KEGG   ORTHOLOGY: K04456Help
Entry
K04456                      KO                                     

Name
AKT
Definition
RAC serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04261  Adrenergic signaling in cardiomyocytes
ko04370  VEGF signaling pathway
ko04371  Apelin signaling pathway
ko04380  Osteoclast differentiation
ko04510  Focal adhesion
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04611  Platelet activation
ko04620  Toll-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04668  TNF signaling pathway
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04728  Dopaminergic synapse
ko04910  Insulin signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04920  Adipocytokine signaling pathway
ko04922  Glucagon signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04926  Relaxin signaling pathway
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04973  Carbohydrate digestion and absorption
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
ko05418  Fluid shear stress and atherosclerosis
Module
M00676  PI3K-Akt signaling
Disease
H00027  Ovarian cancer
H00420  Familial partial lipodystrophy
H01222  Cowden syndrome
H01556  Meningioma
H01649  Schizophrenia
H01885  Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
H01909  Hypoinsulinemic hypoglycemia with hemihypertrophy
H02119  Proteus syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04015 Rap1 signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04010 MAPK signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04370 VEGF signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04371 Apelin signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04630 Jak-STAT signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04668 TNF signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04066 HIF-1 signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04072 Phospholipase D signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04071 Sphingolipid signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04024 cAMP signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04022 cGMP-PKG signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04151 PI3K-Akt signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04152 AMPK signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04150 mTOR signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04456  AKT; RAC serine/threonine-protein kinase
  09143 Cell growth and death
   04210 Apoptosis
    K04456  AKT; RAC serine/threonine-protein kinase
   04218 Cellular senescence
    K04456  AKT; RAC serine/threonine-protein kinase
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04456  AKT; RAC serine/threonine-protein kinase
   04550 Signaling pathways regulating pluripotency of stem cells
    K04456  AKT; RAC serine/threonine-protein kinase
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04456  AKT; RAC serine/threonine-protein kinase
   04620 Toll-like receptor signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04625 C-type lectin receptor signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04660 T cell receptor signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04662 B cell receptor signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04664 Fc epsilon RI signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04666 Fc gamma R-mediated phagocytosis
    K04456  AKT; RAC serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04922 Glucagon signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04923 Regulation of lipolysis in adipocytes
    K04456  AKT; RAC serine/threonine-protein kinase
