K05687                      KO                                     

protein DJ-1 [EC:]
ko05012  Parkinson disease
ko05022  Pathways of neurodegeneration - multiple diseases
H00057  Parkinson disease
H01600  Parkinsonian syndrome
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K05687  PARK7; protein DJ-1
   05022 Pathways of neurodegeneration - multiple diseases
    K05687  PARK7; protein DJ-1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K05687  PARK7; protein DJ-1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K05687  PARK7; protein DJ-1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides  protein deglycase
     K05687  PARK7; protein DJ-1
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C56: PfpI endopeptidase family
   K05687  PARK7; protein DJ-1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K05687  PARK7; protein DJ-1
Other DBs
GO: 0036524
HSA: 11315(PARK7)
PTR: 465864 746063(PARK7)
PPS: 100969783(PARK7)
GGO: 101135675(PARK7)
PON: 100447504(PARK7)
NLE: 100590226(PARK7)
MCC: 708377(PARK7)
MCF: 101865893(PARK7)
CSAB: 103225666(PARK7)
RRO: 104657558(PARK7) 115895970 115895993 115896206
RBB: 108517940(PARK7)
CJC: 100413204(PARK7) 108588492
SBQ: 101052951(PARK7)
MMU: 57320(Park7)
MCAL: 110293202(Park7)
MPAH: 110323526(Park7)
RNO: 117287(Park7)
MUN: 110560422(Park7)
CGE: 100759195(Park7)
NGI: 103725143(Park7)
HGL: 101723322(Park7)
CCAN: 109697924(Park7)
OCU: 100352938(PARK7)
TUP: 102470939(PARK7) 102474007
CFA: 479595(PARK7)
VVP: 112924680(PARK7)
AML: 100475637(PARK7)
UMR: 103666687(PARK7)
UAH: 113270555(PARK7)
ORO: 101380867(PARK7)
ELK: 111154652
FCA: 101092868(PARK7)
PTG: 102959550(PARK7)
PPAD: 109274044(PARK7)
AJU: 106982200(PARK7)
BTA: 511268(PARK7)
BOM: 102288078(PARK7)
BIU: 109570573(PARK7)
BBUB: 102397062(PARK7)
CHX: 102177646(PARK7)
OAS: 101119489(PARK7)
SSC: 780404(PARK7)
CFR: 102503983(PARK7)
CDK: 105106986(PARK7)
BACU: 103019344(PARK7)
LVE: 103082032(PARK7)
OOR: 101275264(PARK7)
DLE: 111187180(PARK7)
PCAD: 102986390(PARK7) 102991297
ECB: 100052123(PARK7)
EPZ: 103561708(PARK7)
EAI: 106844319(PARK7)
MYB: 102263235(PARK7)
MYD: 102774693(PARK7)
MNA: 107538443(PARK7)
HAI: 109381309(PARK7)
DRO: 112299067(PARK7)
PALE: 102884675(PARK7)
RAY: 107517703(PARK7)
MJV: 108391155(PARK7)
LAV: 100664838(PARK7)
TMU: 101357070
MDO: 100010357(PARK7)
SHR: 100923337(PARK7)
PCW: 110199783(PARK7)
OAA: 100073498(PARK7)
GGA: 395277(PARK7)
MGP: 100544576(PARK7)
CJO: 107323475(PARK7)
NMEL: 110408733(PARK7)
APLA: 101794503(PARK7)
ACYG: 106047231(PARK7)
TGU: 100190506(PARK7)
LSR: 110472504(PARK7)
SCAN: 103820830(PARK7)
GFR: 102045424(PARK7)
FAB: 101810201(PARK7)
PHI: 102112820(PARK7)
PMAJ: 107213629(PARK7)
CCAE: 111938587(PARK7) 111945711
CCW: 104693267(PARK7)
ETL: 114060124(PARK7)
FPG: 101920065(PARK7)
FCH: 102046650(PARK7)
CLV: 102092024(PARK7)
EGZ: 104132789(PARK7)
NNI: 104008922(PARK7)
ACUN: 113487774(PARK7)
PADL: 103924749(PARK7)
AAM: 106496706(PARK7)
ASN: 102383069(PARK7)
AMJ: 102576304(PARK7)
PSS: 102460414(PARK7)
CMY: 102930935(PARK7)
CPIC: 101952912(PARK7)
ACS: 100551640(park7)
PVT: 110082464(PARK7)
