KEGG   ORTHOLOGY: K04506Help
Entry
K04506                      KO                                     

Name
SIAH1
Definition
E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]
Pathway
ko04013  MAPK signaling pathway - fly
ko04115  p53 signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04310  Wnt signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04506  SIAH1; E3 ubiquitin-protein ligase SIAH1
 09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K04506  SIAH1; E3 ubiquitin-protein ligase SIAH1
   04310 Wnt signaling pathway
    K04506  SIAH1; E3 ubiquitin-protein ligase SIAH1
 09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    K04506  SIAH1; E3 ubiquitin-protein ligase SIAH1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K04506  SIAH1; E3 ubiquitin-protein ligase SIAH1
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K04506  SIAH1; E3 ubiquitin-protein ligase SIAH1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   SINA (Seven in absentia) proteins
    K04506  SIAH1; E3 ubiquitin-protein ligase SIAH1
BRITE hierarchy
Genes
HSA: 6477(SIAH1)
PTR: 465153(SIAH1) 473557
PPS: 100979152(SIAH1) 100985136
GGO: 101138854 101149013(SIAH1)
PON: 100451947 100461683(SIAH1)
NLE: 100583599(SIAH1) 100595196
MCC: 694921 716629(SIAH1)
MCF: 102143770(SIAH1) 102147140
CSAB: 103231785 103232443(SIAH1)
RRO: 104655445(SIAH1) 104679031
RBB: 108517356 108527408(SIAH1)
CJC: 100397231(SIAH1)
SBQ: 101027912(SIAH1)
MMU: 20437(Siah1a) 20438(Siah1b)
RNO: 140941(Siah1)
CGE: 100774026(Siah1)
NGI: 103725299(Siah1)
HGL: 101702094(Siah1)
CCAN: 109693328 109697813(Siah1)
OCU: 100355829(SIAH1)
TUP: 102487856(SIAH1)
CFA: 100856496(SIAH1)
AML: 100465948(SIAH1)
UMR: 103668098 103673810(SIAH1)
FCA: 101090311(SIAH1) 105261399
PTG: 102959352(SIAH1) 102966971
AJU: 106982593 106985846(SIAH1)
PHD: 102323078(SIAH1) 102336815
SSC: 100520614(SIAH1)
CFR: 102522907(SIAH1)
CDK: 105091167(SIAH1)
BACU: 103002867(SIAH1)
LVE: 103089846(SIAH1)
OOR: 101289867(SIAH1)
ECB: 100057532(SIAH1)
EPZ: 103543609
EAI: 106841484(SIAH1)
MYD: 102767682(SIAH1) 102771558
PALE: 102879482(SIAH1)
LAV: 100669493(SIAH1)
TMU: 101351306
MDO: 100016498(SIAH1)
SHR: 100922952(SIAH1)
OAA: 100682095(SIAH1)
GGA: 374076(SIAH1)
MGP: 100549528(SIAH1)
CJO: 107319235(SIAH1)
APLA: 101794815(SIAH1)
ACYG: 106039576(SIAH1)
TGU: 100222788(SIAH1)
SCAN: 103816614(SIAH1)
GFR: 102040458(SIAH1)
FAB: 101817349(SIAH1)
PHI: 102110589(SIAH1)
PMAJ: 107209844(SIAH1)
CCAE: 111934633(SIAH1)
CCW: 104687448(SIAH1)
FPG: 101911681(SIAH1)
FCH: 102058058(SIAH1)
CLV: 102089742(SIAH1)
EGZ: 104125553(SIAH1)
NNI: 104011275(SIAH1)
ACUN: 113484277(SIAH1)
AAM: 106483212(SIAH1)
ASN: 102370192(SIAH1)
AMJ: 102562469(SIAH1)
PSS: 102454051(SIAH1)
CMY: 102944670(SIAH1)
CPIC: 101953883(SIAH1)
ACS: 100555807(siah1)
PVT: 110076296(SIAH1)
PBI: 103064016(SIAH1)
PMUR: 107290810(SIAH1)
GJA: 107124688(SIAH1)
XLA: 108715479 443864(siah1.L)
XTR: 548553(siah1)
NPR: 108784247(SIAH1)
DRE: 80955(siah1)
IPU: 108264354(siah1)
PHYP: 113534514(siah1)
AMEX: 103035844(siah1)
TRU: 101074163
LCO: 104929133(siah1)
NCC: 104951564(siah1)
MZE: 101487652(siah1)
OLA: 101155925(siah1)
XMA: 102232686(siah1)
PRET: 103466759(siah1)
NFU: 107389144(siah1)
KMR: 108251327
CSEM: 103379652(siah1)
LCF: 108901897(siah1)
SDU: 111225259(siah1)
HCQ: 109526770(siah1)
BPEC: 110169365(siah1)
MALB: 109962566(siah1)
SASA: 106560862(siah1) 106573709
ELS: 105008390(siah1)
LCM: 102361177(SIAH1)
CMK: 103176072(siah1)
CIN: 100176189
SPU: 592708
APLC: 110978437
