KEGG   ORTHOLOGY: K05854
Entry
K05854                      KO                                     
Symbol
LYN
Name
tyrosine-protein kinase Lyn [EC:2.7.10.2]
Pathway
map04062  Chemokine signaling pathway
map04064  NF-kappa B signaling pathway
map04611  Platelet activation
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04730  Long-term depression
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05169  Epstein-Barr virus infection
map05203  Viral carcinogenesis
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05854  LYN; tyrosine-protein kinase Lyn
   04662 B cell receptor signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
   04664 Fc epsilon RI signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
   04666 Fc gamma R-mediated phagocytosis
    K05854  LYN; tyrosine-protein kinase Lyn
   04062 Chemokine signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
  09156 Nervous system
   04730 Long-term depression
    K05854  LYN; tyrosine-protein kinase Lyn
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K05854  LYN; tyrosine-protein kinase Lyn
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05854  LYN; tyrosine-protein kinase Lyn
   05169 Epstein-Barr virus infection
    K05854  LYN; tyrosine-protein kinase Lyn
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05854  LYN; tyrosine-protein kinase Lyn
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05854  LYN; tyrosine-protein kinase Lyn
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05854  LYN; tyrosine-protein kinase Lyn
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05854  LYN; tyrosine-protein kinase Lyn
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05854  LYN; tyrosine-protein kinase Lyn
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K05854  LYN; tyrosine-protein kinase Lyn
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K05854  LYN; tyrosine-protein kinase Lyn
Other DBs
GO: 0004715 0004716
Genes
HSA: 4067(LYN)
PTR: 472771(LYN)
PPS: 100996017(LYN)
GGO: 101145340(LYN)
PON: 100447326(LYN)
NLE: 100593961(LYN)
MCC: 698553(LYN)
MCF: 102118154(LYN)
CSAB: 103236819(LYN)
CATY: 105592167(LYN)
PANU: 101025874(LYN)
TGE: 112630297(LYN)
RRO: 104661780(LYN)
RBB: 108521691(LYN)
TFN: 117079186(LYN)
PTEH: 111524867(LYN)
CJC: 100390096(LYN)
SBQ: 101036887(LYN)
CSYR: 103259066(LYN)
MMUR: 105876398(LYN)
LCAT: 123644610(LYN)
OGA: 100951050(LYN)
MMU: 17096(Lyn)
MPAH: 110338916(Lyn)
RNO: 81515(Lyn)
MCOC: 116088122(Lyn)
MUN: 110541812
CGE: 100754828(Lyn)
MAUA: 101823786(Lyn)
PLEU: 114710233(Lyn)
MORG: 121451525(Lyn)
AAMP: 119826164(Lyn)
NGI: 103734185(Lyn)
HGL: 101696753(Lyn)
CPOC: 100714653(Lyn)
CCAN: 109696666(Lyn)
DORD: 105980494(Lyn)
DSP: 122121929(Lyn)
NCAR: 124985502
OCU: 100340056(LYN)
OPI: 101531240(LYN)
TUP: 102493585(LYN)
CFA: 477886(LYN)
CLUD: 112678466(LYN)
VVP: 112929497(LYN)
VLG: 121498834(LYN)
AML: 100479606(LYN)
UMR: 103677438(LYN)
UAH: 113268089(LYN)
UAR: 123786722(LYN)
ELK: 111155370
LLV: 125096997
MPUF: 101680128(LYN)
ORO: 101383639(LYN)
EJU: 114220924(LYN)
ZCA: 113913209(LYN)
MLX: 118014834(LYN)
FCA: 101096633(LYN)
PYU: 121038252(LYN)
PBG: 122495424(LYN)
PTG: 102957150(LYN)
PPAD: 109250302(LYN)
AJU: 106982528(LYN)
HHV: 120222462(LYN)
BTA: 534996(LYN)
BOM: 102276698(LYN)
BIU: 109568555(LYN)
BBUB: 102394691(LYN)
CHX: 102184639(LYN)
OAS: 100302103(LYN)
ODA: 120878587(LYN)
CCAD: 122451060(LYN)
SSC: 100152890(LYN)
CFR: 102515625(LYN)
CBAI: 105081485(LYN)
CDK: 105097055(LYN)
VPC: 102545554(LYN)
BACU: 103001606(LYN)
LVE: 103074440(LYN)
OOR: 101280666(LYN)
DLE: 111165865(LYN)
PCAD: 102984630(LYN)
PSIU: 116742719(LYN)
ECB: 100053129(LYN)
EPZ: 103552502(LYN)
EAI: 106841654(LYN)
MYB: 102262917(LYN)
MYD: 102755397(LYN)
MMYO: 118670849(LYN)
MLF: 102429660(LYN)
MNA: 107533160(LYN)
PKL: 118718271(LYN)
HAI: 109394449(LYN)
