KEGG   ORTHOLOGY: K05091
Entry
K05091                      KO                                     
Symbol
KIT, SCFR, CD117
Name
proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04072  Phospholipase D signaling pathway
map04151  PI3K-Akt signaling pathway
map04640  Hematopoietic cell lineage
map04916  Melanogenesis
map05200  Pathways in cancer
map05221  Acute myeloid leukemia
map05224  Breast cancer
map05230  Central carbon metabolism in cancer
Disease
H00003  Acute myeloid leukemia
H00023  Testicular cancer
H00031  Breast cancer
H00170  Piebaldism
H01359  Anaphylaxis
H01511  Mast-cell leukemia
H01591  Gastrotintestinal stromal tumor
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04014 Ras signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04015 Rap1 signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04072 Phospholipase D signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04151 PI3K-Akt signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  09152 Endocrine system
   04916 Melanogenesis
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   05230 Central carbon metabolism in cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   05224 Breast cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
CD molecules [BR:ko04090]
 Proteins
  K05091  CD117, KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Genes
HSA: 3815(KIT)
PTR: 461316(KIT)
PPS: 100985935(KIT)
GGO: 101126389(KIT)
PON: 100437110(KIT)
NLE: 100603893(KIT)
MCC: 696759(KIT)
MCF: 102137242(KIT)
CSAB: 103235672(KIT)
CATY: 105591986(KIT)
PANU: 101021734(KIT)
TGE: 112624589(KIT)
RRO: 104658855(KIT)
RBB: 108533749(KIT)
TFN: 117085603(KIT)
PTEH: 111520450(KIT)
CJC: 100411615(KIT)
SBQ: 101037282(KIT)
CSYR: 103249195(KIT)
MMUR: 105867869(KIT)
LCAT: 123624843(KIT)
OGA: 100961872(KIT)
MMU: 16590(Kit)
MCAL: 110294693(Kit)
MPAH: 110330230(Kit)
RNO: 64030(Kit)
MCOC: 116071281(Kit)
MUN: 110565064(Kit)
CGE: 100751027(Kit)
MAUA: 101833265 101844689(Kit)
PLEU: 114683608(Kit)
MORG: 121460800(Kit)
AAMP: 119799770(Kit)
NGI: 103734391(Kit)
HGL: 101726400(Kit)
CPOC: 100726397(Kit)
CCAN: 109698965(Kit)
DORD: 105980320(Kit)
DSP: 122106872(Kit)
NCAR: 124994841
OCU: 100327263(KIT)
OPI: 101536689(KIT)
TUP: 102489301(KIT)
CFA: 403811(KIT)
CLUD: 112652143(KIT)
VVP: 112912596 112933391(KIT)
VLG: 121473772(KIT)
AML: 100465243(KIT)
UMR: 103672804(KIT)
UAH: 113262502(KIT)
UAR: 123803989(KIT)
ELK: 111148912
LLV: 125093731
MPUF: 101685038(KIT)
ORO: 101372059(KIT)
EJU: 114206819(KIT)
ZCA: 113924318(KIT)
MLX: 118010521(KIT)
FCA: 493766(KIT)
PYU: 121035532(KIT)
PBG: 122478870(KIT)
PTG: 102960767(KIT)
PPAD: 109278960(KIT)
AJU: 106983989(KIT)
HHV: 120222581(KIT)
BTA: 280832(KIT)
BOM: 102272986(KIT)
BIU: 109560477(KIT)
BBUB: 102410945(KIT)
