KEGG ORTHOLOGY: K05612

ORTHOLOGY: K05612

Entry

K05612                      KO

Symbol

SLC1A1, EAAT3

Name

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1

Pathway

map04721

Synaptic vesicle cycle

map04724

Glutamatergic synapse

map04974

Protein digestion and absorption

Disease

H00911

Dicarboxylic aminoaciduria

H01649

Schizophrenia

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09154 Digestive system
   04974 Protein digestion and absorption
    K05612  SLC1A1, EAAT3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1
  09156 Nervous system
   04724 Glutamatergic synapse
    K05612  SLC1A1, EAAT3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1
   04721 Synaptic vesicle cycle
    K05612  SLC1A1, EAAT3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K05612  SLC1A1, EAAT3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1
Transporters [BR:ko02000]
Solute carrier family (SLC)
  SLC1: High-affinity glutamate and neutral amino acid transporter
   K05612  SLC1A1, EAAT3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1

Other DBs

GO:

0005314

TC:	2.A.23.2.3

Genes

HSA:	6505(SLC1A1)

PTR:	464974(SLC1A1)

PPS:	100977165(SLC1A1)

GGO:	101144994(SLC1A1)

PON:	100449997(SLC1A1)

NLE:	100603236(SLC1A1)

HMH:	116458428(SLC1A1)

MCC:	694947(SLC1A1)

MCF:	102123578(SLC1A1)

MTHB:

126937560

MNI:	105491831(SLC1A1)

CSAB:

103219505(SLC1A1)

CATY:

105584109(SLC1A1)

PANU:

101010801(SLC1A1)

TGE:	112607978(SLC1A1)

MLEU:

105545427(SLC1A1)

RRO:	104682499(SLC1A1)

RBB:	108514947(SLC1A1)

TFN:	117098535(SLC1A1)

PTEH:

111543311(SLC1A1)

CANG:

105508470(SLC1A1)

CJC:	100410508(SLC1A1)

SBQ:	101054091(SLC1A1)

CIMI:

108281434(SLC1A1)

CSYR:

103265431(SLC1A1)

MMUR:

105856181(SLC1A1)

LCAT:

123646676(SLC1A1)

PCOQ:

105817258(SLC1A1)

OGA:	100950978(SLC1A1)

MMU:	20510(Slc1a1)

MCAL:

110285434(Slc1a1)

MPAH:

110320982(Slc1a1)

RNO:	25550(Slc1a1)

MCOC:

116103703(Slc1a1)

ANU:	117706224(Slc1a1)

MUN:	110547014(Slc1a1)

CGE:	100760895(Slc1a1)

MAUA:

101826834(Slc1a1)

PROB:

127233303(Slc1a1)

PLEU:

114710314(Slc1a1)

MORG:

121454007(Slc1a1)

MFOT:

126511690

AAMP:

119812833(Slc1a1)

NGI:	103740986(Slc1a1)

HGL:	101713753(Slc1a1)

CPOC:

100721255(Slc1a1)

DORD:

105987215(Slc1a1)

DSP:	122124661(Slc1a1)

PLOP:

125358744(Slc1a1)

NCAR:

124964655

MMMA:

107148247(Slc1a1)

OCU:	100009070(SLC1A1)

OPI:	101525212(SLC1A1)

TUP:	102474682(SLC1A1)

GVR:	103608049(SLC1A1)

CFA:	403751(SLC1A1)

CLUD:

112644805(SLC1A1)

VVP:	112922078(SLC1A1)

VLG:	121475853(SLC1A1)

NPO:	129500755(SLC1A1)

AML:	100484877(SLC1A1)

UMR:	103663220(SLC1A1)

UAH:	113270170(SLC1A1)

UAR:	123776553(SLC1A1)

ELK:

111153579

LLV:

125083654

MPUF:

101685453(SLC1A1)

MNP:	132024856(SLC1A1)

MLK:	131812371(SLC1A1)

NVS:	122917745(SLC1A1)

ORO:	101376747(SLC1A1)

EJU:	114219813(SLC1A1)

ZCA:	113934920(SLC1A1)

MLX:	118026342(SLC1A1)

NSU:	110584300(SLC1A1)

