KEGG ORTHOLOGY: K05126

ORTHOLOGY: K05126

Entry

K05126                      KO

Symbol

RET

Name

proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]

Pathway

map04020

Calcium signaling pathway

map05200

Pathways in cancer

map05216

Thyroid cancer

map05223

Non-small cell lung cancer

map05230

Central carbon metabolism in cancer

Disease

H00014

Non-small cell lung cancer

H00032

Thyroid cancer

H00247

Multiple endocrine neoplasia syndrome

H00910

Hirschsprung disease

H01510

Malignant paraganglioma

H01592

Medullary thyroid cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
   05230 Central carbon metabolism in cancer
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
  09162 Cancer: specific types
   05216 Thyroid cancer
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
   05223 Non-small cell lung cancer
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05126  RET; proto-oncogene tyrosine-protein kinase Ret
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  RET family
   K05126  RET; proto-oncogene tyrosine-protein kinase Ret

Genes

HSA:

5979(RET)

PTR:	100612888(RET)

PPS:	100994039(RET)

GGO:	101141559(RET)

PON:	100442682(RET)

NLE:	100602103(RET)

MCC:	703466(RET)

MCF:	102135879(RET)

CSAB:

103215755(RET)

CATY:

105571572(RET)

PANU:

101019433(RET)

TGE:	112631475(RET)

RRO:	104653928(RET)

RBB:	108513309(RET)

TFN:	117082351(RET)

PTEH:

111531334(RET)

CJC:	100403596(RET)

SBQ:	101053966(RET)

CSYR:

103268658(RET)

MMUR:

105879007(RET)

OGA:	100942216(RET)

MMU:	19713(Ret)

MCAL:

110295751(Ret)

MPAH:

110315801(Ret)

RNO:	24716(Ret)

MCOC:

116099474(Ret)

MUN:	110558017 110558019

CGE:	100772741(Ret)

PLEU:

114689662(Ret)

NGI:	103733801(Ret)

HGL:	101717565(Ret)

CPOC:

100733392(Ret)

CCAN:

109676742(Ret)

DORD:

105998878(Ret)

DSP:	122122245(Ret) 122124495

NCAR:

124985472

OCU:	100340710(RET)

OPI:	101535660(RET)

TUP:	102497228(RET)

CFA:	403494(RET)

VVP:	112913604(RET)

VLG:	121485367(RET)

AML:	100467317(RET)

UMR:

103668071

UAH:	113243095(RET)

UAR:	123800367(RET)

ELK:

111145007

LLV:

125085127

MPUF:

101682563(RET)

ORO:	101372117(RET)

EJU:	114205290(RET)

ZCA:	113919740(RET)

MLX:	118023454(RET)

FCA:	101101086(RET)

PYU:	121036970(RET)

PBG:	122493003(RET)

PTG:	102951366(RET)

PPAD:

109264617(RET)

AJU:	106972131(RET)

HHV:	120249234(RET)

BTA:	515924(RET)

BOM:	102284923(RET)

BIU:	109553788(RET)

BBUB:

102404389(RET)

CHX:	102172412(RET)

OAS:	101119787(RET)

ODA:	120860461 120865390

CCAD:

122446823(RET) 122453090

SSC:	100155053(RET)

CFR:	102514431(RET)

CBAI:

105072689(RET)

CDK:	105092504(RET)

VPC:	102542942(RET)

BACU:

103006627(RET)

LVE:	103069161(RET)

OOR:	101288280(RET)

DLE:	111163990(RET)

PCAD:

102984604(RET)

PSIU:

116742042(RET)

ECB:	100146791(RET)

EPZ:	103550619(RET)

EAI:	106831339(RET)

MYB:	102238841(RET)

MYD:	102766212(RET)

MMYO:

118670212(RET)

MLF:	102420377(RET)

MNA:	107532547(RET)

PKL:	118719059(RET)

HAI:	109395552(RET)

DRO:	112305517(RET)

SHON:

118981054(RET)

AJM:	119038025(RET)

PDIC:

114497427(RET)

PHAS:

123821068(RET)

MMF:	118632108(RET)

RFQ:	117036190(RET)

PALE:

102878133(RET)

PGIG:

120594602(RET)

PVP:	105309193(RET)

RAY:	107517623(RET)

MJV:	108392617(RET)

