KEGG   ORTHOLOGY: K06269Help
Entry
K06269                      KO                                     

Name
PPP1C
Definition
serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
Pathway
ko03015  mRNA surveillance pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04113  Meiosis - yeast
ko04114  Oocyte meiosis
ko04218  Cellular senescence
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04390  Hippo signaling pathway
ko04510  Focal adhesion
ko04611  Platelet activation
ko04720  Long-term potentiation
ko04728  Dopaminergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04921  Oxytocin signaling pathway
ko04931  Insulin resistance
ko05031  Amphetamine addiction
ko05034  Alcoholism
ko05168  Herpes simplex infection
ko05205  Proteoglycans in cancer
Disease
H00523  Noonan syndrome and related disorders
H02191  Noonan-like syndrome with loose anagen hair
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04024 cAMP signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04022 cGMP-PKG signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09140 Cellular Processes
  09143 Cell growth and death
   04113 Meiosis - yeast
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04114 Oocyte meiosis
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04218 Cellular senescence
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09152 Endocrine system
   04910 Insulin signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04921 Oxytocin signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04270 Vascular smooth muscle contraction
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09156 Nervous system
   04728 Dopaminergic synapse
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04720 Long-term potentiation
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09160 Human Diseases
  09161 Cancers: Overview
   05205 Proteoglycans in cancer
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09165 Substance dependence
   05031 Amphetamine addiction
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   05034 Alcoholism
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09167 Endocrine and metabolic diseases
   04931 Insulin resistance
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09172 Infectious diseases: Viral
   05168 Herpes simplex infection
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09182 Protein families: genetic information processing
   03021 Transcription machinery
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   03019 Messenger RNA biogenesis
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   03041 Spliceosome
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    Catalytic subunits
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Transcription machinery [BR:ko03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic Type
  mRNA processing factors
   3' end processing
    Cleavage and polyadenylation specificity factor (CPSF) complex
