KEGG   ORTHOLOGY: K04710Help
Entry
K04710                      KO                                     

Name
CERS1_2_3_4, LASS1_2_3_4
Definition
ceramide synthetase [EC:2.3.1.24]
Pathway
ko00600  Sphingolipid metabolism
ko01100  Metabolic pathways
ko04071  Sphingolipid signaling pathway
Module
M00094  Ceramide biosynthesis
M00099  Sphingosine biosynthesis
Disease
H00734  Autosomal recessive congenital ichthyosis
H00810  Progressive myoclonic epilepsy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    K04710  CERS1_2_3_4, LASS1_2_3_4; ceramide synthetase
 09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    K04710  CERS1_2_3_4, LASS1_2_3_4; ceramide synthetase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.24  sphingosine N-acyltransferase
     K04710  CERS1_2_3_4, LASS1_2_3_4; ceramide synthetase
BRITE hierarchy
Other DBs
RN: R01496 R06517
GO: 0050291
Genes
HSA: 10715(CERS1) 204219(CERS3) 29956(CERS2) 79603(CERS4)
PTR: 453683(CERS3) 456435(CERS4) 468773(CERS1) 469482(CERS2)
PPS: 100968130(CERS1) 100973710(CERS4) 100973768(CERS2) 100994802(CERS3)
GGO: 101128445(CERS3) 101148109(CERS2) 109024075(CERS1)
PON: 100174286(CERS2) 100437726(CERS4) 100447528(CERS1) 100451535(CERS3)
NLE: 100579482(CERS4) 100581669(CERS2) 100583004(GDF1) 100590821(CERS3)
MCC: 106994665(CERS1) 693696(CERS3) 706728(CERS4) 716180(CERS2)
MCF: 101926302(CERS4) 102116814(CERS2) 102143963(CERS3) 107128159(CERS1)
CSAB: 103231276(CERS3) 103234393(CERS1) 103247210(CERS2)
RRO: 104676807(CERS3) 104680635(CERS1) 104681063(CERS2) 104682288(CERS4)
RBB: 108512618(CERS3) 108515632(CERS1) 108533256(CERS2) 108534518(CERS4)
CJC: 100406591(CERS3) 100412093(CERS2) 100414013(CERS4) 103789832(CERS1)
SBQ: 101037762(CERS4) 101041201(CERS1) 101042956(CERS3) 101043514(CERS2)
MMU: 545975(Cers3) 67260(Cers4) 76893(Cers2) 93898(Cers1)
MCAL: 110291523(Cers2) 110299355(Cers3) 110299631(Cers1) 110299943(Cers4)
MPAH: 110320738(Cers2) 110333640(Cers3) 110336399(Cers4) 110336871(Cers1)
RNO: 290658(Cers1) 304208(Cers4) 310667(Cers2) 499174(Cers3)
MUN: 110546438(Cers3) 110549168(Cers1) 110560786(Cers2)
CGE: 100758196(Cers4) 100765511(Cers1) 100765986(Cers2) 100770521(Cers3)
NGI: 103726528(Cers4) 103726856(Cers1) 103730090(Cers2) 103747188(Cers3)
HGL: 101702770(Cers3) 101705418(Cers1) 101715336(Cers4) 101716285(Cers2)
CCAN: 109681206(Cers2) 109684934(Cers1) 109698441(Cers4) 109700448(Cers3)
OCU: 100337851(CERS3) 100352973(CERS4)
TUP: 102475021(CERS3) 102475765(CERS1) 102495526(CERS4) 102502685(CERS2)
CFA: 483187(CERS2) 485008(CERS4) 607925(CERS3) 609789(CERS1)
VVP: 112907770(CERS2) 112909651(CERS4) 112913073(CERS1) 112923446(CERS3)
AML: 100466254(CERS3) 100475918(CERS4) 100478537(CERS1) 100481999(CERS2)
UMR: 103659988(CERS3) 103667533(CERS2) 103675149(CERS1) 103681884(CERS4)
UAH: 113242908(CERS4) 113246156(CERS2) 113256735(CERS1) 113263637(CERS3)
