KEGG   ORTHOLOGY: K05553
Entry
K05553                      KO                                     

Name
actI3, oxyC, tcmM, snoa3, aknD, mtmS
Definition
minimal PKS acyl carrier protein
Pathway
ko00253  Tetracycline biosynthesis
ko01056  Biosynthesis of type II polyketide backbone
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
   00253 Tetracycline biosynthesis
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
   01008 Polyketide biosynthesis proteins
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Component type
   K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C12 cyclized polyketide type
    Octaketide PKS
     K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
Other DBs
RN: R06635 R06637 R06641 R06643 R06644 R06645 R09258 R09259 R10960 R11516
Genes
MBD: MEBOL_003042
MSAO: MYCSP_12690
MSAL: DSM43276_02541
NBR: O3I_007455 O3I_010615 O3I_015120
NNO: NONO_c10790
NTP: CRH09_08680
NOZ: DMB37_03460
SCO: SCO1272(2SCG18.19c) SCO5089(actIORF3)
SMA: SAVERM_2373(pks9-1)
SSX: SACTE_5205 SACTE_6348
SFA: Sfla_5316
SBH: SBI_06846
SHY: SHJG_1187
SVE: SVEN_5982
SALS: SLNWT_5123
STRP: F750_1307
SFI: SFUL_4004
SALU: DC74_6592
SALL: SAZ_34280
SGU: SGLAU_26365(tcmM)
STRE: GZL_p00216
SAMB: SAM23877_0194(alpC) SAM23877_7479(alpC)
STRD: NI25_18965
SLAU: SLA_3072
SALJ: SMD11_0677(actI3) SMD11_1145(actI3) SMD11_6046(actI3)
KSK: KSE_58090
LMOI: VV02_05825
TFU: Tfu_1220
TCU: Tcur_2794
SRO: Sros_4152
AMD: AMED_5433(actI)
AMN: RAM_27695
AMM: AMES_5368(actI)
AMZ: B737_5368(actI)
AMYY: YIM_23710
SESP: BN6_54880(acp5)
KAL: KALB_7829
ACTI: UA75_11100
ACAD: UA74_11010
ALO: CRK55093
MIL: ML5_4404
AG: AAD04718(dpsG) AAF70108(aknD) AAG30201(zhuN) AAZ78327(oxyC) CAA12019(snoa3) CAA61991(mtmS)
 » show all
Reference
PMID:1527048
  Authors
Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F
  Title
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.
  Journal
J Biol Chem 267:19278-90 (1992)
  Sequence
[sco:SCO5089]
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:2684656
  Authors
Bibb MJ, Biro S, Motamedi H, Collins JF, Hutchinson CR
  Title
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.
  Journal
EMBO J 8:2727-36 (1989)
DOI:10.1002/j.1460-2075.1989.tb08414.x
  Sequence
Reference
PMID:1592832
  Authors
Shen B, Summers RG, Gramajo H, Bibb MJ, Hutchinson CR
  Title
Purification and characterization of the acyl carrier protein of the Streptomyces glaucescens tetracenomycin C polyketide synthase.
  Journal
J Bacteriol 174:3818-21 (1992)
DOI:10.1128/JB.174.11.3818-3821.1992
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
Reference
PMID:8654997
  Authors
Lombo F, Blanco G, Fernandez E, Mendez C, Salas JA
  Title
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.
  Journal
Gene 172:87-91 (1996)
DOI:10.1016/0378-1119(96)00029-7
  Sequence

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