KEGG   ORTHOLOGY: K04733
Entry
K04733                      KO                                     

Symbol
IRAK4
Name
interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
Pathway
map04010  MAPK signaling pathway
map04064  NF-kappa B signaling pathway
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04624  Toll and Imd signaling pathway
map04722  Neurotrophin signaling pathway
map04936  Alcoholic liver disease
map05130  Pathogenic Escherichia coli infection
map05132  Salmonella infection
map05133  Pertussis
map05135  Yersinia infection
map05140  Leishmaniasis
map05142  Chagas disease
map05145  Toxoplasmosis
map05152  Tuberculosis
map05161  Hepatitis B
map05162  Measles
map05164  Influenza A
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05417  Lipid and atherosclerosis
Disease
H00096  Defects of toll-like receptor signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   04064 NF-kappa B signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   04624 Toll and Imd signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   04621 NOD-like receptor signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05161 Hepatitis B
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05171 Coronavirus disease - COVID-19
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05164 Influenza A
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05162 Measles
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05168 Herpes simplex virus 1 infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05169 Epstein-Barr virus infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05132 Salmonella infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05135 Yersinia infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05133 Pertussis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05152 Tuberculosis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05140 Leishmaniasis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05142 Chagas disease
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04733  IRAK4; interleukin-1 receptor-associated kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  IRAK family
   K04733  IRAK4; interleukin-1 receptor-associated kinase 4
Genes
HSA: 51135(IRAK4)
PTR: 466962(IRAK4)
PPS: 100968191(IRAK4)
GGO: 101141826(IRAK4)
PON: 100447243(IRAK4)
NLE: 100602648(IRAK4)
MCC: 700568(IRAK4)
MCF: 102140231(IRAK4)
CSAB: 103238180(IRAK4)
CATY: 105574390(IRAK4)
PANU: 101007351(IRAK4)
RRO: 104677388(IRAK4)
RBB: 108539989(IRAK4)
TFN: 117090258(IRAK4)
PTEH: 111520209(IRAK4)
CJC: 100402978(IRAK4)
SBQ: 101029005(IRAK4)
MMUR: 105861650(IRAK4)
MMU: 266632(Irak4)
MCAL: 110310638(Irak4)
MPAH: 110334455(Irak4)
RNO: 300177(Irak4)
MCOC: 116078433(Irak4)
MUN: 110563636(Irak4)
CGE: 100751891(Irak4)
PLEU: 114693067(Irak4)
NGI: 103728592(Irak4)
HGL: 101698190(Irak4)
