KEGG   ORTHOLOGY: K05087Help
Entry
K05087                      KO                                     

Name
IGF1R, CD221
Definition
insulin-like growth factor 1 receptor [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04114  Oocyte meiosis
ko04140  Autophagy - animal
ko04144  Endocytosis
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04510  Focal adhesion
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04730  Long-term depression
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
Disease
H00015  Malignant pleural mesothelioma
H00048  Hepatocellular carcinoma
H00050  Synovial sarcoma
H01274  Growth delay due to insulin-like growth factor I resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04015 Rap1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04010 MAPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04066 HIF-1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04068 FoxO signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04151 PI3K-Akt signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04152 AMPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04150 mTOR signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04140 Autophagy - animal
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Cell growth and death
   04114 Oocyte meiosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04520 Adherens junction
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04550 Signaling pathways regulating pluripotency of stem cells
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04914 Progesterone-mediated oocyte maturation
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Nervous system
   04730 Long-term depression
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Aging
   04211 Longevity regulating pathway - mammal
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04213 Longevity regulating pathway - multiple species
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05202 Transcriptional misregulation in cancers
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05205 Proteoglycans in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05225 Hepatocellular carcinoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05214 Glioma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05218 Melanoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05215 Prostate cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05224 Breast cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   01522 Endocrine resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
CD molecules [BR:ko04090]
 Proteins
  K05087  CD221, IGF1R; insulin-like growth factor 1 receptor
BRITE hierarchy
Other DBs
GO: 0005010 0031994
Genes
HSA: 3480(IGF1R)
PTR: 453676(IGF1R)
PPS: 100981083(IGF1R)
GGO: 101154546(IGF1R)
PON: 100172156(IGF1R)
NLE: 100593288(IGF1R)
MCC: 708227(IGF1R)
MCF: 102130142(IGF1R)
CSAB: 103231259(IGF1R)
RRO: 104677192(IGF1R)
RBB: 108538668(IGF1R)
CJC: 100408399(IGF1R)
SBQ: 101039763(IGF1R)
MMU: 16001(Igf1r)
RNO: 25718(Igf1r)
CGE: 100768531(Igf1r)
NGI: 103749467(Igf1r)
HGL: 101710224(Igf1r)
OCU: 100144342(IGF1R)
TUP: 102473496(IGF1R)
CFA: 442951(IGF1R)
AML: 100471374(IGF1R)
ORO: 101386211(IGF1R)
FCA: 100500937(IGF1R)
PTG: 102949680(IGF1R) 102949974
AJU: 106975140 106975144(IGF1R)
BTA: 281848(IGF1R)
BOM: 102278105(IGF1R)
PHD: 102324754(IGF1R)
CHX: 100861165(IGF1R)
OAS: 443515(IGF1R)
SSC: 397350(IGF1R)
CFR: 102524338(IGF1R)
BACU: 103015537(IGF1R)
LVE: 103081291(IGF1R)
OOR: 101281976(IGF1R)
ECB: 100055698(IGF1R)
EPZ: 103559577(IGF1R)
EAI: 106836604(IGF1R)
MYB: 102253516(IGF1R)
MYD: 102770795(IGF1R)
HAI: 109380372(IGF1R)
RSS: 109444913(IGF1R)
PALE: 102885962(IGF1R)
LAV: 100655087(IGF1R)
MDO: 100020095(IGF1R)
SHR: 100916673(IGF1R)
OAA: 100077556(IGF1R)
GGA: 395889(IGF1R)
MGP: 100539720(IGF1R)
CJO: 107318870(IGF1R)
APLA: 101802018(IGF1R)
ACYG: 106036418(IGF1R)
TGU: 100227374(IGF1R)
GFR: 102036037(IGF1R)
FAB: 101819893(IGF1R)
PHI: 102103364(IGF1R)
PMAJ: 107209439(IGF1R)
CCW: 104684080(IGF1R)
FPG: 101914715(IGF1R)
FCH: 102046128(IGF1R)
CLV: 102089963(IGF1R)
EGZ: 104122851(IGF1R) 104122875
AAM: 106485327(IGF1R)
ASN: 102387852(IGF1R)
AMJ: 106736787(IGF1R)
PSS: 102455576(IGF1R)
CMY: 102941686(IGF1R)
CPIC: 101952328(IGF1R)
ACS: 100554064(igf1r)
PVT: 110072986(IGF1R)
PBI: 103049336(IGF1R)
GJA: 107121607(IGF1R)
XLA: 108711478(igf1r.L) 398022(igf1r.S)
XTR: 100329112(igf1r)
NPR: 108787513(IGF1R)
DRE: 245701(igf1ra) 245702(igf1rb)
IPU: 100304999(igf1r) 108271091(Igf1r)
MZE: 101469217 101479543(igf1r)
CSEM: 103379307
HCQ: 109513166 109513874(igf1r)
ELS: 105016672 105023472(igf1r)
LCM: 102367342(IGF1R)
CMK: 103188389(igf1r)
DME: Dmel_CG18402(InR)
DSI: Dsimw501_GD19971(Dsim_GD19971)
MDE: 101894251
TSP: Tsp_12077
HMG: 100214733(HTK7)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8257688
  Authors
Kasuya J, Paz IB, Maddux BA, Goldfine ID, Hefta SA, Fujita-Yamaguchi Y
  Title
Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.
  Journal
Biochemistry 32:13531-6 (1993)
DOI:10.1021/bi00212a019
  Sequence
[hsa:3480]
Reference
PMID:2877871
  Authors
Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, Le Bon T, Kathuria S, Chen E, et al.
  Title
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
  Journal
EMBO J 5:2503-12 (1986)
  Sequence
[hsa:3480]
Reference
  Authors
Siddle K, Urso B, Niesler CA, Cope DL, Molina L, Surinya KH, Soos MA
  Title
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors.
  Journal
Biochem Soc Trans 29:513-25 (2001)
DOI:10.1042/bst0290513

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