ORO: 101372787(CERS2) 101379762(CERS4) 101380694(CERS1) 101381953(CERS3)
FCA: 101089084(CERS1) 101093918(CERS4) 101094362(CERS2) 101099301(CERS3)
PTG: 102961418(CERS1) 102968533(CERS3) 102970444(CERS2) 102972870(CERS4)
PPAD: 109247644(CERS1) 109254210(CERS4) 109257029(CERS2) 109273347(CERS3)
AJU: 106969135(CERS1) 106970780(CERS4) 106972088(CERS3) 106979828(CERS2)
BTA: 505233(CERS4) 539223(CERS2) 614354(CERS3) 615296(CERS1)
BOM: 102264858(CERS2) 102269743(CERS1) 102275684(CERS4) 102282323(CERS3)
BIU: 109555312(CERS2) 109560813(CERS1) 109561659(CERS4) 109575125(CERS3)
BBUB: 102400914(CERS4) 102401086(CERS1) 102405478(CERS3) 102409179(CERS2)
CHX: 102169911(CERS3) 102174737(CERS4) 102182556(CERS2) 102189571(CERS1)
OAS: 101102559(CERS4) 101107095(CERS1) 101109498(CERS2) 101110093(CERS3)
SSC: 100127167(CERS4) 100152265(CERS3) 100156737(CERS2) 100525450(CERS1)
CFR: 102505196(CERS3) 102507344(CERS1) 102511821(CERS2) 102519510(CERS4)
CDK: 105087579(CERS4) 105093450(CERS3) 105101886(CERS1) 105103195(CERS2)
BACU: 103003098(CERS1) 103009608(CERS2) 103009742(CERS4) 103016103(CERS3)
LVE: 103069846(CERS4) 103076923(CERS2) 103082414(CERS3) 103091398(CERS1)
OOR: 101271239(CERS2) 101273399(CERS1) 101287722(CERS3) 101289498(CERS4)
DLE: 111165990(CERS4) 111166519(CERS1) 111169745(CERS2) 111187344(CERS3)
PCAD: 102975484(CERS3) 102977839(CERS1) 102982142(CERS2) 102991761(CERS4)
ECB: 100050135(CERS3) 100055037(CERS2) 100066949(CERS4) 100069594(CERS1)
EPZ: 103543133(CERS4) 103547641(CERS2) 103561069(CERS3) 103565074(CERS1)
EAI: 106839474(CERS3) 106844495(CERS4) 106846409(CERS1) 106846528(CERS2)
MYB: 102242969(CERS3) 102249252(CERS1) 102250642(CERS4) 102256999(CERS2)
MYD: 102759130(CERS3) 102767770(CERS4) 102769776(CERS1) 102772826(CERS2)
MNA: 107527642(CERS3) 107529900(CERS4) 107535343(CERS1) 107539131(CERS2)
HAI: 109372275(CERS2) 109380354(CERS3) 109382399(CERS1) 109396095(CERS4)
DRO: 112305215(CERS1) 112305258(CERS4) 112306075(CERS3) 112313815(CERS2)
PALE: 102885878(CERS1) 102885951(CERS2) 102889613(CERS3) 102890907(CERS4)
RAY: 107499037(CERS2) 107503723(CERS1) 107515791(CERS3) 107519920(CERS4)
MJV: 108386501(CERS3) 108387090(CERS4) 108406026(CERS1) 108409468(CERS2)
LAV: 100667031(CERS1) 100671292(CERS3) 100673086(CERS2) 100674671(CERS4)
MDO: 100014952(CERS2) 100016686(CERS1) 100020588(CERS3) 100025505
OAA: 100078502(CERS1) 100090289(CERS4) 100090484(CERS3) 100091312(CERS2)
GGA: 100859441(CERS2) 420050(CERS4) 420118(CERS1) 428318(CERS4L)
MGP: 100539644 100547857(CERS1) 100550977 104912889(CERS3) 104914444(CERS2)
CJO: 107318875(CERS3) 107324560(CERS2) 107325354(CERS1) 107325374 107325633
NMEL: 110388870(CERS1) 110388988 110389062 110403582(CERS3)
APLA: 101790332 101790516 101794409(CERS3) 101795233(CERS2) 101804779(CERS1)
ACYG: 106036468(CERS3) 106044958 106045005(CERS4) 106047960(CERS1) 106049279(CERS2)
