KEGG   ORTHOLOGY: K05917Help
Entry
K05917                      KO                                     

Name
CYP51
Definition
sterol 14alpha-demethylase [EC:1.14.14.154]
Pathway
ko00100  Steroid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01130  Biosynthesis of antibiotics
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K05917  CYP51; sterol 14alpha-demethylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K05917  CYP51; sterol 14alpha-demethylase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
     K05917  CYP51; sterol 14alpha-demethylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.154  sterol 14alpha-demethylase
     K05917  CYP51; sterol 14alpha-demethylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP51 family
   K05917  CYP51; sterol 14alpha-demethylase
BRITE hierarchy
Other DBs
RN: R05640 R05731
COG: COG2124
GO: 0008398
Genes
HSA: 1595(CYP51A1)
PTR: 463527(CYP51A1)
PPS: 100985833
GGO: 101127636
PON: 100171776(CYP51A1)
NLE: 100582853
MCC: 703490
MCF: 102146764(CYP51)
CSAB: 103226567(CYP51A1)
RRO: 104654375
RBB: 108544026
CJC: 100403815(CYP51A1) 103792683
SBQ: 101036999
MMU: 13121(Cyp51)
RNO: 25427(Cyp51)
CGE: 100762189
NGI: 103725250
HGL: 101724157
CCAN: 109684681
OCU: 100355623
TUP: 102493691
CFA: 475225(CYP51A1)
AML: 100477744
UMR: 103658707
ORO: 101381709
FCA: 101083499
PTG: 102954144
AJU: 106969977
BTA: 505060(CYP51A1)
BOM: 102282237
BIU: 109558194
PHD: 102329296
CHX: 102177400
OAS: 101113583
SSC: 403334(CYP51)
CFR: 102515047
CDK: 105087385
BACU: 103016503
LVE: 103083607
OOR: 101275315
ECB: 100050921
EPZ: 103549183
EAI: 106832249
MYB: 102261507
MYD: 102765294
HAI: 109378118
RSS: 109437435
LAV: 100670599
TMU: 101349253
MDO: 100028071
SHR: 100916047
OAA: 100087589
GGA: 420548(CYP51A1)
MGP: 100538580
CJO: 107309008
APLA: 101791330
ACYG: 106039661
TGU: 100220976
GFR: 102035109
FAB: 101818100
PHI: 102113235
PMAJ: 107199957
CCAE: 111924212
CCW: 104689183
FPG: 101920327
FCH: 102048344
CLV: 102092834
EGZ: 104128884
AAM: 106483616
ASN: 102386214
AMJ: 102567199(CYP51A1)
PSS: 102445540
CMY: 102945327
CPIC: 101934931
ACS: 100557431
PVT: 110074721
PBI: 103065003
GJA: 107108228
XLA: 100037098(cyp51a1.L) 447600(cyp51a1.S)
XTR: 548948(cyp51a1)
NPR: 108787913
DRE: 414331(cyp51)
SRX: 107712294
SANH: 107694387
SGH: 107568024
CCAR: 109111832
IPU: 108274811
AMEX: 103025877
TRU: 101062187
LCO: 104927570
NCC: 104962954
MZE: 101487063
OLA: 101169834
XMA: 102232424
PRET: 103472487
NFU: 107394621
KMR: 108238686
CSEM: 103394548
LCF: 108879466
SDU: 111222971
HCQ: 109512012
BPEC: 110161131
MALB: 109958704
ELS: 105012654
SFM: 108933335
LCM: 102347020