DRO: 112315403(LYN)
SHON: 118974987(LYN)
AJM: 119051466(LYN)
PDIC: 114514669(LYN)
PHAS: 123833051(LYN)
MMF: 118631367(LYN)
RFQ: 117033683(LYN)
PALE: 102880204(LYN)
PGIG: 120607236(LYN)
PVP: 105291403(LYN)
RAY: 107500716(LYN)
TOD: 119241288(LYN)
SARA: 101544577(LYN)
LAV: 100673903(LYN)
TMU: 101353037
DNM: 101429842(LYN)
MDO: 100616821(LYN)
GAS: 123238979(LYN)
SHR: 100929196(LYN)
PCW: 110221373(LYN)
OAA: 100079507(LYN)
GGA: 421127(LYN)
PCOC: 116242212(LYN)
MGP: 100550537(LYN)
CJO: 107310194(LYN)
NMEL: 110393410(LYN)
APLA: 101803881(LYN)
ACYG: 106039045(LYN)
AFUL: 116486610(LYN)
TGU: 100230728(LYN)
LSR: 110484761(LYN)
SCAN: 103812340(LYN)
PMOA: 120499280(LYN)
OTC: 121340169(LYN)
PRUF: 121356860(LYN)
GFR: 102032206(LYN)
FAB: 101812689(LYN)
PHI: 102103954(LYN)
PMAJ: 107200243(LYN)
CCAE: 111924719(LYN)
CCW: 104690380(LYN)
CBRC: 103625501(LYN)
ETL: 114060207(LYN)
ZAB: 102070927(LYN)
FPG: 101914020(LYN)
FCH: 102048730(LYN)
CLV: 102084226(LYN)
EGZ: 104127723(LYN)
NNI: 104019751(LYN)
PLET: 104614756
ACUN: 113477137(LYN)
TALA: 104355933(LYN)
PADL: 103923663(LYN)
ACHC: 115340485(LYN)
HALD: 104316638
CCRI: 104154544(LYN)
CSTI: 104550544(LYN)
CMAC: 104473783(LYN)
FGA: 104070860(LYN)
LDI: 104354879(LYN)
MNB: 103770585(LYN)
OHA: 104332296(LYN)
AAM: 106494468(LYN)
AROW: 112973089(LYN)
NPD: 112956596(LYN)
DNE: 112981685(LYN)
ASN: 102383816(LYN)
AMJ: 102566940(LYN)
CPOO: 109318811(LYN)
GGN: 109304675(LYN)
PSS: 102462919(LYN)
CMY: 102931818(LYN)
CPIC: 101950325(LYN)
TST: 117873498(LYN)
CABI: 116834646(LYN)
MRV: 120397873(LYN)
ACS: 100554372(lyn)
PVT: 110089695(LYN)
SUND: 121928264(LYN)
PBI: 103061071
PMUR: 107284322(LYN)
TSR: 106540519(LYN)
PGUT: 117672810(LYN)
VKO: 123020359(LYN)
PMUA: 114600595(LYN)
ZVI: 118089967(LYN)
GJA: 107113876(LYN)
STOW: 125439224(LYN)
XLA: 108695301(lyn.S) 373649(lyn.L)
XTR: 549989(lyn)
NPR: 108789967(LYN)
RTEM: 120941007(LYN)
BBUF: 121001061(LYN) 121007450
BGAR: 122938101(LYN)
DRE: 447804(lyn)
SANH: 107674289
PPRM: 120482173(lyn)
MAMB: 125251681(lyn)
IPU: 108267808 108280443(lyn)
SMEO: 124387324 124402923(lyn)
TFD: 113640329(lyn) 113657552
TRU: 101072875
LCO: 104929874
NCC: 104963253
CGOB: 115022351
ELY: 117271400(lyn)
EFO: 125902210(lyn)
PLEP: 121951069(lyn)
SLUC: 116042005(lyn)
ECRA: 117954545(lyn)
PFLV: 114564997
GAT: 120815604(lyn)
PPUG: 119209838(lyn)
MSAM: 119902531(lyn)
CUD: 121519992(lyn)
ALAT: 119011557(lyn)
MZE: 101477890
ONL: 100711419
OAU: 116313154(lyn)
OLA: 101167902
OML: 112147318(lyn)
XMA: 102235662
XCO: 114145990
XHE: 116721932
PRET: 103478918
PFOR: 103151544
PLAI: 106961740
PMEI: 106925320
GAF: 122841534(lyn)
CVG: 107091676
CTUL: 119793363(lyn)
GMU: 124869865(lyn)
NFU: 107384206
KMR: 108238651(lyn)
ALIM: 106514931
NWH: 119414478(lyn)
AOCE: 111580728
MCEP: 125011267(lyn)
POV: 109637092
SSEN: 122766440(lyn)
HHIP: 117778259(lyn)
HSP: 118118086(lyn)
LCF: 108883973
SDU: 111239118
SLAL: 111653435
XGL: 120799019(lyn)
HCQ: 109515497
BPEC: 110170453
MALB: 109962671
BSPL: 114844557(lyn)
SASA: 100196779(lyn) 106569254
CCLU: 121535234(lyn) 121580934
ELS: 105022707(lyn)
SFM: 108929639(lyn) 108937715
AANG: 118225568 118234134(lyn)
LOC: 102692416(lyn)
PSPA: 121313441(lyn) 121314381
ARUT: 117394326 117400239(lyn)
LCM: 102360998(LYN)
CMK: 103177046(lyn)
RTP: 109918542
BGT: 106064330
 » show all
Reference
PMID:3561390
  Authors
Yamanashi Y, Fukushige S, Semba K, Sukegawa J, Miyajima N, Matsubara K, Yamamoto T, Toyoshima K
  Title
The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.
  Journal
Mol Cell Biol 7:237-43 (1987)
DOI:10.1128/MCB.7.1.237
  Sequence
[hsa:4067]
Reference
  Authors
Gaul BS, Harrison ML, Geahlen RL, Burton RA, Post CB
  Title
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor.
  Journal
J Biol Chem 275:16174-82 (2000)
DOI:10.1074/jbc.M909044199

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