KEGG   ORTHOLOGY: K06641Help
Entry
K06641                      KO                                     

Name
CHK2
Definition
serine/threonine-protein kinase Chk2 [EC:2.7.11.1]
Pathway
ko04110  Cell cycle
ko04111  Cell cycle - yeast
ko04115  p53 signaling pathway
ko04218  Cellular senescence
ko05166  HTLV-I infection
Module
M00691  DNA damage-induced cell cycle checkpoints
Disease
H00881  Li-Fraumeni syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K06641  CHK2; serine/threonine-protein kinase Chk2
   04111 Cell cycle - yeast
    K06641  CHK2; serine/threonine-protein kinase Chk2
   04115 p53 signaling pathway
    K06641  CHK2; serine/threonine-protein kinase Chk2
   04218 Cellular senescence
    K06641  CHK2; serine/threonine-protein kinase Chk2
 Human Diseases
  Infectious diseases
   05166 HTLV-I infection
    K06641  CHK2; serine/threonine-protein kinase Chk2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00691  DNA damage-induced cell cycle checkpoints
     K06641  CHK2; serine/threonine-protein kinase Chk2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06641  CHK2; serine/threonine-protein kinase Chk2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  RAD53 family
   K06641  CHK2; serine/threonine-protein kinase Chk2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  Check point factors
   Other check point factors
    K06641  CHK2; serine/threonine-protein kinase Chk2
BRITE hierarchy
Other DBs
COG: COG0515
Genes
HSA: 11200(CHEK2)
PTR: 458733(CHEK2)
PPS: 100987687(CHEK2)
GGO: 101124618(CHEK2) 101136352
PON: 100461345(CHEK2)
NLE: 100594542(CHEK2)
MCC: 713668(CHEK2)
MCF: 102122988(CHEK2)
CSAB: 103223122(CHEK2)
RRO: 104658998(CHEK2)
RBB: 108517558(CHEK2)
CJC: 100404949(CHEK2)
SBQ: 101051768(CHEK2)
MMU: 50883(Chek2)
RNO: 114212(Chek2)
CGE: 100769280(Chek2)
NGI: 103750875(Chek2)
HGL: 101721212(Chek2)
CCAN: 109690250(Chek2)
OCU: 100339430(CHEK2)
TUP: 102484993(CHEK2)
CFA: 486338(CHEK2)
AML: 100467146(CHEK2)
UMR: 103659236(CHEK2)
ORO: 101386368(CHEK2)
FCA: 101085665(CHEK2)
PTG: 102960814(CHEK2)
AJU: 106985461(CHEK2)
BTA: 518897(CHEK2)
BOM: 102283552(CHEK2)
BIU: 109571019(CHEK2)
PHD: 102320600(CHEK2)
CHX: 102184180(CHEK2)
OAS: 101105532(CHEK2)
SSC: 100192447(CHEK2)
CFR: 102508820(CHEK2)
CDK: 105099476(CHEK2)
BACU: 103014798(CHEK2)
LVE: 103076926(CHEK2)
OOR: 101289528(CHEK2)
ECB: 100059288(CHEK2)
EPZ: 103554111(CHEK2)
EAI: 106827624(CHEK2)
MYB: 102250232(CHEK2)
MYD: 102766522(CHEK2)
HAI: 109383036(CHEK2)
RSS: 109453412(CHEK2)
PALE: 102882358(CHEK2)
LAV: 100666208(CHEK2)
TMU: 101359759
MDO: 100030584(CHEK2)
SHR: 100932330(CHEK2)
OAA: 100077482(CHEK2)
GGA: 768913(CHEK2)
MGP: 100543068(CHEK2)
CJO: 107321227(CHEK2)
APLA: 101802450(CHEK2)
ACYG: 106043894(CHEK2)
TGU: 100228558(CHEK2)
GFR: 102038788(CHEK2)
FAB: 101811158(CHEK2)
PHI: 102110514(CHEK2)
PMAJ: 107211857(CHEK2)
CCW: 104688640(CHEK2)
FPG: 101911493(CHEK2)
FCH: 102057640(CHEK2)
CLV: 102090751(CHEK2)
