

BTAX:

128067290(NFATC1)

ODA:	120880955(NFATC1)

CCAD:

122425388(NFATC1)

MREE:

136166227(NFATC1)

MBEZ:

129549652(NFATC1)

SSC:	397318(NFATC1)

CFR:	102523589(NFATC1)

CBAI:

105069046(NFATC1)

CDK:	105103850(NFATC1)

VPC:	102543250(NFATC1)

BACU:

102999338(NFATC1)

BMUS:

118879837(NFATC1)

LVE:	103081110(NFATC1)

OOR:	101283533(NFATC1)

DLE:	111167284(NFATC1)

PCAD:

102988344 114484431(NFATC1)

PSIU:

116765202(NFATC1)

NASI:

112406136(NFATC1)

ECB:	100065378(NFATC1)

EPZ:

103563745

EAI:	106834926(NFATC1)

MYB:	102245976(NFATC1)

MYD:	102763205(NFATC1)

MMYO:

118663810(NFATC1)

MLF:	102428507(NFATC1)

MDT:	132239710(NFATC1)

PKL:	118707578(NFATC1)

EFUS:

103304832(NFATC1)

MNA:	107541561(NFATC1)

DRO:	112322654(NFATC1)

SHON:

118979809(NFATC1)

AJM:	119051373(NFATC1)

PDIC:

114506388(NFATC1)

PHAS:

123826011(NFATC1)

MMF:	118618649(NFATC1)

PPAM:

129078786(NFATC1)

HAI:	109383198(NFATC1)

RFQ:	117011750(NFATC1)

PALE:

102880857(NFATC1)

PGIG:

120583821(NFATC1)

PVP:	105303020(NFATC1)

RAY:	107500851(NFATC1)

MJV:	108385943(NFATC1)

TOD:	119242960(NFATC1)

SARA:

101554287(NFATC1)

SETR:

126020311(NFATC1)

LAV:	100655623(NFATC1)

TMU:

101359059

ETF:	101641174(NFATC1)

DNM:	101427882(NFATC1)

MDO:	100023153(NFATC1)

GAS:	123239917(NFATC1)

SHR:	100926364(NFATC1)

AFZ:

127544078

PCW:	110208752(NFATC1)

TVP:	118852739(NFATC1)

OAA:	100078396(NFATC1)

GGA:	420815(NFATC1)

PCOC:

116239690(NFATC1)

MGP:	100545778(NFATC1)

CJO:	107309755(NFATC1)

TPAI:

128087895(NFATC1)

LMUT:

125690581(NFATC1)

NMEL:

110393567(NFATC1)

APLA:

101793899(NFATC1)

ACYG:

106038339(NFATC1)

CATA:

118249618(NFATC1)

AFUL:

116485856(NFATC1)

TGU:	100225123(NFATC1)

LSR:	110483466(NFATC1)

SCAN:

103819427(NFATC1)

PMOA:

120503602(NFATC1)

OTC:	121348224(NFATC1)

PRUF:

121351874(NFATC1)

GFR:	102038895(NFATC1)

FAB:	101811894(NFATC1)

OMA:	130249276(NFATC1)

PHI:	102114296(NFATC1)

PMAJ:

107200735(NFATC1)

CCAE:

111923921

CCW:	104688858(NFATC1)

CBRC:

103618702(NFATC1)

ETL:	114058817(NFATC1)

ZAB:	102062221(NFATC1)

ZLE:	135444047(NFATC1)

ACHL:

103809612 103812220(NFATC1)

SVG:	106854056(NFATC1)

MMEA:

130580403(NFATC1)

HRT:	120750833(NFATC1)

SATI:

136364080(NFATC1)

FPG:	101913726(NFATC1)

FCH:	102046809(NFATC1)

CCRI:

104168351

NNT:	104411737(NFATC1)

SHAB:

115616209(NFATC1)

ACUN:

113477100(NFATC1)

TALA:

104360949(NFATC1)

ACHC:

115353083(NFATC1)

HALD:

104323807

HLE:	104837726(NFATC1)

AGEN:

126048721

GCL:

127013295

CSTI:

104562567(NFATC1)

LDI:	104351188(NFATC1) 104354767

MNB:	103774876(NFATC1)

AVIT:

104271384

BRHI:

104501555(NFATC1)

EGZ:	104125444(NFATC1)

NNI:	104021875(NFATC1)

PCRI:

104027441 104038690(NFATC1)

PCAO:

104047382(NFATC1)

PADL:

103917349(NFATC1)

AFOR:

103897208(NFATC1)

FGA:	104070506(NFATC1) 104074447

GSTE:

104261207(NFATC1)

CLV:	102091094(NFATC1)

MUI:	104543291 104543742(NFATC1)

PGUU:

104468942(NFATC1)

PLET:

104616890 104620171(NFATC1)

EHS:	104511076 104512549(NFATC1)

CMAC:

104479013(NFATC1)

CUCA:

104055770(NFATC1)

TEO:

104383464

BREG:

104639345(NFATC1)

OHA:	104327182(NFATC1)

CPEA:

104398582(NFATC1)

CVF:	104293302(NFATC1)

RTD:	128905495(NFATC1)

AAM:	106500234(NFATC1)

AROW:

112972775(NFATC1)

NPD:	112943669(NFATC1)

TGT:	104567036(NFATC1)

DNE:	112992526(NFATC1)

SCAM:

104153038(NFATC1)

ASN:	102386486(NFATC1)

AMJ:	102559296(NFATC1)

CPOO:

109316541(NFATC1)

GGN:	109302511(NFATC1)

PSS:	102452242(NFATC1)

CMY:	102929542(NFATC1)

CCAY:

125632217(NFATC1)

DCC:	119852225(NFATC1)

CPIC:

101932823(NFATC1)

TST:	117873284(NFATC1)

CABI:

116829505(NFATC1)

MRV:	120398167(NFATC1)

ACS:	100565300(nfatc1)

ASAO:

132774662(NFATC1)

PVT:	110072900(NFATC1)

SUND:

121927622(NFATC1)

PBI:	103053062(NFATC1)

PMUR:

107287411(NFATC1)

CTIG:

120297620(NFATC1)

TSR:	106541363(NFATC1) 106553775

PGUT:

117672572(NFATC1)

APRI:

131194368(NFATC1)

PTEX:

113435562(NFATC1)

NSS:	113413574(NFATC1)

VKO:	123021648(NFATC1)

PMUA:

114600809(NFATC1)

PRAF:

128417683(NFATC1)

ZVI:	118090569(NFATC1)

HCG:	128324514(NFATC1)

GJA:	107111515(NFATC1)

STOW:

125439231(NFATC1)

EMC:	129333326(NFATC1)

XLA:	108695211(nfatc1.S) 444346(nfatc1.L)

XTR:	780197(nfatc1)

NPR:	108784253(NFATC1)

RTEM:

120940799(NFATC1)

BBUF:

121002158(NFATC1)

BGAR:

122937923 122945175

MUO:	115475855(NFATC1)

GSH:	117355611(NFATC1)

DRE:	568315(nfatc1)

SRX:	107739553 107748694(nfatc1)

SANH:

107656600 107697147

SGH:	107563708 107592032

CCAR:

109064027 109112341

CAUA:

113057428 113120110

CGIB:

127935555 127979766

PTET:

122323978(nfatc1)

LROH:

127182089(nfatc1)

OMC:	131526084(nfatc1)

PPRM:

120483336(nfatc1)

RKG:	130085127(nfatc1)

MAMB:

125275441(nfatc1)

CIDE:

127501241

CERY:

137037257(nfatc1)

MASI:

127421404 127425076 127452525 127453811

TROS:

130567005(nfatc1)

TDW:	130415998(nfatc1)

MANU:

129455526(nfatc1)

IPU:	108257496 108280571

IFU:	128600345(nfatc1) 128623962

PHYP:

113536200(nfatc1) 113543208

SMEO:

124376117(nfatc1) 124402962

TFD:	113640328 113661655(nfatc1)

TVC:	132848409 132864289(nfatc1)

TRN:	134302567 134309149(nfatc1)

AMEX:

103031085(nfatc1) 103045210

CMAO:

118797143 118806194(nfatc1)

EEE:	113581708 113583287(nfatc1)

CHAR:

105891992(nfatc1) 105905363

TRU:	101065260 101079060(nfatc1)

TFS:	130518553 130532699

TNG:	GSTEN00004162G001

LCO:	104926509 104931050

NCC:	104943363 104946677

TBEN:

117478105(nfatc1) 117480752

CGOB:

115016101 115021892

PGEO:

117455203(nfatc1) 117461586

GACU:

117553822 117559326(nfatc1)

EMAC:

134861319 134875507(nfatc1)

ELY:	117264146(nfatc1) 117265565 117266142

EFO:	125893444 125904657(nfatc1)

PLEP:

121946226 121957447

SLUC:

116035329 116047157(nfatc1)

ECRA:

117946387 117956558(nfatc1)

ESP:	116691523 116701783

PFLV:

114557221 114568301

GAT:	120810967 120826826(nfatc1)

PPUG:

119198194 119219712(nfatc1)

AFB:	129097321(nfatc1) 129109274

CLUM:

117728254 117739288(nfatc1)

PSWI:

130193810 130213187

CANA:

137781277 137784626(nfatc1)

MSAM:

119897990 119907292(nfatc1)

SCHU:

122864285(nfatc1) 122881863

CUD:	121513106 121524237(nfatc1)

ALAT:

119005327 119017371(nfatc1)

ASTR:

137601712 137607861(nfatc1)

MZE:	101479784 101485322

ONL:	100703522 100711301

OAU:	116315340(nfatc1) 116326767

OLA:	101158005(nfatc1) 101161493

OML:	112138397 112140481

CSAI:

133425592 133460618(nfatc1)

XMA:	102224478 102237484

XCO:	114145370(nfatc1) 114156039

XHE:	116716437 116717747(nfatc1)

PRET:

103460345 103478694(nfatc1)

PFOR:

103130011 103144237 103150565

PLAI:

106936953 106938275 106963750

PMEI:

106919164 106923441

GAF:	122831773 122843587(nfatc1)

PPRL:

129367640 129375811(nfatc1)

CVG:	107089923 107090832

CTUL:

119771377 119786031

GMU:	124864120 124879442(nfatc1)

NFU:	107378925(nfatc1) 107394905

KMR:	108229266 108234144

ALIM:

106525012 106529394

NWH:	119409551 119425804(nfatc1)

AOCE:

111564871 111575245

MCEP:

125016891 125020337(nfatc1)

CSEM:

103388659 103393969

POV:	109631959(nfatc1)

SSEN:

122775063 122786202(nfatc1)

HHIP:

117770333(nfatc1) 117777201

HSP:	118114042 118125071(nfatc1)

PPLT:

128449474 128461439(nfatc1)

SMAU:

118292382(nfatc1) 118312504

LCF:	108887849 108899182

SDU:	111220887 111227860

SLAL:

111645629 111658107(nfatc1)

XGL:	120784675 120786808(nfatc1)

HCQ:	109518367 109529694

SSCV:

125975034 125986526(nfatc1)

SBIA:

133500846 133502491(nfatc1)

PEE:	133395438(nfatc1) 133401997

PTAO:

133470717(nfatc1) 133480004

BPEC:

110171668 110173322

MALB:

109958521 109958765

BSPL:

114843298 114865898(nfatc1)

SJO:	128366228 128374045(nfatc1)

SASA:

106569777 106583607 106588230 106605067

STRU:

115173373 115176114 115176121 115177327

OTW:	112223134 112230033 112232340 112264948(nfatc1)

OMY:	110489695 110496069(nfatc1) 110496087 110518416

OGO:	123997530 124005441 124012992

ONE:	115106182 115128259 115131822 115141377

OKI:	109864481 109902196 109903126 109907638

OKE:	118364026 118367295 118375190 118399170(nfatc1)

SALP:

111956111 111965266

SNH:	120022776 120026743 120031237 120047116

CCLU:

121540876 121554012 121586267

ELS:	105028214 105031624

SFM:	108933294 108940507

PKI:	111845775 111852343(nfatc1)

AANG:

118206434(nfatc1)

LOC:	102686223(nfatc1)

PSPA:

121313331 121314840

ARUT:

117394763 117399482

PSEX:

120515872(nfatc1)

LCM:	102349968 102350112(NFATC1)

CMK:	103183227(nfatc1)

RTP:

109911161

CPLA:

122549204(nfatc1) 122549585

HOC:	132815368(nfatc1)

LERI:

129696667(nfatc1)

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Reference

PMID:8202141

Authors

Northrop JP, Ho SN, Chen L, Thomas DJ, Timmerman LA, Nolan GP, Admon A, Crabtree GR

Title

NF-AT components define a family of transcription factors targeted in T-cell activation.

Journal

Nature 369:497-502 (1994)
DOI:10.1038/369497a0

Sequence

[hsa:4772]

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