CHX: 100861386(KIT)
OAS: 780504(KIT)
ODA: 120862129(KIT)
CCAD: 122428200(KIT)
SSC: 396810(KIT)
CFR: 102521127(KIT)
CBAI: 105077673(KIT)
CDK: 105091541(KIT)
VPC: 102528563(KIT)
BACU: 102999027(KIT)
LVE: 103070834(KIT)
OOR: 101269214(KIT)
DLE: 111169672(KIT)
PCAD: 102985479(KIT)
PSIU: 116754507(KIT)
ECB: 100009704(KIT)
EPZ: 103554972(KIT)
EAI: 106839052(KIT)
MYB: 102263655(KIT)
MYD: 102761085(KIT)
MMYO: 118668862(KIT)
MLF: 102442787(KIT)
MNA: 107532733(KIT)
PKL: 118706624(KIT)
HAI: 109381816(KIT)
DRO: 112316812(KIT)
SHON: 118978582(KIT)
AJM: 119054285(KIT)
PDIC: 114491666(KIT)
PHAS: 123815790(KIT)
MMF: 118615155(KIT)
RFQ: 117022389(KIT)
PALE: 102895969(KIT)
PGIG: 120588075(KIT)
PVP: 105293773(KIT)
RAY: 107499790(KIT)
MJV: 108391899(KIT)
TOD: 119261155(KIT)
SARA: 101547411(KIT)
LAV: 100655943(KIT)
TMU: 101357486
DNM: 101427287(KIT)
MDO: 100017501(KIT)
GAS: 123252398(KIT)
SHR: 100929346(KIT)
PCW: 110200157(KIT)
OAA: 100075317(KIT)
GGA: 378783(KIT)
PCOC: 116225917(KIT)
MGP: 100542786(KIT)
CJO: 107313766(KIT)
NMEL: 110398600(KIT)
APLA: 101796083(KIT)
ACYG: 106030824(KIT)
AFUL: 116488883(KIT)
TGU: 100221238(KIT)
LSR: 110470402(KIT)
SCAN: 103826188(KIT)
PMOA: 120497505(KIT)
OTC: 121335186(KIT)
PRUF: 121348846(KIT)
GFR: 102042215(KIT)
FAB: 101812754(KIT)
PHI: 102103717(KIT)
PMAJ: 107203543(KIT)
CCAE: 111928444(KIT)
CCW: 104690629(KIT)
CBRC: 103622552(KIT)
ETL: 114058322(KIT)
ZAB: 102075290(KIT)
FPG: 101920758(KIT)
FCH: 102058936(KIT)
CLV: 102095499(KIT)
EGZ: 104129461(KIT)
NNI: 104020818(KIT)
PLET: 104617186(KIT)
ACUN: 113479223(KIT)
TALA: 104357918(KIT)
PADL: 103926350(KIT)
ACHC: 115345123(KIT)
HALD: 104322468(KIT)
CCRI: 104163298(KIT)
CSTI: 104549367(KIT)
EHS: 104503388(KIT)
CMAC: 104480516(KIT)
FGA: 104070340(KIT)
GSTE: 104251374(KIT)
LDI: 104351254(KIT)
MNB: 103768083(KIT)
OHA: 104334921(KIT)
AAM: 106490087(KIT)
AROW: 112974611(KIT)
NPD: 112942654(KIT)
DNE: 112979444(KIT)
ASN: 102378355(KIT)
AMJ: 102573437(KIT)
CPOO: 109322321(KIT)
GGN: 109303657(KIT)
PSS: 102451068(KIT)
CMY: 102935862(KIT)
CPIC: 101936545(KIT)
TST: 117878405(KIT)
CABI: 116821226(KIT)
MRV: 120407027(KIT)
ACS: 100551543(kit)
PVT: 110078419(KIT)
SUND: 121930281(KIT)
PBI: 103064280(KIT)
PMUR: 107294049(KIT)
PGUT: 117662143(KIT)
VKO: 123017038(KIT)
PMUA: 114604149(KIT)
ZVI: 118083927(KIT)
GJA: 107106035(KIT)
STOW: 125440237(KIT)
XLA: 373579(kit.L) 373727(g67.L) 373772(kit.S)
XTR: 100216090(kit)
NPR: 108803804(KIT)
RTEM: 120922887(KIT)
BBUF: 120990208(KIT)
BGAR: 122941768(KIT)
DRE: 30256(kita) 497629(kitb)
PPRM: 120493524(kitb) 120493839(kita)
MAMB: 125272588(kitb) 125277997(kita)
IPU: 108258027(kita) 108260969(kitb)
PHYP: 113544438 113546833(kit)
SMEO: 124377049(kita) 124381679(kitb)
TFD: 113642585(kita) 113660651(kitb)
