KEGG   ORTHOLOGY: K06067Help
Entry
K06067                      KO                                     

Name
HDAC1_2
Definition
histone deacetylase 1/2 [EC:3.5.1.98]
Pathway
ko04110  Cell cycle
ko04213  Longevity regulating pathway - multiple species
ko04330  Notch signaling pathway
ko04919  Thyroid hormone signaling pathway
ko05016  Huntington's disease
ko05034  Alcoholism
ko05165  Human papillomavirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05203  Viral carcinogenesis
ko05220  Chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04330 Notch signaling pathway
    K06067  HDAC1_2; histone deacetylase 1/2
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K06067  HDAC1_2; histone deacetylase 1/2
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K06067  HDAC1_2; histone deacetylase 1/2
  Aging
   04213 Longevity regulating pathway - multiple species
    K06067  HDAC1_2; histone deacetylase 1/2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06067  HDAC1_2; histone deacetylase 1/2
   05202 Transcriptional misregulation in cancers
    K06067  HDAC1_2; histone deacetylase 1/2
   05203 Viral carcinogenesis
    K06067  HDAC1_2; histone deacetylase 1/2
   05220 Chronic myeloid leukemia
    K06067  HDAC1_2; histone deacetylase 1/2
  Neurodegenerative diseases
   05016 Huntington's disease
    K06067  HDAC1_2; histone deacetylase 1/2
  Substance dependence
   05034 Alcoholism
    K06067  HDAC1_2; histone deacetylase 1/2
  Infectious diseases
   05169 Epstein-Barr virus infection
    K06067  HDAC1_2; histone deacetylase 1/2
   05165 Human papillomavirus infection
    K06067  HDAC1_2; histone deacetylase 1/2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.98  histone deacetylase
     K06067  HDAC1_2; histone deacetylase 1/2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HDACs (histone deacetylases)
    Class I HDACs
     K06067  HDAC1_2; histone deacetylase 1/2
   HDAC complexes
    Sin3A-HDAC complex
     K06067  HDAC1_2; histone deacetylase 1/2
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    K06067  HDAC1_2; histone deacetylase 1/2
  Chromatin remodeling factors
   NuRD complex
    K06067  HDAC1_2; histone deacetylase 1/2
BRITE hierarchy
Other DBs
GO: 0004407
Genes
HSA: 3065(HDAC1) 3066(HDAC2)
PTR: 462950(HDAC2) 748850
PPS: 100978715(HDAC2) 100980497(HDAC1)
GGO: 101151959(HDAC1) 101153607 109023024(HDAC2)
PON: 100172663(HDAC1) 100294534(HDAC2)
NLE: 100591033(HDAC1) 100591684(HDAC2)
MCC: 694662(HDAC2) 708441(HDAC1)
MCF: 102125039(HDAC1) 102125090 102140882(HDAC2)
CSAB: 103225192(HDAC1) 103239354 103240535(HDAC2)
RRO: 104654770(HDAC1) 104657112(HDAC2) 104677352
RBB: 108512070(HDAC2) 108524017(HDAC1) 108527145
CJC: 100399690(HDAC1) 100402327(HDAC2)
SBQ: 101039964(HDAC1) 101041477(HDAC2) 104650467
MMU: 15182(Hdac2) 433759(Hdac1)
RNO: 297893(Hdac1) 84576(Hdac1l) 84577(Hdac2)
CGE: 100752721(Hdac1) 100761556 100764557(Hdac2)
NGI: 103733778(Hdac2) 103745919(Hdac1)
HGL: 101712029(Hdac2) 101715102(Hdac1)
CCAN: 109682730(Hdac2) 109692991(Hdac1)
OCU: 100355156(HDAC1)
TUP: 102468100(HDAC1) 102503291(HDAC2)
CFA: 475035(HDAC2) 487309(HDAC1)
AML: 100477725(HDAC1) 100478424(HDAC2)
