KEGG   ORTHOLOGY: K05087
Entry
K05087                      KO                                     
Symbol
IGF1R, CD221
Name
insulin-like growth factor 1 receptor [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04066  HIF-1 signaling pathway
map04068  FoxO signaling pathway
map04114  Oocyte meiosis
map04140  Autophagy - animal
map04144  Endocytosis
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04510  Focal adhesion
map04520  Adherens junction
map04550  Signaling pathways regulating pluripotency of stem cells
map04730  Long-term depression
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05205  Proteoglycans in cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05224  Breast cancer
map05225  Hepatocellular carcinoma
Disease
H00015  Malignant pleural mesothelioma
H00048  Hepatocellular carcinoma
H00050  Synovial sarcoma
H01274  Growth delay due to insulin-like growth factor I resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04014 Ras signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04015 Rap1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04066 HIF-1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04068 FoxO signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04151 PI3K-Akt signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04152 AMPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04150 mTOR signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04140 Autophagy - animal
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09143 Cell growth and death
   04114 Oocyte meiosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04520 Adherens junction
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04550 Signaling pathways regulating pluripotency of stem cells
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04914 Progesterone-mediated oocyte maturation
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09156 Nervous system
   04730 Long-term depression
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09149 Aging
   04211 Longevity regulating pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04213 Longevity regulating pathway - multiple species
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05202 Transcriptional misregulation in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05205 Proteoglycans in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05214 Glioma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05218 Melanoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05215 Prostate cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05224 Breast cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   01522 Endocrine resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
CD molecules [BR:ko04090]
 Proteins
  K05087  CD221, IGF1R; insulin-like growth factor 1 receptor
Other DBs
GO: 0005010 0031994
Genes
HSA: 3480(IGF1R)
PTR: 453676(IGF1R)
PPS: 100981083(IGF1R)
GGO: 101154546(IGF1R)
PON: 100172156(IGF1R)
NLE: 100593288(IGF1R)
HMH: 116482110(IGF1R)
MCC: 708227(IGF1R)
MCF: 102130142(IGF1R)
MTHB: 126959327
MNI: 105479398(IGF1R)
CSAB: 103231259(IGF1R)
CATY: 105594004(IGF1R)
PANU: 100126735(IGF1R)
TGE: 112628505(IGF1R)
MLEU: 105531828(IGF1R)