CCAN: 109684435
OCU: 100341605(IRAK4)
TUP: 102490347(IRAK4)
CFA: 486601(IRAK4)
VVP: 112921061(IRAK4)
VLG: 121479634(IRAK4)
AML: 100469127(IRAK4)
UMR: 103675405(IRAK4)
UAH: 113257718(IRAK4)
ORO: 101380365(IRAK4)
ELK: 111157836
MPUF: 101670774(IRAK4)
EJU: 114224086(IRAK4)
MLX: 118008943(IRAK4)
FCA: 101100225(IRAK4)
PYU: 121038701(IRAK4)
PBG: 122473209(IRAK4)
PTG: 102962570(IRAK4)
PPAD: 109248991(IRAK4)
AJU: 106978292(IRAK4)
HHV: 120246010(IRAK4)
BTA: 533692(IRAK4)
BOM: 102284148(IRAK4)
BIU: 109559201(IRAK4)
BBUB: 102402933(IRAK4)
CHX: 102171575(IRAK4)
OAS: 100216438(IRAK4)
ODA: 120857909(IRAK4) 120861265
CCAD: 122427504(IRAK4)
SSC: 100127166(IRAK4)
CFR: 102518467(IRAK4)
CBAI: 105081383(IRAK4)
CDK: 105097094(IRAK4)
BACU: 103013107(IRAK4)
LVE: 103080704(IRAK4)
OOR: 101283238(IRAK4)
DLE: 111174096(IRAK4)
PCAD: 102982312(IRAK4)
ECB: 100054848(IRAK4)
EPZ: 103547487(IRAK4)
EAI: 106828056(IRAK4)
MYB: 102262455(IRAK4)
MYD: 102754676(IRAK4)
MMYO: 118649743(IRAK4)
MNA: 107528202(IRAK4)
HAI: 109388403(IRAK4)
DRO: 112318391(IRAK4)
SHON: 118997428(IRAK4)
AJM: 119061695(IRAK4)
MMF: 118624132(IRAK4)
PALE: 102880867(IRAK4)
PGIG: 120618259(IRAK4)
RAY: 107511752(IRAK4)
MJV: 108396677(IRAK4)
TOD: 119247577(IRAK4)
LAV: 100653528(IRAK4)
TMU: 101349224
MDO: 100019202(IRAK4)
SHR: 100934112(IRAK4)
PCW: 110199045(IRAK4)
OAA: 100093279(IRAK4)
GGA: 417796(IRAK4)
PCOC: 116226644(IRAK4)
MGP: 100538968(IRAK4)
CJO: 107309789(IRAK4)
NMEL: 110392685(IRAK4)
APLA: 101794110(IRAK4)
ACYG: 106047628(IRAK4)
TGU: 100227974(IRAK4)
LSR: 110478580(IRAK4)
SCAN: 103820377(IRAK4)
PMOA: 120510675(IRAK4)
GFR: 102032992(IRAK4)
FAB: 101816877(IRAK4)
PHI: 102100592(IRAK4)
PMAJ: 107204545(IRAK4)
CCAE: 111932046(IRAK4)
CCW: 104698327(IRAK4)
ETL: 114061965(IRAK4)
FPG: 101914647(IRAK4)
FCH: 102057320(IRAK4)
CLV: 102092630(IRAK4)
EGZ: 104129331(IRAK4)
NNI: 104013612(IRAK4)
ACUN: 113475900(IRAK4)
PADL: 103919991(IRAK4)
AAM: 106488895(IRAK4)
AROW: 112976393(IRAK4)
NPD: 112956803(IRAK4)
DNE: 112993775(IRAK4)
ASN: 102375747(IRAK4)
AMJ: 102560034(IRAK4)
CPOO: 109315576(IRAK4)
GGN: 109295655(IRAK4)
PSS: 102445433(IRAK4)
CMY: 102940314(IRAK4)
CPIC: 101931311(IRAK4)
TST: 117877089(IRAK4)
CABI: 116838906(IRAK4)
ACS: 100556834(irak4)
PVT: 110079982(IRAK4)
PBI: 103053361(IRAK4)
PMUR: 107284404(IRAK3)
TSR: 106556721
PGUT: 117660695(IRAK4)
PMUA: 114605640(IRAK4)
ZVI: 118091266(IRAK4)
GJA: 107125917(IRAK4)
XLA: 108711122(irak4.L)
XTR: 733738(irak4)
NPR: 108789468(IRAK4)
DRE: 393132(irak4)
SRX: 107710863(irak4)
SANH: 107695004(irak4)
SGH: 107564744(irak4)
IPU: 100528915(irak4)
PHYP: 113529752(irak4)
AMEX: 103046249(irak4)
EEE: 113571874(irak4)
TRU: 101066430(irak4)
LCO: 104933859(irak4)
NCC: 104950347(irak4)
CGOB: 115009385(irak4)
ELY: 117262485(irak4)
PLEP: 121949826(irak4)
SLUC: 116038435(irak4)
ECRA: 117949437(irak4)
PFLV: 114559818(irak4)
GAT: 120809229(irak4)
