KEGG   ORTHOLOGY: K05410Help
Entry
K05410                      KO                                     

Name
TBK1
Definition
TANK-binding kinase 1 [EC:2.7.11.10]
Pathway
ko04014  Ras signaling pathway
ko04137  Mitophagy - animal
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko04657  IL-17 signaling pathway
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05410  TBK1; TANK-binding kinase 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K05410  TBK1; TANK-binding kinase 1
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05410  TBK1; TANK-binding kinase 1
   04621 NOD-like receptor signaling pathway
    K05410  TBK1; TANK-binding kinase 1
   04622 RIG-I-like receptor signaling pathway
    K05410  TBK1; TANK-binding kinase 1
   04623 Cytosolic DNA-sensing pathway
    K05410  TBK1; TANK-binding kinase 1
   04657 IL-17 signaling pathway
    K05410  TBK1; TANK-binding kinase 1
 09160 Human Diseases
  09167 Infectious diseases
   05162 Measles
    K05410  TBK1; TANK-binding kinase 1
   05164 Influenza A
    K05410  TBK1; TANK-binding kinase 1
   05161 Hepatitis B
    K05410  TBK1; TANK-binding kinase 1
   05160 Hepatitis C
    K05410  TBK1; TANK-binding kinase 1
   05168 Herpes simplex infection
    K05410  TBK1; TANK-binding kinase 1
   05163 Human cytomegalovirus infection
    K05410  TBK1; TANK-binding kinase 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05410  TBK1; TANK-binding kinase 1
   05169 Epstein-Barr virus infection
    K05410  TBK1; TANK-binding kinase 1
   05165 Human papillomavirus infection
    K05410  TBK1; TANK-binding kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05410  TBK1; TANK-binding kinase 1
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05410  TBK1; TANK-binding kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K05410  TBK1; TANK-binding kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   K05410  TBK1; TANK-binding kinase 1
Membrane trafficking [BR:ko04131]
 Autophagy
  Xenophagy
   Other xenophagy associated proteins
    K05410  TBK1; TANK-binding kinase 1
BRITE hierarchy
Genes
HSA: 29110(TBK1)
PTR: 452047(TBK1)
PPS: 100990211(TBK1)
GGO: 101138038(TBK1)
PON: 100433568(TBK1)
NLE: 100582856(TBK1)
MCC: 717427(TBK1)
MCF: 102144774(TBK1)
CSAB: 103238638(TBK1)
RRO: 104680828(TBK1)
RBB: 108529966(TBK1)
CJC: 100399701(TBK1)
SBQ: 101053608(TBK1)
MMU: 56480(Tbk1)
RNO: 299827(Tbk1)
CGE: 100770091(Tbk1)
NGI: 103730726(Tbk1)
HGL: 101713766(Tbk1)
CCAN: 109698137(Tbk1)
OCU: 100358771(TBK1)
TUP: 102484078(TBK1)
CFA: 481145(TBK1)
AML: 100484104(TBK1)
UMR: 103656833(TBK1)
ORO: 101362394(TBK1)
FCA: 101091955(TBK1)
PTG: 102960158(TBK1)
AJU: 106981360(TBK1)
BTA: 533141(TBK1)
BOM: 102279479(TBK1)
BIU: 109559273(TBK1)
PHD: 102341504(TBK1)
CHX: 102181474(TBK1)
OAS: 101110830(TBK1)
SSC: 100125828(TBK1)
CFR: 102514948(TBK1)
CDK: 105089261(TBK1)
BACU: 103013353(TBK1)
LVE: 103081814(TBK1)
OOR: 101290315(TBK1)
ECB: 100051650(TBK1)
EPZ: 103557811(TBK1)
EAI: 106824389(TBK1)
MYB: 102241250(TBK1)
MYD: 102769631(TBK1)
HAI: 109381695(TBK1)
RSS: 109447771(TBK1)
PALE: 102878859(TBK1)
LAV: 100661026(TBK1)
TMU: 101345902
SHR: 100915362(TBK1)
OAA: 100076520(TBK1)
GGA: 417825(TBK1)
MGP: 100542773(TBK1)
CJO: 107310131(TBK1)
APLA: 101800085(TBK1)
ACYG: 106047239(TBK1)
TGU: 100225715(TBK1)
GFR: 102044344(TBK1)
FAB: 101809300(TBK1)
PHI: 102112102(TBK1)
PMAJ: 107204371(TBK1)
CCW: 104698356(TBK1)
FPG: 101911068(TBK1)
FCH: 102051211(TBK1)
CLV: 102085310(TBK1)
EGZ: 104122201(TBK1)
AAM: 106488940(TBK1)
ASN: 102383892(TBK1)
AMJ: 106737001(TBK1)
PSS: 102457979(TBK1)
CMY: 102938424(TBK1)
CPIC: 101947523(TBK1)
ACS: 100553575(tbk1)
PVT: 110075119(TBK1)
PBI: 103049737(TBK1)
GJA: 107110994(TBK1)
XLA: 108712371(tbk1.S) 446351(tbk1.L)
XTR: 100216212(tbk1)
NPR: 108804572(TBK1)
DRE: 692289(tbk1)
SANH: 107658761(tbk1) 107662237
CCAR: 109074329 109074335(tbk1)
IPU: 108279669(tbk1)
AMEX: 103023014(tbk1)
TRU: 101071013
LCO: 104933406(tbk1) 109137588
NCC: 104948701
MZE: 101474803(tbk1)
OLA: 101168192(tbk1)
XMA: 102227107(tbk1)
PRET: 103459804(tbk1)
NFU: 107387745(tbk1)
CSEM: 103382474(tbk1)
LCF: 108882406(tbk1)
HCQ: 109532591(tbk1)
BPEC: 110161450(tbk1)
SASA: 100861582(tbk1) 106594253
ELS: 105026533(tbk1)
SFM: 108931981(tbk1)
LCM: 102356087(TBK1)
CMK: 103179820(tbk1)
CIN: 778650(ikk-epsilon) 780713(ikk-epsilon)
SPU: 579073
SKO: 100372702
DME: Dmel_CG2615(IKKepsilon)
DSI: Dsimw501_GD24274(Dsim_GD24274)
MDE: 101896529
AAG: 5566387
AME: 413493(Mik2)
BIM: 100748635
BTER: 100644806
SOC: 105203581
AEC: 105151453
ACEP: 105620284
PBAR: 105426672
HST: 105187659
CFO: 105250722
LHU: 105677180
NVI: 100122336
TCA: 100141977 658218(ik2)
NVL: 108561216
BMOR: 101737865
PMAC: 106715712
PRAP: 110994808
PXY: 105395113
API: 100168269
DNX: 107165510
ZNE: 110836419
FCD: 110842355
TUT: 107368313
BMY: Bm1_21030
EPA: 110245341
ADF: 107358025
HMG: 100201666
AQU: 100636688
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Pomerantz JL, Baltimore D
  Title
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
  Journal
EMBO J 18:6694-704 (1999)
DOI:10.1093/emboj/18.23.6694
  Sequence
[hsa:29110]
Reference
  Authors
Kishore N, Huynh QK, Mathialagan S, Hall T, Rouw S, Creely D, Lange G, Caroll J, Reitz B, Donnelly A, Boddupalli H, Combs RG, Kretzmer K, Tripp CS
  Title
IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.
  Journal
J Biol Chem 277:13840-7 (2002)
DOI:10.1074/jbc.M110474200

DBGET integrated database retrieval system