CMK: 103181227
SPU: 414330(cyp51)
APLC: 110975221
SKO: 100367489
AQU: 100636481
ATH: AT1G11680(CYP51G1)
THJ: 104807262
CPAP: 110809570
CIT: 102623201
TCC: 18608823
EGR: 104433736
GMX: 100810799
VRA: 106774110
VAR: 108347419
CAM: 101504867
LJA: Lj3g3v0512940.1(Lj3g3v0512940.1)
ADU: 107473174
AIP: 107624804
FVE: 101305627(cyp51)
PPER: 18790148
PMUM: 103322154
PAVI: 110768705
CSV: 101205062
CMO: 103494635
MCHA: 111015169
RCU: 8285703
JCU: 105647292
SLY: 100736446(CYP51)
SPEN: 107003288
SOT: 102601151
CANN: 107838742
NTA: 107764727(CYP51) 107779000(NtCYP51-2)
NSY: 104231276
NTO: 104096055
INI: 109176104
HAN: 110920587
LSV: 111912345
DCR: 108228020
DOSA: Os02t0113200-00(Os02g0113200) Os02t0323600-01(Os02g0323600) Os05t0211100-01(Os05g0211100) Os05t0415800-01(Os05g0415800) Os05t0415900-00(Os05g0415900) Os05t0416400-00(Os05g0416400) Os07t0464700-00(Os07g0464700) Os07t0567100-00(Os07g0567100) Os11t0525200-01(Os11g0525200)
ATS: 109733821(LOC109733821) 109738711(LOC109738711) 109739759(LOC109739759) 109743781(LOC109743781) 109745900(LOC109745900) 109746137(LOC109746137) 109748891(LOC109748891) 109751861(LOC109751861) 109756453(LOC109756453) 109756454(LOC109756454) 109756455(LOC109756455) 109759247(LOC109759247) 109759248(LOC109759248) 109759250(LOC109759250) 109759976(LOC109759976) 109770960(LOC109770960) 109772803(LOC109772803) 109777128(LOC109777128) 109782869(LOC109782869) 109787201(LOC109787201)
DCT: 110107398
PEQ: 110032189
AOF: 109827282
ATR: 18434309
PPP: 112285583
CRE: CHLREDRAFT_196411(CYP51G1)
APRO: F751_0875
SCE: YHR007C(ERG11)
ERC: Ecym_6045
KMX: KLMA_20551(CYP707A7)
NCS: NCAS_0G00960(NCAS0G00960)
NDI: NDAI_0F01100(NDAI0F01100)
TPF: TPHA_0D02710(TPHA0D02710)
TBL: TBLA_0E02810(TBLA0E02810)
TDL: TDEL_0A04550(TDEL0A04550)
KAF: KAFR_0C05720(KAFR0C05720)
PIC: PICST_63421(CP51)
CAL: CAALFM_C500660CA(ERG11)
CDU: CD36_50660(ERG11)
CAUR: QG37_06413
SLB: AWJ20_2398(ERG11)
NCR: NCU02624
NTE: NEUTE1DRAFT119039(NEUTE1DRAFT_119039)
SSCK: SPSK_09044
MAW: MAC_07103
MBE: MBM_02571
ANG: ANI_1_314094(An11g02230) ANI_1_518114(An13g00090)
ZTR: MYCGRDRAFT_110231(CYP-74)
SPO: SPAC13A11.02c(erg11)
CNE: CNA00300
CNB: CNBA0300
HIR: HETIRDRAFT_163926(cpm90) HETIRDRAFT_54612(cpm117)
ABP: AGABI1DRAFT114898(AGABI1DRAFT_114898) AGABI1DRAFT44512(AGABI1DRAFT_44512)
ABV: AGABI2DRAFT191124(AGABI2DRAFT_191124) AGABI2DRAFT73753(AGABI2DRAFT_73753)
MGL: MGL_2415
DDI: DDB_G0279403(CYP51)
DFA: DFA_04411(CYP51)
SMIN: v1.2.021020.t1(symbB.v1.2.021020.t1)
NGD: NGA_0373310(CYP51) NGA_0373320(CYP51)
MCA: MCA2711(cyp51)
MAH: MEALZ_0770(cyp)
MMAI: sS8_2580
GPB: HDN1F_11100(cyp51)
NAR: Saro_3659
MTU: Rv0764c(cyp51)
