KEGG   ORTHOLOGY: K04688
Entry
K04688                      KO                                     

Symbol
RPS6KB
Name
ribosomal protein S6 kinase beta [EC:2.7.11.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04012  ErbB signaling pathway
map04066  HIF-1 signaling pathway
map04140  Autophagy - animal
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04212  Longevity regulating pathway - worm
map04213  Longevity regulating pathway - multiple species
map04350  TGF-beta signaling pathway
map04361  Axon regeneration
map04371  Apelin signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04714  Thermogenesis
map04910  Insulin signaling pathway
map04931  Insulin resistance
map05131  Shigellosis
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05207  Chemical carcinogenesis - receptor activation
map05210  Colorectal cancer
map05212  Pancreatic cancer
map05221  Acute myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05231  Choline metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04350 TGF-beta signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04371 Apelin signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04066 HIF-1 signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04151 PI3K-Akt signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04152 AMPK signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04150 mTOR signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04688  RPS6KB; ribosomal protein S6 kinase beta
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09158 Development and regeneration
   04361 Axon regeneration
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09149 Aging
   04211 Longevity regulating pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04212 Longevity regulating pathway - worm
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04213 Longevity regulating pathway - multiple species
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09159 Environmental adaptation
   04714 Thermogenesis
    K04688  RPS6KB; ribosomal protein S6 kinase beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05205 Proteoglycans in cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05207 Chemical carcinogenesis - receptor activation
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05231 Choline metabolism in cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05212 Pancreatic cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05225 Hepatocellular carcinoma
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05226 Gastric cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05221 Acute myeloid leukemia
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05224 Breast cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05163 Human cytomegalovirus infection
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05165 Human papillomavirus infection
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   01522 Endocrine resistance
    K04688  RPS6KB; ribosomal protein S6 kinase beta
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04688  RPS6KB; ribosomal protein S6 kinase beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04688  RPS6KB; ribosomal protein S6 kinase beta
