KEGG   ORTHOLOGY: K04707Help
Entry
K04707                      KO                                     

Name
CBL
Definition
E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
Pathway
ko04012  ErbB signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04144  Endocytosis
ko04910  Insulin signaling pathway
ko05100  Bacterial invasion of epithelial cells
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05220  Chronic myeloid leukemia
Disease
H00523  Noonan syndrome and related disorders
H02190  CBL syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   05205 Proteoglycans in cancer
    K04707  CBL; E3 ubiquitin-protein ligase CBL
  09162 Cancers: Specific types
   05220 Chronic myeloid leukemia
    K04707  CBL; E3 ubiquitin-protein ligase CBL
  09171 Infectious diseases: Bacterial
   05100 Bacterial invasion of epithelial cells
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   04121 Ubiquitin system
    K04707  CBL; E3 ubiquitin-protein ligase CBL
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K04707  CBL; E3 ubiquitin-protein ligase CBL
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K04707  CBL; E3 ubiquitin-protein ligase CBL
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   CBL proteins
    K04707  CBL; E3 ubiquitin-protein ligase CBL
BRITE hierarchy
Genes
HSA: 867(CBL)
PTR: 451690(CBL)
PPS: 100988815(CBL)
GGO: 101140325(CBL)
PON: 100462634(CBL)
NLE: 100607272(CBL)
MCC: 704311(CBL)
MCF: 102137660(CBL)
CSAB: 103248629(CBL)
RRO: 104657236(CBL)
RBB: 108528599(CBL) 108542282
CJC: 100408313(CBL)
SBQ: 101053489(CBL)
MMU: 12402(Cbl)
RNO: 500985(Cbl)
CGE: 100754737(Cbl)
NGI: 103727895(Cbl)
HGL: 101710004(Cbl)
CCAN: 109696224(Cbl)
OCU: 100342595(CBL)
TUP: 102469580(CBL)
CFA: 489369(CBL)
AML: 100470573(CBL)
UMR: 103662312(CBL)
ORO: 101377544(CBL)
PTG: 102960753(CBL)
AJU: 106983886(CBL)
BTA: 527418(CBL)
BOM: 102279176(CBL)
BIU: 109568806(CBL)
PHD: 102324436(CBL)
CHX: 102185385(CBL)
OAS: 101115401(CBL)
SSC: 100518854(CBL)
CFR: 102504124(CBL)
CDK: 105090203(CBL)
BACU: 103016132(CBL)
LVE: 103082495(CBL)
OOR: 101270049(CBL)
ECB: 100071403(CBL)
EPZ: 103546643(CBL)
EAI: 106840308(CBL)
MYB: 102242908(CBL)
MYD: 102763080(CBL)
HAI: 109393876(CBL)
RSS: 109437227(CBL)
PALE: 102895335(CBL)
LAV: 100658892(CBL)
TMU: 101342874
MDO: 100031184(CBL)
SHR: 100920890(CBL)
OAA: 100091424
GGA: 374038(CBL)
MGP: 100549952(CBL)
CJO: 107324207(CBL)
APLA: 101789789(CBL)
ACYG: 106039784(CBL)
TGU: 100227293(CBL)
GFR: 102036440(CBL)
FAB: 101810639(CBL)
PHI: 102103093(CBL)
PMAJ: 107214346(CBL)
CCAE: 111939301(CBL)
CCW: 104692188(CBL)
FPG: 101919050(CBL)
FCH: 102058724(CBL)
CLV: 102096530(CBL)
EGZ: 104125948(CBL)
AAM: 106495869(CBL)
ASN: 102372644(CBL)
AMJ: 106737050(CBL)
PSS: 102450818(CBL)
CMY: 102937369(CBL)
CPIC: 101937375(CBL)
ACS: 100568145(cbl)
PVT: 110078535(CBL)
PBI: 103056422(CBL)
GJA: 107105501(CBL)
XLA: 108705407(cbl.S) 398194(cbl.L)
XTR: 594900(cbl)
NPR: 108797509(CBL)
DRE: 492364(cbl)
SANH: 107683813(cbl) 107690460
SGH: 107585540(cbl) 107601723
IPU: 108277804(cbl)
AMEX: 103032411(cbl)
TRU: 101070370 101078613(cbl)
LCO: 104921108 104936425(cbl)
OLA: 101163758 101170289(cbl)
XMA: 102233950 102234614(cbl)
PRET: 103474573(cbl) 103476312
NFU: 107380353(cbl) 107387219
KMR: 108238085 108246038(cbl)
CSEM: 103378406(cbl) 103395395
LCF: 108886386(cbl) 108893685
SDU: 111217085 111228025(cbl)
HCQ: 109517915 109529378(cbl)
BPEC: 110154105(cbl) 110174966
MALB: 109959267 109960188(cbl)
ELS: 105011087 105012434(cbl)
LCM: 102345712(CBL) 102349292(CBLC)
CMK: 103191373
CIN: 100176362
APLC: 110989191
DME: Dmel_CG7037(Cbl)
DER: 6545674
DSI: Dsimw501_GD14094(Dsim_GD14094)
AAG: 5572351
AME: 411982
BIM: 100745466
BTER: 100642596
SOC: 105202310
AEC: 105147762
ACEP: 105620476
PBAR: 105429426
HST: 105191070
DQU: 106751772
CFO: 105249224
LHU: 105673746
PCF: 106788578
NVI: 100119672
MDL: 103577747
TCA: 656167
DPA: 109541931
NVL: 108569006
BMOR: 101740182
PMAC: 106709441
PRAP: 110993846
HAW: 110381365
PXY: 105391330
API: 100159071
DNX: 107164289
CLEC: 106665709
ZNE: 110833897
FCD: 110842987
TUT: 107370090
CEL: CELE_M02A10.3(sli-1)
CBR: CBG08124(Cbr-sli-1)
BMY: Bm1_05660
TSP: Tsp_01088
CRG: 105342258
MYI: 110444983
OBI: 106869207
LAK: 106177307
SHX: MS3_04067
EGL: EGR_02348
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wehrle C, Van Slyke P, Dumont DJ
  Title
Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.
  Journal
Biochem J 423:375-80 (2009)
DOI:10.1042/BJ20091010
Reference
  Authors
Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC
  Title
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
  Journal
Science 286:309-12 (1999)
DOI:10.1126/science.286.5438.309
  Sequence
[hsa:867]

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