KEGG ORTHOLOGY: K04865

ORTHOLOGY: K04865

Entry

K04865                      KO

Symbol

CACNB4

Name

voltage-dependent calcium channel beta-4

Pathway

map04010

MAPK signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04921

Oxytocin signaling pathway

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00749

Episodic ataxias

H00808

Idiopathic generalized epilepsies

H02217

Juvenile myoclonic epilepsy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04865  CACNB4; voltage-dependent calcium channel beta-4
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04865  CACNB4; voltage-dependent calcium channel beta-4
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04865  CACNB4; voltage-dependent calcium channel beta-4
   04261 Adrenergic signaling in cardiomyocytes
    K04865  CACNB4; voltage-dependent calcium channel beta-4
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04865  CACNB4; voltage-dependent calcium channel beta-4
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04865  CACNB4; voltage-dependent calcium channel beta-4
   05414 Dilated cardiomyopathy
    K04865  CACNB4; voltage-dependent calcium channel beta-4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04865  CACNB4; voltage-dependent calcium channel beta-4
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04865  CACNB4; voltage-dependent calcium channel beta-4

Other DBs

GO:

0005245

TC:	8.A.22.1.4

Genes

HSA:	785(CACNB4)

PTR:	459660(CACNB4)

PPS:	100976785(CACNB4)

GGO:	101137663(CACNB4)

PON:	100444432(CACNB4)

NLE:	100597041(CACNB4)

HMH:	116810802(CACNB4)

MCC:	695172(CACNB4)

MCF:	102116137(CACNB4)

MTHB:

126933022

MNI:	105492663(CACNB4)

CSAB:

103217090(CACNB4)

CATY:

105575977(CACNB4)

PANU:

101021665(CACNB4)

TGE:	112636036(CACNB4)

MLEU:

105545088(CACNB4)

RRO:	104669805(CACNB4)

RBB:	108525018(CACNB4)

TFN:	117095001(CACNB4)

PTEH:

111546115(CACNB4)

CANG:

105512569(CACNB4)

CJC:	100393056(CACNB4)

SBQ:	101031728(CACNB4)

CIMI:

108300436(CACNB4)

CSYR:

103273638(CACNB4)

MMUR:

105879602(CACNB4)

LCAT:

123643468(CACNB4)

PCOQ:

105822257(CACNB4)

OGA:	100948836(CACNB4)

MMU:	12298(Cacnb4)

MCAL:

110308006(Cacnb4)

MPAH:

110317586(Cacnb4)

RNO:	58942(Cacnb4)

MCOC:

116090169(Cacnb4)

ANU:	117703087(Cacnb4)

MUN:	110563773(Cacnb4)

CGE:	100765888(Cacnb4)

MAUA:

101844274(Cacnb4)

PROB:

127222517(Cacnb4)

PLEU:

114698446(Cacnb4)

MORG:

121433143(Cacnb4)

MFOT:

126500247

AAMP:

119818715(Cacnb4)

NGI:	103738122(Cacnb4)

HGL:	101723713(Cacnb4)

CPOC:

100723776(Cacnb4)

CCAN:

109695158(Cacnb4)

DORD:

105993857(Cacnb4)

DSP:	122110846(Cacnb4)

PLOP:

125350665(Cacnb4)

NCAR:

124979835

MMMA:

107136859(Cacnb4)

OCU:

100344224

OPI:	101534179(CACNB4)

TUP:	102474154(CACNB4)

GVR:	103585423(CACNB4)

CFA:	609361(CACNB4)

CLUD:

112673312(CACNB4)

VVP:	112926879(CACNB4)

VLG:	121482149(CACNB4)

NPO:	129495608 129514650

AML:	100464104(CACNB4)

UMR:	103659848(CACNB4)

UAH:	113250882(CACNB4)

UAR:	123782064(CACNB4)

ELK:

111141476

LLV:

125095828

MPUF:

101673997(CACNB4)

MNP:	132013746(CACNB4)

MLK:	131827214(CACNB4)

NVS:	122902498(CACNB4)

ORO:	101374377(CACNB4)

EJU:	114216479(CACNB4)

ZCA:	113920171(CACNB4)

MLX:	118012447(CACNB4)

NSU:	110591893(CACNB4)

LWW:	102741806(CACNB4)

FCA:	101101576(CACNB4)

PYU:	121030560(CACNB4)

PCOO:

112848734(CACNB4)

PBG:	122481337(CACNB4)

PVIV:

125171985(CACNB4)

LRUF:

124515448

PTG:	102953668(CACNB4)

PPAD:

109271149(CACNB4)

PUC:

125911409

AJU:

106976065

HHV:	120225730(CACNB4)

BTA:	282161(CACNB4)

BOM:	102265990(CACNB4)

BIU:	109567608(CACNB4)

