KEGG   ORTHOLOGY: K04659Help
Entry
K04659                      KO                                     

Name
THBS2S
Definition
thrombospondin 2/3/4/5
Pathway
ko04145  Phagosome
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05144  Malaria
ko05165  Human papillomavirus infection
Disease
H00476  Multiple epiphyseal dysplasia (MED)
H00477  Pseudoachondroplasia (PSACH)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K04659  THBS2S; thrombospondin 2/3/4/5
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K04659  THBS2S; thrombospondin 2/3/4/5
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K04659  THBS2S; thrombospondin 2/3/4/5
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04659  THBS2S; thrombospondin 2/3/4/5
 Human Diseases
  Infectious diseases
   05165 Human papillomavirus infection
    K04659  THBS2S; thrombospondin 2/3/4/5
   05144 Malaria
    K04659  THBS2S; thrombospondin 2/3/4/5
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Opsonins
    K04659  THBS2S; thrombospondin 2/3/4/5
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04659  THBS2S; thrombospondin 2/3/4/5
  Exosomal proteins of colorectal cancer cells
   K04659  THBS2S; thrombospondin 2/3/4/5
  Exosomal proteins of bladder cancer cells
   K04659  THBS2S; thrombospondin 2/3/4/5
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Extracellular matrix molecules
   K04659  THBS2S; thrombospondin 2/3/4/5
BRITE hierarchy
Genes
HSA: 1311(COMP) 7058(THBS2) 7059(THBS3) 7060(THBS4)
PTR: 450172(THBS4) 457359(THBS3) 463138(THBS2) 469068(COMP)
PPS: 100967906(COMP) 100978289(THBS4) 100985431(THBS3) 100991072(THBS2)
GGO: 101128581(THBS4) 101149083(THBS3) 101150111(THBS2) 101152032(COMP)
PON: 100443331(THBS3) 100447159(COMP) 100455895(THBS2) 100461836(THBS4)
NLE: 100580032(THBS2) 100582320(COMP) 100588927(THBS4) 100593174(THBS3)
MCC: 574276(THBS4) 708165(THBS2) 717572(THBS3) 720286(COMP)
MCF: 101867220(COMP) 102120028(THBS3) 102125342(THBS2) 102129227(THBS4)
CSAB: 103223769(THBS4) 103223887(THBS3) 103234192(COMP) 103240966(THBS2)
RRO: 104659600(THBS3) 104680172(THBS4) 104680632(COMP) 104681915(THBS2)
RBB: 108515625(COMP) 108525204 108526834(THBS3) 108528909(THBS4) 108542407(THBS2)
CJC: 100391538(THBS4) 100391690 100397101(THBS3) 100401976(THBS2)
SBQ: 101039744(THBS3) 101040437(COMP) 101043743(THBS2) 101046556(THBS4)
MMU: 12845(Comp) 21826(Thbs2) 21827(Thbs3) 21828(Thbs4)
RNO: 25304(Comp) 29220(Thbs4) 292406(Thbs2) 681309(Thbs3)
CGE: 100752022(Thbs2) 100756924(Thbs3) 100762358(Thbs4) 100766091(Comp)
NGI: 103726858(Comp) 103742336(Thbs2) 103750279(Thbs4) 103750946(Thbs3)
HGL: 101696497(Thbs2) 101703996(Comp) 101704466(Thbs3) 101726773(Thbs4)
CCAN: 109680095(Thbs4) 109687973(Thbs3) 109688824 109694649(Comp) 109700790(Thbs2)
OCU: 100343910(THBS3) 100357137(THBS4) 100357972(THBS2)
TUP: 102476294(COMP) 102485527(THBS4) 102489246(Mucin-1) 102502758(THBS2)
