KEGG ORTHOLOGY: K04727

ORTHOLOGY: K04727

Entry

K04727                      KO

Symbol

AIFM1, PDCD8

Name

apoptosis-inducing factor 1 [EC:1.-.-.-]

Pathway

map04210

Apoptosis

map04214

Apoptosis - fly

map04217

Necroptosis

Disease

H00891

Combined oxidative phosphorylation deficiency

H01209

Deafness, X-linked

H02187

Spondyloepimetaphyseal dysplasia

H02344

Cowchock syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04727  AIFM1, PDCD8; apoptosis-inducing factor 1
   04214 Apoptosis - fly
    K04727  AIFM1, PDCD8; apoptosis-inducing factor 1
   04217 Necroptosis
    K04727  AIFM1, PDCD8; apoptosis-inducing factor 1

Genes

HSA:	9131(AIFM1)

PTR:	100615914(AIFM1)

PPS:	100991065(AIFM1)

GGO:	101144613(AIFM1)

PON:	100460875(AIFM1)

PPYG:

129024336(AIFM1)

NLE:	100605967(AIFM1)

HMH:	116812036(AIFM1)

SSYN:

129475030(AIFM1)

MCC:	702773(AIFM1)

MCF:	102116769(AIFM1)

MTHB:

126946783

MNI:	105481451(AIFM1)

CSAB:

103232547(AIFM1)

CATY:

105586270(AIFM1)

PANU:

101004691(AIFM1)

TGE:	112615333(AIFM1)

MLEU:

105545798(AIFM1)

RRO:	104655379(AIFM1)

RBB:	108523380(AIFM1)

TFN:	117077864(AIFM1)

PTEH:

111531534(AIFM1)

CANG:

105508185(AIFM1)

CJC:	100387002(AIFM1)

SBQ:	101043329(AIFM1)

CIMI:

108288545(AIFM1)

ANAN:

105721644(AIFM1)

CSYR:

103262231(AIFM1)

MMUR:

105863392(AIFM1)

LCAT:

123628344(AIFM1)

PCOQ:

105817653(AIFM1)

OGA:	100940431(AIFM1)

MMU:	26926(Aifm1)

MCAL:

110286577(Aifm1)

MPAH:

110313484(Aifm1)

RNO:	83533(Aifm1)

MCOC:

116080318(Aifm1)

ANU:	117694841(Aifm1)

ASYL:

127674918(Aifm1)

MUN:	110539686(Aifm1)

CGE:	100771367(Aifm1)

MAUA:

101830708(Aifm1)

PROB:

127217964(Aifm1)

PLEU:

114696902 114705473(Aifm1)

MORG:

121441073 121441130

MFOT:

126489616

AAMP:

119804745(Aifm1)

NGI:	103728755(Aifm1)

HGL:	101698690(Aifm1)

CPOC:

100730787(Aifm1)

CCAN:

109687400(Aifm1)

DORD:

105987008(Aifm1)

DSP:	122109936(Aifm1)

PLOP:

125343525(Aifm1)

NCAR:

124971787

MMMA:

107152973(Aifm1)

ITI:	101966199(Aifm1)

OCU:

100347778

OPI:	101536430(AIFM1)

TUP:	102500161(AIFM1)

GVR:	103593731(AIFM1)

CFA:	481048(AIFM1)

CLUD:

112649182(AIFM1)

VVP:	112934631(AIFM1)

VLG:	121483261(AIFM1)

NPO:	129518380(AIFM1)

AML:	100471854(AIFM1)

UMR:	103672928(AIFM1)

UAH:	113270952(AIFM1)

UAR:	123789871(AIFM1)

ELK:

111157271

LLV:

125091848

MPUF:

101691512(AIFM1)

MNP:	132006992(AIFM1)

MLK:	131821391(AIFM1)

NVS:	122896478(AIFM1)

ORO:	101382897(AIFM1)

EJU:	114223734(AIFM1)

ZCA:	113930612(AIFM1)

MLX:	118012968(AIFM1)

NSU:	110576538(AIFM1)

FCA:	768258(AIFM1)

PYU:	121025587(AIFM1)

PCOO:

112871001(AIFM1)

PBG:	122478009(AIFM1)

PVIV:

125157527(AIFM1)

LRUF:

124513976

LGF:	123594134(AIFM1)

AJU:

106981569

PTG:	102957119(AIFM1)

