KEGG   ORTHOLOGY: K06461Help
Entry
K06461                      KO                                     

Name
ITGAM, CD11b
Definition
integrin alpha M
Pathway
ko04015  Rap1 signaling pathway
ko04145  Phagosome
ko04514  Cell adhesion molecules (CAMs)
ko04610  Complement and coagulation cascades
ko04640  Hematopoietic cell lineage
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05133  Pertussis
ko05134  Legionellosis
ko05140  Leishmaniasis
ko05146  Amoebiasis
ko05150  Staphylococcus aureus infection
ko05152  Tuberculosis
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K06461  ITGAM, CD11b; integrin alpha M
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K06461  ITGAM, CD11b; integrin alpha M
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K06461  ITGAM, CD11b; integrin alpha M
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06461  ITGAM, CD11b; integrin alpha M
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06461  ITGAM, CD11b; integrin alpha M
   04610 Complement and coagulation cascades
    K06461  ITGAM, CD11b; integrin alpha M
   04670 Leukocyte transendothelial migration
    K06461  ITGAM, CD11b; integrin alpha M
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K06461  ITGAM, CD11b; integrin alpha M
   05221 Acute myeloid leukemia
    K06461  ITGAM, CD11b; integrin alpha M
  Infectious diseases
   05133 Pertussis
    K06461  ITGAM, CD11b; integrin alpha M
   05134 Legionellosis
    K06461  ITGAM, CD11b; integrin alpha M
   05150 Staphylococcus aureus infection
    K06461  ITGAM, CD11b; integrin alpha M
   05152 Tuberculosis
    K06461  ITGAM, CD11b; integrin alpha M
   05146 Amoebiasis
    K06461  ITGAM, CD11b; integrin alpha M
   05140 Leishmaniasis
    K06461  ITGAM, CD11b; integrin alpha M
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    K06461  ITGAM, CD11b; integrin alpha M
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06461  ITGAM, CD11b; integrin alpha M
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin alpha subunits
   K06461  ITGAM, CD11b; integrin alpha M
CD molecules [BR:ko04090]
 Proteins
  K06461  CD11b, ITGAM; integrin, alpha M
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Adhesion molecules of cell surface
   K06461  ITGAM, CD11b; integrin alpha M
BRITE hierarchy
Genes
HSA: 3684(ITGAM)
PTR: 454069(ITGAM)
PPS: 100992002(ITGAM)
GGO: 101135400(ITGAM)
PON: 100439660(ITGAM)
NLE: 100603969(ITGAM)
MCC: 714832(ITGAM)
MCF: 101866035(ITGAM)
CSAB: 103231383(ITGAM)
RRO: 104661578(ITGAM)
RBB: 108526088 108528119(ITGAM)
CJC: 100389341(ITGAM)
SBQ: 101035688(ITGAM)
MMU: 16409(Itgam)
RNO: 25021(Itgam)
CGE: 100758889(Itgam)
NGI: 103726316(Itgam)
HGL: 101719288(Itgam)
CCAN: 109696521
OCU: 100351865(ITGAM)
TUP: 102483623(ITGAM)
CFA: 489928(ITGAM)
AML: 100475340(ITGAM)
UMR: 103657890(ITGAM)
ORO: 101374774(ITGAM)
FCA: 101087957
PTG: 102966486(ITGAM)
AJU: 106979120(ITGAM)
BTA: 407124(ITGAM)
BOM: 102270519(ITGAM)
PHD: 102328883(ITGAM)
CHX: 102180100(ITGAM)
OAS: 443217(ITGAM)
SSC: 397459(ITGAM)
CFR: 102513083(ITGAM)
CDK: 105089721(ITGAM)
BACU: 103004729(ITGAM)
LVE: 103073578(ITGAM)
OOR: 101287801(ITGAM)
ECB: 100064803(ITGAM)
EPZ: 103547251(ITGAM)
EAI: 106831877(ITGAM)
MYB: 102257478(ITGAM)
MYD: 102754125(ITGAM) 102770846
HAI: 109374167
RSS: 109437821(ITGAM)
PALE: 102889241(ITGAM)
TMU: 101357920
MDO: 100016833
OAA: 100085462(ITGAM)
ACS: 100556984(itgam) 100564209
PVT: 110078524
PBI: 103063967
XTR: 100495489(itgad) 101731775
NPR: 108801695
TRU: 101074990
NCC: 104955738
PRET: 103481408
BPEC: 110159543
SASA: 106564975
LCM: 102360838
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2457584
  Authors
Corbi AL, Kishimoto TK, Miller LJ, Springer TA
  Title
The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.
  Journal
J Biol Chem 263:12403-11 (1988)
  Sequence
[hsa:3684]
Reference
  Authors
Ding C, Ma Y, Chen X, Liu M, Cai Y, Hu X, Xiang D, Nath S, Zhang HG, Ye H, Powell D, Yan J
  Title
Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance.
  Journal
Nat Commun 4:2813 (2013)
DOI:10.1038/ncomms3813

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