KEGG   ORTHOLOGY: K04734Help
Entry
K04734                      KO                                     

Name
NFKBIA
Definition
NF-kappa-B inhibitor alpha
Pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04210  Apoptosis
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko04624  Toll and Imd signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04668  TNF signaling pathway
ko04722  Neurotrophin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04926  Relaxin signaling pathway
ko04931  Insulin resistance
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05134  Legionellosis
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05164  Influenza A
ko05166  HTLV-I infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05215  Prostate cancer
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
Module
M00686  Toll-like receptor signaling
Disease
H00007  Hodgkin lymphoma
H00095  Ectodermal dysplasia associated immunodeficiency (EDA-ID)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04668 TNF signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04024 cAMP signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04624 Toll and Imd signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04621 NOD-like receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04622 RIG-I-like receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04623 Cytosolic DNA-sensing pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04625 C-type lectin receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04660 T cell receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04658 Th1 and Th2 cell differentiation
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04659 Th17 cell differentiation
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04657 IL-17 signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04662 B cell receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04062 Chemokine signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  Endocrine system
   04920 Adipocytokine signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04926 Relaxin signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  Nervous system
   04722 Neurotrophin signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  Development
   04380 Osteoclast differentiation
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05203 Viral carcinogenesis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05220 Chronic myeloid leukemia
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05215 Prostate cancer
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05222 Small cell lung cancer
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  Endocrine and metabolic diseases
   04931 Insulin resistance
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05131 Shigellosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05134 Legionellosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05166 HTLV-I infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05162 Measles
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05164 Influenza A
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05161 Hepatitis B
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05160 Hepatitis C
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05168 Herpes simplex infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05169 Epstein-Barr virus infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05145 Toxoplasmosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05140 Leishmaniasis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05142 Chagas disease (American trypanosomiasis)
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00686  Toll-like receptor signaling
     K04734  NFKBIA; NF-kappa-B inhibitor alpha
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Ankyrin only
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
