KEGG   ORTHOLOGY: K06476Help
Entry
K06476                      KO                                     

Name
ITGA2B, CD41
Definition
integrin alpha 2B
Pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04611  Platelet activation
ko04640  Hematopoietic cell lineage
ko04810  Regulation of actin cytoskeleton
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
ko05410  Hypertrophic cardiomyopathy (HCM)
ko05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ko05414  Dilated cardiomyopathy (DCM)
ko05418  Fluid shear stress and atherosclerosis
Disease
H00226  Glanzmann thrombasthenia
H01740  Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K06476  ITGA2B, CD41; integrin alpha 2B
   04151 PI3K-Akt signaling pathway
    K06476  ITGA2B, CD41; integrin alpha 2B
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06476  ITGA2B, CD41; integrin alpha 2B
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06476  ITGA2B, CD41; integrin alpha 2B
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06476  ITGA2B, CD41; integrin alpha 2B
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06476  ITGA2B, CD41; integrin alpha 2B
   04611 Platelet activation
    K06476  ITGA2B, CD41; integrin alpha 2B
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06476  ITGA2B, CD41; integrin alpha 2B
   05222 Small cell lung cancer
    K06476  ITGA2B, CD41; integrin alpha 2B
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K06476  ITGA2B, CD41; integrin alpha 2B
   05410 Hypertrophic cardiomyopathy (HCM)
    K06476  ITGA2B, CD41; integrin alpha 2B
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06476  ITGA2B, CD41; integrin alpha 2B
   05414 Dilated cardiomyopathy (DCM)
    K06476  ITGA2B, CD41; integrin alpha 2B
  Infectious diseases
   05165 Human papillomavirus infection
    K06476  ITGA2B, CD41; integrin alpha 2B
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06476  ITGA2B, CD41; integrin alpha 2B
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06476  ITGA2B, CD41; integrin alpha 2B
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin alpha subunits
   K06476  ITGA2B, CD41; integrin alpha 2B
CD molecules [BR:ko04090]
 Proteins
  K06476  CD41, ITGA2B; integrin, alpha 2b
BRITE hierarchy
Genes
HSA: 3674(ITGA2B)
PTR: 454730(ITGA2B)
PPS: 100991197(ITGA2B)
GGO: 101136113(ITGA2B)
PON: 100452800(ITGA2B)
NLE: 100601385(ITGA2B)
MCC: 714955(ITGA2B)
MCF: 102119413(ITGA2B)
CSAB: 103243322(ITGA2B)
RRO: 104654717(ITGA2B)
RBB: 108532191(ITGA2B)
CJC: 100408748(ITGA2B)
SBQ: 101031876(ITGA2B)
MMU: 16399(Itga2b)
RNO: 685269(Itga2b)
CGE: 100762814(Itga2b)
NGI: 103738294(Itga2b)
HGL: 101714332(Itga2b)
CCAN: 109686433(Itga2b)
OCU: 100008734(ITGA2B)
TUP: 102493954(ITGA2B)
CFA: 403789(ITGA2B)
AML: 100484185(ITGA2B)
UMR: 103665592(ITGA2B)
ORO: 101369639(ITGA2B)
FCA: 101100930(ITGA2B)
PTG: 102951724(ITGA2B)
AJU: 106974321(ITGA2B)
BTA: 515011(ITGA2B)
BOM: 102275560(ITGA2B)
BIU: 109573568(ITGA2B)
PHD: 102319110(ITGA2B)
CHX: 102183451(ITGA2B)
OAS: 101115719(ITGA2B)
SSC: 397059(ITGA2B)
CFR: 102521427(ITGA2B)
CDK: 105094425(ITGA2B)
BACU: 102999724(ITGA2B)
LVE: 103075356(ITGA2B)
OOR: 101276321(ITGA2B)
ECB: 100009697(ITGA2B)
EPZ: 103551206(ITGA2B)
EAI: 106836459(ITGA2B)
MYB: 102252761(ITGA2B)
MYD: 102767172(ITGA2B)
HAI: 109394948(ITGA2B)
RSS: 109458526(ITGA2B)
PALE: 102883900(ITGA2B)
LAV: 100654429(ITGA2B)
TMU: 101348507
MDO: 100023354(ITGA2B)
SHR: 100932021(ITGA2B)
MGP: 104916711
APLA: 101792319(ITGA2B)
ACYG: 106046909(ITGA2B)
GFR: 106632013(ITGA2B)
FAB: 101814120(ITGA2B)
PHI: 102101807(ITGA2B)
PMAJ: 107215044(ITGA2B)
FPG: 101913845(ITGA2B)
FCH: 102046031(ITGA2B)
CLV: 102098721(ITGA2B)
EGZ: 104132293
ASN: 102372475(ITGA2B)
AMJ: 102570562(ITGA2B)
CMY: 102942431(ITGA2B)
CPIC: 101947159(ITGA2B)
ACS: 100557235(itga2b)
PVT: 110081352(ITGA2B)
PBI: 103054796(ITGA2B)
GJA: 107111368
XLA: 100191022(itga2b.1.S) 495051(itga2b.2.L)
XTR: 100158580(itga2b.1) 100495138(itga2b.2)
DRE: 445380(itga2b)
SRX: 107725055
SANH: 107684632
SGH: 107590780
IPU: 108258137(itga2b)
AMEX: 103045206
LCO: 104938137(itga2b)
XMA: 102221313
PRET: 103469027
LCF: 108873242(itga2b)
ELS: 105023367
SFM: 108941551
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2439501
  Authors
Poncz M, Eisman R, Heidenreich R, Silver SM, Vilaire G, Surrey S, Schwartz E, Bennett JS
  Title
Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.
  Journal
J Biol Chem 262:8476-82 (1987)
  Sequence
[hsa:3674]
Reference
  Authors
Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fassler R, Ginsberg MH
  Title
The mechanism of kindlin-mediated activation of integrin alphaIIbbeta3.
  Journal
Curr Biol 23:2288-95 (2013)
DOI:10.1016/j.cub.2013.09.050

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