LWW:	115937014(SLC1A1)

FCA:	101099844(SLC1A1)

PYU:	121013698(SLC1A1)

PCOO:

112868547(SLC1A1)

PBG:	122475452(SLC1A1)

PVIV:

125150933(SLC1A1)

LRUF:

124524926

PTG:	102957258(SLC1A1)

PPAD:

109275482(SLC1A1)

PUC:

125924532

AJU:

106968167

HHV:	120231001(SLC1A1)

BTA:	282353(SLC1A1)

BOM:	102281036(SLC1A1)

BIU:	109562910(SLC1A1)

BBUB:

102410542(SLC1A1)

BBIS:

105003502(SLC1A1)

CHX:	102176416(SLC1A1)

OAS:	443514(SLC1A1)

BTAX:

128052399(SLC1A1)

ODA:	120860239 120866455(SLC1A1)

CCAD:

122453245(SLC1A1)

MBEZ:

129557611(SLC1A1)

SSC:	397003(SLC1A1)

CFR:	102521832(SLC1A1)

CBAI:

105079178(SLC1A1)

CDK:	105101964(SLC1A1)

VPC:	102542804(SLC1A1)

BACU:

103021071(SLC1A1)

BMUS:

118897139(SLC1A1)

LVE:	103074769(SLC1A1)

OOR:	101273299(SLC1A1)

DLE:	111174642(SLC1A1)

PCAD:

102996882(SLC1A1)

PSIU:

116755943(SLC1A1)

NASI:

112392543(SLC1A1)

ECB:	100059120(SLC1A1)

EPZ:	103563064(SLC1A1)

EAI:	106843615(SLC1A1)

MYB:	102253607(SLC1A1)

MYD:	102764378(SLC1A1)

MMYO:

118667500(SLC1A1)

MLF:	102425043(SLC1A1)

PKL:	118716540(SLC1A1) 118724615

EFUS:

103289142(SLC1A1)

MNA:	107538096(SLC1A1)

DRO:	112299771(SLC1A1)

SHON:

118997863(SLC1A1)

AJM:	119046173(SLC1A1)

PDIC:

114504364(SLC1A1)

PHAS:

123820176(SLC1A1)

MMF:	118629264(SLC1A1)

PPAM:

129078293(SLC1A1)

HAI:	109384505(SLC1A1)

RFQ:	117032255(SLC1A1)

PALE:

102883413(SLC1A1)

PGIG:

120620320(SLC1A1)

PVP:	105303180(SLC1A1)

RAY:	107507287(SLC1A1)

MJV:	108391633(SLC1A1)

TOD:	119231995(SLC1A1)

SARA:

101548877(SLC1A1)

LAV:	100671507(SLC1A1)

TMU:

101358388

ETF:	101638112(SLC1A1)

DNM:	101418577(SLC1A1)

MDO:	100014691(SLC1A1)

GAS:	123230569(SLC1A1)

SHR:	100926284(SLC1A1)

AFZ:

127555519

PCW:	110221645(SLC1A1)

OAA:	100073939(SLC1A1)

GGA:	427352(SLC1A1)

PCOC:

116240135(SLC1A1)

MGP:	104915008(SLC1A1)

CJO:	107306100(SLC1A1)

TPAI:

128089470(SLC1A1)

LMUT:

125687023(SLC1A1)

NMEL:

110389951(SLC1A1)

APLA:

101803318(SLC1A1)

ACYG:

106047392(SLC1A1)

CATA:

118257648(SLC1A1)

AFUL:

116500933(SLC1A1)

TGU:	100221546(SLC1A1)

LSR:	110471255(SLC1A1)

SCAN:

103823847(SLC1A1)

PMOA:

120512009(SLC1A1)

OTC:	121336217(SLC1A1)

PRUF:

121363639(SLC1A1)

GFR:	102039543(SLC1A1)

FAB:	101806778(SLC1A1)

OMA:	130265120(SLC1A1)

PHI:	102111577(SLC1A1)

PMAJ:

107216266(SLC1A1)

CCAE:

111940853(SLC1A1)

CCW:	104685162(SLC1A1)

CBRC:

103614616(SLC1A1)

ETL:	114057337(SLC1A1)

