KEGG   ORTHOLOGY: K05856Help
Entry
K05856                      KO                                     

Name
LCK
Definition
lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
Pathway
ko04064  NF-kappa B signaling pathway
ko04380  Osteoclast differentiation
ko04650  Natural killer cell mediated cytotoxicity
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko05166  HTLV-I infection
ko05340  Primary immunodeficiency
Disease
H00093  Combined immunodeficiencies (CIDs)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04660 T cell receptor signaling pathway
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04658 Th1 and Th2 cell differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04659 Th17 cell differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09158 Development
   04380 Osteoclast differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09160 Human Diseases
  09162 Immune diseases
   05340 Primary immunodeficiency
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09167 Infectious diseases
   05166 HTLV-I infection
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
BRITE hierarchy
Other DBs
GO: 0004715
Genes
HSA: 3932(LCK)
PTR: 456715(LCK)
PPS: 100979670(LCK)
GGO: 101151112(LCK)
PON: 100436326(LCK)
NLE: 100585201(LCK)
MCC: 717704(LCK)
MCF: 102140916(LCK)
CSAB: 103225952(LCK)
RRO: 104654761(LCK)
RBB: 108518588(LCK)
CJC: 100410584(LCK)
SBQ: 101041579(LCK)
MMU: 16818(Lck)
RNO: 313050(Lck)
CGE: 100759316(Lck)
NGI: 103745927(Lck)
HGL: 101714396(Lck)
CCAN: 109692973(Lck)
OCU: 100349102(LCK)
TUP: 102468526(LCK)
CFA: 478151(LCK)
AML: 100477981(LCK)
UMR: 103666444(LCK)
ORO: 101383028(LCK)
FCA: 101098805(LCK)
PTG: 102967826(LCK)
AJU: 106982436(LCK)
BTA: 508890(LCK)
BOM: 102264903(LCK)
BIU: 109572368(LCK)
PHD: 102338729(LCK)
CHX: 102171746(LCK)
OAS: 100216439(LCK)
SSC: 100233188(LCK)
CFR: 102507741(LCK)
CDK: 105085793(LCK)
BACU: 102998192(LCK)
LVE: 103069516(LCK)
OOR: 101271418(LCK)
ECB: 100146139(LCK)
EPZ: 103552084(LCK)
EAI: 106829050(LCK)
MYB: 102242493(LCK)
MYD: 102764895(LCK)
HAI: 109390746(LCK) 109390751
RSS: 109446533(LCK)
PALE: 102891182(LCK)
LAV: 100666557(LCK)
TMU: 101358037
MDO: 100025680(LCK)
SHR: 100922118(LCK)
OAA: 100078190(LCK)
GGA: 396460(LCK)
MGP: 100547084(LCK)
CJO: 107323874(LCK)
APLA: 101797169(LCK)
ACYG: 106037891(LCK)
GFR: 102044922(LCK)
FAB: 101820768(LCK)
PHI: 102102392(LCK)
PMAJ: 107214075(LCK)
CCW: 104694772(LCK)
FPG: 101919897(LCK)
FCH: 102055232(LCK)
CLV: 102085229(LCK)
EGZ: 104134930(LCK)
AAM: 106493274(LCK)
ASN: 102374716(LCK)
AMJ: 102562977(LCK)
PSS: 102450693(LCK)
CMY: 102938279
CPIC: 101942842(LCK)
ACS: 100556474(lck)
PVT: 110082790(LCK)
PBI: 103065569(LCK)
GJA: 107107743(LCK)
XLA: 100036955(lck.L) 108708930(lck.S)
XTR: 100497656(lck)
NPR: 108795316(LCK)
DRE: 414333(lck)
SGH: 107582994(lck) 107583665
IPU: 108270195(LCK)
AMEX: 103032401(lck)
TRU: 101064341(blk) 101075948(lck)
LCO: 104919312(lck) 109139043
NCC: 104946729(lck)
MZE: 101474633(lck)
OLA: 100170631(lck) 101163706(blk)
XMA: 102224821(lck) 102225667(blk)
PRET: 103458632(lck)
NFU: 107392534(lck)
CSEM: 103382672(lck)
LCF: 108898014
HCQ: 109520801(lck)
BPEC: 110155252(lck) 110155529
SASA: 100194878(lck) 106578585(lck)
ELS: 105015810(lck)
SFM: 108931279(lck)
LCM: 102361989(LCK)
CMK: 103184977 103185670(lck)
SPAR: SPRG_12234
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3493153
  Authors
Koga Y, Caccia N, Toyonaga B, Spolski R, Yanagi Y, Yoshikai Y, Mak TW
  Title
A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases.
  Journal
Eur J Immunol 16:1643-6 (1986)
DOI:10.1002/eji.1830161229
  Sequence
[hsa:3932]
Reference
PMID:8293463
  Authors
Weiss A, Littman DR
  Title
Signal transduction by lymphocyte antigen receptors.
  Journal
Cell 76:263-74 (1994)
DOI:10.1016/0092-8674(94)90334-4
Reference
  Authors
Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM
  Title
Centrosome docking at the immunological synapse is controlled by Lck signaling.
  Journal
J Cell Biol 192:663-74 (2011)
DOI:10.1083/jcb.201008140

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