BBUB:

102409578(CACNB4)

BBIS:

104988624(CACNB4)

CHX:	102179332(CACNB4)

OAS:	101117907(CACNB4)

BTAX:

128064089(CACNB4)

ODA:	120854796(CACNB4)

CCAD:

122453844(CACNB4)

MBEZ:

129538305(CACNB4)

SSC:	396585(CACNB4)

CFR:	102518736(CACNB4)

CBAI:

105079160(CACNB4)

CDK:	105093727(CACNB4)

VPC:	102529782(CACNB4)

BACU:

103013367(CACNB4)

BMUS:

118897863(CACNB4)

LVE:	103089902(CACNB4)

OOR:	101269896(CACNB4)

DLE:	111172760(CACNB4)

PCAD:

102977440(CACNB4)

PSIU:

116757004(CACNB4)

NASI:

112393604(CACNB4)

ECB:	100057916(CACNB4)

EPZ:	103558127(CACNB4)

EAI:	106824678(CACNB4)

MYB:	102261332(CACNB4)

MYD:	102752339(CACNB4)

MMYO:

118661875(CACNB4)

MLF:	102418251(CACNB4)

PKL:	118709669(CACNB4)

EFUS:

103283409(CACNB4)

MNA:	107531651(CACNB4)

DRO:	112312991(CACNB4)

SHON:

118974423(CACNB4)

AJM:	119038775(CACNB4)

PDIC:

114494364(CACNB4)

PHAS:

123807622(CACNB4)

MMF:	118625398(CACNB4)

PPAM:

129061885(CACNB4)

HAI:	109384861(CACNB4)

RFQ:	117025859(CACNB4)

PALE:

102896224(CACNB4)

PGIG:

120596875(CACNB4)

PVP:	105292163(CACNB4)

RAY:	107513916(CACNB4)

MJV:	108406382(CACNB4)

TOD:	119255835(CACNB4)

SARA:

101538572(CACNB4)

SETR:

126008765(CACNB4)

LAV:	100656938(CACNB4)

TMU:

101351408

ETF:	101662240(CACNB4)

DNM:	101435286(CACNB4)

MDO:	100019993(CACNB4)

GAS:	123242259(CACNB4)

SHR:	100924116(CACNB4)

AFZ:

127554658

PCW:	110196898(CACNB4)

OAA:	100080287(CACNB4)

GGA:	374259(CACNB4)

PCOC:

116227460(CACNB4)

MGP:	100544561(CACNB4)

CJO:	107316971(CACNB4)

TPAI:

128076880(CACNB4)

LMUT:

125696956(CACNB4)

NMEL:

110399249(CACNB4)

APLA:

101798353(CACNB4)

ACYG:

106046874(CACNB4)

CATA:

118257760(CACNB4)

AFUL:

116490515(CACNB4)

TGU:	100225217(CACNB4)

LSR:	110473132(CACNB4)

SCAN:

103814617(CACNB4)

PMOA:

120497318(CACNB4)

OTC:	121337807(CACNB4)

PRUF:

121353455(CACNB4)

GFR:	102035820(CACNB4)

FAB:	101815605(CACNB4)

OMA:	130255325(CACNB4)

PHI:	102111016(CACNB4)

PMAJ:

107207455(CACNB4)

CCAE:

111932372(CACNB4)

CCW:	104694105(CACNB4)

CBRC:

103616784(CACNB4)

ETL:	114067462(CACNB4)

ZAB:	102062449(CACNB4)

ACHL:

103799219

SVG:	106863709(CACNB4)

MMEA:

130585841(CACNB4)

HRT:	120754936(CACNB4)

FPG:	101918928(CACNB4)

FCH:	102054191(CACNB4)

CLV:	102085477(CACNB4)

EGZ:	104130401(CACNB4)

NNI:	104012362(CACNB4)

PCRI:

104031437(CACNB4)

PLET:

104618560

PCAO:

104041853

ACUN:

113481993(CACNB4)

TALA:

104358353(CACNB4)

PADL:

103912670(CACNB4)

AFOR:

103893884(CACNB4)

ACHC:

115342885(CACNB4)

HALD:

104316713

HLE:	104829054(CACNB4)

AGEN:

126040721

GCL:

127018265

CCRI:

104164251

CSTI:

104553801(CACNB4)

CMAC:

104478541

MUI:	104539809(CACNB4)

BREG:

FGA:

GSTE:

LDI:

MNB:	103780040(CACNB4)

OHA:	104331757(CACNB4)

NNT:

104413858

SHAB:

115607847(CACNB4)

DPUB:

104308270(CACNB4)

PGUU:

104469126

CPEA:

104392820(CACNB4)

CVF:	104285567(CACNB4)

RTD:	128912430(CACNB4)

