KEGG   ORTHOLOGY: K05658Help
Entry
K05658                      KO                                     

Name
ABCB1, CD243
Definition
ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2]
Pathway
ko02010  ABC transporters
ko04976  Bile secretion
ko05206  MicroRNAs in cancer
ko05226  Gastric cancer
Disease
H01227  Inflammatory bowel disease (IBD)
H01529  Avascular necrosis of femoral head
H01709  Glucocorticoid-induced osteonecrosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09131 Membrane transport
   02010 ABC transporters
    K05658  ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K05658  ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1
 09160 Human Diseases
  09161 Cancers: Overview
   05206 MicroRNAs in cancer
    K05658  ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1
  09162 Cancers: Specific types
   05226 Gastric cancer
    K05658  ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K05658  ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1
   04147 Exosome
    K05658  ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1
   04090 CD molecules
    K05658  ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1
Enzymes [BR:ko01000]
 7. Translocases
  7.6  Catalysing the translocation of other compounds
   7.6.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.6.2.2  ABC-type xenobiotic transporter
     K05658  ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1
Transporters [BR:ko02000]
 ABC Transporters, Eukaryotic Type
  ABCB (MDR/TAP) subfamily
   ABCB1, 4, 5 subgroups
    K05658  ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K05658  ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1
CD molecules [BR:ko04090]
 Proteins
  K05658  CD243, ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1
BRITE hierarchy
Other DBs
GO: 0008559
TC: 3.A.1.201
Genes
HSA: 5243(ABCB1)
PTR: 463516(ABCB1)
PPS: 100975579(ABCB1)
GGO: 101140916(ABCB1)
PON: 100452463(ABCB1)
NLE: 100605124(ABCB1)
MCC: 574235(ABCB1)
MCF: 102145631(ABCB1)
CSAB: 103226605(ABCB1)
RRO: 104668036(ABCB1)
RBB: 108515036(ABCB1)
CJC: 100398256(ABCB1)
SBQ: 101052405(ABCB1)
MMU: 18669(Abcb1b) 18671(Abcb1a)
RNO: 170913(Abcb1a) 24646(Abcb1b)
CGE: 100682536(Abcb1) 100682537(Abcb1b)
NGI: 103725176 103725178(Abcb1)
OCU: 100008914(ABCB1)
TUP: 102483808 102485093(ABCB1)
CFA: 403879(ABCB1)
AML: 100475940(ABCB1)
UMR: 103658685(ABCB1)
ORO: 101368656(ABCB1)
FCA: 493707(ABCB1)
PTG: 102971562(ABCB1)
AJU: 106987581(ABCB1)
BTA: 100296627 281585(ABCB1)
BIU: 109557314(ABCB1)
PHD: 102322506(ABCB1)
SSC: 396910(ABCB1)
