KEGG ORTHOLOGY: K04671

ORTHOLOGY: K04671

Entry

K04671                      KO

Symbol

BMPR2

Name

bone morphogenetic protein receptor type-2 [EC:2.7.11.30]

Pathway

map04060

Cytokine-cytokine receptor interaction

map04350

TGF-beta signaling pathway

map04360

Axon guidance

map04390

Hippo signaling pathway

map04550

Signaling pathways regulating pluripotency of stem cells

map05206

MicroRNAs in cancer

map05418

Fluid shear stress and atherosclerosis

Disease

H01619

Primary pulmonary hypertension

H01621

Pulmonary arterial hypertension

H01866

Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04671  BMPR2; bone morphogenetic protein receptor type-2
   04390 Hippo signaling pathway
    K04671  BMPR2; bone morphogenetic protein receptor type-2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04671  BMPR2; bone morphogenetic protein receptor type-2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04671  BMPR2; bone morphogenetic protein receptor type-2
09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K04671  BMPR2; bone morphogenetic protein receptor type-2
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K04671  BMPR2; bone morphogenetic protein receptor type-2
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04671  BMPR2; bone morphogenetic protein receptor type-2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04671  BMPR2; bone morphogenetic protein receptor type-2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04671  BMPR2; bone morphogenetic protein receptor type-2
Protein kinases [BR:ko01001]
Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   K04671  BMPR2; bone morphogenetic protein receptor type-2

Other DBs

GO:

0016362

Genes

HSA:	659(BMPR2)

PTR:	129143431 459885(BMPR2)

PPS:	100987362(BMPR2)

GGO:	101152104(BMPR2)

PON:	100441517(BMPR2)

PPYG:

129032110(BMPR2)

NLE:	100599616(BMPR2)

HMH:	116810431(BMPR2)

SSYN:

129488285(BMPR2)

MCC:	704088(BMPR2)

MCF:	102132657(BMPR2)

MTHB:

126932176

MNI:	105468076(BMPR2)

CSAB:

103217668(BMPR2)

CATY:

105580204(BMPR2)

PANU:

101019906(BMPR2)

TGE:	112636031(BMPR2)

MLEU:

105535403(BMPR2)

RRO:	104680809(BMPR2)

RBB:	108537211(BMPR2)

TFN:	117094639(BMPR2)

PTEH:

111547374(BMPR2)

CANG:

105517394(BMPR2)

CJC:	100402963(BMPR2)

SBQ:	101047869(BMPR2)

CIMI:

108310049(BMPR2)

ANAN:

105712833(BMPR2)

CSYR:

103267609(BMPR2)

MMUR:

105856941(BMPR2)

LCAT:

123643872(BMPR2)

PCOQ:

105819430(BMPR2)

OGA:	100947847(BMPR2)

MMU:	12168(Bmpr2)

MCAL:

110291041(Bmpr2)

MPAH:

110321925(Bmpr2)

RNO:	140590(Bmpr2)

MCOC:

116088482(Bmpr2)

ANU:	117706127(Bmpr2)

ASYL:

127692166(Bmpr2)

MUN:	110559103(Bmpr2)

CGE:	100764519(Bmpr2)

MAUA:

101843211(Bmpr2)

PROB:

127226346(Bmpr2)

PLEU:

114685750(Bmpr2)

MORG:

121445144 121459053

MFOT:

126511851

AAMP:

119804001(Bmpr2)

NGI:	103736034(Bmpr2)

HGL:	101701138(Bmpr2)

CPOC:

100736232(Bmpr2)

CCAN:

109683698(Bmpr2)

DORD:

105985161(Bmpr2)

DSP:	122096406(Bmpr2)

PLOP:

125350388(Bmpr2)

NCAR:

124979034

MMMA:

107138367(Bmpr2)

ITI:	101962809(Bmpr2)

OCU:

100350246

OPI:	101519164(BMPR2)

TUP:	102472860(BMPR2)

GVR:	103592116(BMPR2)

CFA:	478875(BMPR2)

CLUD:

112656670(BMPR2)

VVP:	112922861(BMPR2)

VLG:	121480503(BMPR2)

NPO:	129522836(BMPR2)

AML:	100483427(BMPR2)

UMR:	103659757(BMPR2)

UAH:	113250576(BMPR2)

UAR:	123798214(BMPR2)

ELK:

111141287

LLV:

125095010

MPUF:

101682425(BMPR2)

MNP:	132013465(BMPR2)

MLK:	131827560(BMPR2)

NVS:	122902204(BMPR2)

ORO:	101386632(BMPR2)

EJU:	114203209 114203211

ZCA:	113920971(BMPR2)

MLX:	118012135(BMPR2)

NSU:	110592042(BMPR2)

LWW:	102743492(BMPR2)

FCA:	101096338(BMPR2)

PYU:	121030926(BMPR2)

PCOO:

112871614(BMPR2)

PBG:	122481657(BMPR2)

PVIV:

125172537(BMPR2)

LRUF:

124516263

LGF:	123599325(BMPR2)

AJU:

106978276

PTG:	102972964(BMPR2)

PPAD:

109259182(BMPR2)

PUC:

125911301

PLEZ:

122226504(BMPR2)

HHV:	120248921(BMPR2)

BTA:	407127(BMPR2)

BOM:	102276585(BMPR2)

BIU:	109575608(BMPR2)

BBUB:

102393717(BMPR2)

BBIS:

105003668(BMPR2)

CHX:	102173240(BMPR2)

OAS:	101103793(BMPR2)

BTAX:

128068370(BMPR2)

CSUM:

138076066(BMPR2)

ODA:	120854606(BMPR2)

CCAD:

122426765(BMPR2)

MREE:

136164988(BMPR2)

MBEZ:

129537933(BMPR2)

SSC:	100127483(BMPR2)

CFR:	102504117(BMPR2)

CBAI:

105082288(BMPR2)

CDK:	105098972(BMPR2)

VPC:	102545718(BMPR2)

BACU:

103010629(BMPR2)

BMUS:

118897810(BMPR2)

LVE:	103089843(BMPR2)

OOR:	101276638(BMPR2)

LALB:

132522161(BMPR2)

DLE:	111171741(BMPR2)

PCAD:

102993283(BMPR2)

PSIU:

116756498(BMPR2)

NASI:

112395233(BMPR2)

ECB:	100067195(BMPR2)

EPZ:	103549220(BMPR2)

EAI:	106824062(BMPR2)

MYB:	102255023(BMPR2)

MYD:	102769364(BMPR2)

MMYO:

118662104(BMPR2)

MLF:	102434866(BMPR2)

MDT:	132238134(BMPR2)

MYUM:

139014931(BMPR2)

PKL:	118709938(BMPR2)

EFUS:

103290608(BMPR2)

MNA:	107533955(BMPR2)

DRO:	112307666(BMPR2)

SHON:

118985221(BMPR2)

AJM:	119055277(BMPR2)

PDIC:

114495333(BMPR2)

PHAS:

123824495(BMPR2)

MMF:	118625348(BMPR2)

PPAM:

129080418(BMPR2)

HAI:	109379244(BMPR2)

RFQ:	117025507(BMPR2)

PALE:

102882003(BMPR2)

PGIG:

120587545(BMPR2)

PVP:	105298112(BMPR2)

RAY:	107519367(BMPR2)

MJV:	108409884(BMPR2)

TOD:	119256117(BMPR2)

SARA:

101543447(BMPR2)

SFUM:

130021097(BMPR2)

SETR:

126008897(BMPR2)

LAV:	100661600(BMPR2)

TMU:

101348356

ETF:	101641503(BMPR2)

DNM:	101431096(BMPR2)

MDO:	100018765(BMPR2)

GAS:	123242702(BMPR2)

SHR:	100925781(BMPR2)

AFZ:

127553215

PCW:	110198506(BMPR2)

TVP:	118846513(BMPR2)

PBRV:

138151732(BMPR2)

OAA:	100077247(BMPR2)

TACU:

119930547(BMPR2)

GGA:	374147(BMPR2)

PCOC:

116233992(BMPR2)

MGP:	100551416(BMPR2)

CJO:	107316544(BMPR2)

TPAI:

128077291(BMPR2)

LMUT:

125696888(BMPR2)

NMEL:

110400080(BMPR2)

APLA:

101793707(BMPR2)

ACYG:

106030098(BMPR2)

CATA:

118260495(BMPR2)

AFUL:

116490685(BMPR2)

TGU:	100227149(BMPR2)

LSR:	110484595(BMPR2)

SCAN:

103814497(BMPR2)

PMOA:

120500360(BMPR2)

OTC:	121335268(BMPR2)

PRUF:

121356435(BMPR2)