   04920 Adipocytokine signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04915 Estrogen signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04456  AKT; RAC serine/threonine-protein kinase
   04917 Prolactin signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04926 Relaxin signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04919 Thyroid hormone signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04456  AKT; RAC serine/threonine-protein kinase
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K04456  AKT; RAC serine/threonine-protein kinase
  09156 Nervous system
   04725 Cholinergic synapse
    K04456  AKT; RAC serine/threonine-protein kinase
   04728 Dopaminergic synapse
    K04456  AKT; RAC serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
  09158 Development
   04380 Osteoclast differentiation
    K04456  AKT; RAC serine/threonine-protein kinase
  09149 Aging
   04211 Longevity regulating pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04212 Longevity regulating pathway - worm
    K04456  AKT; RAC serine/threonine-protein kinase
   04213 Longevity regulating pathway - multiple species
    K04456  AKT; RAC serine/threonine-protein kinase
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05230 Central carbon metabolism in cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05231 Choline metabolism in cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04456  AKT; RAC serine/threonine-protein kinase
  09162 Cancers: Specific types
   05210 Colorectal cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K04456  AKT; RAC serine/threonine-protein kinase
   05226 Gastric cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05214 Glioma
    K04456  AKT; RAC serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04456  AKT; RAC serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04456  AKT; RAC serine/threonine-protein kinase
   05218 Melanoma
    K04456  AKT; RAC serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04456  AKT; RAC serine/threonine-protein kinase
   05215 Prostate cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05213 Endometrial cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05224 Breast cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05222 Small cell lung cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04456  AKT; RAC serine/threonine-protein kinase
  09166 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04456  AKT; RAC serine/threonine-protein kinase
  09167 Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04456  AKT; RAC serine/threonine-protein kinase
   04931 Insulin resistance
    K04456  AKT; RAC serine/threonine-protein kinase
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04456  AKT; RAC serine/threonine-protein kinase
  09171 Infectious diseases: Bacterial
   05152 Tuberculosis
    K04456  AKT; RAC serine/threonine-protein kinase
  09172 Infectious diseases: Viral
   05166 Human T-cell leukemia virus 1 infection
    K04456  AKT; RAC serine/threonine-protein kinase
   05170 Human immunodeficiency virus 1 infection
    K04456  AKT; RAC serine/threonine-protein kinase
   05162 Measles
    K04456  AKT; RAC serine/threonine-protein kinase
   05164 Influenza A
    K04456  AKT; RAC serine/threonine-protein kinase
   05161 Hepatitis B
    K04456  AKT; RAC serine/threonine-protein kinase
   05160 Hepatitis C
    K04456  AKT; RAC serine/threonine-protein kinase
   05168 Herpes simplex virus 1 infection
    K04456  AKT; RAC serine/threonine-protein kinase
   05163 Human cytomegalovirus infection
