KEGG ORTHOLOGY: K04520

ORTHOLOGY: K04520

Entry

K04520                      KO

Symbol

APP

Name

amyloid beta A4 protein

Pathway

map04726

Serotonergic synapse

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00056

Alzheimer disease

H01185

Cerebral amyloid angiopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K04520  APP; amyloid beta A4 protein
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04520  APP; amyloid beta A4 protein
   05022 Pathways of neurodegeneration - multiple diseases
    K04520  APP; amyloid beta A4 protein
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04520  APP; amyloid beta A4 protein
  09183 Protein families: signaling and cellular processes
   00535 Proteoglycans
    K04520  APP; amyloid beta A4 protein
   00536 Glycosaminoglycan binding proteins
    K04520  APP; amyloid beta A4 protein
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I2: Kunitz - BPTI family
   K04520  APP; amyloid beta A4 protein
Proteoglycans [BR:ko00535]
Cell surface proteoglycans
  Others
   K04520  APP; amyloid beta (A4) protein
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Others
   K04520  APP; amyloid beta A4 protein

Other DBs

GO:

0004867

Genes

HSA:

351(APP)

PTR:	473931(APP)

PPS:	100971121(APP)

GGO:	101132687(APP)

PON:	100174038(APP)

PPYG:

129022505(APP)

NLE:	100587944(APP)

HMH:	116481858(APP)

SSYN:

129482862(APP)

MCC:	100427716(APP)

MCF:	101926433(APP)

MTHB:

126950748

MNI:	105472804(APP)

CSAB:

103217727(APP)

CATY:

105571836(APP)

PANU:

101003817(APP)

TGE:	112620386(APP)

MLEU:

105552598(APP)

RRO:	104678203(APP)

RBB:	108518214(APP)

TFN:	117095628(APP)

PTEH:

111524713(APP)

CANG:

105500815(APP)

CJC:	100407052(APP)

SBQ:	101032971(APP)

CIMI:

108313502

ANAN:

105732660(APP)

CSYR:

103251367(APP)

MMUR:

105871215(APP)

LCAT:

123630660

PCOQ:

105806913(APP)

OGA:	100948156(APP)

MMU:	11820(App)

MCAL:

110311452(App)

MPAH:

110329604(App)

RNO:	54226(App)

MCOC:

116086086(App)

ANU:	117717816(App)

ASYL:

127665613(App)

MUN:	110561809(App)

CGE:	100689222(App)

MAUA:

101836288

PROB:

127227455(App)

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103745264(App)

HGL:	101724743(App)

CPOC:

100715302(App)

CCAN:

109700792(App)

DORD:

105996812(App)

DSP:

PLOP:

NCAR:

MMMA:

ITI:

OCU:	100009546(APP)

OPI:

101518476

TUP:	102489280(APP)

GVR:	103604174(APP)

CFA:	403407(APP)

CLUD:

112661802

VVP:	112917675(APP)

VLG:

121479288

NPO:	129502077(APP)

AML:	100466827(APP)

UMR:

103673071

UAH:	113269215(APP)

UAR:

123784172

ELK:

111152475

LLV:

125095266

MPUF:

101686001(APP)

MNP:	132012327(APP)

MLK:	131825283(APP)

NVS:

122908359

ORO:	101376189(APP)

EJU:	114218412(APP)

ZCA:

113916785

MLX:	118018789(APP)

NSU:

110570121

LWW:	102748193(APP)

FCA:	101085564(APP)

PYU:

121036049

PCOO:

112849787(APP)

PBG:

122491270

PVIV:

125175654(APP)

LRUF:

124526224

LGF:

123610674

AJU:

106974329

PTG:	102960478(APP)

PPAD:

109277861(APP)

PUC:

125921721

PLEZ:

122198638

HHV:

120235132

BTA:	280722(APP)

BOM:	102267321(APP)

BIU:	109558723(APP)

BBUB:

102416140

BBIS:

104987491(APP)

CHX:	102186997(APP)

OAS:	101111593(APP)

BTAX:

128055528(APP)

CSUM:

138077957(APP)

ODA:

120853653

CCAD:

122428625

MREE:

136152397(APP)

OVR:	110136609(APP)

MBEZ:

129553058(APP)

SSC:	397663(APP)

CFR:	102507265(APP)

CBAI:

105070278(APP)

CDK:	105086807(APP)

VPC:	102533052(APP)

BACU:

103006217(APP)

BMUS:

118894510

LVE:	103090092(APP)

OOR:	101270984(APP)

LALB:

132521283(APP)

DLE:	111174611(APP)

PCAD:

102995649(APP)

PSIU:

116752813(APP)

NASI:

112390938(APP)

ECB:	100066294(APP)

EPZ:	103547122(APP)