ATRC:

139593594(BMPR2)

GFR:	102043611(BMPR2)

FAB:	101806244(BMPR2)

OMA:	130255703(BMPR2)

PHI:	102110191(BMPR2)

PMAJ:

107207396(BMPR2)

CCAE:

111931997(BMPR2)

CCW:	104693787(BMPR2)

CBRC:

103616604(BMPR2)

ACOE:

138113635(BMPR2)

ETL:	114055729(BMPR2)

ZAB:	102071167(BMPR2)

ZLE:	135450038(BMPR2)

ACHL:

103806807(BMPR2)

SVG:	106855066(BMPR2)

MMEA:

130579150(BMPR2)

HRT:	120755246(BMPR2)

SATI:

136363414(BMPR2)

CCIC:

134047292(BMPR2)

FPG:	101919199(BMPR2)

FCH:	102046415(BMPR2)

CCRI:

104157428(BMPR2)

NNT:	104408855(BMPR2)

SHAB:

115608986(BMPR2)

ACUN:

113482567(BMPR2)

TALA:

104365038(BMPR2)

ACHC:

115342468(BMPR2)

HALD:

104319959(BMPR2)

HLE:	104830180(BMPR2)

AGEN:

126037752

HHAR:

128144483(BMPR2)

GCL:

127018160

CSTI:

104551929(BMPR2)

LDI:	104353053(BMPR2)

MNB:	103773388(BMPR2)

DPUB:

104296664(BMPR2)

PPUS:

135184800(BMPR2)

AVIT:

104272837(BMPR2)

BRHI:

104489874(BMPR2)

EGZ:	104130476(BMPR2)

NNI:	104010202(BMPR2)

PCRI:

104034155(BMPR2)

PCAO:

104045110(BMPR2)

PADL:

103923542(BMPR2)

AFOR:

103903448(BMPR2)

FGA:	104081825(BMPR2)

GSTE:

104251324(BMPR2)

CBOY:

140657818(BMPR2)

CLV:	102086688(BMPR2)

MUI:	104538861(BMPR2)

PGUU:

104458903(BMPR2)

PLET:

104621598(BMPR2)

EHS:	104506340(BMPR2)

CMAC:

104484240(BMPR2)

CUCA:

104058315(BMPR2)

TEO:	104382128(BMPR2)

BREG:

104632423(BMPR2)

OHA:	104334220(BMPR2)

ACAR:

104526633(BMPR2)

CPEA:

104397423(BMPR2)

CVF:	104291043(BMPR2)

RTD:	128912458(BMPR2)

CRID:

134518306(BMPR2)

AAM:	106492422(BMPR2)

AROW:

112976108(BMPR2)

NPD:	112956236(BMPR2)

TGT:	104571905(BMPR2)

DNE:	112989301(BMPR2)

SCAM:

104150154(BMPR2)

ASN:	102370042(BMPR2)

AMJ:	102577319(BMPR2)

CPOO:

109322927(BMPR2)

GGN:	109302032(BMPR2)

PSS:	102456232(BMPR2)

CMY:	102929585(BMPR2)

CCAY:

125645172(BMPR2)

DCC:	119863174(BMPR2)

CPIC:

101951829(BMPR2)

TST:	117885249(BMPR2)

CABI:

116821880

MRV:	120375188(BMPR2)

ACS:	100553521(bmpr2)

ASAO:

132779420(BMPR2)

PVT:	110088189(BMPR2)

SUND:

121922601(BMPR2)

PBI:	103060123(BMPR2)

PMUR:

107290699(BMPR2)

CTIG:

120313103(BMPR2)

PGUT:

117673601(BMPR2)

APRI:

131200359(BMPR2)

PTEX:

113433930(BMPR2)

NSS:	113421080(BMPR2)

VKO:	123024245(BMPR2)

PMUA:

114581483(BMPR2)

PRAF:

128400143(BMPR2)

ZVI:	118096116(BMPR2)

HCG:	128338359(BMPR2)

GJA:	107113314(BMPR2)

STOW:

125425744(BMPR2)

EMC:	129324490(BMPR2)

XLA:	108701455(bmpr2.L) 397981(bmpr2.S)

XTR:	100494339(bmpr2)

NPR:	108785044(BMPR2)

RTEM:

120943739(BMPR2)

BBUF:

121009036(BMPR2)

BGAR:

122944413(BMPR2)