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   K04688  RPS6KB; ribosomal protein S6 kinase beta
Other DBs
GO: 0004711
Genes
HSA: 6198(RPS6KB1) 6199(RPS6KB2)
PTR: 468426(RPS6KB1) 746903(RPS6KB2)
PPS: 100986739(RPS6KB2) 100995177(RPS6KB1)
GGO: 101126746(RPS6KB1) 101134525(RPS6KB2)
PON: 100456988(RPS6KB1) 100459428(RPS6KB2) 100462008
NLE: 100593862(RPS6KB1) 100606492(RPS6KB2)
MCC: 711979(RPS6KB1) 721731(RPS6KB2)
MCF: 101925564(RPS6KB1) 102134845(RPS6KB2)
CSAB: 103218141(RPS6KB2) 103242820(RPS6KB1)
CATY: 105577354(RPS6KB2) 105583339(RPS6KB1)
PANU: 101012071(RPS6KB2) 101024761(RPS6KB1)
RRO: 104662932(RPS6KB1) 104664740(RPS6KB2)
RBB: 108518621(RPS6KB2) 108533071(RPS6KB1)
TFN: 117067326(RPS6KB1) 117080241(RPS6KB2)
PTEH: 111522215(RPS6KB2)
CJC: 100397180(RPS6KB2) 100409247(RPS6KB1)
SBQ: 101033758(RPS6KB2) 101038541(RPS6KB1)
MMUR: 105867475(RPS6KB2) 105874527(RPS6KB1)
MMU: 58988(Rps6kb2) 72508(Rps6kb1)
MCAL: 110285417(Rps6kb2) 110304919(Rps6kb1)
MPAH: 110315992(Rps6kb2) 110331448(Rps6kb1)
RNO: 361696(Rps6kb2) 83840(Rps6kb1)
MCOC: 116079205(Rps6kb1) 116103319(Rps6kb2)
MUN: 110553742(Rps6kb1) 110560360(Rps6kb2)
CGE: 100757513(Rps6kb1) 100760227(Rps6kb2)
PLEU: 114685999(Rps6kb2) 114699281(Rps6kb1)
NGI: 103725586(Rps6kb2) 103741760(Rps6kb1)
HGL: 101702911(Rps6kb2) 101724077(Rps6kb1)
CCAN: 109685124(Rps6kb1) 109688624(Rps6kb2)
OCU: 100009260(RPS6KB1)
TUP: 102475423(RPS6KB2) 102493152(RPS6KB1)
CFA: 480580(RPS6KB1) 610499(RPS6KB2)
VVP: 112917940(RPS6KB1) 112924182(RPS6KB2)
VLG: 121471453(RPS6KB2) 121472885(RPS6KB1)
AML: 100464998(RPS6KB2) 100484786(RPS6KB1)
UMR: 103667329(RPS6KB1) 103679516(RPS6KB2)
UAH: 113244028(RPS6KB2) 113268897(RPS6KB1)
ORO: 101365998(RPS6KB1) 101381996(RPS6KB2)
MPUF: 101672818(RPS6KB2) 101677354(RPS6KB1)
EJU: 114213794(RPS6KB1) 114220439(RPS6KB2)
MLX: 118016129(RPS6KB2) 118024673(RPS6KB1)
FCA: 101091812(RPS6KB2) 101092561(RPS6KB1)
PYU: 121023683(RPS6KB2) 121044690(RPS6KB1)
PBG: 122484054(RPS6KB2) 122485296(RPS6KB1)
PTG: 102950850(RPS6KB2) 102960736(RPS6KB1)
PPAD: 109246850(RPS6KB2) 109256121(RPS6KB1)
AJU: 106971103(RPS6KB2) 106972702(RPS6KB1)
HHV: 120233932(RPS6KB2) 120241926(RPS6KB1)
BTA: 404181(RPS6KB1) 506083(RPS6KB2)
BOM: 102271079(RPS6KB2) 102285710(RPS6KB1)
BIU: 109554358(RPS6KB2) 109573726(RPS6KB1)
BBUB: 102402840(RPS6KB1) 102413442(RPS6KB2)
CHX: 100861297(RPS6KB1) 102169319 102182675(RPS6KB2)
OAS: 101107371(RPS6KB1) 101109574(RPS6KB2)
ODA: 120866437(RPS6KB1) 120874776(RPS6KB2)
CCAD: 122430962(RPS6KB2) 122450141(RPS6KB1)
SSC: 100127158(RPS6KB1) 100512153(RPS6KB2)
CFR: 102511731(RPS6KB1) 102518322(RPS6KB2)
CBAI: 105065845(RPS6KB1) 105070333(RPS6KB2)
CDK: 105097829(RPS6KB1) 105104425(RPS6KB2)
BACU: 102998750(RPS6KB2) 103019799(RPS6KB1)
LVE: 103073645(RPS6KB2) 103090358(RPS6KB1)
OOR: 101283084(RPS6KB1) 101286642(RPS6KB2)
DLE: 111163760(RPS6KB1) 111183673(RPS6KB2)
PCAD: 102976885(RPS6KB2) 102990399(RPS6KB1)
ECB: 100053005(RPS6KB2) 100057481(RPS6KB1)
EPZ: 103559935(RPS6KB2) 103565282(RPS6KB1)
EAI: 106833496(RPS6KB2) 106841135(RPS6KB1)
MYB: 102245108(RPS6KB2) 102253735(RPS6KB1)
MYD: 102763828(RPS6KB2) 102775361(RPS6KB1)
