KEGG   ORTHOLOGY: K06255Help
Entry
K06255                      KO                                     

Name
HSPG2
Definition
heparan sulfate proteoglycan 2 (perlecan)
Pathway
ko04512  ECM-receptor interaction
ko05161  Hepatitis B
ko05205  Proteoglycans in cancer
Disease
H00493  Heparan sulfate proteoglycan gene defects
H01777  Schwartz-Jampel syndrome
H02155  Dyssegmental dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
 09160 Human Diseases
  09161 Cancers
   05205 Proteoglycans in cancer
    K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
  09167 Infectious diseases
   05161 Hepatitis B
    K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
   00535 Proteoglycans
    K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
Proteoglycans [BR:ko00535]
 Extracellular matrix (ECM) proteoglycans
  Basement membrane proteoglycans
   K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
BRITE hierarchy
Genes
HSA: 3339(HSPG2)
PTR: 100613114(HSPG2)
PPS: 100969025(HSPG2)
GGO: 101138254(HSPG2)
PON: 100446648(HSPG2)
NLE: 100603335(HSPG2)
MCC: 707213(HSPG2)
MCF: 102145976(HSPG2)
CSAB: 103225428(HSPG2)
RRO: 104663240(HSPG2)
RBB: 108538399(HSPG2)
CJC: 100413695(HSPG2)
SBQ: 101035920(HSPG2)
MMU: 15530(Hspg2)
RNO: 313641(Hspg2)
CGE: 100689041(Hspg2)
NGI: 103746433(Hspg2)
HGL: 101700294(Hspg2)
CCAN: 109694908(Hspg2)
OCU: 100340334(HSPG2)
TUP: 102493755(HSPG2)
CFA: 403440(HSPG2)
AML: 100467831(HSPG2)
UMR: 103666798(HSPG2)
ORO: 101366326(HSPG2)
FCA: 101094520(HSPG2)
PTG: 102954270(HSPG2)
AJU: 106977608(HSPG2)
BTA: 444872(HSPG2)
BOM: 102271087(HSPG2)
PHD: 102317431(HSPG2) 102323898
CHX: 102188640(HSPG2)
OAS: 101122677(HSPG2)
SSC: 100517288(HSPG2)
CFR: 102522322(HSPG2)
CDK: 105088891(HSPG2)
BACU: 103016583(HSPG2)
LVE: 103071665(HSPG2)
OOR: 101272353(HSPG2)
ECB: 100071701(HSPG2)
EPZ: 103558488(HSPG2)
EAI: 106840047(HSPG2)
MYB: 102241192(HSPG2) 102255357
MYD: 102756550(HSPG2)
HAI: 109396746(HSPG2)
RSS: 109435009(HSPG2)
PALE: 102887886(HSPG2)
LAV: 100668646(HSPG2)
TMU: 101349957
MDO: 100617792(HSPG2)
SHR: 100926296(HSPG2) 105750015
OAA: 100088985(HSPG2) 100093007
GGA: 429806(HSPG2)
MGP: 100549236(HSPG2)
CJO: 107323300(HSPG2)
APLA: 101796910(HSPG2)
ACYG: 106048619(HSPG2)
GFR: 102033967(HSPG2)
FAB: 101809010(HSPG2)
PHI: 102108967(HSPG2)
PMAJ: 107213501
CCW: 104698588(HSPG2)
FPG: 101918976(HSPG2)
FCH: 102055079(HSPG2)
CLV: 106145640(HSPG2)
EGZ: 104133199(HSPG2)
ASN: 102377486(HSPG2)
AMJ: 102559592(HSPG2) 106738847
CMY: 102942490(HSPG2)
CPIC: 101931520(HSPG2) 103306769
PVT: 110073100(HSPG2)
PBI: 103053870(HSPG2)
GJA: 107111588(HSPG2)
XLA: 108696836(hspg2.L)
XTR: 100494785(hspg2)
NPR: 108802213(HSPG2)
DRE: 565429(hspg2)
AMEX: 103021689(hspg2)
TRU: 101064605 101065556(hspg2)
LCO: 104928635(hspg2) 104939209
NCC: 104956491
MZE: 101473055(hspg2) 106675852
OLA: 101159991(hspg2)
XMA: 102217130(hspg2)
PRET: 103467813(hspg2)
NFU: 107390415(hspg2)
CSEM: 103385274(hspg2)
LCF: 108888875(hspg2)
HCQ: 109520187(hspg2)
BPEC: 110159404(hspg2)
ELS: 105028690(hspg2)
SFM: 108939266(hspg2)
LCM: 102366028(HSPG2)
CMK: 103181437(hspg2)
APLC: 110979181
DPA: 109537564
FCD: 110852299
CRG: 105328642
MYI: 110462776
OBI: 106879161
HMG: 101240275
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1569102
  Authors
Murdoch AD, Dodge GR, Cohen I, Tuan RS, Iozzo RV
  Title
Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
  Journal
J Biol Chem 267:8544-57 (1992)
  Sequence
[hsa:3339]
Reference
  Authors
Whitelock JM, Melrose J, Iozzo RV
  Title
Diverse cell signaling events modulated by perlecan.
  Journal
Biochemistry 47:11174-83 (2008)
DOI:10.1021/bi8013938

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