KEGG   ORTHOLOGY: K05731
Entry
K05731                      KO                                     

Symbol
TIAM1
Name
T-lymphoma invasion and metastasis-inducing protein 1
Pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04530  Tight junction
map04810  Regulation of actin cytoskeleton
map05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
   04015 Rap1 signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
   04024 cAMP signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
Domain-containing proteins not elsewhere classified [BR:ko04990]
 Pleckstrin homology (PH) domain-containing proteins
  Dbl-Like RhoGEF family proteins
   K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
Genes
HSA: 7074(TIAM1)
PTR: 473949(TIAM1)
PPS: 100967869(TIAM1)
GGO: 101125464(TIAM1)
PON: 100431618(TIAM1)
NLE: 100605316(TIAM1)
MCC: 702288(TIAM1)
MCF: 101865530(TIAM1)
CSAB: 103217191(TIAM1)
CATY: 105575576(TIAM1)
PANU: 101011726(TIAM1)
RRO: 104664652(TIAM1)
RBB: 108536834(TIAM1)
TFN: 117095685(TIAM1)
PTEH: 111524998(TIAM1)
CJC: 100390844(TIAM1)
SBQ: 101042162(TIAM1)
MMUR: 105880123(TIAM1)
MMU: 21844(Tiam1)
MCAL: 110311394(Tiam1)
MPAH: 110330159(Tiam1)
RNO: 304109(Tiam1)
MCOC: 116086106(Tiam1)
CGE: 100756100(Tiam1)
PLEU: 114698453(Tiam1)
NGI: 103736475(Tiam1)
HGL: 101711984(Tiam1)
CCAN: 109700897(Tiam1)
OCU: 100338333(TIAM1)
TUP: 102500733(TIAM1)
CFA: 487731(TIAM1)
VVP: 112909492(TIAM1)
VLG: 121479551(TIAM1)
AML: 105242089(TIAM1)
UMR: 103673212(TIAM1)
UAH: 113266710(TIAM1)
ORO: 101365424(TIAM1)
ELK: 111155650
MPUF: 101693463(TIAM1)
EJU: 114217533(TIAM1)
MLX: 118018814(TIAM1)
FCA: 101094530(TIAM1)
PYU: 121036015(TIAM1)
PTG: 102955456(TIAM1)
PPAD: 109249680(TIAM1)
AJU: 106977842(TIAM1)
HHV: 120229789(TIAM1)
BTA: 536517(TIAM1)
BOM: 102283572(TIAM1)
BIU: 109562052(TIAM1)
BBUB: 102413018(TIAM1)
CHX: 102170463(TIAM1)
OAS: 101103280(TIAM1)
ODA: 120854116(TIAM1)
CCAD: 122428727(TIAM1)
SSC: 100524587(TIAM1)
CBAI: 105070251(TIAM1)
CDK: 105086777(TIAM1)
BACU: 103016623(TIAM1)
LVE: 103073449(TIAM1)
OOR: 101280455(TIAM1)
DLE: 111172246(TIAM1)
PCAD: 102980632(TIAM1)
ECB: 100052764(TIAM1)
EPZ: 103550555(TIAM1)
EAI: 106847274(TIAM1)
MMYO: 118676321(TIAM1)
MNA: 107533494(TIAM1)
HAI: 109393508(TIAM1)
DRO: 112304037(TIAM1)
SHON: 118983246(TIAM1)
AJM: 119061032(TIAM1)
MMF: 118617355(TIAM1)
PALE: 102883973(TIAM1)
PGIG: 120598497(TIAM1)
RAY: 107519567(TIAM1)
TOD: 119257245(TIAM1)
LAV: 100675466(TIAM1)
TMU: 101352570
MDO: 100015064(TIAM1)
SHR: 100920711(TIAM1)
PCW: 110214866(TIAM1)
OAA: 100088712(TIAM1)
GGA: 418491(TIAM1)
PCOC: 116242026(TIAM1)
MGP: 100540208(TIAM1)
CJO: 107322765(TIAM1)
NMEL: 110402256(TIAM1)
APLA: 101803496(TIAM1)
ACYG: 106043428(TIAM1)
TGU: 100219509(TIAM1)
LSR: 110481491(TIAM1)
SCAN: 103818444
PMOA: 120496511(TIAM1)
GFR: 102040520(TIAM1)
FAB: 101806275(TIAM1)
PHI: 102109961(TIAM1)
PMAJ: 107213264(TIAM1)
CCAE: 111942402(TIAM1)
ETL: 114069404(TIAM1)
FPG: 101914291(TIAM1)
FCH: 102057263(TIAM1)