TOD:	119233871(RET)

SARA:

101547575(RET)

LAV:	100672176(RET)

TMU:

101357522

DNM:	101426197(RET)

MDO:	100016023(RET)

GAS:	123234327(RET)

SHR:	100927200(RET)

PCW:	110221483(RET)

OAA:	100076319(RET)

GGA:	396107(RET)

PCOC:

116234790(RET)

MGP:	100550243(RET)

CJO:	107315612(RET)

NMEL:

110399502(RET)

APLA:

101803164(RET)

ACYG:

106032512(RET)

AFUL:

116491283(RET)

TGU:	100219340(RET)

LSR:	110468614(RET)

SCAN:

103814210(RET)

PMOA:

120507297(RET)

OTC:	121336116(RET)

PRUF:

121357411(RET)

GFR:	102042884(RET)

FAB:	101812108(RET)

PHI:	102107711(RET)

PMAJ:

107207043(RET)

CCAE:

111931023(RET)

CCW:	104690242(RET)

ETL:	114062798(RET)

ZAB:	102067895(RET)

FPG:	101922216(RET)

FCH:	102048122(RET)

CLV:	102083695(RET)

EGZ:	104128999(RET)

NNI:	104015433(RET)

ACUN:

113483380(RET)

TALA:

104364998(RET)

PADL:

103924216(RET)

ACHC:

115348153(RET)

AAM:	106498889(RET)

AROW:

112973047(RET)

NPD:

112945067

DNE:	112993309(RET)

ASN:	102371199(RET)

AMJ:	102573157(RET)

CPOO:

109324217(RET)

GGN:	109287344(RET)

PSS:	102459127(RET)

CMY:	102940624(RET)

CPIC:

101938031(RET)

TST:	117880563(RET)

CABI:

116828262(RET)

MRV:	120369304(RET)

ACS:	100563549(ret)

PVT:	110083673(RET)

SUND:

121927379(RET)

PBI:	103058664(RET)

PMUR:

107293255(RET)

TSR:	106555050(RET)

PGUT:

117669197(RET)

VKO:	123018201(RET)

PMUA:

114597095(RET)

ZVI:	118096361(RET)

GJA:	107122192(RET)

STOW:

125438408(RET)

XLA:	108696288(ret.L) 373625(ret.S)

XTR:	100495902(ret)

NPR:	108786609(RET)

RTEM:

120909054(RET)

BBUF:

121004860(RET)

BGAR:

122942424(RET)

DRE:	30512(ret)

SRX:	107726966 107743501

SANH:

107655443 107666456

SGH:	107559333(ret) 107601801

CCAR:

109078964 109091940

CAUA:

113056958 113112663

PPRM:

120473231(ret)

MAMB:

125276928(ret)

IPU:	108262651(ret)

PHYP:

113537802(ret)

SMEO:

124378199(ret)

TFD:	113636332(ret)

AMEX:

103028663(ret)

EEE:	113585232(ret)

TRU:	101070188(ret)

TNG:	GSTEN00024538G001

LCO:	104921882(ret)

NCC:	104952732(ret)

CGOB:

115020027(ret)

ELY:	117248682(ret)

PLEP:

121954725(ret)

SLUC:

116039377(ret)

ECRA:

117960079(ret)

PFLV:

114572052(ret)

GAT:	120820232(ret)

PPUG:

119214572(ret)

MSAM:

119917613(ret)

CUD:	121511238(ret)

MZE:	101475370 112434355

ONL:	100702608(ret)

OAU:	116318763(ret)

OLA:	101156037(ret)

OML:	112161593(ret)

XMA:	102237488(ret)

XCO:	114137568(ret)

XHE:	116713771(ret)

PRET:

103477116(ret)

PFOR:

103148242(ret)

PLAI:

106951787(ret)

PMEI:

106920941(ret)

GAF:	122842268(ret)

CVG:	107088598(ret)

CTUL:

119782899(ret)

GMU:	124858614(ret)

NFU:	107375369(ret)

KMR:	108240623(ret)

ALIM:

106525613(ret)

NWH:	119417522(ret)

AOCE:

111573084(ret)

CSEM:

103387460(ret)

POV:	109636804(ret)

SSEN:

122782182(ret)

HHIP:

117775765(ret)

LCF:	108886252(ret)

SDU:	111220596(ret)

