KEGG   ORTHOLOGY: K04724
Entry
K04724                      KO                                     
Symbol
CFLAR, FLIP
Name
CASP8 and FADD-like apoptosis regulator
Pathway
map04064  NF-kappa B signaling pathway
map04140  Autophagy - animal
map04210  Apoptosis
map04217  Necroptosis
map04668  TNF signaling pathway
map05142  Chagas disease
map05160  Hepatitis C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
   04668 TNF signaling pathway
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
  09143 Cell growth and death
   04210 Apoptosis
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
   04217 Necroptosis
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C14: caspase family
   K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
Genes
HSA: 8837(CFLAR)
PTR: 459872(CFLAR)
PPS: 100972044(CFLAR)
GGO: 101130329(CFLAR)
PON: 100172025(CFLAR)
NLE: 100589650(CFLAR)
MCC: 574234(CFLAR)
MCF: 101867183(CFLAR)
CSAB: 103217632(CFLAR)
CATY: 105580032(CFLAR)
PANU: 101006231(CFLAR)
RRO: 104671861(CFLAR)
RBB: 108532119(CFLAR)
TFN: 117095224(CFLAR)
PTEH: 111547069(CFLAR)
CJC: 100393782(CFLAR)
SBQ: 101028366(CFLAR)
CSYR: 103273363(CFLAR)
MMUR: 105856964(CFLAR)
OGA: 100966424(CFLAR)
MMU: 12633(Cflar)
MCAL: 110293482(Cflar)
MPAH: 110321922(Cflar)
RNO: 117279(Cflar)
MCOC: 116088466(Cflar)
MUN: 110557663(Cflar)
CGE: 100757136(Cflar)
PLEU: 114704457(Cflar)
NGI: 103738673(Cflar)
HGL: 101713835(Cflar)
CPOC: 100717997(Cflar)
CCAN: 109688488(Cflar)
DORD: 105982383(Cflar)
DSP: 122096420(Cflar)
NCAR: 124979040
OCU: 100346964(CFLAR)
OPI: 101521112(CFLAR)
TUP: 102494501(CFLAR)
CFA: 488471(CFLAR)
VVP: 112922876(CFLAR)
VLG: 121480765(CFLAR)
AML: 100474872(CFLAR)
UAR: 123798196(CFLAR)
ELK: 111141134
LLV: 125095000
MPUF: 101675551(CFLAR)
ORO: 101366831(CFLAR)
EJU: 114223358(CFLAR)
ZCA: 113920559(CFLAR)
MLX: 118012153(CFLAR)
FCA: 100142680(CFLAR)
PYU: 121030906(CFLAR)
PBG: 122481639(CFLAR)
PTG: 102963219(CFLAR)
PPAD: 109260755(CFLAR)
AJU: 106987988(CFLAR)
HHV: 120220695(CFLAR)
BTA: 497199(CFLAR)
BOM: 102283650(CFLAR)
BIU: 109569493(CFLAR)
BBUB: 102412372(CFLAR)
CHX: 100860786(CFLAR)
OAS: 101106914(CFLAR)
ODA: 120854626(CFLAR)
CCAD: 122426204(CFLAR)
SSC: 414381(CFLAR)
CFR: 102508474(CFLAR)
CBAI: 105082302(CFLAR)
CDK: 105099179(CFLAR)
VPC: 102541623(CFLAR)
BACU: 103002342(CFLAR)
LVE: 103076340(CFLAR)
OOR: 101282267(CFLAR)
DLE: 111171724(CFLAR)
PCAD: 102981647(CFLAR)
PSIU: 116756986(CFLAR)
ECB: 100068181(CFLAR)
EPZ: 103565999(CFLAR)
EAI: 106823485(CFLAR)
MYB: 102244844(CFLAR)
MYD: 102763362(CFLAR)
MMYO: 118661639(CFLAR)
MLF: 102438769(CFLAR)
MNA: 107533941(CFLAR)
PKL: 118708993(CFLAR)
HAI: 109379239(CFLAR)
DRO: 112307654(CFLAR)
SHON: 118985241(CFLAR)
AJM: 119047616 119065514(CFLAR)
PDIC: 114494605(CFLAR)
PHAS: 123824432(CFLAR)
MMF: 118625230(CFLAR)
RFQ: 117025759(CFLAR)
PALE: 102898217(CFLAR)
PGIG: 120587523(CFLAR)
PVP: 105298129(CFLAR)
RAY: 107503157(CFLAR)
MJV: 108395422(CFLAR)
SARA: 101541834(CFLAR)
LAV: 100660836(CFLAR)
TMU: 101343780
DNM: 101434584(CFLAR)
MDO: 100617513(CFLAR)
GAS: 123242696(CFLAR)
SHR: 100927927(CFLAR)
PCW: 110197210(CFLAR)
OAA: 100076553(CFLAR)
GGA: 424080(CFLAR)
PCOC: 116233977(CFLAR)
MGP: 100549881(CFLAR)
CJO: 107316522(CFLAR)
NMEL: 110400219(CFLAR)
APLA: 101799915(CFLAR)