CLV: 102098791(TIAM1)
EGZ: 104128218(TIAM1)
NNI: 104020113(TIAM1)
ACUN: 113477782(TIAM1)
PADL: 103920307(TIAM1)
AAM: 106494979(TIAM1)
NPD: 112942676(TIAM1)
ASN: 102385589(TIAM1)
AMJ: 106737085(TIAM1)
CPOO: 109305758(TIAM1)
GGN: 109302781(TIAM1)
PSS: 102446695(TIAM1)
CMY: 102934808(TIAM1)
CPIC: 101936219(TIAM1)
TST: 117889410(TIAM1)
CABI: 116835433(TIAM1)
ACS: 100555790(tiam1)
PVT: 110080375(TIAM1)
PBI: 103061969(TIAM1)
PMUR: 107290521(TIAM1)
TSR: 106546455(TIAM1)
PGUT: 117673548(TIAM1)
PMUA: 114596030(TIAM1)
ZVI: 118085763(TIAM1)
GJA: 107109049(TIAM1)
XLA: 108707884(tiam1.L) 735176(tiam1.S)
XTR: 734013(tiam1)
NPR: 108787811(TIAM1)
DRE: 567621(tiam1a)
CCAR: 109097672
IPU: 108277166(tiam1)
PHYP: 113543504
AMEX: 103029595(tiam1)
LCO: 104923304(tiam1) 104923828
NCC: 104963587(tiam1)
CGOB: 115018152(tiam1)
ELY: 117260009(tiam1b)
PLEP: 121943546(tiam1b)
SLUC: 116048370(tiam1b)
ECRA: 117940235(tiam1b)
PFLV: 114552649(tiam1)
GAT: 120821089
MSAM: 119882272 119895291(tiam1a)
CUD: 121517469(tiam1b)
MZE: 101474606(tiam1)
ONL: 100694077(tiam1)
OAU: 116331402
OLA: 101174366
OML: 112149543
XMA: 102234854
XCO: 114161546(tiam1)
XHE: 116737601(tiam1)
PRET: 103474994
CVG: 107095569
CTUL: 119789478
NFU: 107380221
KMR: 108236015
ALIM: 106520557(tiam1)
CSEM: 103378218
POV: 109630293(tiam1)
LCF: 108876057
SDU: 111224422
SLAL: 111657801
XGL: 120792234(tiam1b) 120802632
BPEC: 110175098
MALB: 109967522
SNH: 120028540(tiam1b)
ELS: 105012849
SFM: 108936219
PKI: 111840433
LOC: 102696827(tiam1)
SCLV: 120345627
DME: Dmel_CG34418(sif)
DER: 6544675
DSE: 6610901
DAN: 6506624
DPE: 6600320
DMN: 108151736
DWI: 6639209
DGR: 6558325
DAZ: 108613077
DNV: 108651046
DHE: 111597752
DVI: 6624022
CCAT: 101457257
LCQ: 111690717
ACOZ: 120947288
AARA: 120898095
AAG: 5564449
AALB: 109404936
CPII: 120418013
AME: 725970
BBIF: 117212086
CGIG: 122404140
CCIN: 107271878
TCA: 662876
AGB: 108904957
LDC: 111507020
OTU: 111417827
MSEX: 115444648
BANY: 112047855
PPOT: 106105605
PXU: 106125029
ZCE: 119831579
DCI: 103524833
HHAL: 106685264
NLU: 111051144
CSEC: 111863021
HAME: 121873156
EAF: 111710002
DSV: 119461251
RSAN: 119396301
RMP: 119173865
VDE: 111246320
VJA: 111267705
BGT: 106068964
GAE: 121372630
PMAX: 117328000
 » show all
Reference
  Authors
Minard ME, Kim LS, Price JE, Gallick GE
  Title
The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression.
  Journal
Breast Cancer Res Treat 84:21-32 (2004)
DOI:10.1023/B:BREA.0000018421.31632.e6
Reference
  Authors
Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ
  Title
The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
  Journal
J Mol Biol 398:730-46 (2010)
DOI:10.1016/j.jmb.2010.03.047
Reference
PMID:7999144
  Authors
Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A, Collard JG
  Title
Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.
  Journal
Cell 77:537-49 (1994)
DOI:10.1016/0092-8674(94)90216-X
  Sequence
[mmu:21844]

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