KEGG   ORTHOLOGY: K05552
Entry
K05552                      KO                                     

Name
actI2, oxyB, tcmL, snoa2, aknC, mtmK
Definition
minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
Pathway
ko00253  Tetracycline biosynthesis
ko01056  Biosynthesis of type II polyketide backbone
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
   00253 Tetracycline biosynthesis
    K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
   01008 Polyketide biosynthesis proteins
    K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.235  tetracenomycin F2 synthase
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
    2.3.1.260  tetracycline polyketide synthase
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
    2.3.1.-  
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Component type
   K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C12 cyclized polyketide type
    Octaketide PKS
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
Other DBs
RN: R06635 R06637 R06641 R06643 R06644 R06645 R09258 R09259 R10960 R11516
Genes
MBD: MEBOL_003041
MSAO: MYCSP_12695
MSAL: DSM43276_02542
NBR: O3I_007450 O3I_015115
NNO: NONO_c10800
NTP: CRH09_08675
NOZ: DMB37_03465
SCO: SCO5088(actIORF2)
SMA: SAVERM_2375(pks9-3)
SSX: SACTE_5203 SACTE_6347
SFA: Sfla_5317
SBH: SBI_06845
SHY: SHJG_1188
SVE: SVEN_5981
SALS: SLNWT_5122
STRP: F750_1306(whiE-CLF)
SFI: SFUL_4003
SALU: DC74_6591
SALL: SAZ_34275
STRE: GZL_p00215
STRM: M444_36340
STRD: NI25_18960
SLAU: SLA_3073
SALJ: SMD11_0676(actI2) SMD11_1144(actI2) SMD11_6045(actI2)
LMOI: VV02_05820
TFU: Tfu_1219
TCU: Tcur_2772
SRO: Sros_4151
AMD: AMED_5434(fabF)
AMN: RAM_27700
AMM: AMES_5369(fabF)
AMZ: B737_5369(fabF)
SESP: BN6_54870
KAL: KALB_7830
ACTI: UA75_11095
ACAD: UA74_11005
ALO: CRK55092
MIL: ML5_4403
ACTN: L083_3108
AG: AAA65207(dpsB) AAF70107(aknC) AAG30188(zhuA) AAZ78326(oxyB) CAA12018(snoa2) CAA61990(mtmK)
 » show all
Reference
PMID:1527048
  Authors
Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F
  Title
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.
  Journal
J Biol Chem 267:19278-90 (1992)
  Sequence
[sco:SCO5088]
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:2684656
  Authors
Bibb MJ, Biro S, Motamedi H, Collins JF, Hutchinson CR
  Title
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.
  Journal
EMBO J 8:2727-36 (1989)
DOI:10.1002/j.1460-2075.1989.tb08414.x
  Sequence
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
Reference
PMID:8654997
  Authors
Lombo F, Blanco G, Fernandez E, Mendez C, Salas JA
  Title
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.
  Journal
Gene 172:87-91 (1996)
DOI:10.1016/0378-1119(96)00029-7
  Sequence

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