PPAD:

109253759(AIFM1)

PUC:

125931970

HHV:	120244339(AIFM1)

BTA:	535714(AIFM1)

BOM:	102281208(AIFM1)

BIU:	109555268(AIFM1)

BBUB:

102389029(AIFM1)

CHX:	102176309(AIFM1)

OAS:	101121574(AIFM1)

BTAX:

128069798(AIFM1)

CSUM:

138070789(AIFM1)

ODA:	120881465(AIFM1)

CCAD:

122436016(AIFM1)

MREE:

136153277(AIFM1)

OVR:	110134946(AIFM1)

MBEZ:

129564549(AIFM1)

SSC:	100524062(AIFM1)

CFR:	102512728(AIFM1)

CBAI:

105079650(AIFM1)

CDK:	105098815(AIFM1)

VPC:	102545956(AIFM1)

BACU:

103012032(AIFM1)

BMUS:

118888761(AIFM1)

LVE:	103083924(AIFM1)

OOR:	101282850(AIFM1)

LALB:

132514070(AIFM1)

DLE:	111168016(AIFM1)

PCAD:

102994580(AIFM1)

PSIU:

116747854(AIFM1)

NASI:

112409069(AIFM1)

ECB:	100054546(AIFM1)

EPZ:	103542373(AIFM1)

EAI:	106847102(AIFM1)

MYB:	102256408(AIFM1)

MYD:	102753610(AIFM1)

MMYO:

118654085(AIFM1) 118654203

MLF:	102426852(AIFM1)

MDT:	132224332(AIFM1)

PKL:	118722082(AIFM1)

EFUS:

103297209(AIFM1)

MNA:	107539455(AIFM1)

DRO:	112310632(AIFM1)

SHON:

118996086(AIFM1)

AJM:	119050676(AIFM1)

PDIC:

114504640(AIFM1)

PHAS:

123827786(AIFM1)

MMF:	118635974(AIFM1)

PPAM:

129073366(AIFM1)

HAI:	109388883(AIFM1)

RFQ:	117024181(AIFM1)

PALE:

102889813(AIFM1)

PGIG:

120604314(AIFM1)

PVP:	105308313(AIFM1)

RAY:	107514764(AIFM1)

MJV:	108399769(AIFM1)

TOD:	119245904(AIFM1)

SARA:

101553511(AIFM1)

SFUM:

130017008(AIFM1)

SETR:

125998625(AIFM1)

LAV:	100653663(AIFM1)

TMU:

101352206

ETF:	101655420(AIFM1)

DNM:	101442969(AIFM1)

MDO:	100021984(AIFM1)

GAS:	123253350(AIFM1)

SHR:	100919198(AIFM1)

AFZ:

127542416

PCW:	110196522(AIFM1)

TVP:	118832758(AIFM1)

PBRV:

138150656(AIFM1)

OAA:	100082601(AIFM1)

TACU:

119929752(AIFM1)

GGA:	428688(AIFM1)

PCOC:

116229527(AIFM1)

MGP:	100542480(AIFM1)

CJO:	107312503(AIFM1)

TPAI:

128075890(AIFM1)

LMUT:

125699616(AIFM1)

NMEL:

110403451(AIFM1)

APLA:

101798194 119717912

ACYG:

106037671(AIFM1)

CATA:

118245279(AIFM1)

AFUL:

116494320(AIFM1)

TGU:	100226565(AIFM1)

LSR:	110480101(AIFM1)

SCAN:

103816306(AIFM1)

PMOA:

120512592(AIFM1)

OTC:	121346432(AIFM1)

PRUF:

121362860(AIFM1)

ATRC:

139597457(AIFM1)

GFR:	102042655(AIFM1)

FAB:	101819944(AIFM1)

OMA:	130252968(AIFM1)

PHI:	102114064(AIFM1)

PMAJ:

107204028(AIFM1)

CCAE:

111929276(AIFM1)

CCW:	104691696(AIFM1)

CBRC:

103621990(AIFM1)

ACOE:

138110634(AIFM1)

ETL:	114064655(AIFM1)

ZAB:	102073603(AIFM1)

ZLE:	135447831(AIFM1)

SVG:	106862175(AIFM1)

MMEA:

130578741(AIFM1)

HRT:	120761971(AIFM1)

SATI:

136370437(AIFM1)

CCIC:

134049993(AIFM1)

