KEGG   ORTHOLOGY: K05553
Entry
K05553                      KO                                     
Symbol
actI3, oxyC, tcmM, snoa3, aknD, mtmS
Name
minimal PKS acyl carrier protein
Pathway
map00253  Tetracycline biosynthesis
map01056  Biosynthesis of type II polyketide backbone
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Reaction
R06635  
R06637  
R06641  
R06643  
R06644  
R06645  
R09258  
R09259  
R10960  malonyl-CoA:acetate malonyltransferase (tetracenomycin-F2-forming)
R11516  malonyl-CoA:malonamoyl-[acyl-carrier protein] malonyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
   00253 Tetracycline biosynthesis
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
   01008 Polyketide biosynthesis proteins
    K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Component type
   K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C14 cyclized polyketide type
    Octaketide PKS
     K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
    Nonaketide PKS
     K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
    Decaketide PKS
     K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
Genes
MBD: MEBOL_003042
MSAO: MYCSP_12690
MSAL: DSM43276_02541
CCAW: CCANI_10135
NBR: O3I_007455 O3I_015120
NNO: NONO_c10790
NTP: CRH09_08680
NOZ: DMB37_03460
NAH: F5544_10725 F5544_17030 F5544_31055
NAD: NCTC11293_03460
SCO: SCO1272(2SCG18.19c) SCO5089(actIORF3)
SMA: SAVERM_2373(pks9-1)
SFI: SFUL_4004
SHY: SHJG_1187
SFA: Sfla_5316
SBH: SBI_06846
SVE: SVEN_5982
SALS: SLNWT_5123
STRP: F750_1307
SGU: SGLAU_26365(tcmM)
STRE: GZL_p00216
SAMB: SAM23877_0194(alpC) SAM23877_7479(alpC)
SALU: DC74_6592
SALL: SAZ_34280
STRD: NI25_18965
SLAU: SLA_3072
SALJ: SMD11_0677(actI3) SMD11_1145(actI3) SMD11_6046(actI3)
SAUH: SU9_027645
KSK: KSE_58090
LMOI: VV02_05825
TFU: Tfu_1220
TCU: Tcur_2794
SRO: Sros_4152
AMD: AMED_5433(actI)
AMN: RAM_27695
AMM: AMES_5368(actI)
AMZ: B737_5368(actI)
AMYY: YIM_23710
SESP: BN6_54880(acp5)
KAL: KALB_7829
ACTI: UA75_11100
ACAD: UA74_11010
ALO: CRK55093
MIL: ML5_4404
AG: AAD04718(dpsG) AAF70108(aknD) AAG30201(zhuN) AAZ78327(oxyC) CAA12019(snoa3) CAA61991(mtmS)
 » show all
Reference
PMID:1527048
  Authors
Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F
  Title
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.
  Journal
J Biol Chem 267:19278-90 (1992)
  Sequence
[sco:SCO5089]
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:2684656
  Authors
Bibb MJ, Biro S, Motamedi H, Collins JF, Hutchinson CR
  Title
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.
  Journal
EMBO J 8:2727-36 (1989)
DOI:10.1002/j.1460-2075.1989.tb08414.x
  Sequence
Reference
PMID:1592832
  Authors
Shen B, Summers RG, Gramajo H, Bibb MJ, Hutchinson CR
  Title
Purification and characterization of the acyl carrier protein of the Streptomyces glaucescens tetracenomycin C polyketide synthase.
  Journal
J Bacteriol 174:3818-21 (1992)
DOI:10.1128/JB.174.11.3818-3821.1992
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
Reference
PMID:8654997
  Authors
Lombo F, Blanco G, Fernandez E, Mendez C, Salas JA
  Title
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.
  Journal
Gene 172:87-91 (1996)
DOI:10.1016/0378-1119(96)00029-7
  Sequence

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