ACYG: 106040001(CFLAR)
AFUL: 116490546(CFLAR)
TGU: 100230013(CFLAR)
LSR: 110484600(CFLAR)
SCAN: 103814508(CFLAR)
PMOA: 120497040(CFLAR)
OTC: 121335316(CFLAR)
PRUF: 121356472(CFLAR)
GFR: 102045043(CFLAR)
FAB: 101816960(CFLAR)
PHI: 102104024(CFLAR)
PMAJ: 107207333(CFLAR)
CCAE: 111931986(CFLAR)
CCW: 104693776(CFLAR)
ETL: 114055712(CFLAR)
ZAB: 102073635(CFLAR)
FPG: 101916800(CFLAR)
FCH: 102056426(CFLAR)
CLV: 102084239(CFLAR)
EGZ: 104130513(CFLAR)
NNI: 104010193(CFLAR)
ACUN: 113482557(CFLAR)
TALA: 104369202(CFLAR)
PADL: 103923407(CFLAR)
ACHC: 115343325(CFLAR)
AAM: 106492411(CFLAR)
AROW: 112976386(CFLAR)
NPD: 112956349(CFLAR)
DNE: 112987969(CFLAR)
ASN: 102381131(CFLAR)
AMJ: 102574231(CFLAR)
CPOO: 109322725(CFLAR)
GGN: 109301901(CFLAR)
PSS: 102455949(CFLAR)
CMY: 102931806(CFLAR)
CPIC: 101941100
TST: 117884731(CFLAR)
CABI: 116836066(CFLAR)
MRV: 120374824(CFLAR)
ACS: 100564476(cflar)
PVT: 110089016(CFLAR)
SUND: 121934733(CFLAR)
PBI: 103051805(CFLAR)
PMUR: 107291756
TSR: 106541631(CFLAR)
PGUT: 117673328(CFLAR)
VKO: 123024248(CFLAR)
ZVI: 118095856
GJA: 107122428
STOW: 125426206(CFLAR)
XLA: 108701437(cflar.L) 780745(cflar.S)
XTR: 779578(cflar)
NPR: 108798399(CFLAR)
RTEM: 120943728(CFLAR)
BBUF: 121008981(CFLAR)
BGAR: 122944654(CFLAR)
DRE: 373114(cflara)
PPRM: 120480386(cflara) 120492696
MAMB: 125257039(cflara) 125269848
IPU: 108259510(cflara) 108266354
PHYP: 113525356 113547094(cflar)
SMEO: 124383190
TFD: 113653165
EEE: 113577703 113584644(cflar)
TRU: 101063858(cflar)
LCO: 104928804(cflar)
NCC: 104963314(cflar)
CGOB: 115025951(cflar)
ELY: 117250649
PLEP: 121949553
SLUC: 116049715
ECRA: 117952471
PFLV: 114564036(cflar)
GAT: 100653428(cflar)
PPUG: 119228439
MSAM: 119903999
CUD: 121523134
MZE: 101464799(cflar)
OAU: 116335368
OLA: 100529185(cflar)
OML: 112154781
XMA: 102228359(cflar)
XCO: 114147948(cflar)
XHE: 116722787(cflar)
PRET: 103461648(cflar)
PFOR: 103155490(cflar)
PLAI: 106948030(cflar)
PMEI: 106922760(cflar)
GAF: 122839942
CVG: 107091904(cflar)
CTUL: 119788729
GMU: 124870920
NFU: 107390131(cflar)
KMR: 108240700
ALIM: 106523341(cflar)
NWH: 119419088
AOCE: 111562391(cflar)
CSEM: 103392053(cflar)
POV: 109631097(cflar)
SSEN: 122765595
HHIP: 117754777
LCF: 108880451(cflar)
SDU: 111218114(cflar)
SLAL: 111671504(cflar)
XGL: 120801162
HCQ: 109523284(cflar)
BPEC: 110168798
MALB: 109957132(cflar)
OTW: 112224883
OMY: 110501891
ONE: 115128090
SALP: 112075049(cflar)
SNH: 120036443
ELS: 105007210(cflar)
SFM: 108942112(cflar)
PKI: 111858290(cflar)
LOC: 102682725(cflar)
ARUT: 117413297
LCM: 102359774(CFLAR)
RTP: 109929742(cflar)
MMER: 123538213
 » show all
Reference
PMID:9326610
  Authors
Han DK, Chaudhary PM, Wright ME, Friedman C, Trask BJ, Riedel RT, Baskin DG, Schwartz SM, Hood L
  Title
MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death.
  Journal
Proc Natl Acad Sci U S A 94:11333-8 (1997)
DOI:10.1073/pnas.94.21.11333
  Sequence
[hsa:8837]
Reference
  Authors
Yeh WC, Itie A, Elia AJ, Ng M, Shu HB, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel DV, Mak TW
  Title
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.
  Journal
Immunity 12:633-42 (2000)
DOI:10.1016/S1074-7613(00)80214-9
  Sequence
[mmu:12633]

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