PWL:	138285726(BMPR2)

MUO:	115473941(BMPR2)

GSH:	117360987(BMPR2)

DRE:	555655(bmpr2b) 562822(bmpr2a)

SRX:	107705593 107748564 107751503 107752887(bmpr2)

SANH:

107660075 107668372 107677783(bmpr2) 107688866

SGH:	107555441 107584759 107593012 107596525(bmpr2)

CCAR:

109064687 109066102 109086023 109089386(bmpr2b)

CAUA:

113050799 113053604 113093312 113108852(bmpr2)

CGIB:

127959835 127964496 128015378 128019643

PTET:

122346484(bmpr2a) 122351783(bmpr2b)

LROH:

127166841(bmpr2a) 127170604(bmpr2b)

OMC:	131542012(bmpr2a) 131546556(bmpr2b)

PPRM:

120487333(bmpr2b) 120491687(bmpr2a)

RKG:	130085759(bmpr2b) 130101192(bmpr2a)

MAMB:

125270081(bmpr2b) 125274334(bmpr2a)

CIDE:

127513859 127518321

CERY:

137011183(bmpr2a) 137036064(bmpr2b)

MASI:

127445823 127447178 127447853 127449669

TROS:

130555219(bmpr2b) 130556298(bmpr2a)

TDW:	130425168(bmpr2a) 130427201(bmpr2b)

MANU:

129450335(bmpr2a) 129451878(bmpr2b)

PDAB:

135717880(bmpr2a) 135731109 135782510(bmpr2b)

IPU:	108266402(bmpr2b) 108272897(bmpr2a)

IFU:	128608962(bmpr2b) 128615884(bmpr2a)

PHYP:

113525969(bmpr2) 113538343

SMEO:

124381358(bmpr2b) 124390728(bmpr2a)

TFD:	113654295(bmpr2b) 113663629(bmpr2a)

TVC:	132845009(bmpr2a) 132850288(bmpr2b)

CGAR:

128524601(bmpr2b) 128526686(bmpr2a)

NGRA:

132884751(bmpr2a) 132891966(bmpr2b)

TRN:	134316481(bmpr2a) 134323937(bmpr2b)

AMEX:

103041475(bmpr2a) 103046530(bmpr2b)

CMAO:

118806670(bmpr2b) 118807784(bmpr2a)

EEE:	113578552(bmpr2) 113582596

CHAR:

105912412(bmpr2a)

SPIL:

134062542(bmpr2a) 134078783(bmpr2b)

TRU:	101069366(bmpr2)

TFS:

130522626

TNG:	GSTEN00024860G001

LCO:	104926387(bmpr2) 104931750

NCC:	104958413(bmpr2)

TBEN:

117496743 117498924

CGOB:

115004852 115018188(bmpr2)

PGEO:

117458543

GACU:

117546599 117554725

EMAC:

134860873 134867357

ELY:	117249830 117251488

EFO:	125884706 125899779

PLEP:

121948890 121962685

SLUC:

116044479 116064191

ECRA:

117939245 117953068

ESP:	116673984(bmpr2) 116686627

PFLV:

114550971(bmpr2)

GAT:	120821714 120833691

PPUG:

119218503 119228968

AFB:	129105092 129111828

CLUM:

117741187 117750056

PSWI:

130204365 130205339

CANA:

137793972 137803234

CVE:	137879203 137891640

MSAM:

119901066(bmpr2b) 119903610

SCHU:

122872292 122885291

CUD:	121506160(bmpr2b) 121522426

SPUL:

LMIX:

ALAT:

ASTR:

MZE:	101480484 101485979(bmpr2)

ONL:	100690976(bmpr2) 100694986

OAU:	116313737 116327968

OLA:	101167856(bmpr2)

OML:	112138024 112159966

CSAI:

133425424 133446172

XMA:	102230588 102232740(bmpr2)

XCO:	114140973(bmpr2) 114148757

XHE:	116716136(bmpr2) 116723454

PRET:

103461763 103474116(bmpr2)

PFOR:

103147169(bmpr2) 103152078

PLAI:

106959966 106964126(bmpr2)

PMEI:

106928845 106933583(bmpr2)

GAF:	122827399 122840057

PPRL:

129374562 129378728

CVG:	107087239(bmpr2) 107103972

CTUL:

119794420 119795839

GMU:	124861560 124871630

NFU:	107377073(bmpr2)

