KEGG ORTHOLOGY: K04670

ORTHOLOGY: K04670

Entry

K04670                      KO

Symbol

ACVR2A

Name

activin receptor type-2A [EC:2.7.11.30]

Pathway

map04060

Cytokine-cytokine receptor interaction

map04350

TGF-beta signaling pathway

map04550

Signaling pathways regulating pluripotency of stem cells

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04670  ACVR2A; activin receptor type-2A
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04670  ACVR2A; activin receptor type-2A
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04670  ACVR2A; activin receptor type-2A
09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04670  ACVR2A; activin receptor type-2A
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04670  ACVR2A; activin receptor type-2A
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04670  ACVR2A; activin receptor type-2A
Protein kinases [BR:ko01001]
Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   K04670  ACVR2A; activin receptor type-2A

Other DBs

GO:

0016362

Genes

HSA:	92(ACVR2A)

PTR:	459646(ACVR2A)

PPS:	100978909(ACVR2A)

PON:	100435220(ACVR2A)

PPYG:

129031481(ACVR2A)

NLE:	100583170(ACVR2A)

HMH:	116462882(ACVR2A)

SSYN:

129471879(ACVR2A)

MCC:	707017(ACVR2A)

MCF:	102121129(ACVR2A)

MTHB:

126932908

MNI:	105492701(ACVR2A)

CSAB:

103217052(ACVR2A)

CATY:

105575953(ACVR2A)

PANU:

101009691(ACVR2A)

TGE:	112635816(ACVR2A)

MLEU:

105531383(ACVR2A)

RRO:	104655489(ACVR2A)

RBB:	108512386(ACVR2A)

TFN:	117095028(ACVR2A)

PTEH:

111546133(ACVR2A)

CANG:

105512596(ACVR2A)

CJC:	100397767(ACVR2A)

SBQ:	101036787(ACVR2A)

CIMI:

108300366(ACVR2A)

ANAN:

105720520(ACVR2A)

CSYR:

103262246(ACVR2A)

MMUR:

105860222(ACVR2A)

LCAT:

123643301(ACVR2A)

PCOQ:

105822230(ACVR2A)

OGA:	100943776(ACVR2A)

MMU:	11480(Acvr2a)

MCAL:

110309902(Acvr2a)

MPAH:

110318164(Acvr2a)

RNO:	29263(Acvr2a)

MCOC:

116090146(Acvr2a)

ANU:	117703021(Acvr2a)

MUN:	110539455(Acvr2a)

CGE:	100774605(Acvr2a)

MAUA:

101842415(Acvr2a)

PROB:

127222541(Acvr2a)

PLEU:

114700439(Acvr2a)

MORG:

121433139(Acvr2a)

MFOT:

126500227

AAMP:

119818383(Acvr2a)

NGI:	103727329(Acvr2a)

HGL:	101707586(Acvr2a)

CPOC:

100731791(Acvr2a)

CCAN:

109689204(Acvr2a)

DORD:

105996506(Acvr2a)

DSP:	122110790(Acvr2a)

PLOP:

125350695(Acvr2a)

NCAR:

124981189

MMMA:

107136837(Acvr2a)

OCU:

100008631

OPI:	101536630(ACVR2A)

TUP:	102499226(ACVR2A)

GVR:	103592000(ACVR2A)

CFA:	476140(ACVR2A)

CLUD:

112649428(ACVR2A)

VVP:	112926859(ACVR2A)

VLG:	121482017(ACVR2A)

NPO:	129495412 129514449

AML:	100472026(ACVR2A)

UMR:	103667704(ACVR2A)

UAH:	113250906(ACVR2A)

UAR:	123782213(ACVR2A)

ELK:

111145945

LLV:

125095863

MPUF:

101685213(ACVR2A)

MNP:	132013902(ACVR2A)

MLK:	131826989(ACVR2A)

NVS:	122902672(ACVR2A)

ORO:	101369734(ACVR2A)