EGZ: 104122580(CHEK2)
AAM: 106492744(CHEK2)
ASN: 102386466(CHEK2)
AMJ: 102574431(CHEK2)
PSS: 102461937(CHEK2)
CMY: 102947582(CHEK2)
CPIC: 101952469(CHEK2)
PVT: 110083425(CHEK2)
PBI: 103066019(CHEK2)
GJA: 107123921(CHEK2)
XLA: 398179(chek2.L)
XTR: 100144952(chek2) 105946289
NPR: 108788045(CHEK2)
DRE: 336998(chek2)
SRX: 107723314(chek2) 107751420
IPU: 108255821(chek2)
AMEX: 103034962(chek2)
TRU: 101063164(chek2)
NCC: 104963420
MZE: 101485707(chek2)
OLA: 101170645(chek2)
XMA: 102224037
PRET: 103460387(chek2)
NFU: 107386179(chek2)
CSEM: 103397943(chek2)
LCF: 108894515(chek2)
HCQ: 109525295(chek2)
BPEC: 110169250(chek2)
ELS: 105014423(chek2)
SFM: 108927301(chek2)
LCM: 102362683(CHEK2)
CMK: 103184008(chek2)
CIN: 100175326
SPU: 589861
APLC: 110976646
SKO: 100372241
DME: Dmel_CG10895(lok)
DSI: Dsimw501_GD24241(Dsim_GD24241)
MDE: 101896859
AAG: 5569344
AME: 551949(lok)
BIM: 100745014
BTER: 100649762
SOC: 105195435
AEC: 105151042
ACEP: 105619804
PBAR: 105422193
HST: 105181538
CFO: 105258386
LHU: 105668387
PGC: 109861563
NVI: 100117742
TCA: 661264
DPA: 109538347
NVL: 108558766
BMOR: 692482(Chk2)
PMAC: 106717857
PRAP: 111003433
PXY: 105381643
API: 100163511
DNX: 107174043
CEL: CELE_T08D2.7(T08D2.7) CELE_Y60A3A.12(chk-2)
CBR: CBG20512(Cbr-chk-2)
CRG: 105318723
MYI: 110445255
OBI: 106878443
LAK: 106155701
SHX: MS3_02323
EPA: 110232754
ADF: 107341547
HMG: 100207948
SCE: YDL101C(DUN1)
ERC: Ecym_5624
KMX: KLMA_20647(DUN1)
NCS: NCAS_0B05910(NCAS0B05910)
NDI: NDAI_0B03190(NDAI0B03190)
TPF: TPHA_0C04570(TPHA0C04570)
TBL: TBLA_0B07330(TBLA0B07330)
TDL: TDEL_0G02820(TDEL0G02820)
KAF: KAFR_0K02450(KAFR0K02450)
CAL: CAALFM_C505100CA(DUN1)
CAUR: QG37_04599
NCR: NCU02814(prd-4)
NTE: NEUTE1DRAFT133979(NEUTE1DRAFT_133979)
MGR: MGG_01596
MAW: MAC_01056
MAJ: MAA_05678
CMT: CCM_01421
MBE: MBM_06218
ANI: AN4279.2
ANG: ANI_1_520114(An13g00100)
ABE: ARB_00949
TVE: TRV_00735
PNO: SNOG_03701(SNOG_03700)
PTE: PTT_12246
MBR: MONBRDRAFT_15828(Cds1)
DDI: DDB_G0281567(fhkC)
DFA: DFA_02485(fhkE) DFA_05550(fhkA) DFA_07254(fhkD) DFA_10013(fhkC)
EHI: EHI_011510(90.t00001)
SMIN: v1.2.014603.t1(symbB.v1.2.014603.t1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H
  Title
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.
  Journal
Mol Cell Biol 28:5874-85 (2008)
DOI:10.1128/MCB.00821-08
  Sequence
[hsa:11200]
Reference
  Authors
Bahassi EM, Ovesen JL, Riesenberg AL, Bernstein WZ, Hasty PE, Stambrook PJ
  Title
The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.
  Journal
Oncogene 27:3977-85 (2008)
DOI:10.1038/onc.2008.17
  Sequence
[hsa:11200]
Reference
  Authors
Stolz A, Ertych N, Kienitz A, Vogel C, Schneider V, Fritz B, Jacob R, Dittmar G, Weichert W, Petersen I, Bastians H
  Title
The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells.
  Journal
Nat Cell Biol 12:492-9 (2010)
DOI:10.1038/ncb2051
  Sequence
[hsa:11200]

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