UMR: 103666443(HDAC1) 103676974(HDAC2)
ORO: 101365273(HDAC2) 101384069(HDAC1)
FCA: 101088165(HDAC2) 101099228(HDAC1)
PTG: 102952507(HDAC2) 102968123(HDAC1)
AJU: 106968918(HDAC2) 106982428(HDAC1)
BTA: 404126(HDAC1) 407223(HDAC2)
BOM: 102265183(HDAC1) 102279602(HDAC2)
BIU: 109563503(HDAC2) 109572356(HDAC1)
PHD: 102333560(HDAC2) 102339088(HDAC1)
CHX: 102177165(HDAC2) 102187544(HDAC1)
OAS: 100820752(HDAC1) 101107708(HDAC2)
SSC: 100156170(HDAC2) 100622482(HDAC1)
CFR: 102504100(HDAC2) 102508320(HDAC1)
CDK: 105085792(HDAC1) 105099222(HDAC2)
BACU: 102998477(HDAC1) 103000794 103015711(HDAC2)
LVE: 103070161(HDAC1) 103070274(HDAC2)
OOR: 101271170(HDAC1) 101277640(HDAC2)
ECB: 100070281(HDAC1) 100072578(HDAC2)
EPZ: 103552097(HDAC1) 103561341(HDAC2)
EAI: 106829049(HDAC1) 106847042(HDAC2)
MYB: 102242800(HDAC1) 102243153(HDAC2)
MYD: 102764610(HDAC1) 102773716(HDAC2)
HAI: 109384760(HDAC2) 109391669(HDAC1)
RSS: 109440913 109446534(HDAC1) 109453287(HDAC2)
PALE: 102878536(HDAC2) 102890938(HDAC1)
LAV: 100666845(HDAC1) 100673540(HDAC2)
MDO: 100022756(HDAC2) 100032301(HDAC1)
SHR: 100913322 100922375(HDAC1) 100927352(HDAC2)
OAA: 100081366 100093591(HDAC2)
GGA: 373961(HDAC1) 395635(HDAC2)
MGP: 100541443(HDAC2) 100546927(HDAC1)
CJO: 107311872(HDAC2) 107323875(HDAC1)
APLA: 101793506(HDAC2) 101797531(HDAC1)
ACYG: 106032573(HDAC2) 106038059(HDAC1)
TGU: 100218599(HDAC2) 100220830(HDAC1)
GFR: 102038486(HDAC2) 102045090(HDAC1)
FAB: 101809249(HDAC2) 101819193(HDAC1)
PHI: 102102768(HDAC1) 102104750(HDAC2)
PMAJ: 107202331(HDAC2) 107214077(HDAC1)
CCW: 104691262(HDAC2) 104694685(HDAC1)
FPG: 101920073(HDAC1) 101923969(HDAC2)
FCH: 102055405(HDAC1) 102057203(HDAC2)
CLV: 102085406(HDAC1) 102096090(HDAC2)
EGZ: 104131983(HDAC2) 104134931(HDAC1)
AAM: 106489693(HDAC2) 106493331(HDAC1)
ASN: 102375203(HDAC1) 102378546(HDAC2)
AMJ: 102561334(HDAC2) 106737180(HDAC1)
PSS: 102447815(HDAC1) 102452071(HDAC2)
CMY: 102936348(HDAC2) 102938055(HDAC1)
CPIC: 101943126(HDAC1) 101948365(HDAC2)
ACS: 100554517(hdac1) 100566341(hdac2)
PVT: 110082788(HDAC1) 110088770(HDAC2)
GJA: 107107742(HDAC1) 107121973
XLA: 108716821 379083(hdac1.S) 397868(hdac1.L) 399252(hdac2.S)
XTR: 447995(hdac2) 594953(hdac1)
NPR: 108789383(HDAC2) 108795331(HDAC1)
DRE: 192302(hdac1)
SANH: 107691506(hdac1)
IPU: 108255500(hdac2) 108272688
AMEX: 103028934(hdac2) 103046670
TRU: 101072042 101076176(hdac1) 101079482(hdac2)
NCC: 104946727(hdac1) 104950753
NFU: 107392535(hdac1) 107397144
CSEM: 103380629(hdac2) 103381923 103382849(hdac1)
LCF: 108899297(hdac2) 108900358(hdac1)
ELS: 105015808(hdac1) 105017885(hdac2) 105030237
SFM: 108929090(hdac2) 108938855
LCM: 102364559(HDAC1)
CMK: 103182606(hdac2) 103185671(hdac1)
CIN: 100186761
SPU: 373339(HDAC1)
APLC: 110985520
SKO: 100375702
DME: Dmel_CG7471(HDAC1)
DPO: Dpse_GA20378(Dpse_Rpd3)
DAN: Dana_GF25085(Dana_Rpd3)
DER: Dere_GG15241(Dere_Rpd3)
DSI: Dsimw501_GD13856(Dsim_Rpd3)
DWI: Dwil_GK16595(Dwil_Rpd3)
DYA: Dyak_GE21462(Dyak_Rpd3)
DMO: Dmoj_GI12742(Dmoj_Rpd3)
DVI: Dvir_GJ15512(Dvir_Rpd3)
MDE: 101901606
AAG: 5565108
AME: 411503(HDAC1)
BIM: 100748118
BTER: 100642763
HST: 105192422
PGC: 109852353
NVI: 100116051(Rpd3)
TCA: 655044
DPA: 109541726
NVL: 108563590
