KEGG ORTHOLOGY: K06619

ORTHOLOGY: K06619

Entry

K06619                      KO

Symbol

ABL1

Name

abelson tyrosine-protein kinase 1 [EC:2.7.10.2]

Pathway

map04012

ErbB signaling pathway

map04014

Ras signaling pathway

map04110

Cell cycle

map04360

Axon guidance

map04722

Neurotrophin signaling pathway

map05130

Pathogenic Escherichia coli infection

map05200

Pathways in cancer

map05206

MicroRNAs in cancer

map05208

Chemical carcinogenesis - reactive oxygen species

map05220

Chronic myeloid leukemia

map05416

Viral myocarditis

Disease

H00001

B-cell acute lymphoblastic leukemia

H00004

Chronic myeloid leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K06619  ABL1; abelson tyrosine-protein kinase 1
   04014 Ras signaling pathway
    K06619  ABL1; abelson tyrosine-protein kinase 1
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06619  ABL1; abelson tyrosine-protein kinase 1
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K06619  ABL1; abelson tyrosine-protein kinase 1
  09158 Development and regeneration
   04360 Axon guidance
    K06619  ABL1; abelson tyrosine-protein kinase 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06619  ABL1; abelson tyrosine-protein kinase 1
   05206 MicroRNAs in cancer
    K06619  ABL1; abelson tyrosine-protein kinase 1
   05208 Chemical carcinogenesis - reactive oxygen species
    K06619  ABL1; abelson tyrosine-protein kinase 1
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    K06619  ABL1; abelson tyrosine-protein kinase 1
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K06619  ABL1; abelson tyrosine-protein kinase 1
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K06619  ABL1; abelson tyrosine-protein kinase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06619  ABL1; abelson tyrosine-protein kinase 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K06619  ABL1; abelson tyrosine-protein kinase 1
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  ABL family
   K06619  ABL1; abelson tyrosine-protein kinase 1

Other DBs

GO:

0004715

Genes

HSA:

25(ABL1)

PTR:	107976801(ABL1)

PPS:	100994981(ABL1)

GGO:	101127165(ABL1)

PON:	100453216(ABL1)

NLE:	100601002(ABL1)

MCC:	722449(ABL1)

MCF:	102115803(ABL1)

CSAB:

103239742(ABL1)

CATY:

105576174(ABL1)

PANU:

101007628(ABL1)

TGE:	112607912(ABL1)

RRO:	104660552(ABL1)

RBB:	108513941(ABL1)

TFN:	117073329(ABL1)

PTEH:

111545838(ABL1)

CJC:	100398414(ABL1)

SBQ:	101046557(ABL1)

CSYR:

103258968(ABL1)

MMUR:

105865709(ABL1)

OGA:	100961758(ABL1)

MMU:	11350(Abl1)

MCAL:

110289525(Abl1)

MPAH:

110318646(Abl1)

RNO:	311860(Abl1)

MCOC:

116089976(Abl1)

MUN:	110558915(Abl1)

CGE:	100768098(Abl1)

PLEU:

114703784(Abl1)

NGI:	103727721(Abl1)

HGL:	101724428(Abl1)

CPOC:

100720976(Abl1)

CCAN:

109700215(Abl1)

DORD:

105989403(Abl1)

DSP:	122108952(Abl1)

OCU:	100345909(ABL1)

OPI:	101517017(ABL1)

TUP:	102470554(ABL1)

CFA:	491292(ABL1)

VVP:	112927987(ABL1)

VLG:	121472660(ABL1)

AML:	100466468(ABL1)

UMR:	103670413(ABL1)

UAH:	113266525(ABL1)

UAR:	123775749(ABL1)

ELK:

111146116

MPUF:

101689921(ABL1)

ORO:	101370651(ABL1)

EJU:	114198844(ABL1)

ZCA:	113934229(ABL1)

MLX:	118017579(ABL1)

FCA:	101087622(ABL1)

PYU:	121035113(ABL1)

PBG:	122474547(ABL1)

PTG:	102949569(ABL1)

PPAD:

109250012(ABL1)

AJU:	106985340(ABL1)

HHV:	120230153(ABL1)

BTA:	540876(ABL1)

BOM:	102266301(ABL1)

BIU:	109566554(ABL1)

BBUB:

102401862(ABL1)

CHX:	102184349(ABL1)

OAS:	101122941(ABL1)

ODA:	120852101(ABL1)