MMYO: 118649569 118649570 118665219(RPS6KB2) 118671643(RPS6KB1)
MNA: 107530082(RPS6KB1) 107537414(RPS6KB2)
HAI: 109379764(RPS6KB1) 109384219(RPS6KB2)
DRO: 112316527(RPS6KB1) 112317229(RPS6KB2)
SHON: 118991818(RPS6KB2) 119003484(RPS6KB1)
AJM: 119041842(RPS6KB2) 119062679(RPS6KB1)
MMF: 118627654(RPS6KB2) 118634239(RPS6KB1)
PALE: 102889369(RPS6KB1) 102891214(RPS6KB2)
PGIG: 120584753(RPS6KB2) 120620825(RPS6KB1)
RAY: 107503682(RPS6KB2) 107510136(RPS6KB1)
MJV: 108393161(RPS6KB2) 108401175(RPS6KB1)
TOD: 119232527(RPS6KB1) 119249909(RPS6KB2)
LAV: 100653946(RPS6KB1) 100671034(RPS6KB2)
MDO: 100010269(RPS6KB1) 100011566 100014573(RPS6KB2)
SHR: 100930707(RPS6KB1) 100935081(RPS6KB2)
PCW: 110195494(RPS6KB2) 110212045(RPS6KB1)
OAA: 100078852(RPS6KB1) 100087780(RPS6KB2)
GGA: 417637(RPS6KB1) 429557(RPS6KB2)
PCOC: 116227961(RPS6KB1) 116242909(RPS6KB2)
MGP: 100548374(RPS6KB2) 100551178(RPS6KB1)
CJO: 107314239(RPS6KB2) 107322434(RPS6KB1)
NMEL: 110407933(RPS6KB1)
APLA: 101792883(RPS6KB1)
ACYG: 106046854(RPS6KB1)
TGU: 100226155(RPS6KB1) 115495414(RPS6KB2)
LSR: 110467654(RPS6KB1) 110485073(RPS6KB2)
SCAN: 103820173(RPS6KB1) 103822256(RPS6KB2)
PMOA: 120499581(RPS6KB2) 120507611(RPS6KB1)
GFR: 102036821(RPS6KB1)
FAB: 101810135(RPS6KB1) 101817600(RPS6KB2)
PHI: 102100544(RPS6KB1) 102108348(RPS6KB2)
PMAJ: 107206395(RPS6KB2) 107212783(RPS6KB1)
CCAE: 111937833(RPS6KB1)
CCW: 104691002(RPS6KB1)
ETL: 114063332(RPS6KB2) 114067697(RPS6KB1)
FPG: 101910744(RPS6KB1)
FCH: 102057985(RPS6KB1)
CLV: 102090789(RPS6KB2) 102091507(RPS6KB1)
EGZ: 104121880(RPS6KB1)
NNI: 104016535(RPS6KB1)
ACUN: 113487063(RPS6KB1)
PADL: 103916836(RPS6KB1)
AAM: 106492594 106500339(RPS6KB1)
AROW: 112963284(RPS6KB2) 112968798(RPS6KB1)
NPD: 112954566(RPS6KB1) 112957576(RPS6KB2)
DNE: 112988674(RPS6KB2) 112991971(RPS6KB1)
ASN: 102370189(RPS6KB2) 102387892(RPS6KB1)
AMJ: 102571014(RPS6KB2) 106736874(RPS6KB1)
CPOO: 109317169(RPS6KB1) 109324623(RPS6KB2)
GGN: 109293289(RPS6KB1)
PSS: 102458972(RPS6KB1) 102460281(RPS6KB2)
CMY: 102932417(RPS6KB2) 102948337(RPS6KB1)
CPIC: 101938925(RPS6KB1) 101949346(RPS6KB2)
TST: 117867436(RPS6KB1) 117876021(RPS6KB2)
CABI: 116827410(RPS6KB1) 116833425(RPS6KB2)
ACS: 100557539(rps6kb2) 100565927(rps6kb1)
PVT: 110075522(RPS6KB1) 110085635(RPS6KB2)
PBI: 103054324(RPS6KB1) 103056543(RPS6KB2)
PMUR: 107293632(RPS6KB2) 107298703(RPS6KB1)
TSR: 106538899(RPS6KB2) 106553908(RPS6KB1)
PGUT: 117675339(RPS6KB2) 117675678(RPS6KB1)
PMUA: 114585225(RPS6KB1) 114602120(RPS6KB2)
ZVI: 118090279(RPS6KB2) 118096774(RPS6KB1)
XLA: 394276(rps6kb1.S) 394347(rps6kb1.L)
XTR: 394938(rps6kb1)
NPR: 108796234 108798072(RPS6KB1)
DRE: 406349(rps6kb1b) 562242(rps6kb1a)
CCAR: 109083699
IPU: 108260512 108278249(rps6kb1)
PHYP: 113532841(rps6kb1)
AMEX: 103031203(rps6kb2) 103035647(rps6kb1)
EEE: 113568160 113584368(rps6kb1)
LCO: 104930044 104933515(rps6kb1)
NCC: 104949480(rps6kb1) 104965260
CGOB: 115013736 115018012 115018618(rps6kb1)
ELY: 117255533 117259591 117268077(rps6kb1a)
PLEP: 121941910 121942813 121952739(rps6kb1a)
SLUC: 116043815(rps6kb1b) 116048440 116058279(rps6kb1a)
ECRA: 117938607(rps6kb1b) 117955517(rps6kb1a) 117957782
PFLV: 114552495 114566849(rps6kb1) 114571970
GAT: 120821610(rps6kb1a) 120825409 120828045(rps6kb1b)
