KEGG   ORTHOLOGY: K04809
Entry
K04809                      KO                                     

Name
CHRNA7
Definition
nicotinic acetylcholine receptor alpha-7
Pathway
ko04020  Calcium signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04725  Cholinergic synapse
ko05010  Alzheimer disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05033  Nicotine addiction
ko05204  Chemical carcinogenesis
Disease
H01877  Chromosome 15q13.3 microdeletion syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
 09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
   05022 Pathways of neurodegeneration - multiple diseases
    K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
  09165 Substance dependence
   05033 Nicotine addiction
    K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
Ion channels [BR:ko04040]
 Ligand-gated channels
  Acetylcholine (nicotinic)
   K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
Other DBs
GO: 0004889 0015464
TC: 1.A.9.1
Genes
HSA: 1139(CHRNA7)
PTR: 467639(CHRNA7)
PPS: 100977072(CHRNA7)
GGO: 101131793(CHRNA7)
PON: 100456533(CHRNA7)
NLE: 100588609(CHRNA7)
MCC: 574230(CHRNA7)
MCF: 102118754(CHRNA7)
CSAB: 103245932(CHRNA7)
RRO: 104668890(CHRNA7)
RBB: 108531792(CHRNA7)
CJC: 100385253(CHRNA7)
SBQ: 101050618(CHRNA7)
MMU: 11441(Chrna7)
MCAL: 110298419(Chrna7)
MPAH: 110323262(Chrna7)
RNO: 25302(Chrna7)
MUN: 110561495(Chrna7)
CGE: 100760319
NGI: 103748066
HGL: 101720562(Chrna7)
CCAN: 109674332
OCU: 100342986(CHRNA7)
TUP: 102493539(CHRNA7)
CFA: 488696(CHRNA7)
VVP: 112910145(CHRNA7)
AML: 100469287(CHRNA7)
UMR: 103659968(CHRNA7)
UAH: 113263604
ORO: 101363826(CHRNA7)
ELK: 111152691
FCA: 751113(CHRNA7)
PTG: 102955772(CHRNA7)
PPAD: 109258939
AJU: 106967817
BTA: 282178(CHRNA7)
BOM: 102272741(CHRNA7)
BIU: 109575699(CHRNA7)
BBUB: 102397911
CHX: 102179705(CHRNA7)
OAS: 101113104(CHRNA7)
SSC: 100415931(CHRNA7)
CFR: 102524002(CHRNA7)
CDK: 105104257(CHRNA7)
BACU: 103019913
LVE: 103084703
OOR: 101280887(CHRNA7)
DLE: 111177885(CHRNA7)
PCAD: 102990403(CHRNA7)
ECB: 100060521
EPZ: 103562081
EAI: 106834056(CHRNA7)
MYB: 102246452(CHRNA7)
MYD: 102764475(CHRNA7)
MNA: 107527910
HAI: 109372169
DRO: 112306123
PALE: 102889630
RAY: 107515755
MJV: 108409828
LAV: 100656157
TMU: 101347897
MDO: 100027128
SHR: 100930913(CHRNA7)
PCW: 110205402(CHRNA7)
OAA: 100087588(CHRNA7)
GGA: 374001(CHRNA7) 396120(CHRNA7L)
MGP: 100543989(CHRNA7)
CJO: 107306401 107318653(CHRNA7)
APLA: 101793841 101795859(CHRNA7)
SCAN: 103816170(CHRFAM7A) 103821221
FAB: 101815421(CHRNA7) 101818819
PHI: 102107326 102109591(CHRNA7)
PMAJ: 107198461 107209183(CHRFAM7A)
CCAE: 111934178(CHRFAM7A) 111941714
ETL: 114056374(CHRNA7) 114067172
FPG: 101911506(CHRNA7) 101922648
FCH: 102054617(CHRNA7) 102054706
CLV: 102095407 102098551(CHRFAM7A)
EGZ: 104124489 104130764(CHRFAM7A)
NNI: 104016767(CHRFAM7A) 104017557
ACUN: 113484104
PADL: 103914854(CHRFAM7A) 103923234
AAM: 106496424(CHRNA7)
ASN: 102371460 102376107(CHRNA7)
AMJ: 102561740 102565383(CHRNA7)
CMY: 102942875 102945251(CHRFAM7A)
CPIC: 101936924 101950931(CHRNA7)
PVT: 110074548(CHRFAM7A) 110081449 110083158
XLA: 108706777 108711357(chrna7.L) 108712944(chrna7.S) 108719663
XTR: 100487782 100493611(chrna7)
NPR: 108788185 108793324(CHRNA7)
DRE: 100537531(si:ch73-380n15.2) 101882451 394199(chrna7a) 566141(chrna11)
KMR: 108234752(chrna7a) 108236399(chrna8) 108241051 108242134(chrna11) 108243019
LCM: 102362835 102366146(CHRNA7)
CMK: 103177743 103187814(chrna7)
RTP: 109921580(chrna7)
BFO: 118423661
APLC: 110991066
CSCU: 111619885
PTEP: 107455795
PCAN: 112564818
MYI: 110452062
 » show all
Reference
PMID:8145738
  Authors
Peng X, Katz M, Gerzanich V, Anand R, Lindstrom J
  Title
Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes.
  Journal
Mol Pharmacol 45:546-54 (1994)
  Sequence
[hsa:1139]
Reference
  Authors
Papke RL, Horenstein NA, Kulkarni AR, Stokes C, Corrie LW, Maeng CY, Thakur GA
  Title
The activity of GAT107, an allosteric activator and positive modulator of alpha7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface.
  Journal
J Biol Chem 289:4515-31 (2014)
DOI:10.1074/jbc.M113.524603

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