CCAD:

122442277(ABL1)

SSC:	100524544(ABL1)

CFR:	102519310(ABL1)

CBAI:

105069698(ABL1)

CDK:	105092528(ABL1)

BACU:

102998508(ABL1)

LVE:	103076172(ABL1)

OOR:	101281151(ABL1)

DLE:	111177117(ABL1)

PCAD:

102988541(ABL1)

PSIU:

116755284(ABL1)

ECB:	100069715(ABL1)

EPZ:	103562771(ABL1)

EAI:	106845390(ABL1)

MYB:	102255271(ABL1)

MYD:	102757649(ABL1)

MMYO:

118666952(ABL1)

MLF:	102433845(ABL1)

MNA:	107524646(ABL1)

PKL:	118706629(ABL1)

HAI:	109380669(ABL1)

DRO:	112306226(ABL1)

SHON:

118980343(ABL1)

AJM:	119059032(ABL1)

PDIC:

114508748(ABL1)

PHAS:

123823364(ABL1)

MMF:	118629546(ABL1)

RFQ:	117031775(ABL1)

PALE:

102895947(ABL1)

PGIG:

120602712(ABL1)

PVP:	105298669(ABL1)

RAY:	107504550(ABL1)

MJV:	108408195(ABL1)

TOD:	119232154(ABL1)

SARA:

101539877(ABL1)

LAV:	100677152(ABL1)

TMU:

101341732

DNM:	101425834(ABL1)

MDO:	100619549(ABL1)

GAS:	123237223(ABL1)

SHR:	100930047(ABL1)

PCW:	110198907(ABL1)

OAA:	100075676(ABL1)

GGA:	417181(ABL1)

PCOC:

116234254(ABL1)

MGP:	100550407(ABL1)

CJO:	107321848(ABL1)

NMEL:

110406778(ABL1)

APLA:

101794358(ABL1)

ACYG:

106044113(ABL1)

AFUL:

116496816(ABL1)

TGU:	100223450(ABL1)

LSR:	110477593(ABL1)

SCAN:

103818997(ABL1)

PMOA:

120507414(ABL1)

OTC:	121336931(ABL1)

PRUF:

121357526(ABL1)

GFR:	102042232(ABL1)

FAB:	101817037(ABL1)

PHI:	102099348(ABL1)

PMAJ:

107212136(ABL1)

CCAE:

111937004(ABL1)

CCW:	104688306(ABL1)

ETL:	114073812(ABL1)

ZAB:	102064957(ABL1)

FPG:	101918950(ABL1)

FCH:	102052443(ABL1)

CLV:	102086741(ABL1)

EGZ:	104129817(ABL1)

NNI:	104023169(ABL1)

ACUN:

113486462(ABL1)

TALA:

104367901(ABL1)

PADL:

103915284(ABL1)

ACHC:

115335151(ABL1)

AAM:	106486072(ABL1)

AROW:

112964293(ABL1)

NPD:	112955850(ABL1)

DNE:	112984139(ABL1)

ASN:	102368526(ABL1)

AMJ:	102564337(ABL1)

CPOO:

109313946(ABL1)

GGN:	109292969(ABL1)

PSS:	102455334(ABL1)

CMY:	102943857(ABL1)

CPIC:

101935179(ABL1)

TST:	117889431(ABL1)

CABI:

116835135(ABL1)

MRV:	120386715(ABL1)

ACS:	100557530(abl1)

PVT:	110079629(ABL1)

SUND:

121936304(ABL1)

PBI:

103059276

PMUR:

107291344(ABL1)

TSR:	106554736(ABL1)

PGUT:

117676555(ABL1)

VKO:	123028336(ABL1)

PMUA:

114589465(ABL1)

ZVI:	118083916(ABL1)

GJA:	107108928(ABL1)

XLA:	108699954(abl1.S) 108704697(abl1.L)

XTR:	100490771(abl1)

NPR:	108788711(ABL1)

RTEM:

120914143(ABL1)

BBUF:

121009124(ABL1)

BGAR:

122919939 122919940

DRE:	100000720(abl1)

SRX:	107729293 107745339(abl1)

SANH:

107670387 107674916

SGH:	107566858 107577903 107597931

CCAR:

109048738(abl1) 109057589

CAUA:

113048747 113084559

IPU:	108259985(abl1)

PHYP:

113531133(abl1)

SMEO:

124378757(abl1)