RRO: 104677192(IGF1R)
RBB: 108538668(IGF1R)
TFN: 117070145(IGF1R)
PTEH: 111548389(IGF1R)
CANG: 105523056(IGF1R)
CJC: 100408399(IGF1R)
SBQ: 101039763(IGF1R)
CIMI: 108294997(IGF1R)
CSYR: 103257652(IGF1R)
MMUR: 105871266(IGF1R)
LCAT: 123645036(IGF1R)
PCOQ: 105809892(IGF1R)
OGA: 100944394(IGF1R)
MMU: 16001(Igf1r)
MCAL: 110297825(Igf1r)
MPAH: 110324292(Igf1r)
RNO: 25718(Igf1r)
MCOC: 116102373(Igf1r)
ANU: 117715978(Igf1r)
MUN: 110547261(Igf1r)
CGE: 100768531(Igf1r)
MAUA: 101825606(Igf1r)
PROB: 127238044(Igf1r)
PLEU: 114695462(Igf1r)
MORG: 121453621(Igf1r)
MFOT: 126505922
AAMP: 119802616(Igf1r)
NGI: 103749467(Igf1r)
HGL: 101710224(Igf1r)
CPOC: 100734840(Igf1r)
CCAN: 109687530
DORD: 105982453(Igf1r)
DSP: 122123999(Igf1r)
PLOP: 125368530(Igf1r)
NCAR: 124978062
MMMA: 107148359(Igf1r)
OCU: 100144342
OPI: 101535483(IGF1R)
TUP: 102473496(IGF1R)
GVR: 103595208(IGF1R)
CFA: 442951(IGF1R)
CLUD: 112653816(IGF1R)
VVP: 112922150(IGF1R)
VLG: 121490029(IGF1R)
NPO: 129510268(IGF1R)
AML: 100471374(IGF1R)
UMR: 103660044(IGF1R)
UAH: 113263646(IGF1R)
UAR: 123790797(IGF1R)
ELK: 111152643
LLV: 125105350
MPUF: 101681935(IGF1R)
MNP: 131999088(IGF1R)
MLK: 131835676(IGF1R)
NVS: 122893272(IGF1R)
ORO: 101386211(IGF1R)
EJU: 114223793(IGF1R)
ZCA: 113909166(IGF1R)
MLX: 118023006(IGF1R)
NSU: 110572370(IGF1R)
LWW: 102731850
FCA: 100500937(IGF1R)
PYU: 121042474(IGF1R)
PCOO: 112855479(IGF1R)
PBG: 122468290(IGF1R)
LRUF: 124517265
PTG: 102949680(IGF1R)
PPAD: 109273360(IGF1R)
PUC: 125910252
AJU: 106975144
HHV: 120233674(IGF1R)
BTA: 281848(IGF1R)
BOM: 102278105(IGF1R)
BIU: 109575129
BBUB: 102403092(IGF1R)
BBIS: 104992840(IGF1R)
CHX: 100861165(IGF1R)
OAS: 443515(IGF1R)
BTAX: 128066571(IGF1R)
ODA: 120875257(IGF1R)
CCAD: 122454848(IGF1R)
MBEZ: 129550230(IGF1R)
SSC: 397350(IGF1R)
CFR: 102524338(IGF1R)
CBAI: 105075161(IGF1R)
CDK: 105093441(IGF1R)
VPC: 102535933(IGF1R)
BACU: 103015537(IGF1R)
LVE: 103081291(IGF1R)
OOR: 101281976(IGF1R)
DLE: 111187347(IGF1R)
PCAD: 102977826(IGF1R)
PSIU: 116748753(IGF1R)
NASI: 112390977(IGF1R)
ECB: 100055698(IGF1R)
EPZ: 103559577(IGF1R)
EAI: 106836604(IGF1R)
MYB: 102253516(IGF1R)
MYD: 102770795(IGF1R)
MMYO: 118679204(IGF1R)
MLF: 102430595(IGF1R)
MNA: 107527774(IGF1R)
PKL: 118704316(IGF1R)
EFUS: 103301950(IGF1R)
HAI: 109380372(IGF1R)
DRO: 112306076(IGF1R)
SHON: 118992013(IGF1R)
AJM: 119049802(IGF1R)
PDIC: 114488551(IGF1R)
PHAS: 123809769(IGF1R)
MMF: 118640813(IGF1R)
RFQ: 117018797(IGF1R)
PPAM: 129061268(IGF1R)
PALE: 102885962(IGF1R)
PGIG: 120587362(IGF1R)
PVP: 105290270(IGF1R)
RAY: 107509347
MJV: 108403280
TOD: 119245137(IGF1R)
SARA: 101549049(IGF1R)
LAV: 100655087(IGF1R)
TMU: 101355333
ETF: 101643319(IGF1R)
DNM: 101416767(IGF1R)
MDO: 100020095(IGF1R)
GAS: 123238083(IGF1R)
SHR: 100916673(IGF1R)
AFZ: 127551347
PCW: 110192705(IGF1R)
OAA: 100077556(IGF1R)
GGA: 395889(IGF1R)
PCOC: 116225423(IGF1R)
MGP: 100539720(IGF1R)
CJO: 107318870(IGF1R)
TPAI: 128075328(IGF1R)
LMUT: 125698369(IGF1R)
NMEL: 110403525(IGF1R)
APLA: 101802018(IGF1R)
ACYG: 106036418(IGF1R)
CATA: 118251997(IGF1R)
AFUL: 116493472(IGF1R)
TGU: 100227374(IGF1R)
LSR: 110482986(IGF1R)
SCAN: 103816222(IGF1R)
PMOA: 120508810(IGF1R)
OTC: 121343296(IGF1R)
PRUF: 121354271(IGF1R)
GFR: 102036037(IGF1R)
FAB: 101819893(IGF1R)