FPG:	101923051(AIFM1)

FCH:	102053359(AIFM1)

CCRI:

104162909(AIFM1)

NNT:	104413012(AIFM1)

SHAB:

115613305(AIFM1)

ACUN:

113479877(AIFM1)

TALA:

104366650(AIFM1)

ACHC:

115333742(AIFM1)

HALD:

104318791

HLE:	104832763(AIFM1)

AGEN:

126050400

HHAR:

128153683(AIFM1)

GCL:

127019693

CSTI:

104561145

MNB:	103773931(AIFM1)

DPUB:

104307203

PPUS:

135183921(AIFM1)

AVIT:

104281104(AIFM1)

BRHI:

104499410

EGZ:	104134640(AIFM1)

NNI:	104021124(AIFM1)

PCRI:

104034289

PCAO:

104047346

PADL:

103925908(AIFM1)

AFOR:

103894119(AIFM1)

GSTE:

104251107(AIFM1)

CLV:	102091048(AIFM1)

MUI:

104542595

PGUU:

104458075(AIFM1)

PLET:

104613725(AIFM1)

EHS:	104513401(AIFM1)

CMAC:

104483335(AIFM1)

CUCA:

104060509(AIFM1)

TEO:	104382534(AIFM1)

BREG:

104633578

OHA:	104327441(AIFM1)

ACAR:

104519203(AIFM1)

CPEA:

104393942(AIFM1)

CVF:	104292643(AIFM1)

RTD:	128914505(AIFM1)

CRID:

134520510(AIFM1)

AAM:	106484118(AIFM1)

AROW:

112969149(AIFM1)

NPD:	112946993(AIFM1)

TGT:	104578131(AIFM1)

DNE:	112990893(AIFM1)

SCAM:

104142863(AIFM1)

AMJ:	102568057(AIFM1)

PSS:	102445556(AIFM1)

CMY:	102938553(AIFM1)

CCAY:

125642226(AIFM1)

DCC:	119861206(AIFM1)

CPIC:

101940981(AIFM1)

TST:	117883173(AIFM1)

CABI:

116828049(AIFM1)

MRV:	120371667(AIFM1)

ACS:	100562576(aifm1)

ASAO:

132763021(AIFM1)

PVT:	110084926(AIFM1)

SUND:

121936296(AIFM1)

PBI:	103061710(AIFM1)

PMUR:

107291569(AIFM1)

CTIG:

120302461(AIFM1)

TSR:	106551340(AIFM1)

PGUT:

117669546(AIFM1)

APRI:

131205187(AIFM1)

PTEX:

113437814(AIFM1)

NSS:	113416708(AIFM1)

VKO:	123022036(AIFM1)

PMUA:

114588939(AIFM1)

PRAF:

128406232(AIFM1)

ZVI:	118088903(AIFM1)

HCG:	128335348(AIFM1)

GJA:	107106067(AIFM1)

STOW:

125443094(AIFM1)

EMC:	129341135(AIFM1)

XLA:	108698277(aifm1.L)

XTR:	549998(aifm1)

NPR:	108805000(AIFM1)

RTEM:

120913100(AIFM1)

BBUF:

121009326(AIFM1)

BGAR:

122946127(AIFM1)

PWL:	138265867(AIFM1)

MUO:	115473887(AIFM1)

GSH:	117360793(AIFM1)

DRE:	373125(aifm1)

SRX:	107733365 107741186

SANH:

107672651 107680381

SGH:	107565417 107597251

CCAR:

109051775 109083128

CAUA:

113048840 113091443

CGIB:

127957569 128011950

PTET:

122345371(aifm1)

LROH:

127165540(aifm1)

OMC:	131540530(aifm1)

PPRM:

120469979 120469981

RKG:	130091914(aifm1)

MAMB:

125266557(aifm1)

CIDE:

127512388

CERY:

137033981(aifm1)

MASI:

127423061 127438747

TROS:

130570883(aifm1)

TDW:	130419663(aifm1)

MANU:

129439934(aifm1)

PDAB:

135732490(aifm1)

IPU:

108259910

IFU:	128603656(aifm1)

PHYP:

113531486

SMEO:

124379035(aifm1)

TFD:	113662863(aifm1)

TVC:	132840804(aifm1)

CGAR:

128512461(aifm1)

NGRA:

132876132(aifm1)

TRN:	134303266(aifm1)

