KEGG ORTHOLOGY: K05615

ORTHOLOGY: K05615

Entry

K05615                      KO

Symbol

SLC1A4, SATT

Name

solute carrier family 1 (neutral amino acid transporter), member 4

Disease

H02282

Spastic tetraplegia, thin corpus callosum, and progressive microcephaly

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K05615  SLC1A4, SATT; solute carrier family 1 (neutral amino acid transporter), member 4
Transporters [BR:ko02000]
Solute carrier family (SLC)
  SLC1: High-affinity glutamate and neutral amino acid transporter
   K05615  SLC1A4, SATT; solute carrier family 1 (neutral amino acid transporter), member 4

Other DBs

GO:

0015175

TC:	2.A.23.3.1

Genes

HSA:	6509(SLC1A4)

PTR:	459278(SLC1A4)

PPS:	100983184(SLC1A4)

GGO:	101144035(SLC1A4)

PON:	100447643(SLC1A4)

NLE:	100587032(SLC1A4)

HMH:	116483506(SLC1A4)

MCC:	699288(SLC1A4)

MCF:	101926023(SLC1A4)

MTHB:

126934210

MNI:	105465157(SLC1A4)

CSAB:

103220154(SLC1A4)

CATY:

105576474(SLC1A4)

PANU:

100997744(SLC1A4)

TGE:	112604590(SLC1A4)

MLEU:

105543535(SLC1A4)

RRO:	104656193(SLC1A4)

RBB:	108540814(SLC1A4)

TFN:	117099743(SLC1A4)

PTEH:

111550535(SLC1A4)

CANG:

105514141(SLC1A4)

CJC:	100397568(SLC1A4)

SBQ:	101036914(SLC1A4)

CIMI:

108299702(SLC1A4)

CSYR:

103267771

MMUR:

105871534(SLC1A4)

LCAT:

123636980(SLC1A4)

PCOQ:

105806159(SLC1A4)

OGA:	100949559(SLC1A4)

MMU:	55963(Slc1a4)

MCAL:

110304748(Slc1a4)

MPAH:

110330279(Slc1a4)

RNO:	305540(Slc1a4)

MCOC:

116068992(Slc1a4)

ANU:	117713031(Slc1a4)

MUN:	110555310(Slc1a4)

CGE:	100689351(Slc1a4)

MAUA:

101826175(Slc1a4)

PROB:

127233847(Slc1a4)

PLEU:

114703679(Slc1a4)

MORG:

121459492(Slc1a4)

MFOT:

126500738

AAMP:

119823923(Slc1a4)

NGI:	103748100(Slc1a4)

HGL:	101713943(Slc1a4)

CPOC:

100724004(Slc1a4)

CCAN:

109685014(Slc1a4)

DORD:

105990156(Slc1a4)

DSP:	122117503(Slc1a4)

PLOP:

125356260(Slc1a4)

NCAR:

124963620

OCU:

100348633

OPI:	101518368(SLC1A4)

TUP:	102478011(SLC1A4)

GVR:	103602672(SLC1A4)

CFA:	481391(SLC1A4)

CLUD:

112673665(SLC1A4)

VVP:	112934397(SLC1A4)

VLG:	121491621(SLC1A4)

NPO:	129511644(SLC1A4)

AML:	100465696(SLC1A4)

UMR:	103671796(SLC1A4)

UAH:	113244860(SLC1A4)

UAR:	123785995(SLC1A4)

ELK:

111148015

LLV:

125108877

MPUF:

101681958(SLC1A4)

NVS:	122916537(SLC1A4)

ORO:	101380667(SLC1A4)

EJU:	114201280(SLC1A4)

ZCA:	113938295(SLC1A4)

MLX:	118008052(SLC1A4)

NSU:	110588789(SLC1A4)

LWW:

102730697

FCA:	101087055(SLC1A4)

PYU:	121019102(SLC1A4)