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Spliceosome [BR:ko03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   Other SAPs
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
BRITE hierarchy
Other DBs
COG: COG0639
GO: 0004722
Genes
HSA: 5499(PPP1CA) 5500(PPP1CB) 5501(PPP1CC)
PTR: 459118(PPP1CB) 462795(PPP1CC) 743656 745709(PPP1CA)
PPS: 100974889(PPP1CC) 100978326(PPP1CB) 100992486(PPP1CA)
GGO: 101129953(PPP1CB) 101135243(PPP1CA) 101143438(PPP1CC)
PON: 100173410(PPP1CB) 100458223(PPP1CC) 100459799(PPP1CA)
NLE: 100587142(PPP1CB) 100603005(PPP1CA) 100605408(PPP1CC)
MCC: 703302(PPP1CB) 709935(PPP1CC) 721735(PPP1CA)
MCF: 101925057(PPP1CC) 102133300(PPP1CB) 102138402(PPP1CA)
CSAB: 103218909(PPP1CA) 103220572(PPP1CB) 103239526(PPP1CC)
RRO: 104664823(PPP1CA) 104668466(PPP1CB) 104675136(PPP1CC)
RBB: 108512265(PPP1CC) 108518604(PPP1CA) 108532746(PPP1CB)
SBQ: 101030626 101048398(PPP1CB) 101048497(PPP1CA) 101050671(PPP1CC)
MMU: 19045(Ppp1ca) 19046(Ppp1cb) 19047(Ppp1cc) 434233(Ppp1ccb)
RNO: 24668(Ppp1ca) 24669(Ppp1cc) 25594(Ppp1cb)
CGE: 100760810(Ppp1ca) 100761524(Ppp1cb) 100774547(Ppp1cc)
NGI: 103725581(Ppp1ca) 103730228(Ppp1cb) 103739088(Ppp1cc)
HGL: 101698044(Ppp1cb) 101705408(Ppp1ca) 101714468(Ppp1cc)
CCAN: 109679334(Ppp1cb) 109685544 109685547 109688628(Ppp1ca)
OCU: 100009298(PPP1CA) 100009587(PPP1CB) 100353054(PPP1CC)
TUP: 102469176 102476316(PPP1CC) 102477186(PPP1CA) 102496931(PPP1CB)
CFA: 403557(PPP1CC) 403558(PPP1CB) 403609(PPP1CA)
AML: 100464499(PPP1CA) 100471456(PPP1CB) 100476029(PPP1CC)
UMR: 103661277(PPP1CC) 103671909(PPP1CB) 103679611(PPP1CA)
ORO: 101372346(PPP1CB) 101382867(PPP1CA) 101386053(PPP1CC)
FCA: 101092932(PPP1CB) 101100922(PPP1CC) 109492306(PPP1CA)
PTG: 102948702(PPP1CC) 102970154(PPP1CB) 107180886(PPP1CA)
AJU: 106967586(PPP1CC) 106967920(PPP1CB) 106971182(PPP1CA)
BTA: 282318(PPP1CC) 516175(PPP1CA) 538829(PPP1CB)
BOM: 102266876(PPP1CB) 102270793(PPP1CA) 102275429(PPP1CC)
BIU: 109554414(PPP1CA) 109566263(PPP1CB) 109571193(PPP1CC)
PHD: 102315478(PPP1CC) 102323423(PPP1CB) 102332733 102340215(PPP1CA)
CHX: 102170985(PPP1CB) 102181064(PPP1CC) 102181571(PPP1CA)
OAS: 101106284(PPP1CC) 101117953 101119264(PPP1CA) 101123197(PPP1CB)
SSC: 397378(PPP1CB) 733611(PPP1CA) 733612(PPP1CC)
CFR: 102505354(PPP1CA) 102520782(PPP1CB) 102522874(PPP1CC)
CDK: 105098564(PPP1CB) 105102484(PPP1CC) 105104430(PPP1CA)
BACU: 103000500(PPP1CB) 103008250 103008309(PPP1CA) 103017316(PPP1CC)
LVE: 103072994(PPP1CC) 103074387(PPP1CA) 103080471(PPP1CB) 103086084
OOR: 101280558(PPP1CB) 101285623(PPP1CA) 101286983(PPP1CC)
ECB: 100058160(PPP1CC) 100059233(PPP1CA) 100071067(PPP1CB)
EPZ: 103541647(PPP1CC) 103549472(PPP1CB) 103560150(PPP1CA)
EAI: 106833503(PPP1CA) 106837075(PPP1CB) 106842216(PPP1CC)
MYB: 102239740(PPP1CC) 102244214(PPP1CA) 102248545(PPP1CB) 102253559
MYD: 102753893(PPP1CC) 102760260(PPP1CB) 102764391(PPP1CA) 102775047
HAI: 109384139(PPP1CA) 109385685(PPP1CB) 109386108(PPP1CC)
PALE: 102881448(PPP1CB) 102887827(PPP1CC) 102892254(PPP1CA)