OMA: 130257330(IGF1R)
PHI: 102103364(IGF1R)
PMAJ: 107209439(IGF1R)
CCAE: 111933868(IGF1R)
CCW: 104684080(IGF1R)
CBRC: 103619295(IGF1R)
ETL: 114054644(IGF1R)
ZAB: 102066292(IGF1R)
ACHL: 103798238(IGF1R)
SVG: 106852146(IGF1R)
MMEA: 130578912(IGF1R)
HRT: 120758822(IGF1R)
FPG: 101914715(IGF1R)
FCH: 102046128(IGF1R)
CLV: 102089963(IGF1R)
EGZ: 104122851(IGF1R)
NNI: 104017228(IGF1R)
PCRI: 104034958(IGF1R)
PLET: 104621030(IGF1R)
EHS: 104510387(IGF1R)
PCAO: 104039385(IGF1R)
ACUN: 113483985(IGF1R)
TALA: 104359828(IGF1R)
PADL: 103914830(IGF1R)
AFOR: 103900344(IGF1R)
ACHC: 115341184(IGF1R)
HALD: 104317439(IGF1R)
HLE: 104834576(IGF1R)
AGEN: 126043427
GCL: 127020876
CCRI: 104161223(IGF1R)
CSTI: 104550485(IGF1R)
CMAC: 104485700(IGF1R)
MUI: 104541385(IGF1R)
BREG: 104636598(IGF1R)
FGA: 104078904(IGF1R)
GSTE: 104263004(IGF1R)
LDI: 104352591
MNB: 103776523(IGF1R)
OHA: 104339317(IGF1R)
NNT: 104402233(IGF1R)
SHAB: 115612454(IGF1R)
DPUB: 104298885(IGF1R)
PGUU: 104461336(IGF1R)
ACAR: 104528088(IGF1R)
CPEA: 104386703(IGF1R)
AVIT: 104273657(IGF1R)
CVF: 104288725(IGF1R)
RTD: 128915086(IGF1R)
CUCA: 104062934(IGF1R)
TEO: 104375651(IGF1R)
BRHI: 104492992(IGF1R)
AAM: 106485327(IGF1R)
AROW: 112970160(IGF1R)
NPD: 112948275(IGF1R)
TGT: 104574034(IGF1R)
DNE: 112996278(IGF1R)
SCAM: 104148380(IGF1R)
ASN: 102387852(IGF1R)
AMJ: 106736787(IGF1R)
CPOO: 109309154(IGF1R)
GGN: 109288473(IGF1R)
PSS: 102455576(IGF1R)
CMY: 102941686(IGF1R)
CCAY: 125643327(IGF1R)
DCC: 119862152(IGF1R)
CPIC: 101952328(IGF1R)
TST: 117884524(IGF1R)
CABI: 116826364(IGF1R)
MRV: 120372851(IGF1R)
ACS: 100554064(igf1r)
ASAO: 132762556(IGF1R)
PVT: 110072986(IGF1R)
SUND: 121933049(IGF1R)
PBI: 103049336(IGF1R)
PMUR: 107290589(IGF1R)
CTIG: 120316466(IGF1R)
TSR: 106545511(IGF1R) 106555187
PGUT: 117676169(IGF1R)
APRI: 131184878(IGF1R)
PTEX: 113442022(IGF1R)
NSS: 113415602(IGF1R)
VKO: 123030778(IGF1R)
PMUA: 114584984(IGF1R)
PRAF: 128401604(IGF1R)
ZVI: 118092682(IGF1R)
HCG: 128334748(IGF1R)
GJA: 107121607(IGF1R)
STOW: 125424423(IGF1R)
EMC: 129345172(IGF1R)
XLA: 108711478(igf1r.L) 398022(igf1r.S)
XTR: 100329112(igf1r)
NPR: 108787513(IGF1R)
RTEM: 120931158(IGF1R)
BBUF: 120985975(IGF1R)
BGAR: 122927524(IGF1R)
MUO: 115459902(IGF1R)
GSH: 117348218(IGF1R)
DRE: 245701(igf1ra) 245702(igf1rb)
PTET: 122349311(igf1rb) 122363083(igf1ra)
LROH: 127167905(igf1rb) 127180463(igf1ra)
OMC: 131524230(igf1ra) 131543547(igf1rb)
PPRM: 120469797(igf1rb) 120487871(igf1ra)
RKG: 130088147(igf1ra) 130091356(igf1rb)
MAMB: 125253737(igf1ra) 125264449(igf1rb)
TROS: 130552567(igf1rb) 130563103(igf1ra)
TDW: 130417899(igf1rb) 130435165(igf1ra)
MANU: 129418564(igf1ra) 129420648(igf1rb)
IPU: 100304999(igf1ra) 108271091(igf1rb)
IFU: 128606740(igf1ra) 128613996(igf1rb)
PHYP: 113534424(igf1r) 113536568
SMEO: 124391334(igf1rb) 124396130(igf1ra)
TFD: 113652381(igf1ra) 113653192(igf1rb)
TVC: 132851207(igf1ra) 132855624(igf1rb)
CMAO: 118818325(igf1ra) 118819471(igf1rb)
CHAR: 105893090 105904485(igf1ra)
TFS: 130514606 130535722(igf1ra)
LCO: 104920736(igf1r) 104921706
TBEN: 117491654(igf1ra) 117497008
CGOB: 115009816(igf1r)
PGEO: 117448090(igf1ra)
GACU: 117541527 117557655(igf1ra)
ELY: 117253608 117261726(igf1ra)
EFO: 125887452(igf1ra) 125901306