CUCA:

104056204(CACNB4)

TEO:

104374666

AAM:	106482299(CACNB4)

AROW:

112962267(CACNB4)

NPD:	112946348(CACNB4)

TGT:	104569151(CACNB4)

DNE:	112984858(CACNB4)

SCAM:

104138745(CACNB4)

ASN:	102368360(CACNB4)

AMJ:	106736635(CACNB4)

CPOO:

109323099(CACNB4)

GGN:	109301310(CACNB4)

PSS:	102450169(CACNB4)

CMY:	102932640(CACNB4)

CCAY:

125644948(CACNB4)

DCC:	119863607(CACNB4)

CPIC:

101941206(CACNB4)

TST:	117884730(CACNB4)

CABI:

116826774(CACNB4)

MRV:	120374744(CACNB4)

ACS:	100337606(cacnb4)

ASAO:

132775750(CACNB4)

PVT:	110080837(CACNB4)

SUND:

121936727(CACNB4)

PBI:	103053209(CACNB4)

PMUR:

107286075

CTIG:

120304625(CACNB4)

TSR:	106550522(CACNB4)

PGUT:

117670118(CACNB4)

APRI:

131203006(CACNB4)

PTEX:

113434160(CACNB4)

NSS:	113420241 113420250

VKO:	123017266(CACNB4)

PMUA:

114605085(CACNB4)

PRAF:

128422665(CACNB4)

ZVI:	118092935(CACNB4)

HCG:	128338973(CACNB4)

GJA:	107125599(CACNB4)

STOW:

125425798(CACNB4)

EMC:	129324824(CACNB4)

XLA:	108701326 108702958

XTR:	100216182(cacnb4)

NPR:	108784717(CACNB4)

RTEM:

120944109(CACNB4)

BBUF:

121008665(CACNB4)

BGAR:

122944833(CACNB4)

MUO:	115473972(CACNB4)

GSH:	117361405(CACNB4)

DRE:	562422(cacnb4a) 678560(cacnb4b)

SRX:	107705621 107714393 107741900 107748538

SANH:

107660102 107660636 107673733 107688838

SGH:	107555918(cacnb4) 107566792 107596082 107596307

CCAR:

109056079 109064838 109071291 109079342

CAUA:

113050765 113053056 113093884 113108401

CGIB:

127960198 127964447 128015412 128020013

PTET:

122341544 122347603(cacnb4b) 122352078(cacnb4a)

LROH:

127166856(cacnb4b) 127171005(cacnb4a)

OMC:	131542555(cacnb4b) 131547319(cacnb4a)

PPRM:

120461475(cacnb4a) 120476804(cacnb4b)

RKG:	130096613(cacnb4a) 130101221(cacnb4b)

MAMB:

125270203(cacnb4a) 125274289(cacnb4b)

CIDE:

127514640 127519101

MASI:

127446618 127446874 127448501 127449237

TROS:

130555612(cacnb4a) 130557129(cacnb4b)

TDW:	130424532(cacnb4b) 130427441(cacnb4a)

MANU:

129450721(cacnb4b) 129451918(cacnb4a)

IPU:	108266240(cacnb4a) 108272385(cacnb4b)

IFU:	128608652(cacnb4a) 128615813(cacnb4b)

PHYP:

113525997 113538467

SMEO:

124382810(cacnb4a) 124390797(cacnb4b)

TFD:	113634595(cacnb4b) 113654126(cacnb4a)

TVC:	132844803(cacnb4b) 132850114(cacnb4a)

AMEX:

103031296(cacnb4) 103041078

CMAO:

118807752(cacnb4b) 118809457(cacnb4a)

EEE:	113574052 113591692

CHAR:

105889629(cacnb4b) 122131761(cacnb4a)

TRU:	101065065(cacnb4.1) 101070730(cacnb4)

TFS:	130521794(cacnb4a) 130522267

TNG:	GSTEN00027037G001 GSTEN00029194G001

LCO:	104918232(cacnb4) 104931468

NCC:	104962611(cacnb4)

TBEN:

117496098(cacnb4a) 117499242

CGOB:

115019250 115026075(cacnb4)

PGEO:

117460267 117466638(cacnb4a)

GACU:

117546902 117549650(cacnb4a)

EMAC:

134860964 134867402(cacnb4a)

ELY:	117251525(cacnb4a) 117255209

EFO:	125885207 125899935(cacnb4a)

PLEP:

121949240(cacnb4a) 121962819

SLUC:

116044723 116066557(cacnb4a)

ECRA:

117939616 117952805(cacnb4a)

ESP:	116673752 116697891

PFLV:

114550852 114564014(cacnb4)

GAT:	100192309(cacnb4.1) 120834172(cacnb4a)

PPUG:

119211730 119228737(cacnb4a)