AMEX:

103022605(aifm1)

CMAO:

118814412(aifm1)

EEE:	113568934(aifm1)

CHAR:

105897208(aifm1)

SPIL:

134080206(aifm1)

TRU:	101063298(aifm1)

TFS:	130537452(aifm1)

TNG:	GSTEN00022244G001

LCO:	104934644(aifm1)

TBEN:

117469044(aifm1)

CGOB:

115018714(aifm1)

PGEO:

117458974(aifm1)

GACU:

117552925(aifm1)

EMAC:

134871807(aifm1)

ELY:	117266479(aifm1)

EFO:	125898240(aifm1)

PLEP:

121952453(aifm1)

SLUC:

116064854(aifm1)

ECRA:

117955154(aifm1)

ESP:	116700450(aifm1)

PFLV:

114567195(aifm1)

GAT:	120822052(aifm1)

PPUG:

119215229(aifm1)

AFB:	129113187(aifm1)

CLUM:

117742701(aifm1)

PSWI:

130191677(aifm1)

CANA:

137802493(aifm1)

CVE:	137876637(aifm1)

MSAM:

119895094(aifm1)

SCHU:

122887864(aifm1)

CUD:	121519133(aifm1)

SPUL:

138604675(aifm1)

LMIX:

132988279(aifm1)

ALAT:

119030848(aifm1)

ASTR:

137606558(aifm1)

MZE:	101487956(aifm1)

ONL:	100704380(aifm1)

OAU:	116313111(aifm1)

OLA:	101163683(aifm1)

OML:	112142638(aifm1)

CSAI:

133459740(aifm1)

XMA:	102230294(aifm1)

XCO:	114153387(aifm1)

XHE:	116728609(aifm1)

PRET:

103475853 103475891

PFOR:

103133951(aifm1)

PLAI:

106955553(aifm1)

PMEI:

106906133(aifm1)

GAF:	122845010(aifm1)

PPRL:

129368638(aifm1)

CVG:	107095387(aifm1)

CTUL:

119786233(aifm1)

GMU:	124875863(aifm1)

NFU:	107386580(aifm1)

KMR:	108233891(aifm1)

ALIM:

106516432(aifm1)

NWH:	119420116(aifm1)

AOCE:

111584770(aifm1)

EJA:	138196595(aifm1)

BFRE:

138622067(aifm1)

MCEP:

125021103(aifm1)

CSEM:

103395291(aifm1)

POV:	109628601(aifm1)

SSEN:

122771321(aifm1)

SSOE:

131458804(aifm1)

HHIP:

117774558(aifm1)

HSP:	118122630(aifm1)

PPLT:

128457473(aifm1)

SMAU:

118300708(aifm1)

LCF:

108893607

SDU:	111222321(aifm1)

SLAL:

111658297

XGL:	120803087(aifm1)

HCQ:	109512542(aifm1)

SSCV:

125982010(aifm1)

SBIA:

133491411(aifm1)

PEE:	133415752(aifm1)

PTAO:

133467480(aifm1)

BPEC:

110168092(aifm1)

MALB:

109959575(aifm1)

BSPL:

114869620(aifm1)

SJO:	128371380(aifm1)

SSCO:

133993927(aifm1)

GMH:	115547193(aifm1)

SASA:

106567766(aifm1)

STRU:

115149103(aifm1)

OTW:	112257643(aifm1)

OMY:	110537263(aifm1)

OGO:	123998921(aifm1)

ONE:	115105758(aifm1)

OKI:	109892573(aifm1)

OKE:	118391344(aifm1)

OMM:	135548396(aifm1)

OCLA:

139422934

SALP:

111980256(aifm1)

SNH:	120045076(aifm1)

CCLU:

121573739(aifm1) 121579919

ELS:	105025037(aifm1)

SFM:	108931051(aifm1)

PKI:	111854398(aifm1)

AANG:

118235791(aifm1)

AROT:

135263021(aifm1)

CCOG:

133132656(aifm1)

LOC:	102683044(aifm1)

PSPA:

121295587 121318793

ARUT:

117411826 117430314 117963438

PSEX:

120537224(aifm1)

LCM:	102361781(AIFM1)

CMK:	103177612(aifm1)

RTP:	109931829(aifm1)

CPLA:

122557136(aifm1)

HOC:	132820220(aifm1)

LERI:

129702246(aifm1)

