KEGG   ORTHOLOGY: K04697Help
Entry
K04697                      KO                                     

Name
SOCS4
Definition
suppressor of cytokine signaling 4
Pathway
ko04630  JAK-STAT signaling pathway
ko04910  Insulin signaling pathway
ko04917  Prolactin signaling pathway
ko04930  Type II diabetes mellitus
Module
M00388  ECS complex
M00684  JAK-STAT signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    K04697  SOCS4; suppressor of cytokine signaling 4
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04697  SOCS4; suppressor of cytokine signaling 4
   04917 Prolactin signaling pathway
    K04697  SOCS4; suppressor of cytokine signaling 4
 09160 Human Diseases
  09167 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04697  SOCS4; suppressor of cytokine signaling 4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K04697  SOCS4; suppressor of cytokine signaling 4
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00388  ECS complex
     K04697  SOCS4; suppressor of cytokine signaling 4
 Functional set
  Cellular processes
   Cell signaling
    M00684  JAK-STAT signaling
     K04697  SOCS4; suppressor of cytokine signaling 4
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   ECS complex
    Target recognizing subunit (SOCS box)
     K04697  SOCS4; suppressor of cytokine signaling 4
BRITE hierarchy
Genes
HSA: 122809(SOCS4)
PTR: 452919(SOCS4)
PPS: 100989690(SOCS4)
GGO: 101131192(SOCS4)
PON: 100171842(SOCS4)
NLE: 100590972(SOCS4)
MCC: 696146(SOCS4)
MCF: 102141350(SOCS4)
CSAB: 103229025(SOCS4)
RRO: 104669147(SOCS4)
RBB: 108530661(SOCS4)
CJC: 100386210(SOCS4)
SBQ: 101034850(SOCS4)
MMU: 67296(Socs4)
RNO: 305828(Socs4)
CGE: 100750379(Socs4)
NGI: 103739222(Socs4)
HGL: 101704725(Socs4)
CCAN: 109693954(Socs4)
OCU: 100357417(SOCS4)
TUP: 102468675(SOCS4)
CFA: 100687271(SOCS4)
AML: 100464791(SOCS4)
UMR: 103673077(SOCS4)
ORO: 101383881(SOCS4)
FCA: 101080974(SOCS4)
PTG: 102971697(SOCS4)
AJU: 106984332(SOCS4)
BTA: 540412(SOCS4)
BOM: 102270424(SOCS4)
BIU: 109565183(SOCS4)
PHD: 102333116(SOCS4)
CHX: 102185842(SOCS4)
OAS: 101117935(SOCS4)
SSC: 100302366(SOCS4)
CFR: 102515584(SOCS4)
CDK: 105091440(SOCS4)
BACU: 103014060(SOCS4)
LVE: 103076129(SOCS4)
OOR: 101275711(SOCS4)
ECB: 100050301(SOCS4)
EPZ: 103554102(SOCS4)
EAI: 106846111(SOCS4)
MYB: 102247430(SOCS4)
MYD: 102767035(SOCS4)
HAI: 109384171(SOCS4)
RSS: 109444383(SOCS4)
PALE: 102879275(SOCS4)
LAV: 100662743(SOCS4)
TMU: 101358025
MDO: 100024207(SOCS4)
SHR: 100921040(SOCS4)
OAA: 100091294
GGA: 423557(SOCS4)
MGP: 100549827(SOCS4)
CJO: 107315453(SOCS4)
APLA: 101804231(SOCS4)
ACYG: 106044059(SOCS4)
TGU: 100230629(SOCS4)
SCAN: 103826330(SOCS4)
GFR: 102043937(SOCS4)
FAB: 101815072(SOCS4) 101816294
PHI: 102109006(SOCS4)
PMAJ: 107206463(SOCS4)
CCAE: 111929669(SOCS4)
CCW: 104687619(SOCS4)
FPG: 101924304(SOCS4)
FCH: 102048310(SOCS4)
CLV: 102086690(SOCS4)
EGZ: 104122986(SOCS4)
NNI: 104019434(SOCS4)
ACUN: 113480674(SOCS4)
AAM: 106493674(SOCS4)
ASN: 102384587(SOCS4)
AMJ: 102572731(SOCS4)
PSS: 102453072(SOCS4)
CMY: 102931468(SOCS4)
CPIC: 101953043(SOCS4)
ACS: 100561266(socs4)
PVT: 110070093(SOCS4)
PBI: 103053679(SOCS4)
PMUR: 107293655(SOCS4)
GJA: 107113082(SOCS4)
XLA: 108698764(socs4.L) 108699788(socs4.S)
XTR: 549828(socs4)
NPR: 108789412(SOCS4)
DRE: 100003691(socs9)
IPU: 108270091(SOCS4)
PHYP: 113534177
AMEX: 103045167
TRU: 100144313(socs4)
LCO: 104929608
NCC: 104964293
MZE: 101469365
OLA: 100144385(socs4)
XMA: 102232061
PRET: 103462934
NFU: 107381831
KMR: 108242119(socs4)
CSEM: 103398397
LCF: 108888048(socs4)
SDU: 111224920
HCQ: 109514287
MALB: 109974789
SASA: 106602930(socs4)
ELS: 105023278(socs4)
SFM: 108919519
LCM: 102362805(SOCS4)
CMK: 103175235(socs4)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.
  Title
The SOCS box: a tale of destruction and degradation.
  Journal
Trends Biochem Sci 27:235-41 (2002)
DOI:10.1016/S0968-0004(02)02085-6
  Sequence
[hsa:122809]
Reference
  Authors
Kario E, Marmor MD, Adamsky K, Citri A, Amit I, Amariglio N, Rechavi G, Yarden Y
  Title
Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.
  Journal
J Biol Chem 280:7038-48 (2005)
DOI:10.1074/jbc.M408575200
  Sequence
[hsa:122809]

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