EJU:	114224562(ACVR2A)

ZCA:	113919393(ACVR2A)

MLX:	118012466(ACVR2A)

NSU:	110591839(ACVR2A)

LWW:	102726739(ACVR2A)

FCA:	101097750(ACVR2A)

PYU:	121030536(ACVR2A)

PCOO:

112871725(ACVR2A)

PBG:	122481313(ACVR2A)

PVIV:

125172951(ACVR2A)

LRUF:

124516063

PTG:	102948807(ACVR2A)

PPAD:

109270733(ACVR2A)

PUC:

125911887

AJU:

106971526

HHV:	120240004(ACVR2A)

BTA:	281598(ACVR2A)

BOM:	102269861(ACVR2A)

BIU:	109567962(ACVR2A)

BBUB:

102408304(ACVR2A)

BBIS:

104988599(ACVR2A)

CHX:	100860918(ACVR2A)

OAS:	443304(ACVR2A)

BTAX:

128069136(ACVR2A)

ODA:	120854769(ACVR2A)

CCAD:

122453864(ACVR2A)

MBEZ:

129538665(ACVR2A)

SSC:	397282(ACVR2A)

CFR:	102518044(ACVR2A)

CBAI:

105065196(ACVR2A)

CDK:	105084601(ACVR2A)

VPC:	102524712(ACVR2A)

BACU:

103002388(ACVR2A)

BMUS:

118897886(ACVR2A)

LVE:	103079492(ACVR2A)

OOR:	101283151(ACVR2A)

DLE:	111172738(ACVR2A)

PCAD:

102976118(ACVR2A)

PSIU:

116756664(ACVR2A)

NASI:

112399108(ACVR2A)

ECB:	100049823(ACVR2A)

EPZ:	103549990(ACVR2A)

EAI:	106825091(ACVR2A)

MYB:	102253638(ACVR2A)

MYD:	102768276(ACVR2A)

MMYO:

118662002(ACVR2A)

MLF:	102440476(ACVR2A)

MDT:	132238657(ACVR2A)

PKL:	118709272(ACVR2A)

EFUS:

103283424(ACVR2A)

MNA:	107531463(ACVR2A)

DRO:	112313101(ACVR2A)

SHON:

118974389(ACVR2A)

AJM:	119065590(ACVR2A)

PDIC:

114495284(ACVR2A)

PHAS:

123813825(ACVR2A)

MMF:	118625581(ACVR2A)

PPAM:

129061744(ACVR2A)

HAI:	109388998(ACVR2A)

RFQ:	117025927(ACVR2A)

PALE:

102891559(ACVR2A)

PGIG:

120597054(ACVR2A)

PVP:	105291730(ACVR2A)

RAY:	107513936(ACVR2A)

MJV:	108391910(ACVR2A)

TOD:	119255811(ACVR2A)

SARA:

101555829(ACVR2A)

SETR:

126008764(ACVR2A)

LAV:	100672302(ACVR2A)

TMU:

101346907

ETF:	101641411(ACVR2A)

DNM:	101438319(ACVR2A)

MDO:	100018756(ACVR2A)

GAS:	123242271(ACVR2A)

SHR:	100918537(ACVR2A)

AFZ:

127554382

PCW:	110207162(ACVR2A)

TVP:	118837833(ACVR2A)

OAA:	100089503(ACVR2A)

GGA:	396324(ACVR2A)

PCOC:

116227445(ACVR2A)

MGP:	100545173(ACVR2A)

CJO:	107317053(ACVR2A)

TPAI:

128077078(ACVR2A)

LMUT:

125697207(ACVR2A)

NMEL:

110399402(ACVR2A)

APLA:

101789784(ACVR2A)

ACYG:

106041002(ACVR2A)

CATA:

118252577(ACVR2A)

AFUL:

116490812(ACVR2A)

TGU:	100224301(ACVR2A)

LSR:	110476487(ACVR2A)