PMRN:

116943000(AIFM1)

LRJ:	133343033(AIFM1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG7263(AIF)

DER:

6541375

DSE:

6620616

DSI:	Dsimw501_GD23134(Dsim_GD23134)

DYA:	Dyak_GE17954

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI15735

DAZ:

108611313

DNV:

108649881

DHE:

111599402

DVI:	6628503(AIF)

CCAT:

101461236

BOD:

106616781

BDR:

105228745

RZE:	108354105 108380212

AOQ:

129247838

ALUD:

128863462

TDA:

119687577

MDE:	101889229 131805473

SCAC:

106080830

LCQ:

111687173

LSQ:

119603571

CVJ:	135951800(AIF)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002642

CNS:	116339873 116349490

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139107477(Aif)

TLN:	139818857(Aif)

HST:

DQU:

CFO:

FEX:

PMEC:

138940442(Aif)

LHU:	105678244(AIF)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124221847(AIF)

NFB:

NLO:

NVG:

AROA:

TCA:	661587(aif)

TMOL:

138134182(AIF)

DPA:

109541676

ESIM:

136417487(AIF)

EFOR:

136340686(AIF)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100529220(aif) 101739771

BMAN:

114247048 114252023

MSEX:

115442465 115453424

DPL:	KGM_204643 KGM_211545

BANY:

112049102

MJU:	123876117 123876485

NIQ:

126776954

VCD:	124537945 124537987

MCIX:

123662676 123662802

PMAC:

106715105 106715117

PPOT:

106103884

PXU:	106120564 106120567

BPHI:

PRAP:

PBX:

PNAP:

ZCE:	119837296 119837303 119837309

CCRC:

123701232

LSIN:

126978069 126978104

AAGE:

121725913

HAW:	110380328 110380382

HZE:	124635806 124635927

TNL:

113499912

SLIU:

111354575

OFU:	114350308 114357411 114358859

ONU:	135081350 135081364

ATRA:

106140245 106142183

GMW:	113512069 113512211

PGW:	126375476 126375805

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM544470

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139691575(AIF)

DPX:	DAPPUDRAFT_189511

DMK:

116926040

DPZ:

124315170

AFRA:

136025242

PVM:	113827463 113827464

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123765266(AIF)

CQD:

128686142

PTRU:

123515811

ESN:	127003725 127003733

MNZ:

135209635

MRJ:	136855317(AIF)

PORN:

139755381(AIF)

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136979248(AIF)

PTEP:

107456812

ABRU:

129973029

SDM:	118186153 118205959

LPOL:

106464050

PMEO:

129600199

CEL:	CELE_Y56A3A.32(wah-1)

CBR:	CBG_13330(Cbr-wah-1)

CRQ:	GCK72_010183

NAI:	NECAME_03889

BMY:	BM_BM6884(Bma-wah-1)

LOA:	LOAG_11795

TSP:

Tsp_00984

HRO:	HELRODRAFT_67025

LGI:	LOTGIDRAFT_213277

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:	115208864 115228112 115228120

LJP:

135472635

LAK:	106153013 106174297

SMM:	Smp_137540

OVI:	T265_04424

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:	114521384 114542062

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_33763

AQU:

100632533

CME:	CYME_CMO099C

GSL:	Gasu_32820 Gasu_53600

CCP:	CHC_T00004739001 CHC_T00006972001

MBR:	MONBRDRAFT_32548

SRE:	PTSG_07958

DDI:	DDB_G0288247(aif)

DPP:	DICPUDRAFT_157558

DFA:	DFA_02636(psmD7)

PIF:	PITG_21182

PSOJ:

PHYSODRAFT_333464

BLAC:

94350202(CCR75_006461)

SPAR:

SPRG_14581

NGR:	NAEGRDRAFT_81133

GTT:	GUITHDRAFT_113308 GUITHDRAFT_145603

» show all

Reference

PMID:17094969

Authors

Kim JT, Kim KD, Song EY, Lee HG, Kim JW, Kim JW, Chae SK, Kim E, Lee MS, Yang Y, Lim JS

Title

Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g).

Journal

FEBS Lett 580:6375-83 (2006)
DOI:10.1016/j.febslet.2006.10.049

Sequence

[hsa:9131]

All links

Gene (2107)   
   MGENES (208)   
   RefGene (1888)   
   OC (11)   
All databases (2107)   

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