CFR: 102511767(ABCB1) 102520213
CDK: 105087358(ABCB1)
BACU: 103005128(ABCB1)
LVE: 103091243(ABCB1)
OOR: 101279434(ABCB1)
ECB: 100034074(ABCB1)
EPZ: 103567918(ABCB1)
EAI: 106844768(ABCB1)
MYB: 102245646(ABCB1)
MYD: 102756283(ABCB1)
HAI: 109371291(ABCB1)
PALE: 102879811(ABCB1)
LAV: 100673458(ABCB1)
TMU: 101349645
MDO: 100027271 100027288(ABCB1)
OAA: 100077826(ABCB1)
GGA: 395712(ABCB1) 420606(ABCB5)
MGP: 100303709(ABCB1) 100547526(ABCB5)
CJO: 107309218(ABCB5)
APLA: 101793099(ABCB5) 101797943
ACYG: 106030181(ABCB5) 106039634
TGU: 100221908(ABCB1) 100229243
GFR: 102035452(ABCB5) 102036795(ABCB1)
FAB: 101817707(ABCB5) 101820267(ABCB1)
PHI: 102110379(ABCB5) 102110628(ABCB1)
PMAJ: 107198574(ABCB1) 107200640(ABCB5)
CCW: 104689119(ABCB5) 104689196(ABCB1)
FPG: 101917620(ABCB1) 101922679
FCH: 102049734(ABCB1) 102055901(ABCB5)
CLV: 102093820(ABCB5) 102094962
EGZ: 104126159(ABCB5)
AAM: 106483432(ABCB5) 106490936
ASN: 102375248(ABCB1) 102380238(ABCB5)
AMJ: 102564067
PSS: 102454707(ABCB1)
CMY: 102940117
ACS: 100555474(abcb1) 100566687(abcb5)
PVT: 110073074(ABCB5)
GJA: 107107578 107122985(ABCB5)
XTR: 100494740(abcb1) 100494753 100496268(abcb1)
DRE: 798527(abcb5)
IPU: 108256530(abcb1) 108267330
LCO: 104923078
NCC: 104959183
MZE: 101470858(abcb1)
OLA: 101171435(abcb1)
XMA: 102224768(abcb1)
PRET: 103478129(abcb1)
NFU: 107379650(abcb1)
KMR: 108241145
CSEM: 103388176
LCF: 108889588(abcb1)
SDU: 111237185(abcb1)
HCQ: 109528973
BPEC: 110163198
MALB: 109964166
SFM: 108927435 108940694(abcb1)
LCM: 102358502(ABCB1)
CMK: 103181561(abcb1) 103185032
SPU: 587897 591668(ABCB1)
APLC: 110975177
DME: Dmel_CG10181(Mdr65) Dmel_CG10226(CG10226) Dmel_CG3879(Mdr49) Dmel_CG8523(Mdr50)
DSI: Dsimw501_GD11033(Dsim_GD11033) Dsimw501_GD13132(Dsim_GD13132) Dsimw501_GD13133(Dsim_GD13133) Dsimw501_GD25799(Dsim_GD25799)
AAG: 5573277
AME: 551167
BIM: 100745824
BTER: 100650108
SOC: 105195263
AEC: 105146941
ACEP: 105627156
PBAR: 105433319
HST: 105183497
DQU: 106744576
CFO: 105256714
LHU: 105680135
PGC: 109858738
PCF: 106792531
NVI: 100115608
CEL: CELE_C34G6.4(pgp-2) CELE_C47A10.1(pgp-9) CELE_DH11.3(pgp-11) CELE_F22E10.1(pgp-12) CELE_F22E10.2(pgp-13) CELE_F22E10.3(pgp-14) CELE_F42E11.1(pgp-4) CELE_K08E7.9(pgp-1) CELE_ZK455.7(pgp-3)
CBR: CBG00078 CBG00079(Cbr-pgp-14) CBG00083 CBG00086(Cbr-pgp-12) CBG04013 CBG05664(Cbr-pgp-9) CBG12969 CBG13514(Cbr-pgp-1) CBG17356(Cbr-pgp-4) CBG17357(Cbr-pgp-3) CBG17574 CBG24214
OBI: 106870660
HMG: 100202442(abcb1) 100213972(abcb1)