    K04456  AKT; RAC serine/threonine-protein kinase
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04456  AKT; RAC serine/threonine-protein kinase
   05169 Epstein-Barr virus infection
    K04456  AKT; RAC serine/threonine-protein kinase
   05165 Human papillomavirus infection
    K04456  AKT; RAC serine/threonine-protein kinase
  09174 Infectious diseases: Parasitic
   05145 Toxoplasmosis
    K04456  AKT; RAC serine/threonine-protein kinase
   05142 Chagas disease (American trypanosomiasis)
    K04456  AKT; RAC serine/threonine-protein kinase
  09176 Drug resistance: Antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04456  AKT; RAC serine/threonine-protein kinase
   01524 Platinum drug resistance
    K04456  AKT; RAC serine/threonine-protein kinase
   01522 Endocrine resistance
    K04456  AKT; RAC serine/threonine-protein kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04456  AKT; RAC serine/threonine-protein kinase
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00676  PI3K-Akt signaling
     K04456  AKT; RAC serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04456  AKT; RAC serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   K04456  AKT; RAC serine/threonine-protein kinase
BRITE hierarchy
Genes
HSA: 10000(AKT3) 207(AKT1) 208(AKT2)
PTR: 100609583(AKT3) 456035(AKT2) 740898(AKT1)
PPS: 100969217(AKT3) 100969444(AKT1) 100991804(AKT2)
GGO: 101124923(AKT1) 101137723(AKT2) 101138019(AKT3)
PON: 100442100(AKT1) 100448114(AKT3) 100454279(AKT2)
NLE: 100587109(AKT1) 100587864(AKT2) 100604331(AKT3)
MCC: 697747(AKT1) 700591(AKT2) 714717(AKT3)
MCF: 102132744(AKT2) 102142406(AKT1) 102144461(AKT3)
CSAB: 103229784(AKT1) 103230869(AKT3) 103234702(AKT2)
RRO: 104654186(AKT3) 104673041(AKT1) 104673058 104676121(AKT2)
RBB: 108512498(AKT3) 108521880(AKT1) 108528544 108539069(AKT2)
CJC: 100388080(AKT2) 100399039(AKT3) 100404447(AKT1)
SBQ: 101034861(AKT1) 101040766(AKT2) 101045714(AKT3)
MMU: 11651(Akt1) 11652(Akt2) 23797(Akt3)
RNO: 24185(Akt1) 25233(Akt2) 29414(Akt3)
CGE: 100752454(Akt3) 100768351(Akt2) 100769460(Akt1)
NGI: 103746884(Akt3) 103750757(Akt2) 103752536(Akt1)
HGL: 101700695(Akt1) 101701289(Akt3) 101719164(Akt2)
CCAN: 109686235(Akt3) 109688536(Akt2) 109691810(Akt1)
OCU: 100342852(AKT2) 100353706(AKT3)
TUP: 102472172(AKT2) 102474297(AKT3) 102492771(AKT1)
CFA: 442964(AKT3) 449021(AKT2) 490878(AKT1)
AML: 100465793(AKT1) 100468763(AKT2) 100480414(AKT3)
UMR: 103661038(AKT2) 103666688(AKT3) 103676878(AKT1)
ORO: 101374757(AKT2) 101382320(AKT3) 101383166(AKT1)
FCA: 100499544(AKT2) 101087931(AKT1) 101092818(AKT3)
PTG: 102952603(AKT3) 102954757(AKT2)
AJU: 106975558(AKT3) 106979622(AKT2) 106985046(AKT1)
BTA: 100137872(AKT3) 280991(AKT1) 534923(AKT2)
BOM: 102265427(AKT3) 102275199(AKT2) 102283212(AKT1)
BIU: 109570286(AKT3) 109572496(AKT2)
PHD: 102333230(AKT3) 102339842(AKT2)
CHX: 100860904(AKT1) 102174051(AKT3) 102187521(AKT2)
OAS: 100294652(AKT1) 101118462(AKT3) 101119242(AKT2)
SSC: 100126861(AKT1) 100127478(AKT2) 100513811(AKT3)
CFR: 102503460(AKT2) 102515350(AKT3) 106729149(AKT1)
CDK: 105093393(AKT2) 105099264(AKT3) 105104845(AKT1) 105106735
BACU: 103002026(AKT3) 103004139(AKT2) 103013147(AKT1)
LVE: 103068921(AKT3) 103076365(AKT1) 103084975(AKT2)
OOR: 101272095(AKT2) 101273316(AKT1) 101288103(AKT3)
ECB: 100054961(AKT3) 100061130(AKT1) 100064671(AKT2)
EPZ: 103540249(AKT1) 103555421(AKT3) 103560497(AKT2)
MYB: 102251050(AKT1) 102254191(AKT2) 102254864(AKT3)
MYD: 102772266(AKT3) 102773065(AKT2)
HAI: 109374859(AKT2) 109381083(AKT1) 109385353(AKT3) 109385878
RSS: 109446949 109455332(AKT3) 109455576(AKT1) 109458076(AKT2)