BMOR: 101744526
PRAP: 111003029
PXY: 105394770
DNX: 107164123
ZNE: 110831612
FCD: 110842105
DPX: DAPPUDRAFT_442930(RPD3)
CEL: CELE_C08B11.2(hda-2) CELE_C53A5.3(hda-1) CELE_R06C1.1(hda-3)
CBR: CBG04588(Cbr-hda-1) CBG09063 CBG13352(Cbr-hda-2) CBG15416 CBG18689(Cbr-hda-3)
CRG: 105337120
MYI: 110457536
OBI: 106878991
LAK: 106169904
SHX: MS3_08618
ADF: 107334457
AQU: 100635349
ATH: AT3G44490(hda17) AT3G44660(hda10) AT3G44680(HDA9) AT4G38130(HD1) AT5G35600(HDA7) AT5G63110(HDA6)
LJA: Lj0g3v0137449.1(Lj0g3v0137449.1) Lj0g3v0201999.1(Lj0g3v0201999.1) Lj0g3v0201999.2(Lj0g3v0201999.2) Lj0g3v0201999.3(Lj0g3v0201999.3) Lj0g3v0332349.1(Lj0g3v0332349.1) Lj1g3v0318630.1(Lj1g3v0318630.1) Lj3g3v2996000.1(Lj3g3v2996000.1) Lj3g3v2996000.2(Lj3g3v2996000.2) Lj4g3v1440790.1(Lj4g3v1440790.1) Lj4g3v1440870.1(Lj4g3v1440870.1)
DOSA: Os02t0214900-01(Os02g0214900) Os02t0215200-01(Os02g0215200) Os04t0409600-01(Os04g0409600) Os06t0583400-01(Os06g0583400) Os08t0344100-01(Os08g0344100) Os11t0200000-01(Os11g0200000) Os11t0201400-00(Os11g0201400)
ATS: 109744463(LOC109744463) 109748937(LOC109748937) 109751992(LOC109751992) 109760015(LOC109760015) 109773768(LOC109773768) 109785724(LOC109785724)
ZMA: 100193206 100276617(pco095363) 109942815 541681(hda108) 541931(hda101) 541953(hda102)
OLU: OSTLU_119518(hda) OSTLU_119545(hda2)
SCE: YNL330C(RPD3)
ERC: Ecym_2010
KMX: KLMA_20628(RPD3)
NCS: NCAS_0C04320(NCAS0C04320)
NDI: NDAI_0G03740(NDAI0G03740)
TPF: TPHA_0A00300(TPHA0A00300)
TBL: TBLA_0I00560(TBLA0I00560)
TDL: TDEL_0A00270(TDEL0A00270)
KAF: KAFR_0A08630(KAFR0A08630)
CAUR: QG37_06894
SLB: AWJ20_5009(RPD3)
NCR: NCU00824(hda-3)
NTE: NEUTE1DRAFT132812(NEUTE1DRAFT_132812)
MGR: MGG_05857
NHE: NECHADRAFT_31703(HDA2104)
MAW: MAC_05475
MAJ: MAA_05232
CMT: CCM_00128
BFU: BCIN_05g02590(Bcrpd3)
MBE: MBM_03926
ANI: AN4493.2
ANG: ANI_1_980064(An07g07850)
ABE: ARB_00299
TVE: TRV_06317
PTE: PTT_14524
ZTR: MYCGRDRAFT_51809(HDA2402)
SPO: SPBC36.05c(clr6)
LBC: LACBIDRAFT_186850(HDA16204) LACBIDRAFT_245877(HDA16202)
ABP: AGABI1DRAFT110107(AGABI1DRAFT_110107) AGABI1DRAFT72379(AGABI1DRAFT_72379)
ABV: AGABI2DRAFT198321(AGABI2DRAFT_198321) AGABI2DRAFT212147(AGABI2DRAFT_212147)
EHI: EHI_119320(232.t00006)
PYO: PY17X_0829800(PY03877)
PCB: PCHAS_082680(PC000948.01.0)
TAN: TA12690
TPV: TP02_0039
BBO: BBOV_III011020(17.m07949)
TGO: TGME49_227290(HDAC3)
NGD: NGA_0147500(HDAC1_2)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hayakawa T, Nakayama J
  Title
Physiological roles of class I HDAC complex and histone demethylase.
  Journal
J Biomed Biotechnol 2011:129383 (2011)
DOI:10.1155/2011/129383
Reference
PMID:8602529
  Authors
Taunton J, Hassig CA, Schreiber SL
  Title
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.
  Journal
Science 272:408-11 (1996)
DOI:10.1126/science.272.5260.408
  Sequence
[hsa:3065]
Reference
  Authors
Senese S, Zaragoza K, Minardi S, Muradore I, Ronzoni S, Passafaro A, Bernard L, Draetta GF, Alcalay M, Seiser C, Chiocca S
  Title
Role for histone deacetylase 1 in human tumor cell proliferation.
  Journal
Mol Cell Biol 27:4784-95 (2007)
DOI:10.1128/MCB.00494-07
  Sequence
[hsa:3065]

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