SCAN:

103814260(ACVR2A)

PMOA:

120503401(ACVR2A)

OTC:	121335608(ACVR2A)

PRUF:

121356446(ACVR2A)

GFR:	102039219(ACVR2A)

FAB:	101821260(ACVR2A)

OMA:	130255799(ACVR2A)

PHI:	102113171(ACVR2A)

PMAJ:

107207587(ACVR2A)

CCAE:

111932342(ACVR2A)

CCW:	104694095(ACVR2A)

CBRC:

103616770(ACVR2A)

ETL:	114070947(ACVR2A)

ZAB:	102073262(ACVR2A)

ZLE:	135450460(ACVR2A)

SVG:	106849883(ACVR2A)

MMEA:

130582991(ACVR2A)

HRT:	120755507(ACVR2A)

SATI:

136363732(ACVR2A)

FPG:	101915701(ACVR2A)

FCH:	102053325(ACVR2A)

CCRI:

104168653(ACVR2A)

NNT:	104408661(ACVR2A)

SHAB:

115608311(ACVR2A)

ACUN:

113481999(ACVR2A)

TALA:

104359780(ACVR2A)

ACHC:

115342594(ACVR2A)

HALD:

104315854(ACVR2A)

HLE:	104836541(ACVR2A)

AGEN:

126044910

GCL:

127018204

CSTI:

104550395(ACVR2A)

LDI:	104346166(ACVR2A)

MNB:	103779561(ACVR2A)

DPUB:

104308269(ACVR2A)

AVIT:

104272637 104274910(ACVR2A)

BRHI:

104498027(ACVR2A)

EGZ:	104130385(ACVR2A)

NNI:	104009770(ACVR2A)

PCRI:

104025271(ACVR2A)

PCAO:

104048292(ACVR2A)

PADL:

103912640(ACVR2A)

AFOR:

103903938(ACVR2A)

FGA:	104083027(ACVR2A)

GSTE:

104255206(ACVR2A)

CLV:	102098638(ACVR2A)

MUI:	104548931(ACVR2A)

PGUU:

104462896(ACVR2A)

PLET:

104625396(ACVR2A)

EHS:	104505914(ACVR2A)

CMAC:

104482580(ACVR2A)

CUCA:

104057544(ACVR2A)

TEO:	104372713(ACVR2A)

BREG:

104641234

OHA:	104331754(ACVR2A)

ACAR:

104531704(ACVR2A)

CPEA:

104395849(ACVR2A)

CVF:	104287627(ACVR2A)

RTD:	128912250(ACVR2A)

AAM:	106498516(ACVR2A)

AROW:

112977075(ACVR2A)

NPD:	112948612(ACVR2A)

TGT:

104577773

DNE:	112981726(ACVR2A)

SCAM:

104145692(ACVR2A)

ASN:	102368733(ACVR2A)

AMJ:	102562921(ACVR2A)

CPOO:

109322767(ACVR2A)

GGN:	109301328(ACVR2A)

PSS:	102454507(ACVR2A)

CMY:	102945188(ACVR2A)

CCAY:

125645134(ACVR2A)

DCC:	119863213(ACVR2A)

CPIC:

101933615(ACVR2A)

TST:	117884643(ACVR2A)

CABI:

116831627(ACVR2A)

MRV:	120374534(ACVR2A)

ACS:	100562173(acvr2a)

ASAO:

132775577(ACVR2A)

PVT:	110074952(ACVR2A)

SUND:

121919301(ACVR2A)

PBI:	103055188(ACVR2A)

PMUR:

107294303(ACVR2A)

CTIG:

120301136(ACVR2A)

TSR:	106545601(ACVR2A)

PGUT:

117669944(ACVR2A)

APRI:

131203250(ACVR2A)

PTEX:

113434170(ACVR2A)

NSS:	113415905(ACVR2A)

VKO:	123027299(ACVR2A)

PMUA:

114604932(ACVR2A)

PRAF:

128422357(ACVR2A)

ZVI:	118092702(ACVR2A)

HCG:	128330595(ACVR2A)

GJA:	107108802(ACVR2A)

STOW:

125426767(ACVR2A)

EMC:	129324054(ACVR2A)

XLA:	399283(acvr2a.L) 495087(acvr2a.S)

XTR:	100216172(acvr2a)

NPR:	108795499(ACVR2A)

RTEM:

120944125(ACVR2A)

BBUF:

121008845(ACVR2A)

BGAR:

122944589(ACVR2A)

MUO:	115473769(ACVR2A)

GSH:	117360939(ACVR2A)

DRE:	100331014(acvr2ab) 553359(acvr2aa)

SRX:	107705816 107705898 107709421 107724023

SANH:

107666699 107673126 107675352 107691069

SGH:	107555835 107572302 107582301 107601072

CCAR:

109056978(acvr2a) 109066983 109102232

CAUA:

113051000 113053255 113089469 113108715

CGIB:

127959989 127964857 128015280 128019816

PTET:

122333282(acvr2ab) 122351491(acvr2aa)

LROH:

127167413(acvr2ab) 127170616(acvr2aa)

OMC:	131542687(acvr2ab) 131546598(acvr2aa)

PPRM:

120466776(acvr2aa) 120467934(acvr2ab)

RKG:	130078533(acvr2ab) 130085952(acvr2aa)

MAMB:

125270224(acvr2aa) 125274472

CIDE:

127514861 127518488

CERY:

137010811(acvr2ab) 137036515(acvr2aa)

MASI:

127446199 127446906 127448384 127449057

TROS:

130555845(acvr2aa) 130556443(acvr2ab)

TDW:	130424512(acvr2ab) 130427364(acvr2aa)

MANU:

129450435(acvr2ab) 129451491(acvr2aa)

IPU:	108266626(acvr2aa) 108272703

IFU:	128608617(acvr2aa) 128615392

PHYP:

113535046 113538182

SMEO:

124382650(acvr2aa) 124389249(acvr2ab)

TFD:	113646266(acvr2aa) 113651132(acvr2ab)

TVC:	132844918(acvr2ab) 132849823(acvr2aa)

TRN:	134317090(acvr2ab) 134323986(acvr2aa)

AMEX:

103032572(acvr2aa) 103040899(acvr2ab)

CMAO:

118807865(acvr2ab) 118808510(acvr2aa)

EEE:	113581626(acvr2a) 113588617

CHAR:

105893095(acvr2aa) 105901787(acvr2ab)

TRU:	101067920(acvr2a) 101071858

TFS:	130522848 130536732(acvr2aa)

LCO:	104926240(acvr2a) 104935816

NCC:	104960238(acvr2a)

TBEN:

117486205

CGOB:

115018276(acvr2a)

PGEO:

117457566

GACU:

117539281

EMAC:

134860794 134867309(acvr2aa)

ELY:	117250046 117251307(acvr2aa)

EFO:	125884886 125899797(acvr2aa)

PLEP:

121948851 121963066

SLUC:

116048622(acvr2ab) 116064172(acvr2aa)

ECRA:

117939485(acvr2ab) 117953066

ESP:	116674031(acvr2a) 116679314

PFLV:

114550865(acvr2a) 114563875

GAT:	120815576(acvr2ab)

PPUG:

119212689 119228726

AFB:	129104573 129111556

CLUM:

117740968 117750290(acvr2aa)

PSWI:

130204385 130206978(acvr2aa)

MSAM:

119903741(acvr2aa) 119905275(acvr2ab)

SCHU:

122872371 122885386(acvr2aa)

CUD:	121506438(acvr2ab) 121522379

ALAT:

119015236 119025671(acvr2aa)

MZE:	101464704 101481875(acvr2a)

ONL:	100694010 100709514

OAU:	116316406(acvr2ab) 116316813(acvr2aa)

