KEGG   ORTHOLOGY: K06054Help
Entry
K06054                      KO                                     

Name
HES1
Definition
hairy and enhancer of split 1
Pathway
ko03460  Fanconi anemia pathway
ko04330  Notch signaling pathway
ko04950  Maturity onset diabetes of the young
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Replication and repair
   03460 Fanconi anemia pathway
    K06054  HES1; hairy and enhancer of split 1
 Environmental Information Processing
  Signal transduction
   04330 Notch signaling pathway
    K06054  HES1; hairy and enhancer of split 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06054  HES1; hairy and enhancer of split 1
   05224 Breast cancer
    K06054  HES1; hairy and enhancer of split 1
  Endocrine and metabolic diseases
   04950 Maturity onset diabetes of the young
    K06054  HES1; hairy and enhancer of split 1
  Infectious diseases
   05165 Human papillomavirus infection
    K06054  HES1; hairy and enhancer of split 1
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Basic helix-loop-helix (bHLH)
   Hairy, Hairy/E(SPL)
    K06054  HES1; hairy and enhancer of split 1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  DSBR (double strand breaks repair)
   FA (Fanconi anemia) pathway
    FA core complex binding factors
     K06054  HES1; hairy and enhancer of split 1
BRITE hierarchy
Genes
HSA: 3280(HES1)
PTR: 460942(HES1)
PPS: 100975593(HES1)
GGO: 101137927(HES1)
PON: 100455979(HES1)
NLE: 100603131(HES1)
MCC: 707140(HES1)
MCF: 102146862(HES1)
CSAB: 103241935(HES1)
RRO: 104669884(HES1)
RBB: 108530502(HES1)
CJC: 100398058(HES1)
SBQ: 101047984(HES1)
MMU: 15205(Hes1)
RNO: 29577(Hes1)
CGE: 100752756(Hes1)
NGI: 103738854(Hes1)
HGL: 101697897(Hes1)
CCAN: 109697826(Hes1)
OCU: 100358704(HES1)
TUP: 102495758(HES1)
AML: 100481439(HES1)
UMR: 103676171(HES1)
ORO: 101385029(HES1)
FCA: 101091223(HES1)
PTG: 102955935(HES1)
AJU: 106976345(HES1)
BTA: 539547(HES1)
BOM: 102264508(HES1)
BIU: 109556511(HES1)
PHD: 102323229(HES1)
CHX: 102177474(HES1)
OAS: 101106560(HES1)
SSC: 100499567(HES1)
CFR: 102503828
CDK: 105101259(HES1)
BACU: 103018658(HES1)
LVE: 103079775(HES1)
OOR: 101288687(HES1)
ECB: 100069015(HES1)
EPZ: 103560632(HES1)
EAI: 106832571(HES1)
MYB: 102247384(HES1)
MYD: 102755556(HES1)
HAI: 109387269(HES1)
RSS: 109442990(HES1)
PALE: 102890128(HES1)
LAV: 100660397(HES1)
TMU: 101350794
MDO: 100011897(HES1) 100027474(HES4)
SHR: 111720114
OAA: 100081083(HES1)
GGA: 395128(HES4) 769039(HES1)
MGP: 100543952(HES4) 104912623(HES1)
CJO: 107318289(HES1) 107323568(HES4)
APLA: 101792654(HES4)
TGU: 100225879(HES1)
GFR: 102033320(HES1)
FAB: 101816382(HES1) 101817621(HES4)
PHI: 102100435(HES1) 102101553(HES4)
PMAJ: 107208546(HES1) 107213594(HES4)
CCW: 104693506(HES1)
FPG: 101912686(HES1) 101916136(HES4)
FCH: 102046674(HES1) 102047850
CLV: 102095829 102097253(HES4)
EGZ: 104127092(HES1) 104133390
ASN: 102386735(HES4)
AMJ: 106737359(HES1) 109280377 109284733(HES4)
PSS: 102458752(HES1) 102463824(HES4)
CMY: 102940045(HES1) 102942708
CPIC: 101931539(HES1) 101940738(HES4)
ACS: 100558110(hes1) 100558625(hes4) 103280462
PVT: 110073268(HES4) 110087091(HES1) 110088260
PBI: 103049451(HES1) 103056990
GJA: 107108767(HES1) 107110838(HES4) 107120729
XLA: 379073(hes1.S) 397813(hes1.L) 398258(hes4.S) 398579(hes4.L)
XTR: 394465(hes4) 496617(hes1)
DRE: 140613(her9) 30288(her6)
IPU: 108272284(hes1) 108275484(hes4)
AMEX: 103024511 103029084(hes1) 103034898(hes4)
LCO: 104920985 104923504(hes1) 104927063(hes4)
MZE: 101470131(hes4) 101479362(hes1) 101482682
OLA: 100049440 100049441(hes4) 100049484(hes1)
XMA: 102220497(hes1) 102221827 102224196(hes4)
PRET: 103463479(hes1) 103467205(hes4) 103479094
NFU: 107384489 107390761(hes4) 107392731(hes1)
CSEM: 103385044(hes4) 103393710(hes1) 103396119
HCQ: 109511838(hes4) 109519150(hes1) 109520474
BPEC: 110153389 110160167(hes1) 110164673(hes4)
SASA: 106567371(HES1) 106568808(HES1) 106572133(HES1) 106574089 106599183 106613513(HES1)
CMK: 103173662(Her6.1) 103187419
SKO: 100303558(hes1)
TCA: 664077
DPA: 109543608
NVL: 108567683
API: 100159053
DNX: 107162838
TSP: Tsp_06034
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8020957
  Authors
Feder JN, Li L, Jan LY, Jan YN
  Title
Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy.
  Journal
Genomics 20:56-61 (1994)
DOI:10.1006/geno.1994.1126
  Sequence
[hsa:3280]
Reference
  Authors
Tremblay CS, Huang FF, Habi O, Huard CC, Godin C, Levesque G, Carreau M
  Title
HES1 is a novel interactor of the Fanconi anemia core complex.
  Journal
Blood 112:2062-70 (2008)
DOI:10.1182/blood-2008-04-152710

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