Membrane trafficking [BR:ko04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
BRITE hierarchy
Other DBs
GO: 0051059
Genes
HSA: 4792(NFKBIA)
PTR: 467426(NFKBIA)
PPS: 100972867(NFKBIA)
GGO: 101128204(NFKBIA)
PON: 100459445
NLE: 100599351(NFKBIA)
MCC: 695335(NFKBIA)
MCF: 101867458(NFKBIA)
CSAB: 103228823(NFKBIA)
RRO: 104679802(NFKBIA)
RBB: 108519636(NFKBIA)
CJC: 100402266(NFKBIA)
SBQ: 101048714(NFKBIA)
MMU: 18035(Nfkbia)
RNO: 25493(Nfkbia)
CGE: 100754153(Nfkbia)
NGI: 103734016(Nfkbia)
HGL: 101709256(Nfkbia)
CCAN: 109697260(Nfkbia)
OCU: 100357341(NFKBIA)
TUP: 102494635(NFKBIA)
CFA: 480291(NFKBIA)
AML: 100466997(NFKBIA)
UMR: 103666055(NFKBIA)
ORO: 101384149(NFKBIA)
FCA: 101090622(NFKBIA)
PTG: 102956127(NFKBIA)
AJU: 106965509(NFKBIA)
BTA: 282291(NFKBIA)
BOM: 102275402(NFKBIA)
BIU: 109575581(NFKBIA)
PHD: 102316700(NFKBIA)
CHX: 102169137(NFKBIA)
OAS: 780520(NFKBIA)
SSC: 406188(NFKBIA)
CFR: 102519409(NFKBIA)
CDK: 105092140(NFKBIA)
BACU: 103002206(NFKBIA)
LVE: 103069029(NFKBIA)
OOR: 101289477(NFKBIA)
ECB: 100058000(NFKBIA)
EPZ: 103546400(NFKBIA)
EAI: 106838803(NFKBIA)
MYB: 102256580(NFKBIA)
MYD: 102763089(NFKBIA)
HAI: 109383860(NFKBIA)
RSS: 109457499(NFKBIA)
PALE: 102891056(NFKBIA)
LAV: 100675651(NFKBIA)
TMU: 101355353
MDO: 100011769(NFKBIA)
SHR: 100919027(NFKBIA)
OAA: 100090081(NFKBIA)
GGA: 396093(NFKBIA)
MGP: 100549878(NFKBIA)
CJO: 107315054(NFKBIA)
APLA: 101791396(NFKBIA)
ACYG: 106038777(NFKBIA)
TGU: 100220015(NFKBIA)
GFR: 102042109(NFKBIA)
FAB: 101816754(NFKBIA)
PHI: 102109715(NFKBIA)
PMAJ: 107205249(NFKBIA)
CCW: 104688451(NFKBIA)
FPG: 101923842(NFKBIA)
FCH: 102051665(NFKBIA)
CLV: 102094222(NFKBIA)
EGZ: 104133251(NFKBIA)
AAM: 106483033(NFKBIA)
ASN: 102381268(NFKBIA)
AMJ: 102559903(NFKBIA)
PSS: 102460666(NFKBIA)
CMY: 102937973(NFKBIA)
CPIC: 101937790(NFKBIA)
ACS: 100554664(nfkbia)
PVT: 110083506(NFKBIA)
PBI: 103057929(NFKBIA)
GJA: 107119990(NFKBIA)
XLA: 446833(nfkbia.L) 734297(nfkbia.S)
XTR: 448138(nfkbia)
NPR: 108795750(NFKBIA)
DRE: 323099(nfkbiab) 406463(nfkbiaa)
IPU: 108258222(Nfkbia) 108269796(nfkbia)
AMEX: 103038271 103043190(nfkbia)
TRU: 101064726(nfkbia) 101068711
LCO: 104928653(nfkbia) 104931204
MZE: 101464752 101484153(nfkbia)
OLA: 101162015 101168165(nfkbia)
XMA: 102217801 102228531(nfkbia)
PRET: 103457805 103458779(nfkbia)
NFU: 107396025 107396129(nfkbia)
CSEM: 103377625(nfkbia) 103380734
LCF: 108895835 108896130(nfkbia)
BPEC: 110155259(nfkbia) 110162763
SASA: 106571222(IKBA) 106601178(IKBA) 106607598(IKBA) 106611175(IKBA)
ELS: 105015312 105015478(nfkbia)
SFM: 108919418(nfkbia) 108923979
LCM: 102347685(NFKBIA)
DME: Dmel_CG5848(cact)
DSI: Dsimw501_GD21920(Dsim_cact)
DYA: Dyak_GE19366(Dyak_cact)
MDE: 101889324
AGA: AgaP_AGAP007938(CACT)
AAG: 5565922
AME: 411012(cact-2) 725124(cact1)
BIM: 100743215
BTER: 100631059
SOC: 105201775
HST: 105190318
CFO: 105252756
NVI: 100119352(Cact3)
TCA: 657221(Cact)
DPA: 109538735
NVL: 108561090
BMOR: 100379185(cact)
PMAC: 106712709
PRAP: 111003662
PXY: 105384975
API: 100165906(Cact)
ZNE: 110829682
FCD: 110843006
TUT: 107365267
CRG: 105319824
OBI: 106873926
ADF: 107347858
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9990853
  Authors
Spencer E, Jiang J, Chen ZJ
  Title
Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP.
  Journal
Genes Dev 13:284-94 (1999)
DOI:10.1101/gad.13.3.284
Reference
  Authors
Hatakeyama S, Kitagawa M, Nakayama K, Shirane M, Matsumoto M, Hattori K, Higashi H, Nakano H, Okumura K, Onoe K, Good RA, Nakayama K
  Title
Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.
  Journal
Proc Natl Acad Sci U S A 96:3859-63 (1999)
DOI:10.1073/pnas.96.7.3859
Reference
PMID:1829648
  Authors
Haskill S, Beg AA, Tompkins SM, Morris JS, Yurochko AD, Sampson-Johannes A, Mondal K, Ralph P, Baldwin AS Jr
  Title
Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity.
  Journal
Cell 65:1281-9 (1991)
DOI:10.1016/0092-8674(91)90022-Q
  Sequence
[hsa:4792]

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