ZAB:	102064246(SLC1A1)

ACHL:

103812231

SVG:	106855160(SLC1A1)

MMEA:

130579223(SLC1A1)

HRT:	120765708(SLC1A1)

FPG:	101920899(SLC1A1)

FCH:	102057696(SLC1A1)

CLV:	102098003(SLC1A1)

EGZ:	104123578(SLC1A1)

NNI:	104021487(SLC1A1)

PCRI:

104031007(SLC1A1)

PLET:

104624618(SLC1A1)

PCAO:

104039634

ACUN:

113490381(SLC1A1)

TALA:

104368815(SLC1A1)

PADL:

103919732(SLC1A1)

AFOR:

103898303(SLC1A1)

ACHC:

115336954(SLC1A1)

HALD:

104322153(SLC1A1)

HLE:	104841298(SLC1A1)

AGEN:

126036281

GCL:

127027108

CCRI:

104168961(SLC1A1)

CSTI:

104552792

CMAC:

104482436(SLC1A1)

BREG:

104642797(SLC1A1)

FGA:	104079685(SLC1A1)

GSTE:

104257852(SLC1A1)

LDI:	104352270(SLC1A1)

MNB:	103773534(SLC1A1)

OHA:	104330791(SLC1A1)

NNT:	104408745(SLC1A1)

SHAB:

115600719(SLC1A1)

DPUB:

104299646(SLC1A1)

ACAR:

104528184

CPEA:

104391379(SLC1A1)

AVIT:

104280725(SLC1A1)

CVF:	104285819(SLC1A1)

RTD:	128903119(SLC1A1)

CUCA:

104064000(SLC1A1)

TEO:	104377072(SLC1A1)

BRHI:

104493035(SLC1A1)

AAM:	106496782(SLC1A1)

AROW:

112975955(SLC1A1)

NPD:	112947579(SLC1A1)

TGT:	104570161(SLC1A1)

DNE:	112994869(SLC1A1)

SCAM:

104142589(SLC1A1)

ASN:	102374740(SLC1A1)

AMJ:	102565707(SLC1A1)

CPOO:

109323650(SLC1A1)

GGN:	109298105(SLC1A1)

PSS:	102457926(SLC1A1)

CMY:	102939154(SLC1A1)

CCAY:

125636805(SLC1A1)

DCC:	119855870(SLC1A1)

CPIC:

101950785(SLC1A1)

TST:	117879101(SLC1A1)

CABI:

116837445(SLC1A1)

MRV:	120408606(SLC1A1)

ACS:	100566728(slc1a1)

ASAO:

132767388(SLC1A1)

PVT:	110083242(SLC1A1)

SUND:

121923915(SLC1A1)

PBI:	103053707(SLC1A1)

PMUR:

107291606(SLC1A1)

CTIG:

120317683(SLC1A1)

TSR:	106545686(SLC1A1)

PGUT:

117661486(SLC1A1)

APRI:

131192567(SLC1A1)

PTEX:

113438406(SLC1A1)

NSS:	113417379(SLC1A1)

VKO:	123031533(SLC1A1)

PMUA:

114587537(SLC1A1)

PRAF:

128404986(SLC1A1)

ZVI:	118097799(SLC1A1)

HCG:	128346735(SLC1A1)

GJA:	107107204(SLC1A1)

STOW:

125436676(SLC1A1)

EMC:	129334694(SLC1A1)

XLA:	108704908(slc1a1.S) 108714280(slc1a1.L)

XTR:	100498100(slc1a1)

NPR:	108791542(SLC1A1)

RTEM:

120943826(SLC1A1)

BBUF:

120989193(SLC1A1)

BGAR:

122921785(SLC1A1)

MUO:	115463373(SLC1A1)

GSH:	117350842(SLC1A1)

DRE:	436939(slc1a1)

SRX:	107738354 107747385(slc1a1)

SANH:

107659129 107691854

SGH:	107552979 107561518

CCAR:

109087373 109102854

CAUA:

113051827 113106435

CGIB:

127961667 128016465

PTET:

122349398(slc1a1)

LROH:

127168339(slc1a1)

OMC:	131544581(slc1a1)

PPRM:

120477813(slc1a1)

RKG:	130075627(slc1a1)

MAMB:

125265683(slc1a1)

CIDE:

127515649

MASI:

127418565 127455714

TROS:

130559027(slc1a1)

TDW:	130427676(slc1a1)

MANU:

129450213(slc1a1)

IPU:

108267129

IFU:	128610008(slc1a1)

PHYP:

113540305(slc1a1)

SMEO:

124387855(slc1a1)

TFD:	113657424(slc1a1)

TVC:	132848582(slc1a1)

AMEX:

103039160(slc1a1)

CMAO:

118826749(slc1a1)

EEE:	113580802(slc1a1) 113582957

CHAR:

105893788 105912799(slc1a1)

TRU:	101067022(slc1a1)

TFS:	130522588(slc1a1)

TNG:	GSTEN00008959G001

LCO:	104932815(slc1a1)

NCC:	104960555(slc1a1) 104968117

TBEN:

117481318 117481343 117482685(slc1a1)

CGOB:

115023674(slc1a1)

PGEO:

117441834 117451354 117451521 117454222 117455529 117461128 117463631(slc1a1)

GACU:

117536895 117539874 117559910(slc1a1) 117562542

EMAC:

134864476 134864836 134875822(slc1a1) 134877995

ELY:	117246147(slc1a1)

EFO:	125884079(slc1a1)

PLEP:

121940907 121941329 121944099 121962385(slc1a1)

SLUC:

116039651 116039652 116045774 116060488 116060642 116060916(slc1a1)

ECRA:

117943874 117948221 117956277 117962177(slc1a1)

ESP:	116689992 116693165 116702648 116707457(slc1a1)

PFLV:

114545575(slc1a1) 114557640 114570921 114571354

GAT:	120822502(slc1a1) 120824780 120824789 120831016

PPUG:

119219583 119223201(slc1a1) 119225475

AFB:	129093085(slc1a1) 129095406 129096034 129113642

CLUM:

117726509 117729385 117742268 117747436(slc1a1)

PSWI:

130188576 130190342 130194117 130202198 130211987(slc1a1)

MSAM:

119889740 119894861 119899924 119912845(slc1a1)

SCHU:

122870441(slc1a1) 122872824 122873390 122881520

CUD:	121504081(slc1a1)

ALAT:

119027671(slc1a1)

MZE:	101471477(slc1a1)

ONL:	100700566 100701129 100708032 100709518 100711441(slc1a1)

OAU:	116309255(slc1a1) 116313247 116328587 116331492

OLA:	101172361(slc1a1)

OML:	112155763(slc1a1)

CSAI:

133420358(slc1a1)

XMA:	102217761 102218272 102218530 102218781 102229847 102231191 106699659 111609670 111609885

XCO:	114133923 114141633 114142636 114143409 114144071 114145179 114145435 114149444 114157384(slc1a1) 114157443

XHE:	116709510 116710855 116719501 116719620 116719631 116719743 116723243 116724950 116732081

PRET:

103458696 103467142 103467143 103467144 103467146 103467156 103467226 103480068(slc1a1) 108166423

PFOR:

103131125 103132277(slc1a1) 103138919 103154014 103154015 103154016 103155414 107834683 107835391

PLAI:

106939346 106939347 106939348 106943088(slc1a1) 106949119 106957207 106963019 106963020 106963028

PMEI:

106905172 106905174 106908699 106908700 106908701 106910465 106910651(slc1a1) 106911299 106919903 106927849

GAF:	122819391 122820094 122820628(slc1a1) 122830905 122830922 122830931 122830937 122830954 122830960 122830985 122833265 122834591 122845995

PPRL:

129365374 129371591 129372236 129376870(slc1a1) 129377082 129377085 129377086 129377135 129377136 129377147 129377177 129377178 129377179

CVG:	107080745(slc1a1)

CTUL:

119772085(slc1a1)

GMU:	124857897 124881083(slc1a1)

NFU:	107383771 107384424 107384749(slc1a1) 107387867 107389204

KMR:	108235985 108237798 108238806 108242294(slc1a1)

ALIM:

106526470 106536110

NWH:	119408021(slc1a1) 119415905 119419394 119421233

AOCE:

111563811 111584482(slc1a1)

MCEP:

125004005 125004139 125005654 125021317(slc1a1)

CSEM:

103385209(slc1a1)

POV:	109637680(slc1a1)

SSEN:

122766494(slc1a1)

HHIP:

117779172(slc1a1)

HSP:	118102205(slc1a1)

SMAU:

118301482(slc1a1)

LCF:	108882647 108888815 108895205

SDU:	111216544 111223601(slc1a1) 111237964

SLAL:

111659578 111663261 111667999(slc1a1)

XGL:	120797376(slc1a1) 120801333

HCQ:	109520374(slc1a1)

SSCV:

125992329

SBIA:

133494429(slc1a1)

PEE:	133397603(slc1a1)

PTAO:

133472380(slc1a1)

BPEC:

110170754(slc1a1)

MALB:

109957181(slc1a1)

BSPL:

114843185(slc1a1)

SJO:	128357036 128365804 128366692 128384294(slc1a1)

SASA:

106577598 106608636

STRU:

115194227 115198219

OTW:	112214727 112259995(slc1a1)

OMY:	110500880 110531767

OGO:	124008749(slc1a1) 124014095

ONE:	115133575 115138110

OKI:	109897045 109906527

OKE:	118368728(slc1a1) 118391953

SALP:

111954569 111960448

SNH:	120030602(slc1a1) 120049484

CCLU:

121554307(slc1a1) 121571164

ELS:	105022117(slc1a1)

SFM:	108925698 108925749 108938808

PKI:	111848692(slc1a1) 111853120 111853159

AANG:

118228203 118232522(slc1a1)

LOC:	102687626 102691675

PSPA:

121295678 121322403

ARUT:

117408336 117420413

PSEX:

120533113(slc1a1)

LCM:	102365330(SLC1A1)

CMK:	103178089(slc1a1)

RTP:	109910924(slc1a1)

CPLA:

122539436(slc1a1)

HOC:	132829541(slc1a1)

LERI:

129695650(slc1a1)

PMRN:

116948944

LRJ:

133352077

CIN:	100176691 100183879

SCLV:

120337594 120345901

SPU:	115928807 576432

APLC:

MDE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ000673

CPII:

BCOO:

SOC:

MPHA:

AEC:

PBAR:

VEM:

CFO:

LHU:

OBO:

TCA:

ATD:

FCD:

PVM:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

HAZT:

EAF:

DSV:	119432833 119433501

RSAN:

RMP:

DPTE:

PTEP:

ABRU:

UDV:

LPOL:

PMEO:

PVUL:

BGT:	106052998 106062914 106066006

GAE:	121367708 121373720 121373937

HRF:	124117257 124117258 124126516 124127639 124127717 124147324

HRJ:	124265179 124267317 124287977 124291563

CVN:	111104312 111112640

CANU:

128163128

MYI:

110454706

PMAX:

117314733 117325349 117326061 117336867 117342721

MCAF:

127730763

MMER:

123524557 123524559 123524723 123536672

RPHI:

DPOL:

OSN:

LAK:

OVI:	T265_00484

EGL:

EGR_01271

ATEN:

116291701 116291702

XEN:	124440337 124445937

TAN:

TA10315

TOT:	TOT_040000897

BEQ:	BEWA_009820

CPC:

Cpar_1403

PAA:

Paes_1002

PROC:

Ptc2401_01063(gltP)

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Reference

PMID:7914198

Authors

Kanai Y, Stelzner M, Nussberger S, Khawaja S, Hebert SC, Smith CP, Hediger MA

Title

The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport.

Journal

J Biol Chem 269:20599-606 (1994)

Sequence

[hsa:6505]

Reference

PMID:18195088

Authors

Broer S

Title

Amino acid transport across mammalian intestinal and renal epithelia.

Journal

Physiol Rev 88:249-86 (2008)
DOI:10.1152/physrev.00018.2006

Reference

PMID:12176072

Authors

Amara SG, Fontana AC

Title

Excitatory amino acid transporters: keeping up with glutamate.

Journal

Neurochem Int 41:313-8 (2002)
DOI:10.1016/S0197-0186(02)00018-9

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