MTC: MT0788
MRA: MRA_0773(cyp51)
MTUR: CFBS_0803(cyp51)
MTO: MTCTRI2_0783(cyp51)
MTN: ERDMAN_0846(cyp51)
MTUC: J113_05390
MTUE: J114_04080
MTUH: I917_05415
MTUL: TBHG_00756
MTUT: HKBT1_0803(cyp51)
MTUU: HKBT2_0804(cyp51)
MTQ: HKBS1_0803(cyp51)
MBO: BQ2027_MB0787C(cyp51)
MBB: BCG_0816c(cyp51)
MBT: JTY_0786(cyp51)
MBM: BCGMEX_0787c(cyp51)
MBX: BCGT_0565
MAF: MAF_07760(cyp51)
MMIC: RN08_0853
MCE: MCAN_07681(cyp51)
MCQ: BN44_10834(cyp)
MCV: BN43_20199(cyp)
MCX: BN42_20522(cyp)
MCZ: BN45_20033(cyp)
MPA: MAP_0598c
MAO: MAP4_3267
MAVI: RC58_16215
MAVU: RE97_16245
MAV: MAV_0708
MIA: OCU_06050
MID: MIP_01081
MYO: OEM_06100
MIR: OCQ_06160
MUL: MUL_0473(cyp51B1)
MMC: Mmcs_4582
MKM: Mkms_4670
MJL: Mjls_4965
MMI: MMAR_4932(cyp51B1)
MMAE: MMARE11_47420(cyp51B1)
MMM: W7S_02950
MHAD: B586_05055
MSG: MSMEI_5704(cyp51)
MVA: Mvan_5161
MGI: Mflv_1596
MVQ: MYVA_5043
MAB: MAB_1214c
MABB: MASS_1212
MCHE: BB28_06025
MSTE: MSTE_01180
MJD: JDM601_3604(cyp51B1)
MTER: 4434518_03583(cyp51B1)
NFA: NFA_25890(cyp51)
NCY: NOCYR_4381(cyp)
NNO: NONO_c19250(cyp51)
RER: RER_33770(cyp51)
REY: O5Y_15560
ROP: ROP_47700(cyp51)
REQ: REQ_13820
GBR: Gbro_3843
GPO: GPOL_c37060(cyp)
GOR: KTR9_3783
PSIM: KR76_04945
SEN: SACE_3928(cyp51)
SESP: BN6_77630(cyp51)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8619637
  Authors
Stromstedt M, Rozman D, Waterman MR
  Title
The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols.
  Journal
Arch Biochem Biophys 329:73-81 (1996)
DOI:10.1006/abbi.1996.0193
  Sequence
[hsa:1595]
Reference
PMID:1872829
  Authors
Aoyama Y, Yoshida Y
  Title
Different substrate specificities of lanosterol 14a-demethylase (P-45014DM) of Saccharomyces cerevisiae and rat liver for 24-methylene-24,25-dihydrolanosterol and 24,25-dihydrolanosterol.
  Journal
Biochem Biophys Res Commun 178:1064-71 (1991)
DOI:10.1016/0006-291X(91)91000-3
Reference
  Authors
Kushiro M, Nakano T, Sato K, Yamagishi K, Asami T, Nakano A, Takatsuto S, Fujioka S, Ebizuka Y, Yoshida S
  Title
Obtusifoliol 14alpha-demethylase (CYP51) antisense Arabidopsis shows slow growth and long life.
  Journal
Biochem Biophys Res Commun 285:98-104 (2001)
DOI:10.1006/bbrc.2001.5122
Reference
PMID:9076987
  Authors
Bak S, Kahn RA, Olsen CE, Halkier BA
  Title
Cloning and expression in Escherichia coli of the obtusifoliol 14 alpha-demethylase of Sorghum bicolor (L.) Moench, a cytochrome P450 orthologous to the sterol 14 alpha-demethylases (CYP51) from fungi and mammals.
  Journal
Plant J 11:191-201 (1997)
DOI:10.1046/j.1365-313X.1997.11020191.x
  Sequence
[sbi:8074834]

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