KEGG   ORTHOLOGY: K05824
Entry
K05824                      KO                                     
Symbol
LYS12
Name
homoisocitrate dehydrogenase [EC:1.1.1.87]
Pathway
map00300  Lysine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
Reaction
R01934  (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
R01936  (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
R04862  (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K05824  LYS12; homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.87  homoisocitrate dehydrogenase
     K05824  LYS12; homoisocitrate dehydrogenase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K05824
Other DBs
COG: COG0473
GO: 0047046
Genes
SCE: YIL094C(LYS12)
SEUB: DI49_2692
SPAO: SPAR_I00750
AGO: AGOS_ADL214C
ERC: Ecym_3326
KLA: KLLA0_E08339g
KMX: KLMA_80130(LYS12)
LTH: KLTH0G10384g
VPO: Kpol_1003p39
ZRO: ZYRO0A01914g
NCS: NCAS_0B06250(NCAS0B06250)
NDI: NDAI_0B03550(NDAI0B03550)
TPF: TPHA_0C03410(TPHA0C03410)
TBL: TBLA_0B05940(TBLA0B05940)
TDL: TDEL_0G02180(TDEL0G02180)
KAF: KAFR_0J01360(KAFR0J01360)
KNG: KNAG_0A05420(KNAG0A05420)
PIC: PICST_50442(LYS12)
LEL: PVL30_000182(LYS12)
CAL: CAALFM_CR01400WA(LYS12)
SLB: AWJ20_5129(LYS12)
BNN: FOA43_004130(LYS12)
BBRX: BRETT_002820(LYS12)
NCR: NCU02954(lys-7)
NTE: NEUTE1DRAFT119171(NEUTE1DRAFT_119171)
PBEL: QC761_106340(LYS12)
PPSD: QC762_106340(LYS12)
PPSP: QC763_106340(LYS12)
PPSA: QC764_106340(LYS12)
MGR: MGG_01566
PGRI: PgNI_03934
SSCK: SPSK_09424
FPOA: FPOAC1_001498(LYS12)
FMU: J7337_000493(LYS12)
MAW: MAC_01875
MAJ: MAA_00573
CMT: CCM_06018
PTKZ: JDV02_009506(LYS12)
MBE: MBM_09266
ALUC: AKAW2_60443S(LYS12)
ACHE: ACHE_11370S(LYS12)
APUU: APUU_41359S(LYS12)
ABE: ARB_06194
TVE: TRV_01663
PTE: PTT_19273
SOM: SOMG_00247(lys12)
CNE: CND03850
CNB: CNBD2460
CDEU: CNBG_0832
TASA: A1Q1_01965
CCAC: CcaHIS019_0111110(LYS12)
ABP: AGABI1DRAFT113649(AGABI1DRAFT_113649)
ABV: AGABI2DRAFT191701(AGABI2DRAFT_191701)
SCM: SCHCO_02623734(SCHCODRAFT_02623734)
MGL: MGL_3003
MRT: MRET_3610
PCQ: PcP3B5_09520(hicd)
PKC: PKB_4900(leub3)
PSET: THL1_4856
AMAH: DLM_3455
RCA: Rcas_3471
CAU: Caur_0331
CAG: Cagg_3600
HAU: Haur_3304
ATM: ANT_08240
LEK: hrd7_27880(hicd)
DRA: DR_1674
DGE: Dgeo_1458
DFC: DFI_05685
TRA: Trad_2841
TTH: TT_C1012
TTJ: TTHA1378(TTHA1378)
TSC: TSC_c20650(icd2)
TAQ: TO73_0559
MRB: Mrub_2738
 » show all
Reference
PMID:4395693
  Authors
Rowley B, Tucci AF
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
  Sequence
[sce:YIL094C]

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