ATH: AT1G02520(ABCB11) AT1G02530(ABCB12) AT1G10680(PGP10) AT1G27940(ABCB13) AT1G28010(ABCB14) AT2G36910(ABCB1) AT2G39480(ABCB6) AT2G47000(ABCB4) AT3G28345(ABCB15) AT3G28360(ABCB16) AT3G28380(ABCB17) AT3G28390(ABCB18) AT3G28415(ABCB22) AT3G28860(ABCB19) AT3G55320(ABCB20) AT3G62150(ABCB21) AT4G01820(ABCB3) AT4G01830(ABCB5) AT4G18050(ABCB9) AT4G25960(ABCB2) AT5G46540(ABCB7)
LJA: Lj0g3v0066079.1(Lj0g3v0066079.1) Lj0g3v0066079.2(Lj0g3v0066079.2) Lj0g3v0066079.3(Lj0g3v0066079.3) Lj0g3v0285989.1(Lj0g3v0285989.1) Lj0g3v0285989.2(Lj0g3v0285989.2) Lj0g3v0304749.1(Lj0g3v0304749.1) Lj0g3v0304759.1(Lj0g3v0304759.1) Lj0g3v0323809.1(Lj0g3v0323809.1) Lj0g3v0323809.2(Lj0g3v0323809.2) Lj1g3v3194580.1(Lj1g3v3194580.1) Lj1g3v3207790.1(Lj1g3v3207790.1) Lj1g3v4591210.1(Lj1g3v4591210.1) Lj1g3v4591220.1(Lj1g3v4591220.1) Lj1g3v4830300.1(Lj1g3v4830300.1) Lj1g3v4830300.2(Lj1g3v4830300.2) Lj2g3v0855230.1(Lj2g3v0855230.1) Lj2g3v1022420.1(Lj2g3v1022420.1) Lj2g3v1022430.1(Lj2g3v1022430.1) Lj2g3v1022510.1(Lj2g3v1022510.1) Lj2g3v1022510.2(Lj2g3v1022510.2) Lj2g3v1055960.1(Lj2g3v1055960.1) Lj3g3v1011060.1(Lj3g3v1011060.1) Lj3g3v2477640.1(Lj3g3v2477640.1) Lj3g3v2576200.1(Lj3g3v2576200.1) Lj3g3v2576200.2(Lj3g3v2576200.2) Lj4g3v2226770.1(Lj4g3v2226770.1) Lj4g3v2226780.1(Lj4g3v2226780.1) Lj4g3v2227820.1(Lj4g3v2227820.1) Lj4g3v2227830.1(Lj4g3v2227830.1) Lj4g3v2227880.1(Lj4g3v2227880.1) Lj4g3v2227890.1(Lj4g3v2227890.1) Lj4g3v2227920.1(Lj4g3v2227920.1) Lj4g3v2227930.1(Lj4g3v2227930.1) Lj5g3v0240200.1(Lj5g3v0240200.1) Lj5g3v0240200.2(Lj5g3v0240200.2) Lj5g3v0240200.3(Lj5g3v0240200.3) Lj5g3v0240200.4(Lj5g3v0240200.4) Lj5g3v2182120.1(Lj5g3v2182120.1) Lj5g3v2288460.1(Lj5g3v2288460.1) Lj6g3v1955280.1(Lj6g3v1955280.1) Lj6g3v1966330.1(Lj6g3v1966330.1)
DOSA: Os01t0533900-01(Os01g0533900) Os01t0534700-00(Os01g0534700) Os01t0695700-00(Os01g0695700) Os01t0723800-01(Os01g0723800) Os01t0976100-01(Os01g0976100) Os02t0189800-00(Os02g0189800) Os02t0190000-00(Os02g0190000) Os02t0190300-01(Os02g0190300) Os02t0323000-01(Os02g0323000) Os02t0693700-01(Os02g0693700) Os03t0181675-00(Os03g0181675) Os03t0181750-00(Os03g0181750) Os03t0280000-01(Os03g0280000) Os04t0459000-01(Os04g0459000) Os04t0481700-01(Os04g0481700) Os04t0642000-01(Os04g0642000) Os05t0137100-01(Os05g0137100) Os05t0137200-01(Os05g0137200) Os05t0548300-01(Os05g0548300) Os05t0548500-00(Os05g0548500) Os08t0153000-00(Os08g0153000) Os08t0564300-01(Os08g0564300)