PCOO:

112869084(SLC1A4)

PBG:	122496914(SLC1A4)

LRUF:

124504181

PTG:	102972703(SLC1A4)

PPAD:

109259761(SLC1A4)

PUC:

125936270

AJU:

106976225

HHV:	120239058(SLC1A4)

BTA:	326577(SLC1A4)

BOM:	102267216(SLC1A4)

BIU:	109566213(SLC1A4)

BBUB:

102400304(SLC1A4)

BBIS:

105005349(SLC1A4)

CHX:	102179486(SLC1A4)

OAS:	101113480(SLC1A4)

BTAX:

128055485(SLC1A4)

ODA:	120851332(SLC1A4)

CCAD:

122441842(SLC1A4)

MBEZ:

129539548(SLC1A4)

SSC:	396600(SLC1A4)

CFR:	102508628(SLC1A4)

CBAI:

105075818(SLC1A4)

CDK:	105088935(SLC1A4)

VPC:	102535973(SLC1A4)

BACU:

102997837(SLC1A4)

LVE:	103073887(SLC1A4)

OOR:	101285218(SLC1A4)

DLE:	111186562(SLC1A4)

PCAD:

102985034(SLC1A4)

PSIU:

116764507(SLC1A4)

NASI:

112404884(SLC1A4)

ECB:	100063163(SLC1A4)

EPZ:	103561040(SLC1A4)

EAI:	106828358(SLC1A4)

MYB:	102249710(SLC1A4)

MYD:	102754975(SLC1A4)

MMYO:

118668937(SLC1A4)

MLF:	102426659(SLC1A4)

MNA:	107545947(SLC1A4)

PKL:	118717434(SLC1A4)

EFUS:

103291482(SLC1A4)

HAI:	109379128(SLC1A4)

DRO:	112297874(SLC1A4)

SHON:

118988444(SLC1A4)

AJM:	119035069(SLC1A4)

PDIC:

114499970(SLC1A4)

PHAS:

123811579(SLC1A4)

MMF:	118631152(SLC1A4)

RFQ:	117033178(SLC1A4)

PALE:

102897420(SLC1A4)

PGIG:

120621580(SLC1A4)

PVP:	105306690(SLC1A4)

RAY:	107518319(SLC1A4)

MJV:	108387375(SLC1A4)

TOD:	119258999(SLC1A4)

SARA:

101552368(SLC1A4)

LAV:	100667231(SLC1A4)

TMU:

101346614

ETF:	101638496(SLC1A4)

DNM:	101419527(SLC1A4)

MDO:	100031837(SLC1A4)

GAS:	123234732(SLC1A4)

SHR:	100922427(SLC1A4)

AFZ:

127548142

PCW:	110207684(SLC1A4)

OAA:	100082655(SLC1A4)

GGA:	769612(SLC1A4)

PCOC:

116232805(SLC1A4)

MGP:	100539185(SLC1A4)

CJO:	107310676(SLC1A4)

TPAI:

128088529(SLC1A4)

LMUT:

125689067(SLC1A4)

NMEL:

110397126(SLC1A4)

APLA:

101791164(SLC1A4)

ACYG:

106044685(SLC1A4)

CATA:

118251113(SLC1A4)

AFUL:

116487067(SLC1A4)

TGU:	100228071(SLC1A4)

LSR:	110484896(SLC1A4)

SCAN:

103821354(SLC1A4)

PMOA:

120506865(SLC1A4)

OTC:	121335788(SLC1A4)

PRUF:

121358552(SLC1A4)

FAB:	101816942(SLC1A4)

OMA:	130250926(SLC1A4)

PHI:	102110028(SLC1A4)

PMAJ:

107202170(SLC1A4)

CCAE:

111926526(SLC1A4)

CCW:	104696592(SLC1A4)

CBRC:

103617183(SLC1A4)

ETL:	114054876(SLC1A4)