CFA: 476665(COMP) 484087(THBS2) 488930(THBS4) 610359(THBS3)
AML: 100471588(THBS4) 100475917(THBS3) 100479895(COMP) 100481026(THBS2)
UMR: 103660792(THBS2) 103668378(THBS3) 103674931(COMP) 103681497(THBS4)
ORO: 101367458(THBS3) 101379053(THBS4) 101379820(COMP) 101381226(THBS2)
FCA: 101087199(THBS4) 101088820(COMP) 101093580(THBS3) 101100567(THBS2)
PTG: 102961939(THBS4) 102970054(THBS2) 102970726(THBS3) 102971808(COMP)
AJU: 106969137(COMP) 106972141(THBS4) 106978641(THBS2) 106981523(THBS3)
BTA: 281088(COMP) 338092(THBS2) 504323(THBS3) 541281(THBS4)
BOM: 102267028(COMP) 102271065(THBS3) 102277745 102284714(THBS4) 106701188(THBS2)
BIU: 109553708(THBS3) 109561393(COMP) 109564125(THBS2) 109564670(THBS4)
PHD: 102321875(THBS3) 102325197(THBS4) 102331784(THBS2) 102337395(COMP)
CHX: 102179674(THBS2) 102179675(THBS4) 102190117(COMP) 102190652(THBS3)
OAS: 101107864(COMP) 101115211(THBS4) 101116784(THBS3) 101116840(THBS2) 105606081
SSC: 100153940(THBS2) 100155108(THBS3) 100513005(THBS4) 396554(COMP)
CFR: 102511726(COMP) 102513826(THBS2) 102520625(THBS3) 102524625(THBS4)
CDK: 105084831(THBS4) 105088884(THBS3) 105091818(THBS2) 105101885(COMP)
BACU: 102998613(THBS4) 102999752(THBS2) 103007252(COMP) 103007962(THBS3)
LVE: 103068905(THBS3) 103083668(THBS4) 103086398(THBS2) 103090939(COMP)
OOR: 101271822(THBS3) 101272205(THBS2) 101274051(COMP) 101284998(THBS4)
ECB: 100033911(COMP) 100050044(THBS2) 100063449(THBS3) 100073261(THBS4)
EPZ: 103546470(THBS2) 103552847(THBS3) 103556665(THBS4) 103565076(COMP)
EAI: 106828497(THBS3) 106841151(THBS4) 106846480(COMP) 106846766(THBS2)
MYB: 102242389(THBS2) 102248184(THBS4) 102249845(COMP) 102250634(THBS3)
MYD: 102752804(THBS4) 102759156(THBS3) 102759906(THBS2) 102770367(COMP)
HAI: 109381904(THBS4) 109382454(COMP) 109391677(THBS2) 109393407(THBS3)
RSS: 109434678(THBS3) 109438035(THBS2) 109445657(THBS4) 109449974(COMP)
PALE: 102880862(THBS2) 102885384(COMP) 102890277(THBS3) 102898345(THBS4)
LAV: 100657841(THBS3) 100667600(COMP) 100673862(THBS4) 100677407(THBS2)
MDO: 100016186(COMP) 100022025(THBS3) 100032579(THBS4) 100032659(THBS2)
SHR: 100913793(THBS2) 100926884(THBS4) 100928896(THBS3) 100934583(COMP)
OAA: 100082089(THBS2)
GGA: 396306(THBS4) 414837(THBS2) 420120(COMP)
MGP: 100545155(THBS2) 100548314(COMP)
CJO: 107305921(THBS4) 107311485(THBS2) 107325349(COMP)
APLA: 101797309(THBS3) 101797964(THBS2) 101801619(THBS4) 101803344(COMP)
ACYG: 106042117(THBS4) 106044590(THBS2) 106047968(COMP) 106048533(THBS3)
TGU: 100217632(THBS3) 100221289(THBS2) 100223523(THBS4)
GFR: 102035426(COMP) 102041416(THBS3) 102042662(THBS2) 102043756(THBS4)
FAB: 101807800(COMP) 101812668(THBS4) 101813407(THBS2) 101822081(THBS3)
PHI: 102105229(THBS2) 102107320(COMP) 102111962(THBS3) 102113828(THBS4)
PMAJ: 107201101(THBS2) 107214594(THBS3) 107215384(COMP) 107216117(THBS4)
CCW: 104683533 104684330(THBS2) 104695692(THBS4) 104697387(COMP)