OLA:	100049489(acvr2a)

OML:

112156615

CSAI:

133425416(acvr2ab)

XMA:	102217256 102227541(acvr2a)

XCO:	114141013(acvr2a) 114147517

XHE:	116715774(acvr2a) 116723094

PRET:

103457427(acvr2a) 103460036

PFOR:

103149472(acvr2a) 103152084

PLAI:

106936383(acvr2a) 106963634

PMEI:

106905709(acvr2a) 106931128

GAF:	122826996(acvr2ab) 122840146(acvr2aa)

PPRL:

129353448(acvr2ab) 129374564(acvr2aa)

CVG:	107082824(acvr2a) 107091036

CTUL:

119794423 119798385

GMU:	124861389 124871236

NFU:	107384683(acvr2a)

KMR:	108245115 108250825(acvr2aa)

ALIM:

106535166(acvr2a)

NWH:

119428750

AOCE:

111563996 111581847

MCEP:

125000655 125018199

CSEM:

103389624(acvr2a)

POV:	109639027(acvr2a) 109642017

SSEN:

122784346

HHIP:

117754867(acvr2aa) 117776118

HSP:	118103478 118119824(acvr2aa)

PPLT:

128431253(acvr2ab) 128455749

SMAU:

118282891 118312297(acvr2ab)

LCF:	108873081 108874503(acvr2aa) 108888565

SDU:	111230419 111233326(acvr2a)

SLAL:

111656765 111670353(acvr2a)

XGL:	120798097 120801179(acvr2aa)

HCQ:	109528490(acvr2a)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110153188(acvr2a)

MALB:

109955601(acvr2a) 109970419

BSPL:

114845792(acvr2ab) 114846906

SJO:	128353996 128367618(acvr2aa)

SASA:

106574301 106575234 106582410 106586327

STRU:

115155533 115160846 115179829 115195962

OTW:	112225629 112237546 112253978 112266566

OMY:	110495930 110501883 110520186(acvr2aa) 110527542

OGO:	124008116 124010571 124043937(acvr2aa) 124048601

ONE:	115109988 115129641 115130367 115134071

OKI:	109867401 109870874 109890681 109906676

OKE:	118363694 118366991 118370160 118386387

SALP:

111953286 111959585 111970997 111976339

SNH:	120033424 120051243 120058299 120064143

CCLU:

121536712 121555172 121562507 123486065

ELS:	105016248 105022549

SFM:	108924278 108929958(acvr2a)

PKI:	111846093 111849470

AANG:

118214263 118223535

LOC:	102685062(acvr2a)

PSPA:

121322327 121322905

ARUT:

117410738 117427134

PSEX:

120531704

LCM:	102354804(ACVR2A)

CMK:

RTP:

CPLA:

HOC:

LERI:

BBEL:

SPU:

LPIC:

ARUN:

RZE:

FAS:

DAM:

AGIF:

SOY:

AGRG:

CSET:

AGB:

LDC:

APLN:

PPYR:

OTU:

CCRN:

DCI:

HHAL:

106684227(put)

MQU:

FOC:

TPAL:

SGRE:

DMK:

DPZ:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

ESN:

HAZT:

TCF:

VDE:

VJA:

BGT:

CVN:	111126321 111128797

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

NVE:

ATEN:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

Reference

PMID:1311955

Authors

Matzuk MM, Bradley A

Title

Cloning of the human activin receptor cDNA reveals high evolutionary conservation.

Journal

Biochim Biophys Acta 1130:105-8 (1992)
DOI:10.1016/0167-4781(92)90472-C

Sequence

[hsa:92]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Drug (3)   
   KEGG DRUG (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1091)   
   KEGG GENES (582)   
   KEGG MGENES (149)   
   RefGene (356)   
   OC (4)   
Literature (1)   
   PubMed (1)   
All databases (1108)   

Download RDF

DBGET integrated database retrieval system