AMEX:

103046185(abl1)

EEE:

113583945

TRU:	101064177(abl1)

TNG:	GSTEN00017201G001

LCO:	104924853(abl1)

NCC:	104956356(abl1)

CGOB:

115016527(abl1)

ELY:	117269831(abl1)

PLEP:

121959503(abl1)

SLUC:

116035156(abl1)

ECRA:

117959703(abl1)

PFLV:

114570717(abl1)

GAT:	120831583(abl1)

PPUG:

119227134(abl1)

MSAM:

119914667(abl1)

CUD:	121524967(abl1)

MZE:	101475377(abl1)

ONL:	100709901(abl1)

OAU:	116322539(abl1)

OLA:	101155287(abl1)

OML:	112163252(abl1)

XMA:	102230386(abl1)

XCO:	114149479(abl1)

XHE:	116723812(abl1)

PRET:

103473791(abl1)

PFOR:

103149563(abl1)

PLAI:

106944514(abl1)

PMEI:

106924238(abl1)

GAF:	122819488(abl1)

CVG:	107088442(abl1)

CTUL:

119781545(abl1)

NFU:	107374064(abl1)

KMR:	108230984(abl1)

ALIM:

106532564(abl1)

NWH:	119424800(abl1)

AOCE:

111578179(abl1)

CSEM:

103390173(abl1)

POV:

109626307

SSEN:

122758241(abl1)

HHIP:

117771273(abl1)

LCF:	108888951(abl1)

SDU:	111237780(abl1)

SLAL:

111664729(abl1)

XGL:	120806168(abl1)

HCQ:

109514691

BPEC:

110160463(abl1)

MALB:

109960591

SASA:

106563284 106566947

OTW:	112219306 112230988

OMY:	110509795 110523582

OGO:	124006697 124048965

ONE:	115101169 115122653

SALP:

111961611 111964018

SNH:	120021211 120025692

ELS:	105015016(abl1)

SFM:	108922661 108938597

PKI:	111842668 111843474

AANG:

118206601 118212827

LOC:

102691842

PSPA:

121309712(abl1)

ARUT:

117396922 117422371

LCM:	102355014(ABL1)

CMK:	103183028(abl1)

RTP:

109930229

BFO:

118420419

BBEL:

109461989 109461990 109465071 109470447 109484645

CIN:

SCLV:

SPU:

APLC:

SKO:	100374571(ABL2)

DME:	Dmel_CG4032(Abl)

DER:

6544214

DSE:

6605990

DYA:	Dyak_GE22200

DAN:

6493382

DSR:

110183566

DPO:	Dpse_GA17894

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16710

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

MDE:

SCAC:

LCQ:

AGA:	AgaP_AGAP004989

ACOZ:

AARA:

AAG:

AALB:

CQU:	CpipJ_CPIJ003985 CpipJ_CPIJ009602

CPII:

CNS:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200085

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

HAW:

OFU:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM538010

FOC:

ZNE:

CSEC:

FCD:

DMK:

PVM:

PJA:

HAME:

PCLA:

PTRU:

HAZT:

EAF:	111716984 111717929

ISC:	IscW_ISCW000295

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

107439649 107446009 122268962

SDM:	118185970 118186282

CEL:	CELE_M79.1(abl-1)

CBR:	CBG_04507(Cbr-abl-1)

BMY:	BM_BM5124(Bma-abl-1)

LOA:	LOAG_05868

NAI:	NECAME_06130

TSP:

Tsp_09251

HRO:	HELRODRAFT_166124

PCAN:

BGT:

GAE:

HRF:

HRJ:	124259814 124269735

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:

SMM:	Smp_128790 Smp_169230

OVI:	T265_05581 T265_08093

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

AQU:

MNG:

TVS:	TRAVEDRAFT_171082

HIR:	HETIRDRAFT_124459

FME:	FOMMEDRAFT_17451

CCI:	CC1G_13961

MBR:	MONBRDRAFT_44322

SRE:	PTSG_06415 PTSG_08747

ACAN:

ACA1_065920 ACA1_307790

VG:	1491873(gag-abl)

» show all

Reference

PMID:20841568

Authors

Colicelli J

Title

ABL tyrosine kinases: evolution of function, regulation, and specificity.

Journal

Sci Signal 3:re6 (2010)
DOI:10.1126/scisignal.3139re6

Sequence

[hsa:25]

DBGET integrated database retrieval system