TGU: 100217479(CERS4) 100223140(CERS3) 100228761(CERS2) 100230030(CERS1)
LSR: 110469450(CERS4) 110476809(CERS2) 110478333(CERS1) 110482993(CERS3)
GFR: 102032032(CERS2) 102034358 102035945(CERS1) 102036650(CERS3) 102042316
FAB: 101809766(CERS1) 101812995(CERS4) 101818464(CERS3)
PHI: 102104999(CERS3) 102105767 102106078(CERS2) 102107684(CERS1) 102114515
PMAJ: 107199043(CERS1) 107209495(CERS3) 107214659(CERS2) 107215358 107215532
CCAE: 111934002(CERS3) 111939476(CERS2) 111940267(CERS1) 111940438(CERS4) 111940456
FPG: 101915529(CERS3) 101919852(CERS2) 101922241 101923637(CERS1)
FCH: 102046386(CERS1) 102047202 102049480(CERS2) 102054381(CERS3)
CLV: 102084875 102090020(CERS3) 102098532(CERS1)
EGZ: 104122870(CERS3) 104126317(CERS4) 104129703(CERS2) 104129784(CERS1)
NNI: 104013688(CERS1) 104014462(CERS2) 104017067(CERS3) 104022916(CERS4)
ACUN: 113484146(CERS3) 113489365(CERS1) 113489464 113489465
PADL: 103914771(CERS3) 103916058 103916087 103923274(CERS1)
AAM: 106490998 106495414(CERS2) 106495821(CERS3) 106497727(CERS4)
ASN: 102368101 102383180(CERS2) 102384359(CERS1) 102388749(CERS3)
AMJ: 102563913(CERS1) 102575439(CERS3) 102575869(CERS2) 102576734(CERS4)
PSS: 102445918(CERS2) 102447507(CERS4) 102449546(CERS1) 102452581(CERS3)
CMY: 102929497(CERS2) 102935204(CERS1) 102939917(CERS3)
CPIC: 101932603(CERS2) 101945509 101945790 101947682(CERS3) 103305686(CERS1)
ACS: 100554835(cers3) 100565999(cers2)
PVT: 110072464(CERS4) 110072532(CERS1) 110072978(CERS3) 110081442(CERS2)
PBI: 103050368 103052910(CERS2) 103067220(CERS3) 103067620(CERS1)
PMUR: 107282886(CERS1) 107283879(CERS3) 107291598 107292912(CERS2) 107302088
TSR: 106543865(CERS1) 106544882
PMUA: 114584561 114586234(CERS2) 114588341(CERS4) 114588648(CERS1)
XLA: 108699337 108700334 108703695(cers1.S) 108713514(cers1.L) 379135(cers3.L) 444162(cers3.S)
XTR: 100036728(cers2) 100379773(cers4) 100485129(cers1) 448139(cers3)
NPR: 108789800(CERS2) 108790075(CERS3) 108792262 108796582(CERS1)
DRE: 100330155(cers4b) 259251(cers2a) 568169(cers1)
CSEM: 103378927(cers3) 103388281 103393467(cers1) 103393881
LCM: 102351990(CERS1) 102356427(CERS2) 102362821(CERS4) 102365974(CERS3)
CMK: 103181964(cers1) 103183569(cers4) 103187682(cers3)
CIN: 100101810(lag1-like3) 100184115
SPU: 592336
TUT: 107366570
CSCU: 111612809
CEL: CELE_Y6B3B.10(lagr-1)
CBR: CBG13635(Cbr-lagr-1)
TSP: Tsp_14433
LAK: 106174562
SHX: MS3_08053
EPA: 110240089
ADF: 107340796
AMIL: 114966382
DGT: 114522828
HMG: 100215789
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lahiri S, Park H, Laviad EL, Lu X, Bittman R, Futerman AH
  Title
Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner.
  Journal
J Biol Chem 284:16090-8 (2009)
DOI:10.1074/jbc.M807438200
Reference
  Authors
Levy M, Futerman AH
  Title
Mammalian ceramide synthases.
  Journal
IUBMB Life 62:347-56 (2010)
DOI:10.1002/iub.319

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