EAI:

106842471

MYB:	102238735(APP)

MYD:	102751589(APP)

MMYO:

118677629

MLF:	102432337(APP)

MDT:	132230003(APP)

MYUM:

139004190(APP)

PKL:

118724175

EFUS:

103289750(APP)

MNA:	107525473(APP)

DRO:	112306663(APP)

SHON:

119000222

AJM:	119056733(APP)

PDIC:

114489650

PHAS:

123826747

MMF:

118616898

PPAM:

129075422(APP)

HAI:	109393097(APP)

RFQ:	117034292(APP)

PALE:

102878629(APP)

PGIG:

120598931

PVP:	105290808(APP)

RAY:	107498323(APP)

MJV:

108391271

TOD:	119257256(APP)

SARA:

101542803(APP)

SFUM:

130018503(APP)

SETR:

126026048(APP)

LAV:	100677270(APP)

TMU:

101347228

ETF:	101649379 101656411

DNM:	101413574(APP)

MDO:	100021944(APP)

GAS:

123242484

SHR:	100932185(APP)

AFZ:

127553819

PCW:	110214782(APP)

TVP:

118835857

PBRV:

138151516(APP)

OAA:

100090292

TACU:

119945079

GGA:	374198(APP)

PCOC:

116241955(APP)

MGP:	100547713(APP)

CJO:	107322621(APP)

TPAI:

128072792(APP)

LMUT:

125703482

NMEL:

110402060(APP)

APLA:

101804251

ACYG:

106037003(APP)

CATA:

118247539(APP)

AFUL:

116486762(APP)

TGU:	100220100(APP)

LSR:	110471638(APP)

SCAN:

103823757(APP)

PMOA:

120500562

OTC:

121341331

PRUF:

121353422

ATRC:

139593047(APP)

GFR:	102035016(APP)

FAB:	101811303(APP)

OMA:	130255061(APP)

PHI:	102108517(APP)

PMAJ:

107201974(APP)

CCAE:

111940966(APP)

CCW:

104686955

CBRC:

103613824(APP)

ACOE:

138102529(APP)

ETL:	114066989(APP)

ZAB:	102068511(APP)

ZLE:	135454332(APP)

ACHL:

103799985(APP)

SVG:	106859393(APP)

MMEA:

130576878(APP)

HRT:	120748762(APP)

SATI:

136375255(APP)

CCIC:

134058208(APP)

FPG:	101924306(APP)

FCH:	102057007(APP)

NNT:	104405435(APP)

SHAB:

115604313(APP)

ACUN:

113491090(APP)

TALA:

104363994

ACHC:

115343587

HLE:	104842753(APP)

AGEN:

126053237

HHAR:

128144692(APP)

GCL:

127029741

CSTI:

104557779(APP)

MNB:	103780315(APP)

DPUB:

104304892(APP)

PPUS:

135180112(APP)

AVIT:

104271822(APP)

BRHI:

104494665(APP)

EGZ:

104128210

NNI:	104020104(APP)

PCRI:

104032085(APP)

PCAO:

104046151(APP)

PADL:

103920137(APP)

AFOR:

103901950(APP)

CLV:	102084867(APP)

PGUU:

104463620

PLET:

104628477(APP)

EHS:	104506933(APP)

CUCA:

104064778(APP)

BREG:

104634445

OHA:	104328329(APP)

CPEA:

104386772(APP)

CVF:	104295191(APP)

RTD:	128901242(APP)

CRID:

134521100(APP)

AAM:	106494942(APP)

NPD:	112942677(APP)

TGT:	104570890(APP)

DNE:	112980968(APP)

SCAM:

104141609(APP)

ASN:	102385872(APP)

AMJ:	102571861(APP)

CPOO:

109305731(APP)

GGN:	109302499(APP)

PSS:	102444626(APP)

CMY:

CCAY:

DCC:

CPIC:

TST:	117889196(APP)

CABI:

116825711(APP)

MRV:

120399100

ACS:	100553307(app)

ASAO:

132771916(APP)

PVT:	110076980(APP)

SUND:

121925384

PBI:	103052290(APP)

PMUR:

107292284(APP)

CTIG:

120314547

TSR:	106541697(APP)

PGUT:

117671384(APP)

APRI:

131200217(APP)

PTEX:

113436300(APP)

NSS:	113409852(APP)

VKO:

123029243

PMUA:

114596012(APP)

PRAF:

128412942(APP)

ZVI:	118084828(APP)

HCG:	128350010(APP)

GJA:	107121303(APP)

STOW:

125430957

EMC:	129325476(APP)

XLA:	379251(app.S) 398223(app.L)

XTR:	448208(app)

NPR:	108792096(APP)

RTEM:

120927870

BBUF:

120994554

BGAR:

122930768

PWL:	138249886(APP)

MUO:	115470762(APP)

GSH:	117358999(APP)

DRE:	170846(appb) 58083(appa)

SRX:	107728004(app) 107748127 107751095 107756757

SANH:

107665808(app) 107695460 107698920

SGH:	107557257(app) 107582259 107593741 107595805 107597486

CCAR:

109056413 109065275

CAUA:

113044670 113053080 113081566(app) 113108133 113108470

CGIB:

127948783 127965506 127992895 128019985

PTET:

122345903(appa) 122351451(appb)

LROH:

127162956(appa) 127171159(appb)

OMC:	131537786(appa) 131546627(appb)

PPRM:

120489048(appa) 120490018(appb)

RKG:	130069176(appb)

MAMB:

125270172(appb) 125272980(appa)

CIDE:

127518630 127521108 127521122

CERY:

137033154(appa) 137035609(appb)

MASI:

127443768 127445341 127447500 127448493

TROS:

130552689(appa) 130556206(appb)

TDW:	130428033(appb) 130435370(appa)

MANU:

129445134(appa) 129451406(appb)

PDAB:

135733408(appb) 135735626(appa)

IPU:	108258852(appa) 108266463(appb)

IFU:	128601802(appa) 128608749(appb)

PHYP:

113537234(app) 113546423

SMEO:

124378638(appa) 124382449(appb)

TFD:	113648738(appa) 113654473(appb)

TVC:	132839759(appa) 132850130(appb)

CGAR:

128506232(appa) 128524285(appb)

NGRA:

132866073(appa) 132891801(appb)

TRN:	134324709(appb) 134329438(appa)

AMEX:

103044691(appa) 103046668(appb)

CMAO:

118798224(appa) 118821037(appb)

EEE:	113567924 113574579(app)

CHAR:

105889592(appa) 105907928(appb)

SPIL:

134061827(appa) 134078200(appb)

TRU:	101066792 101078447

TFS:	130522427(appa) 130522667

TNG:	GSTEN00025991G001 GSTEN00027170G001

LCO:	104932346 104937711

NCC:	104945593 104954656

TBEN:

117481442 117499117(appa)

CGOB:

115019800(app) 115026240

PGEO:

117459626(appa) 117466687(appb)

GACU:

117546677(appa) 117556872

EMAC:

134860651(appa) 134867488(appb)

ELY:	117249893(appa) 117251207(appb)

EFO:	125884907(appa) 125899208

PLEP:

121949599 121963038(appa)

SLUC:

116044635(appa) 116046636(appb)

ECRA:

117939197(appa) 117953348(appb)

ESP:	116673939(app) 116697735

PFLV:

114550761(app) 114564701

GAT:	120824652(appa) 120834357

PPUG:

119219323(appa) 119229137(appb)

AFB:	129105056(appb) 129111914(appa)

CLUM:

117741067(appa) 117750089(appb)

PSWI:

130201021 130204360(appa)

CANA:

137793883(appa) 137803360

CVE:	137868267(appb) 137868565(appa) 137890188

MSAM:

119902450(appa) 119904244

SCHU:

122871848(appa) 122885470

CUD:	121506050(appa) 121522826(appb)

SPUL:

138592647 138603706(appa)

LMIX:

132959652(appa) 132986782(appb)

ALAT:

119015581(appa) 119026189

ASTR:

137591571(appa) 137604631(appb)

MZE:	101473127(app) 101478308

ONL:	100694218 100709268

OAU:	116316063 116319222(appa)

OLA:	101162104 101172288

OML:	112154862 112159995(appa)

CSAI:

133424880(appa) 133445846

XMA:	102232739 102232862

XCO:	114137601(app) 114147977

XHE:	116715798 116722913

PRET:

103459816 103475742(app)

PFOR:

103140299 103147106

PLAI:

106940919 106958320

PMEI:

106927431 106930156

GAF:	122827195(appa) 122839399

PPRL:

129360937(appb) 129379018(appa)

CVG:	107094739(app) 107104503

CTUL:

119781804(appa) 119786351

GMU:	124861541(appa) 124871500

NFU:	107381083(app) 107389838

KMR:	108232458 108248770(appa)

ALIM:

106523944 106524657 106533086

NWH:	119419670 119428958(appa)

AOCE:

111568091 111575428(appa)

EJA:	138200996(appb) 138207192(appa)

BFRE:

138629712(appb) 138634915(appa)

MCEP:

125001131(appA) 125018012

CSEM:

103389699(app) 103391597

POV:	109631268(app) 109640224 109642832

SSEN:

122761289 122765448

SSOE:

131445714(appa) 131446373

HHIP:

117755417(appb) 117776814(appa)