SKO: 100375002
DME: Dmel_CG13030(sinah) Dmel_CG9949(sina)
DSI: Dsimw501_GD14671(Dsim_GD14671) Dsimw501_GD14672(Dsim_GD14672)
DVI: Dvir_GJ12342(Dvir_sina) Dvir_GJ12343
MDE: 101894291
AAG: 5572199
AME: 410808
BIM: 100748470
BTER: 100649684
SOC: 105203583
AEC: 105153922
ACEP: 105618086
HST: 105183140
DQU: 106741682
PGC: 109858782
OBO: 105280771
PCF: 106788688
NVI: 100119052
TUT: 107369001
DPTE: 113790013
CEL: CELE_Y37E11AR.2(siah-1)
CBR: CBG08288(Cbr-siah-1)
BMY: Bm1_36670
CRG: 105333460
MYI: 110466049
OBI: 106875559
LAK: 106182012
SHX: MS3_10053
EPA: 110254171
ADF: 107345438
PDAM: 113671340
SPIS: 111329609
HMG: 100204840
AQU: 100639566
LJA: Lj0g3v0008999.1(Lj0g3v0008999.1) Lj0g3v0316759.1(Lj0g3v0316759.1) Lj0g3v0316759.2(Lj0g3v0316759.2) Lj0g3v0324189.1(Lj0g3v0324189.1) Lj0g3v0324189.2(Lj0g3v0324189.2) Lj0g3v0341609.1(Lj0g3v0341609.1) Lj1g3v0984440.1(Lj1g3v0984440.1) Lj1g3v4372170.1(Lj1g3v4372170.1) Lj1g3v4372170.2(Lj1g3v4372170.2) Lj1g3v5034850.1(Lj1g3v5034850.1) Lj3g3v2443180.1(Lj3g3v2443180.1) Lj4g3v0310490.1(Lj4g3v0310490.1)
DOSA: Os01t0121900-00(Os01g0121900) Os01t0121950-00(Os01g0121950) Os01t0123700-00(Os01g0123700) Os01t0234900-01(Os01g0234900) Os02t0128800-01(Os02g0128800) Os02t0293400-01(Os02g0293400) Os03t0356414-01(Os03g0356414) Os05t0152600-00(Os05g0152600) Os05t0152900-00(Os05g0152900) Os06t0311300-01(Os06g0311300) Os07t0659800-01(Os07g0659800)
ATS: 109734739(LOC109734739) 109735484(LOC109735484) 109735998(LOC109735998) 109738362(LOC109738362) 109738387(LOC109738387) 109738396(LOC109738396) 109738397(LOC109738397) 109738932(LOC109738932) 109739124(LOC109739124) 109739125(LOC109739125) 109739409(LOC109739409) 109739659(LOC109739659) 109740634(LOC109740634) 109741786(LOC109741786) 109742739(LOC109742739) 109748784(LOC109748784) 109752085(LOC109752085) 109755682(LOC109755682) 109757127(LOC109757127) 109757174(LOC109757174) 109757938(LOC109757938) 109759620(LOC109759620) 109759833(LOC109759833) 109760128(LOC109760128) 109760476(LOC109760476) 109760669(LOC109760669) 109760680(LOC109760680) 109760920(LOC109760920) 109761406(LOC109761406) 109762607(LOC109762607) 109763003(LOC109763003) 109763384(LOC109763384) 109763722(LOC109763722) 109764721(LOC109764721) 109766818(LOC109766818) 109768132(LOC109768132) 109769729(LOC109769729) 109770495(LOC109770495) 109771721(LOC109771721) 109774207(LOC109774207) 109777789(LOC109777789) 109778011 109779691(LOC109779691) 109781817(LOC109781817) 109782100(LOC109782100) 109783182(LOC109783182) 109783186(LOC109783186) 109786253(LOC109786253) 109786317(LOC109786317) 109786608(LOC109786608) 109787006(LOC109787006) 109787007(LOC109787007) 109787387(LOC109787387)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Venables JP, Dalgliesh C, Paronetto MP, Skitt L, Thornton JK, Saunders PT, Sette C, Jones KT, Elliott DJ
  Title
SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome.
  Journal
Hum Mol Genet 13:1525-34 (2004)
DOI:10.1093/hmg/ddh165
  Sequence
[hsa:6477]
Reference
PMID:8799150
  Authors
Nemani M, Linares-Cruz G, Bruzzoni-Giovanelli H, Roperch JP, Tuynder M, Bougueleret L, Cherif D, Medhioub M, Pasturaud P, Alvaro V, der Sarkissan H, Cazes L, Le Paslier D, Le Gall I, Israeli D, Dausset J, Sigaux F, Chumakov I, Oren M, Calvo F, Amson RB, Cohen D, Telerman A
  Title
Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression.
  Journal
Proc Natl Acad Sci U S A 93:9039-42 (1996)
DOI:10.1073/pnas.93.17.9039
  Sequence
[hsa:6477]

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