MSAM: 119882554(rps6kb1b) 119895400(rps6kb1a) 119899805
CUD: 121507968 121518564(rps6kb1a) 121519529(rps6kb1b)
OAU: 116320240 116326711(rps6kb1a) 116330420(rps6kb1b)
OML: 112138696(rps6kb1a) 112149160(rps6kb1b) 112157403
CTUL: 119782278 119783834(rps6kb1b) 119791578
NFU: 107380537(rps6kb1) 107396767
KMR: 108238123 108246184(rps6kb1a) 108247815
ALIM: 106520615(rps6kb1) 106524356 106537330
AOCE: 111566696(rps6kb1) 111579842 111588930
CSEM: 103377585(rps6kb1) 103383966 103395203
SLAL: 111654555 111663925(rps6kb1) 111673584
XGL: 120792170 120800006 120802434(rps6kb1a)
PKI: 111839121 111854744(rps6kb1)
AANG: 118209632 118227797 118234815(rps6kb1a)
LOC: 102691816 102695696(rps6kb1)
PSPA: 121302105 121308414(rps6kb1a)
LCM: 102353676(RPS6KB1) 102361574
CMK: 103186905(rps6kb1)
RTP: 109911139
BFO: 118425804
BBEL: 109462865
CIN: 100178579
SCLV: 120346821
SPU: 575764
APLC: 110990034
SKO: 100376001
DME: Dmel_CG10539(S6k)
DER: 6544636
DSE: 6610921
DSI: Dsimw501_GD13174(Dsim_GD13174)
DAN: 6493312
DSR: 110190825
DPE: 6602941
DMN: 108151753
DWI: 6638935
DGR: 6557538
DAZ: 108614230
DNV: 108651078
DHE: 111594833
DVI: 6622444
CCAT: 101454982
MDE: 101896302
LCQ: 111684608
ACOZ: 120952346
AARA: 120906826
AAG: 5566289
AALB: 109418942
CPII: 120432601
AME: 552549
TCA: 661481
DPA: 109545103
ATD: 109594784
NVL: 108561831
PPYR: 116176331
OTU: 111415769
BMOR: 100174852
MSEX: 115443136
BANY: 112049395
PMAC: 106710712
PPOT: 106109175
PXU: 106128332
PRAP: 110996455
ZCE: 119835168
HAW: 110369906
TNL: 113504422
PXY: 105380575
API: 100162508
DNX: 107172741
AGS: 114128810
RMD: 113551748
BTAB: 109037417
DCI: 103510728
CLEC: 106664197
HHAL: 106691622
NLU: 111044135
ZNE: 110838355
CSEC: 111868310
DMK: 116931739
PVM: 113817000
HAME: 121859740
HAZT: 108682123
DSV: 119445459
RMP: 119169107
TUT: 107361083
DPTE: 113797177
CSCU: 111640927
PTEP: 107451200
CEL: CELE_R04A9.7(R04A9.7) CELE_Y47D3A.16(rsks-1)
CBR: CBG08151 CBG10201 CBG13216(Cbr-rsks-1)
BMY: BM_BM6597(Bma-rsks-1)
TSP: Tsp_06286
BGT: 106072640
GAE: 121367855
CRG: 105324844
MYI: 110457708
PMAX: 117332670
OBI: 106872574
LAK: 106160338
EGL: EGR_03446
NVE: 5512874
EPA: 110232607
ATEN: 116291028
AMIL: 114957964
PDAM: 113665493
SPIS: 111345005
DGT: 114523875
HMG: 100209609
AQU: 100638046
ATH: AT3G08720(S6K2) AT3G08730(PK1)
CPAP: 110811621
LJA: Lj0g3v0157689.1(Lj0g3v0157689.1) Lj2g3v2172980.1(Lj2g3v2172980.1) Lj4g3v1586940.1(Lj4g3v1586940.1)
CSV: 101214867
CMO: 103493951
BHJ: 120070555
DOSA: Os03t0334000-02(Os03g0334000) Os07t0680900-01(Os07g0680900)
ZMA: 100273759 100281573(IDP300) 542142(S6K)
PDA: 103722170
MUS: 103986206
APRO: F751_2597
 » show all
Reference
PMID:1922062
  Authors
Grove JR, Banerjee P, Balasubramanyam A, Coffer PJ, Price DJ, Avruch J, Woodgett JR
  Title
Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini.
  Journal
Mol Cell Biol 11:5541-50 (1991)
DOI:10.1128/MCB.11.11.5541
Reference
  Authors
Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG
  Title
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.
  Journal
EMBO J 20:4370-9 (2001)
DOI:10.1093/emboj/20.16.4370
  Sequence
[hsa:6198]

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