KMR:	108242164 108247756

ALIM:

106511674 106535653 106536951

NWH:	119419776 119428639(bmpr2b) 119429438

AOCE:

111565854

EJA:	138197610 138201209

BFRE:

138635692 138636858

MCEP:

125000870(bmpr2b) 125018042

CSEM:

103389452(bmpr2)

POV:

SSEN:

SSOE:

HHIP:

HSP:	118103208 118119902

PPLT:

128431002 128455447

SMAU:

118282887 118306109

LCF:	108874243 108880213

SDU:	111222709(bmpr2)

SLAL:

111655508 111672388(bmpr2)

XGL:	120797983 120801369

HCQ:	109507796(bmpr2)

SSCV:

125989450(bmpr2b)

SBIA:

133509540

PEE:

133405945

PTAO:

133483626

BPEC:

110153178(bmpr2)

ENY:	140359286 140372336

MALB:

109951513(bmpr2) 109970434

BSPL:

114847607 114865648

SJO:	128354056 128368280

SSCO:

133976270

GMH:	115541821(bmpr2)

SASA:

106593270 106594345

STRU:

115156264 115161448 115184541

OTW:	112236680 112237638(bmpr2b) 112239976(bmpr2a)

OMY:	110504983 110511378(bmpr2b) 110524928

OGO:	123993020(bmpr2b) 124027043 124044489

OKI:	109884546 109886111 116361478

OKE:	118383437 127931043(bmpr2b)

OMM:	135538087(bmpr2b) 135538098

OCLA:

139372817 139380998 139386378 139404863

SNH:

120037761

CCLU:

121554954(bmpr2b) 121560083 121563972

ELS:	105007022 105020079

OEP:	134007203 134017295(bmpr2b)

SFM:	108920640 108942470(bmpr2)

PKI:	111840727 111858338(bmpr2)

AANG:

118213566

AROT:

135240461

CCOG:

133116484

LOC:	102688466(bmpr2)

PSPA:

121322106 121322799

ARUT:

117407627 117426670

PSEX:

120531931

LCM:	102353534(BMPR2)

CMK:	103189999(bmpr2b)

RTP:	109916147(bmpr2b)

CPLA:

122551451(bmpr2b)

HOC:	132817273(bmpr2b)

LERI:

129698876(bmpr2b)

PMRN:

116938739(BMPR2) 116946141 116954639

LRJ:	133345034 133345921 133358182 133358204

BFO:

BBEL:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG10776(wit)

DER:

6543570

DSE:

6610709

DSI:	Dsimw501_GD13298(Dsim_GD13298)

DYA:	Dyak_GE20653

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI11419

DAZ:

108613396

DNV:

108651397

DHE:

111597498

DVI:	6623303(wit)

CCAT:

101460483

BOD:

106616585

BDR:

105224874

RZE:	108369546 108371647 108373913

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135953295(wit)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ004526

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139109101(Wit)

TLN:	139825398(Wit)

HST:

DQU:

CFO:

FEX:

PMEC:

138939886(Wit)

LHU:	105676358(wit)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

VCAN:

CCIN:

TCA:	663692(wit)

TMOL:

138122634(wit)

DPA:

109536255

ESIM:

136419616(wit)

EFOR:

136341700(wit)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209095

BANY:

MJU:

VCD:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:	114353308 114365362

ONU:

135084798

ATRA:

106131238

GMW:	113515868 128200162

LGLY:

CSTB:

CFEL:

CCRN:

BTAB:

CLEC:

HHAL:

106680512(wit)

NLU:

HVI:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138706766(wit)

BROR:

134539386

HAMR:

139693749(wit)

FCD:

AFRA:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

DPTE:

CSCU:

CVS:	136976164 136978731

PTEP:

107454377 107454396

ABRU:

129963781 129981369

UDV:	129225536 129235146

SDM:	118191370 118203447

HRO:	HELRODRAFT_107474

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

MYI:

PMAX:

AIRR:

MMER:

RPHI:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

HMG:

HSY:

Reference

PMID:7791754

Authors

Liu F, Ventura F, Doody J, Massague J.

Title

Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.

Journal

Mol Cell Biol 15:3479-86 (1995)
DOI:10.1128/MCB.15.7.3479

Sequence

[hsa:659]

All links

Ontology (1)   
   GO (1)   
Gene (943)   
   MGENES (308)   
   RefGene (629)   
   OC (6)   
All databases (944)   

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