PBI: 103055741(PARK7)
PMUR: 107284672(PARK7)
PMUA: 114602370(PARK7)
GJA: 107108653(PARK7)
XLA: 399179(park7.L) 444724(park7.S)
XTR: 548568(park7)
NPR: 108783953(PARK7) 108796089
DRE: 449674(park7)
SRX: 107708261
SGH: 107580665 107592885(park7)
IPU: 108255284(park7)
PHYP: 113537791(park7)
AMEX: 103030353(park7)
EEE: 113572456(park7)
TRU: 101065925(park7)
LCO: 104919346(park7)
NCC: 104963216(park7)
MZE: 101464488(park7)
ONL: 100709464(park7)
OLA: 100049299(park7)
XMA: 102227669(park7)
XCO: 114134940(park7)
PRET: 103464454(park7)
CVG: 107087537(park7)
NFU: 107385278(park7)
KMR: 108231526(park7)
ALIM: 106513834(park7)
AOCE: 111580698(park7)
CSEM: 103385637(park7)
POV: 109635367(park7)
LCF: 108899924(park7)
SDU: 111223981(park7)
SLAL: 111657909(park7)
HCQ: 109529237(park7)
BPEC: 110168456(park7)
MALB: 109961751(park7)
SASA: 100136349(dj-1) 100286560(park7)
ELS: 105017254(park7)
SFM: 108918226(park7)
PKI: 111856937(park7)
LCM: 102361342(PARK7)
CMK: 103181420(park7)
RTP: 109913779(park7)
BFO: 118430146
CIN: 100178410
SPU: 579485
APLC: 110979135
SKO: 100374964
DSI: Dsimw501_GD21547(Dsim_GD21547) Dsimw501_GD25730(Dsim_GD25730)
DSR: 110186607
DPE: 6595173
DMN: 108157490
DWI: 6646117
DAZ: 108615159
DNV: 108653503
DHE: 111592182
DVI: 6624790
MDE: 101899019
LCQ: 111690252
AAG: 5564065
AALB: 109431398
AME: 551882
BIM: 100746681
BTER: 100652254
CCAL: 108627814
OBB: 114876347
SOC: 105194188
MPHA: 105838043
AEC: 105143166
ACEP: 105627554
PBAR: 105427177
VEM: 105563246
HST: 105189556
DQU: 106747877
CFO: 105254489
LHU: 105677024
PGC: 109862046
OBO: 105286946
PCF: 106793099
NVI: 100113484
CSOL: 105366644
TCA: 662087
DPA: 109544051
ATD: 109604166
BMOR: 100422789(BmDJ-1beta)
BMAN: 114246571
PMAC: 106708309
PRAP: 110998205
TNL: 113499066
API: 100165029
DNX: 107173112
AGS: 114125908
RMD: 113553863
BTAB: 109040733
CLEC: 106670124
ZNE: 110832294
FCD: 110852136
PVM: 113803523
TUT: 107369780
CSCU: 111625578
PTEP: 107443625
CEL: CELE_B0432.2(djr-1.1) CELE_C49G7.11(djr-1.2)
CBR: CBG07015(Cbr-djr-1.2) CBG07016(Cbr-djr-1.1)
BMY: Bm1_07685
TSP: Tsp_11803
PCAN: 112557206
CRG: 105330226
MYI: 110462923
OBI: 106867205
LAK: 106174742
SHX: MS3_06918
EGL: EGR_07383
NVE: 5507766
EPA: 110234343
ADF: 107351224
AMIL: 114968125
PDAM: 113669128
SPIS: 111321528
DGT: 114519950
HMG: 100211338
AQU: 100636722
PNO: SNOG_07399(SNOG_07398)
PTE: PTT_13806
MGL: MGL_3627
MRT: MRET_0381
SCL: sce6209
 » show all
Shendelman S, Jonason A, Martinat C, Leete T, Abeliovich A
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.
PLoS Biol 2:e362 (2004)
Clements CM, McNally RS, Conti BJ, Mak TW, Ting JP
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.
Proc Natl Acad Sci U S A 103:15091-6 (2006)
[hsa:11315] [mmu:57320]
Richarme G, Mihoub M, Dairou J, Bui LC, Leger T, Lamouri A
Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues.
J Biol Chem 290:1885-97 (2015)
Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H
DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras.
Biochem Biophys Res Commun 231:509-13 (1997)

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