SLAL:

111669539(ret)

XGL:	120796812(ret)

HCQ:	109523240(ret)

BPEC:

110162334(ret)

MALB:

109958407(ret)

SASA:

106576823 106604566

OTW:	112252648 112252802(ret)

OMY:	110502270 110526355(ret)

OGO:	124038110 124041440(ret)

ONE:	115113390 115135308

SALP:

111952048 111978543

SNH:	120017384(ret) 120045844

ELS:	105028647(ret)

SFM:	108932773(ret)

PKI:	111848989(ret)

AANG:

118217945(ret)

LOC:	102697421(ret)

PSPA:

121325980(ret)

ARUT:

117417619(ret)

LCM:	102358285(RET)

CMK:	103182663(ret)

RTP:	109921507(ret)

CIN:	100182804 100186039

SCLV:

120332675

SPU:	105437406 105444549 577861 582279 586619

APLC:

110977552 110985025 110987129

SKO:	100369916 102804897

DME:	Dmel_CG14396(Ret)

DER:

6548796

DSE:

6618258

DSI:	Dsimw501_GD21645(Dsim_GD21645)

DYA:	Dyak_GE12994

DSR:

110187405

DPO:	Dpse_GA12952

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17995

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:	106615713 106621157

MDE:

101890374

SCAC:

106083080

LCQ:

111678362

AGA:	AgaP_AGAP008899

ACOZ:

120958181

AARA:

120902437

AAG:	110680434 5568762

AALB:

109420544 109621254

CQU:	CpipJ_CPIJ000502

CPII:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:	107038031 107038798

AGIF:

122861055

CCIN:

107271995

TCA:	657748(ret)

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:	111502550 111511317

NVL:

108566823

APLN:

108741709

PPYR:

116176008 116180281

OTU:	111421624 111425271

API:

DNX:

AGS:

RMD:

DCI:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM495270

FOC:	113211815 113212347

ZNE:

CSEC:

FCD:

DMK:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

HAZT:

LSM:

ISC:	IscW_ISCW003506

DSV:

RSAN:

RMP:

VDE:

VJA:	111266387 111271643

CSCU:

111620592 111621481 111621482 111622754

PTEP:

107447239

SDM:	118189676 118190652

BGT:	106054275 106056831 106065621

GAE:	121370023 121379467 121383165

HRF:	124119095 124132410 124145276 124150005

HRJ:	124275614 124283699 124286728

CRG:	105320394 105324638 105330510

MYI:	110461040 110466000

PMAX:

117322864 117324338 117339136

MMER:

123528975 123529699 123546441 123564824

OBI:	106879436 106879437 106883560

OSN:	115224493 115227037 115229190

LAK:	106152770 106154548 106155165 106155174 106155178 106163283 106171307

SMM:	Smp_175590

EPA:

110251418

ATEN:

116295097 116295551 116295558 116299340 116300124 116300134 116300137

ADF:	107328041 107328278 107341295 107344246 107346416 107355358

AMIL:

114947144 114948672 114956152 114963035 114967418 114969236 114970158 114974412

PDAM:

113670427 113673162 113676074 113676584 113679283 113681729

SPIS:

111325544 111329741 111329799 111332573 111337283 111338500 111338502 111338863 111340958 111340993 111341760 111344722 111346136 111346412 111347582

DGT:	114515600 114526994 114538351

XEN:	124441362 124457361 124458692

HMG:	100205623 100209956 101239423

AQU:	100636517 100638869 100639009

» show all

Reference

PMID:15331579

Authors

Santoro M, Melillo RM, Carlomagno F, Vecchio G, Fusco A

Title

Minireview: RET: normal and abnormal functions.

Journal

Endocrinology 145:5448-51 (2004)
DOI:10.1210/en.2004-0922

Reference

PMID:11114739

Authors

Jhiang SM

Title

The RET proto-oncogene in human cancers.

Journal

Oncogene 19:5590-7 (2000)
DOI:10.1038/sj.onc.1203857

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (10)   
   KEGG PATHWAY (10)   
Disease (6)   
   KEGG DISEASE (6)   
Drug (16)   
   KEGG DRUG (16)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1265)   
   KEGG GENES (546)   
   KEGG MGENES (134)   
   RefGene (569)   
   OC (16)   
Literature (2)   
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