LAV: 100660199(PPP1CB) 100671604(PPP1CC) 100673814(PPP1CA)
MDO: 100019898(PPP1CC) 100031298(PPP1CB)
SHR: 100915116(PPP1CA) 100920526(PPP1CC) 100930570(PPP1CB)
OAA: 100074395(PPP1CC) 100078635(PPP1CB)
GGA: 100858156(PPP1CA) 396019(PPP1CB) 416872(PPP1CC)
MGP: 100544698(PPP1CB) 100546973(PPP1CC) 100550782(PPP1CA)
CJO: 107311180(PPP1CB) 107314245(PPP1CA) 107321188(PPP1CC)
APLA: 101792735(PPP1CC) 101798783(PPP1CB) 101800204
ACYG: 106029776(PPP1CB) 106031410(PPP1CC)
TGU: 100190013(PPP1CA) 100190751(PPP1CC)
GFR: 102032151(PPP1CB) 102039437(PPP1CA) 102042078(PPP1CC)
FAB: 101810420(PPP1CA) 101813100(PPP1CB) 107603979(PPP1CC)
PHI: 102099963(PPP1CA) 102101654(PPP1CC) 102114757(PPP1CB)
PMAJ: 107201313(PPP1CB) 107205266(PPP1CA) 107211824(PPP1CC)
CCAE: 111927633(PPP1CB) 111930402 111936713(PPP1CC)
CCW: 104684134 104685699(PPP1CB) 104688680(PPP1CC)
FPG: 101913968(PPP1CA) 101916649(PPP1CB) 101924787(PPP1CC)
FCH: 102053170(PPP1CA) 102054093(PPP1CC) 102058478(PPP1CB)
CLV: 102083732(PPP1CB) 102086082(PPP1CC) 102096027(PPP1CA)
EGZ: 104121755 104122715(PPP1CC) 104128553 104135633(PPP1CB)
AAM: 106485498(PPP1CB) 106495691(PPP1CC) 106495808
ASN: 102373171(PPP1CA) 102375415(PPP1CC) 102383008(PPP1CB)
AMJ: 102560817(PPP1CB) 102564750(PPP1CC) 102565419(PPP1CA)
PSS: 102449920 102450584(PPP1CC) 102463695(PPP1CA) 102463789(PPP1CB)
CPIC: 101931881(PPP1CC) 101942402 101946001(PPP1CB) 101948239(PPP1CA)
ACS: 100552053(ppp1cb) 100558590(ppp1ca) 100565990(ppp1cc)
PVT: 110078692(PPP1CB) 110083839(PPP1CC) 110085633(PPP1CA)
PBI: 103056218(PPP1CC) 103057409(PPP1CA) 103062218(PPP1CB)
GJA: 107112146(PPP1CC) 107124492(PPP1CB)
XLA: 108704179 108717671 379914(ppp1ca.L) 380598(ppp1cc) 397767(ppp1cc.L) 443852(ppp1cb.L)
XTR: 100145598(ppp1ca) 407879(ppp1cc) 496958(ppp1cb)
NPR: 108786345(PPP1CB) 108788527(PPP1CC) 108796512
DRE: 100003223(ppp1cb) 327301(ppp1cab) 334597(ppp1cbl) 407980(ppp1caa) 571753(ppp1cc)
LCM: 102359594 102359947(PPP1CB) 102361180(PPP1CA) 102361284 102362859(PPP1CC)
CMK: 103184322(ppp1cc) 103189617(ppp1cb)
DME: Dmel_CG10138(PpD5) Dmel_CG2096(flw) Dmel_CG3245(PpN58A) Dmel_CG41534(Pp1-Y1) Dmel_CG5650(Pp1-87B) Dmel_CG6593(Pp1alpha-96A) Dmel_CG8822(PpD6) Dmel_CG9156(Pp1-13C)
DSI: Dsimw501_GD15211(Dsim_GD15211) Dsimw501_GD15806(Dsim_GD15806) Dsimw501_GD16975(Dsim_GD16975) Dsimw501_GD20567(Dsim_GD20567) Dsimw501_GD21106(Dsim_GD21106) Dsimw501_GD23208(Dsim_GD23208) Dsimw501_GD25158(Dsim_GD25158) Dsimw501_GD25428(Dsim_GD25428)
ACEP: 105617778
CEL: CELE_F29F11.6(gsp-1) CELE_F56C9.1(gsp-2)
CBR: CBG00598(Cbr-gsp-2) CBG09676(Cbr-gsp-1)
ATH: AT1G64040(TOPP3) AT2G29400(TOPP1) AT2G39840(TOPP4) AT3G05580(TOPP9) AT3G46820(TOPP5) AT4G11240(TOPP7) AT5G27840(TOPP8) AT5G43380(TOPP6) AT5G59160(TOPP2)
LJA: Lj0g3v0278189.1(Lj0g3v0278189.1) Lj0g3v0300529.1(Lj0g3v0300529.1) Lj1g3v4918780.1(Lj1g3v4918780.1) Lj2g3v2661450.1(Lj2g3v2661450.1) Lj3g3v0461550.1(Lj3g3v0461550.1) Lj3g3v0461630.1(Lj3g3v0461630.1) Lj4g3v2991200.1(Lj4g3v2991200.1) Lj4g3v2991200.2(Lj4g3v2991200.2) Lj5g3v1170950.1(Lj5g3v1170950.1) Lj5g3v1341890.1(Lj5g3v1341890.1) Lj5g3v1341900.1(Lj5g3v1341900.1)