ZAB:	102060874(SLC1A4)

ACHL:

103801316(SLC1A4)

SVG:	106863645(SLC1A4)

MMEA:

130583813(SLC1A4)

HRT:	120750391(SLC1A4)

FPG:	101912263(SLC1A4)

FCH:	102059797(SLC1A4)

CLV:	102093261(SLC1A4)

EHS:	104513750(SLC1A4)

ACUN:

113478020(SLC1A4)

TALA:

104357906(SLC1A4)

PADL:

103917820(SLC1A4)

AFOR:

103908481(SLC1A4)

ACHC:

115344992(SLC1A4)

HALD:

104316288(SLC1A4)

HLE:	104836438(SLC1A4)

AGEN:

126038774

GCL:

127014494

SHAB:

115609407(SLC1A4)

DPUB:

104300957(SLC1A4)

CPEA:

104385047(SLC1A4)

AAM:	106497525(SLC1A4)

AROW:

112973166(SLC1A4)

NPD:	112942912(SLC1A4)

TGT:	104566127(SLC1A4)

DNE:	112989360(SLC1A4)

SCAM:

104151860(SLC1A4)

ASN:	102373056(SLC1A4)

AMJ:	102567218(SLC1A4)

CPOO:

109319543(SLC1A4)

GGN:	109296941(SLC1A4)

PSS:	102444886(SLC1A4)

CMY:	102933958(SLC1A4)

CCAY:

125633432(SLC1A4)

DCC:	119852515(SLC1A4)

CPIC:

101952916(SLC1A4)

TST:	117874272(SLC1A4)

CABI:

116840131(SLC1A4)

MRV:	120401560(SLC1A4)

ACS:	100562665(slc1a4)

PVT:	110084207(SLC1A4)

SUND:

121935292(SLC1A4)

PBI:	103055296(SLC1A4)

PMUR:

107284228(SLC1A4)

CTIG:

120307848(SLC1A4)

TSR:	106556130(SLC1A4)

PGUT:

117674451(SLC1A4)

APRI:

131197888(SLC1A4)

PTEX:

113444202(SLC1A4)

NSS:	113412692(SLC1A4)

VKO:	123035721(SLC1A4)

PMUA:

114593566(SLC1A4)

PRAF:

128409906(SLC1A4)

ZVI:	118082566(SLC1A4)

HCG:	128339881(SLC1A4)

GJA:	107119304(SLC1A4)

STOW:

125435327(SLC1A4)

EMC:	129340698(SLC1A4)

XLA:	108716584(slc1a4.L)

XTR:	100124992(slc1a4)

NPR:	108786374(SLC1A4)

RTEM:

120937767(SLC1A4)

BBUF:

120999240(SLC1A4)

BGAR:

122935785(SLC1A4)

MUO:	115465693(SLC1A4)

GSH:	117358078(SLC1A4)

DRE:	368885(slc1a4)

SRX:

107725464

SANH:

107666559(slc1a4)

SGH:	107552941 107601789

CAUA:

113056996 113112723

CGIB:

127969986 128026224

PTET:

122356099(slc1a4)

LROH:

127174929(slc1a4)

OMC:	131552570(slc1a4)

PPRM:

120480028(slc1a4)

MAMB:

125276886(slc1a4)

CIDE:

127525494

MASI:

127411811 127414213

TROS:

130558909(slc1a4)

IPU:

108263765

PHYP:

113545937(slc1a4)

SMEO:

124396244(slc1a4)

TFD:	113661059(slc1a4)

AMEX:

103039293

CMAO:

118810698(slc1a4)

EEE:	113582081(slc1a4)

CHAR:

105893429(slc1a4)

TRU:	101068457(slc1a4)

TFS:	130533462(slc1a4)

TNG:	GSTEN00018793G001

LCO:	104932741(slc1a4)

CGOB:

115020063(slc1a4)