MSAM: 119893462(irak4)
CUD: 121514729(irak4)
MZE: 101482950(irak4)
ONL: 100707440(irak4)
OAU: 116332712(irak4)
OLA: 101158603(irak4)
OML: 112142118 112152049(irak4)
XMA: 102235789(irak4)
XCO: 114158068(irak4)
XHE: 116736373(irak4)
PRET: 103465840(irak4)
CVG: 107089506(irak4)
CTUL: 119780397(irak4)
NFU: 107388500(irak4)
KMR: 108246966(irak4)
ALIM: 106526262(irak4)
AOCE: 111569910(irak4)
CSEM: 103380353(irak4)
POV: 109624486(irak4)
LCF: 108888551(irak4)
SDU: 111229598(irak4)
SLAL: 111650410(irak4)
XGL: 120792990(irak4)
HCQ: 109529881(irak4)
BPEC: 110168058(irak4)
MALB: 109973145(irak4)
SASA: 100196744(irak4)
OTW: 112218414(irak4)
OMY: 110493646
SALP: 111962246(irak4)
SNH: 120066164
ELS: 105026619(irak4)
SFM: 108931599(irak4)
PKI: 111833297(irak4)
AANG: 118219282(irak4)
LOC: 102693125(irak4)
PSPA: 121319978(irak4)
ARUT: 117419673(irak4)
LCM: 102365908(IRAK4)
CMK: 103186122(irak4)
RTP: 109935969(irak4)
BFO: 118415803
BBEL: 109476755
CIN: 100179860
SCLV: 120339699
SPU: 579511
APLC: 110983878
SKO: 100371791
DME: Dmel_CG10520(tub)
DER: 6552132
DSE: 6613818
DSI: Dsimw501_GD19725(Dsim_tub)
DYA: Dyak_GE25413(Dyak_tub)
DAN: 6500989
DSR: 110176403
DPE: 6591319
DMN: 108156569
DWI: 6650039
DGR: 6569885
DAZ: 108619657
DNV: 108652303
DHE: 111602009
CCAT: 101459242
MDE: 101888716
LCQ: 111681529
AGA: AgaP_AGAP003062(TUBE)
AARA: 120896690
AAG: 5569460
AALB: 109412409
CPII: 120423850
AME: 725368
ACER: 107996597
BIM: 100744966
BBIF: 117216542
BTER: 100643452
CCAL: 108629527
OBB: 114880216
NMEA: 116426821
CGIG: 122396314
SOC: 105197305
MPHA: 105831492
AEC: 105147253
ACEP: 105625035
VEM: 105558553
HST: 105180475
DQU: 106741442
CFO: 105259295
FEX: 115234974
LHU: 105667498
PGC: 109858712
OBO: 105278893
PCF: 106789276
NVI: 100122761
CSOL: 105361279
MDL: 103573816
CCIN: 107270376
TCA: 663280
DPA: 109545504
ATD: 109603470
NVL: 108563060
APLN: 108736487
OTU: 111427400
BMOR: 101746674
BMAN: 114242113
BANY: 112048494
PMAC: 106720650
PPOT: 106103749
PXU: 106115815
PRAP: 110995204
ZCE: 119840375
HAW: 110383958
TNL: 113500756
PXY: 105383258
API: 100165647
DNX: 107161307
AGS: 114131683
RMD: 113558107
BTAB: 109033636
CLEC: 106672583
HHAL: 106680239
NLU: 111064322
ZNE: 110831970
CSEC: 111868124
FCD: 110862708
DMK: 116928387
PVM: 113829427
HAME: 121862278
HAZT: 108680611
EAF: 111697825
DSV: 119460738
RMP: 119174651
VDE: 111253161
VJA: 111264266
TUT: 107372022
PTEP: 107439900
SDM: 118202301
PCAN: 112555277
BGT: 106072724
GAE: 121367943
CRG: 105329202
MYI: 110451150
PMAX: 117342817
AQU: 100631706
AHF: 112754658
TWL: 120004203
 » show all
Reference
  Authors
Li S, Strelow A, Fontana EJ, Wesche H
  Title
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.
  Journal
Proc Natl Acad Sci U S A 99:5567-72 (2002)
DOI:10.1073/pnas.082100399
  Sequence
[hsa:51135]

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