DOSA: Os01t0349400-01(Os01g0349400) Os02t0820000-01(Os02g0820000) Os03t0268000-01(Os03g0268000) Os06t0164100-02(Os06g0164100) Os08t0455600-01(Os08g0455600)
ATS: 109732086(LOC109732086) 109733774(LOC109733774) 109743491(LOC109743491) 109743734(LOC109743734) 109755301(LOC109755301) 109756658(LOC109756658) 109765679(LOC109765679) 109769708(LOC109769708)
CRE: CHLREDRAFT_160030(PP1A)
MNG: MNEG_1738
MIS: MICPUN_104871(PP1)
APRO: F751_2630
SCE: YDR436W(PPZ2) YER133W(GLC7) YML016C(PPZ1) YPL179W(PPQ1)
KMX: KLMA_30142(GLC7) KLMA_30328(PPQ1) KLMA_40596(PPZ1)
NCS: NCAS_0B04450(NCAS0B04450) NCAS_0H01100(NCAS0H01100) NCAS_0H02660(NCAS0H02660)
NDI: NDAI_0B01900(NDAI0B01900) NDAI_0C00960(NDAI0C00960) NDAI_0F02190(NDAI0F02190)
TPF: TPHA_0D02470(TPHA0D02470) TPHA_0H00280(TPHA0H00280) TPHA_0K00420(TPHA0K00420) TPHA_0N01200(TPHA0N01200)
TBL: TBLA_0A06980(TBLA0A06980) TBLA_0A08840(TBLA0A08840) TBLA_0B05260(TBLA0B05260) TBLA_0D01510(TBLA0D01510)
TDL: TDEL_0A04110(TDEL0A04110) TDEL_0B04530(TDEL0B04530) TDEL_0F01790(TDEL0F01790)
KAF: KAFR_0B02190(KAFR0B02190) KAFR_0C05490(KAFR0C05490) KAFR_0G03660(KAFR0G03660)
SLB: AWJ20_1480(PPZ1) AWJ20_1973(GLC7) AWJ20_1974(GLC7) AWJ20_2933(PPZ1)
NCR: NCU00043(pph-3) NCU07489(pzl-1)
NTE: NEUTE1DRAFT116927(NEUTE1DRAFT_116927) NEUTE1DRAFT70184(NEUTE1DRAFT_70184)
ANG: ANI_1_1062064(An07g08600) ANI_1_1610104(An12g02980)
SPO: SPAC57A7.08(pzh1) SPBC776.02c(dis2) SPCC31H12.05c(sds21)
ABP: AGABI1DRAFT117366(AGABI1DRAFT_117366) AGABI1DRAFT86604(AGABI1DRAFT_86604)
ABV: AGABI2DRAFT147675(AGABI2DRAFT_147675) AGABI2DRAFT152533(AGABI2DRAFT_152533)
DDI: DDB_G0275619(pppB)
DFA: DFA_09009(pppB)
EHI: EHI_176170(156.t00006)
PYO: PY17X_1030700(PY07156)
PCB: PCHAS_102910(PC302339.00.0)
TAN: TA12680
TPV: TP02_0350
BBO: BBOV_III006130(17.m07543)
CPV: cgd7_2670
SMIN: v1.2.001664.t1(symbB.v1.2.001664.t1) v1.2.001665.t1(symbB.v1.2.001665.t1) v1.2.001666.t1(symbB.v1.2.001666.t1) v1.2.006043.t1(symbB.v1.2.006043.t1) v1.2.009502.t1(symbB.v1.2.009502.t1) v1.2.018377.t1(symbB.v1.2.018377.t1) v1.2.018377.t2(symbB.v1.2.018377.t2) v1.2.018377.t3(symbB.v1.2.018377.t3) v1.2.018377.t4(symbB.v1.2.018377.t4) v1.2.024954.t1(symbB.v1.2.024954.t1) v1.2.025535.t1(symbB.v1.2.025535.t1) v1.2.025541.t1(symbB.v1.2.025541.t1) v1.2.028716.t1(symbB.v1.2.028716.t1) v1.2.028944.t1(symbB.v1.2.028944.t1)
MFC: BRM9_1242
MBAR: MSBR2_0799
MBAK: MSBR3_0059
MMAC: MSMAC_2570
VG: 20041718(JO84_gp297)
 » show all
TaxonomyVtaxonomyKoalaUniProt
Reference
  Authors
Bollen M
  Title
Combinatorial control of protein phosphatase-1.
  Journal
Trends Biochem Sci 26:426-31 (2001)
DOI:10.1016/S0968-0004(01)01836-9
Reference
  Authors
Lee JH, You J, Dobrota E, Skalnik DG
  Title
Identification and characterization of a novel human PP1 phosphatase complex.
  Journal
J Biol Chem 285:24466-76 (2010)
DOI:10.1074/jbc.M110.109801
  Sequence
[hsa:5499 5500 5501]

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