PALE: 102879337(AKT3) 102885144(AKT1) 102898305(AKT2)
LAV: 100657536(AKT3) 100660187(AKT1) 100663184(AKT2)
MDO: 100014564(AKT2) 100019947(AKT1) 100027373(AKT3)
OAA: 100081473 100083320(AKT3)
GGA: 101750560 395928(AKT1) 421497(AKT3)
MGP: 100539659(AKT1) 100545672(AKT3)
CJO: 107307290 107311258(AKT3) 107315293(AKT1)
APLA: 101800458(AKT1) 101801994 101804556(AKT3)
ACYG: 106037213(AKT1) 106049522(AKT3) 106049631
TGU: 100217811(AKT3) 100232504(AKT1)
SCAN: 103817751(AKT3) 103826388(AKT1)
GFR: 102036745(AKT1) 102036791(AKT3)
FAB: 101814876(AKT1) 101819472(AKT3)
PHI: 102104813(AKT1) 102112828(AKT3)
PMAJ: 107201442(AKT3) 107205807(AKT1)
CCAE: 111922589 111927570(AKT3) 111929760(AKT1)
CCW: 104684403(AKT3) 104687008(AKT1)
FPG: 101910975(AKT1) 101918846(AKT3) 101918868(AKT2)
FCH: 102050094(AKT3) 102055811(AKT1) 102060018(AKT2)
CLV: 102095269(AKT1) 102095875 102098970(AKT3)
EGZ: 104125648(AKT1) 104131524(AKT3)
NNI: 104011272(AKT3) 104014534(AKT1) 104020263(AKT2)
ACUN: 113477826(AKT3) 113480539(AKT1) 113490822(AKT2)
AAM: 106482997(AKT1) 106485509(AKT3) 106493726(AKT2)
ASN: 102372104(AKT1) 102388207(AKT2) 102388514(AKT3)
AMJ: 102558879(AKT3) 102564996(AKT1) 102574794(AKT2) 106739782
PSS: 102448379(AKT3) 102453850(AKT1) 106732780
CMY: 102929975(AKT3) 102939884(AKT1) 102947630(AKT2)
CPIC: 101944155(AKT1) 101946335(AKT2) 101946510(AKT3)
ACS: 100553927(akt3) 100555477(akt2) 100556289(akt1)
PVT: 110075706(AKT2) 110075943(AKT3) 110090951(AKT1)
PBI: 103055559(AKT2) 103058510(AKT3) 103061866(AKT1)
PMUR: 107285678(AKT2) 107292994(AKT3) 107302433(AKT1)
XLA: 108698803 379783(akt2.L) 399170(akt1.S) 432172(MGC78893)
XTR: 100144709(akt2) 100490038(akt1)
NPR: 108787157(AKT1) 108794095(AKT2)
DRE: 100149794(akt3b) 101910198(akt1) 378972(akt2) 403146(akt2l) 560549(akt3a)
IPU: 108259077 108263416(akt3) 108264340(AKT2) 108269621(akt1)
PHYP: 113526529(akt2) 113537325 113538792(akt1) 113543804(akt3)
LCM: 102346546(AKT3) 102359272(AKT2) 102359797(AKT1)
CMK: 103174353 103175285(akt1) 103181750(akt3)
APLC: 110975151
SKO: 100303458(akt3-like)
DME: Dmel_CG4006(Akt1)
DER: 6553218
DPE: 6594177
DSI: Dsimw501_GD19074(Dsim_GD19074)
MDE: 101899191
AAG: 5571066
AME: 413430
BIM: 100748042
BTER: 100643457
SOC: 105199955
MPHA: 105837266
AEC: 105147255
ACEP: 105623661
PBAR: 105429603
HST: 105182849
DQU: 106747596
CFO: 105251500
LHU: 105676176
PGC: 109856121
OBO: 105274717
PCF: 106783605
NVI: 100122383
MDL: 103579801
TCA: 656423
DPA: 109547011
NVL: 108559424
BMOR: 100141438(Akt)
PMAC: 106708391
PRAP: 110991938
HAW: 110369787
TNL: 113495656
PXY: 105380907
API: 100160970
DNX: 107167157
CLEC: 106662816
ZNE: 110839136
FCD: 110845158
TUT: 107363011
DPTE: 113798652
CEL: CELE_C12D8.10(akt-1) CELE_F28H6.1(akt-2)
CBR: CBG09565(Cbr-akt-1)
BMY: Bm1_51830
TSP: Tsp_02503
CRG: 105336892
MYI: 110459812
LAK: 106171911
SHX: MS3_03128
EGL: EGR_02613
EPA: 110244155
PDAM: 113681836
SPIS: 111333333
HMG: 100210496(akt3)
AQU: 100633427
DDI: DDB_G0268620(pkbA)
DFA: DFA_07907(pkbA)
EHI: EHI_042150(11.t00019) EHI_138540(35.t00048) EHI_188930(9.t00044)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1851997
  Authors
Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA
  Title
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.
  Journal
Proc Natl Acad Sci U S A 88:4171-5 (1991)
DOI:10.1073/pnas.88.10.4171
  Sequence
[hsa:207]
Reference
PMID:1409633
  Authors
Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR
  Title
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.
  Journal
Proc Natl Acad Sci U S A 89:9267-71 (1992)
DOI:10.1073/pnas.89.19.9267
  Sequence
[hsa:208]

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