PLEP: 121941149(igf1rb) 121949679(igf1ra)
SLUC: 116045678(igf1ra) 116057296
ECRA: 117945857(igf1rb) 117948865(igf1ra)
PPUG: 119195567(igf1ra) 119198402(igf1rb)
AFB: 129107750(igf1ra) 129108015
CLUM: 117727293(igf1rb) 117732564(igf1ra)
MSAM: 119889848(igf1rb) 119894125(igf1ra)
SCHU: 122874941(igf1rb) 122875174(igf1ra)
CUD: 121507367 121514568(igf1ra)
ALAT: 119017814 119023710(igf1ra)
MZE: 101469217 101479543(igf1r)
OAU: 116313500 116325617(igf1rb)
OML: 112152311(igf1ra) 112160640(igf1rb)
GAF: 122822814 122835010(igf1ra)
PPRL: 129361114(igf1ra) 129364100
CVG: 107087242(igf1r) 107097409
GMU: 124866795 124885065(igf1ra)
KMR: 108230129(igf1ra) 108243323(igf1rb)
ALIM: 106514315 106531111(igf1r)
NWH: 119416283(igf1ra) 119423732(igf1rb)
MCEP: 125005277(igf1rb) 125014422(igf1ra)
CSEM: 103379307
POV: 109624556 109625052(igf1r)
SSEN: 122772252 122775584(igf1ra)
HHIP: 117754056(igf1rb) 117763797(igf1ra)
HSP: 118109282(igf1ra) 118122842(igf1rb)
LCF: 108875244(igf1ra) 108897720(igf1rb)
XGL: 120790593 120793054(igf1ra)
HCQ: 109513166 109513874(igf1r)
SBIA: 133498213(igf1rb) 133502174
PEE: 133398212(igf1rb) 133403348(igf1ra)
PTAO: 133474106(igf1rb) 133478285(igf1ra)
BSPL: 114852027(igf1rb) 114856925(igf1ra)
SJO: 128356204(igf1rb) 128358344(igf1ra)
OGO: 124000795 124036813(igf1ra)
OKE: 118396693(igf1ra) 118401242
SALP: 111952526 111962390(igf1r)
SNH: 120053452 120065838(igf1ra)
ELS: 105016672 105023472(igf1r)
SFM: 108926605(igf1r) 108941092
PKI: 111845000(igf1r) 111845734
AANG: 118215508(igf1ra) 118227904
LOC: 102690467(igf1r)
PSPA: 121294410 121298882(igf1ra)
PSEX: 120541537
LCM: 102367342(IGF1R)
CMK: 103188389(igf1ra)
CPLA: 122542552(igf1ra)
HOC: 132834684(igf1ra)
LERI: 129713499(igf1ra)
PMRN: 116939503
DME: Dmel_CG18402(InR)
DER: 6553414
DSE: 6614334
DSI: Dsimw501_GD19971(Dsim_GD19971)
DSR: 110188261
DPO: 6897736
DPE: 6591473
DMN: 108155588
DAZ: 108621684
CCAT: 101456194
BOD: 106616531
BDR: 105230971
RZE: 108361740
AOQ: 129236393
TDA: 119680082
MDE: 101894251
SCAC: 106084784
LSQ: 119616560
ECOE: 129939889
CLON: 129614270
SOY: 115874628
AGRG: 126749572
AGB: 108905775
OTU: 111425015
MSEX: 115452173
BANY: 112049048
PRAP: 110996929
HAW: 110369826
TNL: 113496051
SLIU: 111356704
CCRN: 123293403
HVI: 124356788
MQU: 128985780
TPAL: 117641970
HAME: 121858835
CQD: 128685185
ESN: 127009269
PPOI: 119105504
RMP: 119188263
TSP: Tsp_12077
HMG: 100214733
 » show all
Reference
PMID:8257688
  Authors
Kasuya J, Paz IB, Maddux BA, Goldfine ID, Hefta SA, Fujita-Yamaguchi Y
  Title
Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.
  Journal
Biochemistry 32:13531-6 (1993)
DOI:10.1021/bi00212a019
  Sequence
[hsa:3480]
Reference
PMID:2877871
  Authors
Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, Le Bon T, Kathuria S, Chen E, et al.
  Title
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
  Journal
EMBO J 5:2503-12 (1986)
DOI:10.1002/j.1460-2075.1986.tb04528.x
  Sequence
[hsa:3480]
Reference
  Authors
Siddle K, Urso B, Niesler CA, Cope DL, Molina L, Surinya KH, Soos MA
  Title
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors.
  Journal
Biochem Soc Trans 29:513-25 (2001)
DOI:10.1042/bst0290513

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