ATS: 109731795(LOC109731795) 109733830(LOC109733830) 109744385(LOC109744385) 109746580(LOC109746580) 109750807(LOC109750807) 109750810(LOC109750810) 109750964(LOC109750964) 109754592(LOC109754592) 109754936(LOC109754936) 109755049(LOC109755049) 109755064(LOC109755064) 109755065(LOC109755065) 109755998(LOC109755998) 109759238(LOC109759238) 109767011(LOC109767011) 109767209(LOC109767209) 109768923(LOC109768923) 109774378(LOC109774378) 109774662(LOC109774662) 109776869(LOC109776869) 109781483(LOC109781483) 109782270(LOC109782270) 109782996(LOC109782996) 109787569(LOC109787569)
APRO: F751_1263
SCE: YKL209C(STE6)
ERC: Ecym_3612
KMX: KLMA_30034(STE6)
NCS: NCAS_0G03510(NCAS0G03510)
NDI: NDAI_0D01540(NDAI0D01540)
TPF: TPHA_0O00160(TPHA0O00160)
TBL: TBLA_0B10070(TBLA0B10070)
TDL: TDEL_0F00340(TDEL0F00340)
KAF: KAFR_0E00230(KAFR0E00230)
PIC: PICST_40758(HST6)
CAL: CAALFM_C306510CA(HST6)
CDU: CD36_86480(HST6)
SLB: AWJ20_2160(STE6) AWJ20_493(STE6) AWJ20_5338(STE6) AWJ20_81(MDL2)
NTE: NEUTE1DRAFT122557(NEUTE1DRAFT_122557) NEUTE1DRAFT85055(NEUTE1DRAFT_85055) NEUTE1DRAFT92339(NEUTE1DRAFT_92339)
ANG: ANI_1_1766184(An04g03690) ANI_1_1996074(An08g05360) ANI_1_2126184(An04g08340) ANI_1_244154(An17g01770)
SPO: SPBC25B2.02c(mam1) SPCC663.03(pmd1)
ABP: AGABI1DRAFT107447(AGABI1DRAFT_107447) AGABI1DRAFT109968(AGABI1DRAFT_109968) AGABI1DRAFT122189(AGABI1DRAFT_122189) AGABI1DRAFT74549(AGABI1DRAFT_74549)
ABV: AGABI2DRAFT180250(AGABI2DRAFT_180250) AGABI2DRAFT188750(AGABI2DRAFT_188750) AGABI2DRAFT207384(AGABI2DRAFT_207384)
DDI: DDB_G0291714(abcB3) DDB_G0293438(abcB2)
DFA: DFA_06954(abcB2) DFA_08677
EHI: EHI_016380(80.t00022) EHI_101230(10.t00041) EHI_114150(148.t00006) EHI_175450(315.t00008) EHI_186350(405.t00006)
PYO: PY17X_1241000(PY00245)
PCB: PCHAS_123820(PC300305.00.0)
CPV: cgd6_4700
SMIN: v1.2.000036.t1(symbB.v1.2.000036.t1) v1.2.002775.t1(symbB.v1.2.002775.t1) v1.2.005301.t1(symbB.v1.2.005301.t1) v1.2.012251.t1(symbB.v1.2.012251.t1) v1.2.022168.t1(symbB.v1.2.022168.t1) v1.2.022429.t1(symbB.v1.2.022429.t1) v1.2.022641.t1(symbB.v1.2.022641.t1) v1.2.027872.t1(symbB.v1.2.027872.t1) v1.2.029611.t1(symbB.v1.2.029611.t1) v1.2.030826.t1(symbB.v1.2.030826.t1) v1.2.030826.t2(symbB.v1.2.030826.t2)
LMA: LMJF_26_2670(ABCB2) LMJF_34_0990(MDR1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2876781
  Authors
Chen CJ, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB
  Title
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.
  Journal
Cell 47:381-9 (1986)
DOI:10.1016/0092-8674(86)90595-7
  Sequence
[hsa:5243]
Reference
  Authors
Klaassen CD, Aleksunes LM
  Title
Xenobiotic, bile acid, and cholesterol transporters: function and regulation.
  Journal
Pharmacol Rev 62:1-96 (2010)
DOI:10.1124/pr.109.002014

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