AFB:	129105115(cacnb4a) 129111573

CLUM:

117745826 117750246(cacnb4a)

PSWI:

130204599

MSAM:

119903240 119904440(cacnb4a)

SCHU:

122872190 122885103(cacnb4a)

CUD:	121506207 121523116(cacnb4a)

ALAT:

119015381 119026369(cacnb4a)

MZE:	101466725 101481806(cacnb4)

ONL:	100697371 100697725(cacnb4)

OAU:	116314771(cacnb4a) 116316921(cacnb2b) 116327191

OLA:	100192310(cacnb4.1) 101158981(cacnb4) 101163462

OML:	112136806 112154990(cacnb4a)

CSAI:

133425425 133445740(cacnb4a)

XMA:	102233017 102234485(cacnb4)

XCO:	114138204 114147959

XHE:	116716039 116722992(cacnb4)

PRET:

103475101 103478450(cacnb4)

PFOR:

103134832(cacnb4) 103151962

PLAI:

106934812(cacnb4) 106938228

PMEI:

106925852(cacnb4) 106926546

GAF:	122826866 122840435(cacnb4a)

PPRL:

129355400 129361286(cacnb4a)

CVG:	107092231 107098701(cacnb4)

CTUL:

119778485(cacnb4a) 119792313

GMU:	124861210 124871371(cacnb4a)

NFU:	107380913 107389651(cacnb4)

KMR:	108238841(cacnb4a) 108244163

ALIM:

106529643 106536644

NWH:

119428723

AOCE:

111564146(cacnb4) 111586012

MCEP:

125000954 125017902(cacnb4a)

CSEM:

103389337 103391617(cacnb4)

POV:	109638020(cacnb4) 109640071

SSEN:

122765064 122765078(cacnb4a)

HHIP:

117754995(cacnb4a) 117777765

HSP:	118103622 118120030(cacnb4a)

SMAU:

118282497(cacnb4a) 118300716

LCF:	108892915 108897092(cacnb4a)

SDU:	111218646(cacnb4) 111239914

SLAL:

111657545(cacnb4) 111665294

XGL:	120787369 120798376 120801781(cacnb4a)

HCQ:	109520929 109521895

SSCV:

125973909 125988909

SBIA:

133492612 133512475(cacnb4a)

PEE:	133411085(cacnb4a) 133411109

PTAO:

133486884(cacnb4a) 133490252

BPEC:

110156629(cacnb4) 110163257

MALB:

109960559 109974011(cacnb4)

BSPL:

114846903(cacnb4a) 114851089

SJO:	128354560 128368451(cacnb4a)

SASA:

106575807 106582346 106586393

STRU:

115155601 115160934 115179349 115196485

OTW:	112225596 112238503 112253618

OMY:	110501812 110520263 110527258 110527259

OGO:	124011405 124027933 124043986 124048060

ONE:	115110736 115130141

OKI:	109868051 109871003 109876447 109876649

OKE:	118366917 118379658 118386349

SALP:

111959873 111977107

SNH:	120050549 120050568 120057914 120063766

CCLU:

121537025(cacnb4a) 121555007 121582941

ELS:	105016118(cacnb4) 105023164

SFM:	108930040(cacnb4) 108936607

PKI:	111851740(cacnb4)

AANG:

118214156 118222173(cacnb4a)

LOC:	102689881(cacnb4)

PSPA:

121322389 121323228

ARUT:

117410861 117426960

PSEX:

120530715(cacnb4a)

LCM:	102367248(CACNB4)

CMK:	103180441(cacnb4a)

RTP:	109915118(cacnb4a)

CPLA:

122551757(cacnb4a)

HOC:	132817396(cacnb4a)

LERI:

129699085(cacnb4a)

LPOL:

106458736 106474022

ATEN:

116302860

TAD:	TRIADDRAFT_22195

» show all

Reference

PMID:22892567

Authors

Tadmouri A, Kiyonaka S, Barbado M, Rousset M, Fablet K, Sawamura S, Bahembera E, Pernet-Gallay K, Arnoult C, Miki T, Sadoul K, Gory-Faure S, Lambrecht C, Lesage F, Akiyama S, Khochbin S, Baulande S, Janssens V, Andrieux A, Dolmetsch R, Ronjat M, Mori Y, De Waard M

Title

Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy.

Journal

EMBO J 31:3730-44 (2012)
DOI:10.1038/emboj.2012.226

Sequence

[hsa:785]

All links

Ontology (4)   
   KEGG BRITE (2)   
   GO (1)   
   TC (1)   
Pathway (14)   
   KEGG PATHWAY (14)   
Disease (3)   
   KEGG DISEASE (3)   
Gene (783)   
   KEGG GENES (533)   
   KEGG MGENES (103)   
   RefGene (145)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (805)   

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