HSP:	118103347(appa) 118119675

PPLT:

128430836(appa) 128455715

SMAU:

118283162(appb) 118300896(appa)

LCF:	108872952(appa) 108880432 108880489

SDU:	111218784 111222650(app)

SLAL:

111646183(app) 111662051

XGL:	120798014(appa) 120801306

HCQ:	109520870(app) 109524673

SSCV:

125973761 125988539(appa)

SBIA:

133491751(appa) 133512476(appb)

PEE:	133410412 133410492(appa)

PTAO:

133487108(appb) 133489466(appa)

BPEC:

110166290(app) 110173110

MALB:

109965420 109973228(app)

BSPL:

114846772(appb) 114870397(appa)

SJO:	128354404(appa) 128368417

SSCO:

133976620(appa) 133992555(appb)

GMH:	115533009 115541382(app)

SASA:

106574335 106575113(app) 106582144 106586687

STRU:

115156313 115161211 115179148(app) 115195916

OTW:	112225405 112241784 112253908 112254014(appa)

OMY:	110495970 110502007(appb) 110520491 110527583(appa)

OGO:	124007658(appa) 124010529 124044150

ONE:	115112824 115125132 115129609 115134468

OKI:	109869985 109871012 109890713(app) 109906642

OKE:	118363662 118366612 118370123(appa) 118386185

OMM:	135519071 135542449(appa) 135543619 135547382

OCLA:

139373289 139380668 139404288 139413120

SALP:

111953228 111959686 111971030(app) 111979392

SNH:	120033751(appa) 120051216 120058466 120064178

CCLU:

121536506 121553666(appa) 121571616

ELS:	105009137(app) 105027332

SFM:	108931713 108938103(app)

PKI:	111855882(app)

AANG:

118213932

AROT:

135240525 135251975

CCOG:

133117117 133123356

LOC:	102689007(app)

PSPA:

121320521(appa) 121327542

ARUT:

117405677 117407049

PSEX:

120522557

LCM:	102350152(APP)

CMK:	103185176(appa)

RTP:	109935395(appa)

CPLA:

122555414(appa)

HOC:	132821198(appa)

LERI:

129703041

PMRN:

116957700

LRJ:	133340128 133340130

BBEL:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG7727(Appl)

DER:

6555540

DSE:

6615873

DSI:	Dsimw501_GD16511(Dsim_GD16511)

DYA:	Dyak_GE16620

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14839

DAZ:

108619883

DNV:

115564528

DHE:

111597367

DVI:	6631546(Appl)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135957946(Appl)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ014395

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139101798(Appl)

TLN:	139810936(Appl)

HST:

DQU:

CFO:

FEX:

PMEC:

138938284(Appl)

LHU:	105676434(Appl)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124221933(Appl)

NFB:

NLO:

NVG:

AROA:

TMOL:

138133981(Appl)

DPA:

109533359

ESIM:

136408610(Appl)

EFOR:

136339476(Appl)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:	114324187 126885570

NVL:

108557573

DCOR:

135791795(Appl)

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

106685259(Appl)

NLU:

111050965

HVI:

124357199

MQU:

128986603

PHU:	Phum_PHUM287170

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139687920(Appl)

FCD:

110844727

DPX:	DAPPUDRAFT_313180

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123766477(Appl)

CQD:	128699658(Appl)

PTRU:

123504269

ESN:

127006122

MNZ:

135203139

MRJ:	136834978(Appl)

PORN:

139755055(Appl)

HAZT:

108674920

EAF:	111702878 111714978

LSM:	121117895(Appl)

TCF:

PPOI:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136980989(Appl)

PTEP:

ABRU:

UDV:

SDM:

CEL:	CELE_C42D8.8(apl-1)

CBR:	CBG_14611(Cbr-apl-1)

NAI:	NECAME_00101

BMY:	BM_BM2713(Bma-apl-1)

LOA:	LOAG_05890

TSP:	Tsp_02062 Tsp_02070

HRO:	HELRODRAFT_192286

LGI:	LOTGIDRAFT_204381

PCAN:

BGT:

GAE:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111124717 111127229

OED:

MYI:

MAEA:

OBI:

LJP:

LAK:

SMM:	Smp_149740

OVI:	T265_04117

NVE:

EPA:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_55959

» show all

Reference

PMID:12859342

Authors

Tang K, Wang C, Shen C, Sheng S, Ravid R, Jing N

Title

Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639.

Journal

Eur J Neurosci 18:102-8 (2003)
DOI:10.1046/j.1460-9568.2003.02731.x

Sequence

[hsa:351]

All links

Ontology (1)   
   GO (1)   
Gene (2578)   
   MGENES (305)   
   RefGene (2269)   
   OC (4)   
All databases (2579)   

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