ELY:

117248142

EFO:	125903441(slc1a4)

PLEP:

121954507(slc1a4)

SLUC:

116067398(slc1a4)

ECRA:

117960941(slc1a4)

ESP:

116696460

PFLV:

114572141

GAT:	120820955(slc1a4)

PPUG:

119214049(slc1a4)

AFB:	129092234(slc1a4)

CLUM:

117743809(slc1a4)

MSAM:

119917067(slc1a4)

SCHU:

122884573(slc1a4)

CUD:	121510911(slc1a4)

ALAT:

119034096(slc1a4)

MZE:	101483383(slc1a4)

ONL:	100702029(slc1a4)

OAU:	116321329(slc1a4)

OLA:	101170329(slc1a4)

OML:	112137321(slc1a4)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

106939792(slc1a4)

PMEI:

106930918(slc1a4)

GAF:	122842278(slc1a4)

CVG:	107081771(slc1a4)

CTUL:

119792728(slc1a4)

GMU:	124859026(slc1a4)

NFU:

107376424

KMR:	108239161(slc1a4)

ALIM:

106515319

NWH:	119413711(slc1a4)

AOCE:

111574676(slc1a4)

MCEP:

125018393(slc1a4)

CSEM:

103386919(slc1a4)

POV:

109636536

SSEN:

122782219(slc1a4)

HHIP:

117775139(slc1a4)

HSP:	118118852(slc1a4)

LCF:	108893026 108895754

SDU:

111220579

SLAL:

111669510(slc1a4)

XGL:	120796234(slc1a4)

HCQ:

109523149

SSCV:

125978463

BPEC:

110162857

MALB:

109952147(slc1a4)

BSPL:

114870466(slc1a4)

SASA:

106562888 106577368(slc1a4)

STRU:

115152783 115193518

OTW:

121844083

OMY:	110531632 110531639(slc1a4)

OGO:

124020082

OKI:	109876736 109877318

SNH:	120017773(slc1a4)

CCLU:

121557643(slc1a4)

ELS:	105008809(slc1a4)

SFM:	108927004 108933608

PKI:	111850750 111858524

AANG:

118217306 118218008(slc1a4)

LOC:	102696281(slc1a4)

PSPA:

121316124 121317248

ARUT:

117402344 117411503

PSEX:

120516399(slc1a4)

LCM:	102353598(SLC1A4)

CMK:

103177921

RTP:

109924202

CPLA:

122553128(slc1a4)

RSAN:

RMP:

PCAN:

HRJ:

CVN:

OED:

PSOJ:

Reference

PMID:8101838

Authors

Arriza JL, Kavanaugh MP, Fairman WA, Wu YN, Murdoch GH, North RA, Amara SG

Title

Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.

Journal

J Biol Chem 268:15329-32 (1993)
DOI:10.1016/S0021-9258(18)82257-8

Sequence

[hsa:6509]

Reference

PMID:26041762

Authors

Damseh N, Simonin A, Jalas C, Picoraro JA, Shaag A, Cho MT, Yaacov B, Neidich J, Al-Ashhab M, Juusola J, Bale S, Telegrafi A, Retterer K, Pappas JG, Moran E, Cappell J, Anyane Yeboa K, Abu-Libdeh B, Hediger MA, Chung WK, Elpeleg O, Edvardson S

Title

Mutations in SLC1A4, encoding the brain serine transporter, are associated with developmental delay, microcephaly and hypomyelination.

Journal

J Med Genet 52:541-7 (2015)
DOI:10.1136/jmedgenet-2015-103104

Sequence

[hsa:6509]

All links

Ontology (4)   
   KEGG BRITE (2)   
   GO (1)   
   TC (1)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (491)   
   KEGG GENES (353)   
   KEGG MGENES (56)   
   RefGene (79)   
   OC (3)   
Literature (2)   
   PubMed (2)   
All databases (498)   

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