FPG: 101920098(THBS4) 101921164(THBS3) 101923157(THBS2) 101923991(COMP)
FCH: 102046521(THBS3) 102049450(THBS4) 102058509(COMP) 102059472(THBS2)
CLV: 102088266(THBS2) 102095550(THBS3) 102097761(THBS4) 102098894(COMP)
EGZ: 104124903(THBS4) 104128875(THBS2) 104129782(COMP) 104134863(THBS3)
AAM: 106487359(THBS2) 106494326(THBS3) 106496803(COMP) 106497564 106499036
ASN: 102368490(THBS2) 102376216(COMP) 102384190(THBS4) 102388282(THBS3)
AMJ: 102565816(THBS3) 102573791(THBS4) 102576627(THBS2) 106737012(COMP) 106737441
PSS: 102447492(THBS4) 102453824 102459232(THBS2) 102462619(COMP)
CMY: 102939257(COMP) 102941449(THBS2) 102942106(THBS3) 102946626(THBS4)
CPIC: 101930762(THBS2) 101934649(THBS4) 101937108(THBS3) 101937854(COMP)
ACS: 100559567(thbs3) 100563584(thbs2) 100563715(thbs4) 100564230(comp)
PVT: 110072531(COMP) 110073932(THBS4) 110080993(THBS3) 110083084(THBS2)
PBI: 103049428(THBS3) 103057878(THBS4) 103065576(THBS2) 103067390(COMP)
GJA: 107106668(THBS2) 107115485(THBS4) 107117080(THBS3) 107125775(COMP)
XLA: 108695262 108700446(thbs3.S) 108706910 108716699 108717845 380339(thbs3.L) 397943(thbs4) 446985(thbs4.S)
XTR: 100494714(comp) 100494997(thbs2) 496875(thbs3) 780130(thbs4)
NPR: 108789855(THBS2) 108794774(THBS3) 108796348 108797516(THBS4)
DRE: 100318854(comp) 100535241(thbs2a) 252849(thbs3a) 252850(thbs4b) 563429(thbs4a)
TRU: 101070052 101071532(comp) 101075106(thbs4) 101077022(thbs2) 101079662(thbs3)
LCO: 104920415(comp) 104921293(thbs4) 104922466 104934561 104937267(thbs3) 104940043(thbs2)
PRET: 103463136(comp) 103470407(thbs4) 103473457 103477036(thbs2) 103477525(thbs3) 103481557
CSEM: 103381578 103387278(thbs2) 103388114(thbs3) 103390445 103395640(comp) 103398290(thbs4)
LCM: 102345222(THBS4) 102349677(THBS3) 102360244(COMP) 102363612(THBS2)
CMK: 103174435 103174809(thbs2) 103177771(thbs4) 103182059(comp)
CIN: 100169670(thbsb) 100169671(thbsbi)
SPU: 576669(thbs3) 585488
DME: Dmel_CG11326(Tsp)
DSI: Dsimw501_GD22550(Dsim_GD22550) Dsimw501_GD27031(Dsim_GD27031)
MDE: 101901673
AAG: 5569974
AME: 413782(Tsp)
BIM: 100750023
BTER: 100650650
SOC: 105205371
AEC: 105153996
ACEP: 105618023
HST: 105181268
CFO: 105250842
LHU: 105675000
NVI: 100114667
TCA: 655453
NVL: 108568621
BMOR: 101743002
PMAC: 106716790
PRAP: 111002663
API: 100168802
DNX: 107166897
ZNE: 110838833
FCD: 110863343
TUT: 107360433
OBI: 106872747
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1559694
  Authors
LaBell TL, Milewicz DJ, Disteche CM, Byers PH
  Title
Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans.
  Journal
Genomics 12:421-9 (1992)
DOI:10.1016/0888-7543(92)90430-Z
  Sequence
[hsa:7058]
Reference
  Authors
Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, Lawler J, Mosher DF, Bornstein P, Barres BA
  Title
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.
  Journal
Cell 120:421-33 (2005)
DOI:10.1016/j.cell.2004.12.020

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