AMEX: 103022298(kit) 103024973
EEE: 113586384(kit) 113591595
TRU: 101073765(kit) 101078652
NCC: 104947075(kit) 104968028
CGOB: 115006950(kit) 115014745
ELY: 117253553(kita) 117254624(kitb)
EFO: 125886243(kitb) 125895405(kita)
PLEP: 121940439(kita) 121941887(kitb)
SLUC: 116040457(kitb) 116058801(kita)
ECRA: 117936515(kitb) 117950146(kita)
PFLV: 114561268(kit) 114570046
GAT: 120824108(kita) 120824891(kitb)
PPUG: 119217068(kita) 119218477(kitb)
MSAM: 119899140(kitb) 119901063(kita)
CUD: 121508502(kitb) 121511801(kita)
ALAT: 119028307(kita) 119029433(kitb)
MZE: 101472356(kit) 101477603
ONL: 100692323(kit) 100706409
OAU: 116326005(kitb) 116331301(kita)
OLA: 101161964(kit) 101164953
OML: 112137013(kita) 112156999(kitb)
XMA: 102225575(kit) 102237809
XCO: 114144177 114151106(kit)
XHE: 116719795 116726148(kit)
PRET: 103463839(kit) 103468941
PFOR: 103137116(kit) 103137773
PLAI: 106954373 106963478(kit)
PMEI: 106918698 106924200(kit)
GAF: 122829997(kitb) 122838006(kita)
CVG: 107091570(kit) 107093495
CTUL: 119780619(kita) 119788451(kitb)
GMU: 124868634(kitb) 124874526(kita)
NFU: 107382191 107393389(kit)
KMR: 108241514(kitb) 108243393(kita)
ALIM: 106515208 106524095(kit)
NWH: 119407522(kitb) 119408215(kita)
AOCE: 111569601(kit) 111569809
MCEP: 125003666(kitb) 125009650(kita)
CSEM: 103376706(kit) 103383759
POV: 109625665(kit) 109637735
SSEN: 122760340(kitb) 122780312(kita)
HHIP: 117760289(kitb) 117760333(kita)
HSP: 118101384(kitb) 118121339(kita)
LCF: 108879101(kit) 108896458
SDU: 111226336(kit) 111231521
SLAL: 111644342(kit) 111664577
XGL: 120790846(kita) 120800656(kitb)
HCQ: 109511237 109532261(kit)
BPEC: 110154760(kit) 110172572
BSPL: 114852997(kitb) 114854103(kita)
ONE: 115108535 115145128(kit)
SALP: 111972317(kit) 111976175
SNH: 120036035(kitb) 120052583(kita) 120054924
ELS: 105011837(kit) 105020866
SFM: 108922805(kit)
PKI: 111850065(kit)
AANG: 118225724(kita) 118226705(kitb)
LOC: 102682431(kit)
PSPA: 121298152 121320044(kita)
LCM: 102363945(KIT)
CMK: 103178222(kita)
CGLO: 123269770
DMK: 123470180
 » show all
Reference
PMID:2448137
  Authors
Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A
  Title
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.
  Journal
EMBO J 6:3341-51 (1987)
DOI:10.1002/j.1460-2075.1987.tb02655.x
  Sequence
[hsa:3815]
Reference
  Authors
Roskoski R Jr
  Title
Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor.
  Journal
Biochem Biophys Res Commun 338:1307-15 (2005)
DOI:10.1016/j.bbrc.2005.09.150
Reference
PMID:1698611
  Authors
Nocka K, Buck J, Levi E, Besmer P
  Title
Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.
  Journal
EMBO J 9:3287-94 (1990)
DOI:10.1002/j.1460-2075.1990.tb07528.x
  Sequence
[mmu:16590]

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