KEGG ORTHOLOGY: K06645

ORTHOLOGY: K06645

Entry

K06645                      KO

Symbol

CDC25A

Name

M-phase inducer phosphatase 1 [EC:3.1.3.48]

Pathway

map04110

Cell cycle

map04218

Cellular senescence

map04914

Progesterone-mediated oocyte maturation

map05206

MicroRNAs in cancer

map05207

Chemical carcinogenesis - receptor activation

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06645  CDC25A; M-phase inducer phosphatase 1
   04218 Cellular senescence
    K06645  CDC25A; M-phase inducer phosphatase 1
09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K06645  CDC25A; M-phase inducer phosphatase 1
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K06645  CDC25A; M-phase inducer phosphatase 1
   05207 Chemical carcinogenesis - receptor activation
    K06645  CDC25A; M-phase inducer phosphatase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06645  CDC25A; M-phase inducer phosphatase 1
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K06645  CDC25A; M-phase inducer phosphatase 1
   03400 DNA repair and recombination proteins
    K06645  CDC25A; M-phase inducer phosphatase 1
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K06645  CDC25A; M-phase inducer phosphatase 1
Protein phosphatases and associated proteins [BR:ko01009]
Protein tyrosine phosphatases (PTPs)
  Class III PTPs
   CDC25s
    K06645  CDC25A; M-phase inducer phosphatase 1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Other centrosome duplication proteins
     K06645  CDC25A; M-phase inducer phosphatase 1
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  Check point factors
   Other check point factors
    K06645  CDC25A; M-phase inducer phosphatase 1

Other DBs

GO:

0004725

Genes

HSA:	993(CDC25A)

PTR:	460341(CDC25A)

PPS:	100985899(CDC25A)

GGO:	101142222(CDC25A)

PON:	100460228(CDC25A)

NLE:	100588003(CDC25A)

HMH:	116473518(CDC25A)

MCC:	710858(CDC25A)

MCF:	102137696(CDC25A)

MTHB:

126948666

MNI:	105480393(CDC25A)

CSAB:

103228635(CDC25A)

CATY:

105573640(CDC25A)

PANU:

101017438(CDC25A)

TGE:	112618658(CDC25A)

MLEU:

105540400(CDC25A)

RRO:	104671299(CDC25A)

RBB:	108517663(CDC25A)

TFN:	117080687(CDC25A)

PTEH:

111555493(CDC25A)

CANG:

105509746(CDC25A)

CJC:	100408832(CDC25A)

SBQ:	101041208(CDC25A)

CIMI:

108305295(CDC25A)

CSYR:

103251011(CDC25A)

MMUR:

105874913(CDC25A)

LCAT:

123623323(CDC25A)

PCOQ:

105811317(CDC25A)

OGA:	100942877(CDC25A)

MMU:	12530(Cdc25a)

MCAL:

110301556(Cdc25a)

MPAH:

110327415(Cdc25a)

RNO:	171102(Cdc25a)

MCOC:

116072801(Cdc25a)

ANU:	117693812(Cdc25a)

MUN:	110565748(Cdc25a)

CGE:	100767961(Cdc25a)

MAUA:

101826345(Cdc25a)

PROB:

127236150(Cdc25a)

PLEU:

114705236(Cdc25a)

MORG:

121464398(Cdc25a)

MFOT:

126499932

AAMP:

119810533(Cdc25a)

NGI:	103750230(Cdc25a)

HGL:	101699133(Cdc25a)

CPOC:

100721008(Cdc25a)

CCAN:

109699005(Cdc25a)

DORD:

105994612(Cdc25a)

DSP:	122095677(Cdc25a)

PLOP:

125342401(Cdc25a)

NCAR:

124969415

MMMA:

107145391(Cdc25a)

OCU:

100354280

OPI:	101519009(CDC25A)

TUP:	102482369(CDC25A)

GVR:	103591612(CDC25A)

CFA:	484780(CDC25A)

CLUD:

112665734(CDC25A)

VVP:	112912171(CDC25A)

VLG:	121494228(CDC25A)

NPO:	129522597(CDC25A)

AML:	100477247(CDC25A)

UMR:	103675112(CDC25A)

UAH:	113256823(CDC25A)

UAR:	123779966(CDC25A)

ELK:

111144080

LLV:

125080840

MPUF:

101680806(CDC25A)

MNP:	132011276(CDC25A)

MLK:	131823881(CDC25A)

NVS:	122909467(CDC25A)

ORO:	101369809(CDC25A)

EJU:	114225128(CDC25A)

ZCA:	113918722(CDC25A)

MLX:	118005263(CDC25A)

NSU:	110577660(CDC25A)

LWW:	102747860(CDC25A)

FCA:	101098445(CDC25A)

PYU:	121011146(CDC25A)

PCOO:

112852660(CDC25A)

PBG:	122487215(CDC25A)

PVIV:

125158956(CDC25A)

LRUF:

124523955

PTG:	102957057(CDC25A)

PPAD:

109247747(CDC25A)

PUC:

125930666

AJU:

106979176

HHV:	120229362(CDC25A)

BTA:	520188(CDC25A)

BOM:	102285046(CDC25A)

BIU:	109576463(CDC25A)

BBUB:

102415490(CDC25A)

BBIS:

105004673(CDC25A)

CHX:	102181731(CDC25A)

OAS:	101113178(CDC25A)

BTAX:

128054910(CDC25A)

ODA:	120868201(CDC25A)

CCAD:

122424249(CDC25A)

MBEZ:

129547792(CDC25A)

SSC:	100737380(CDC25A)

CFR:	102509600(CDC25A)

CBAI:

105083373(CDC25A)

CDK:	105103857(CDC25A)

VPC:	102532416(CDC25A)

BACU:

103016547(CDC25A)

BMUS:

118904114(CDC25A)

LVE:	103085456(CDC25A)

OOR:	101282274(CDC25A)

DLE:	111174440(CDC25A)

PCAD:

102992519(CDC25A)

PSIU:

116762728(CDC25A)

NASI:

112403815(CDC25A)

ECB:	100064223(CDC25A)

EPZ:	103567910(CDC25A)

EAI:	106821782(CDC25A)

MYB:	102240322(CDC25A) 102252775 102252873

MYD:	102760761(CDC25A)

MMYO:

118668522(CDC25A)

MLF:	102425819 102434301 102439293(CDC25A)

PKL:	118715710(CDC25A)

EFUS:

103300851(CDC25A)

MNA:	107529418(CDC25A)

DRO:	112309765(CDC25A)

SHON:

118976202(CDC25A)

AJM:	119038075(CDC25A)

PDIC:

114501673(CDC25A)

PHAS:

123830798(CDC25A)

MMF:	118633065(CDC25A)

PPAM:

129087811(CDC25A)

HAI:	109375294(CDC25A)

RFQ:	117037274(CDC25A)

PALE:

102897196(CDC25A)

PGIG:

120582298(CDC25A)

PVP:	105302354(CDC25A)

RAY:	107513304(CDC25A)

MJV:	108402658(CDC25A)

TOD:	119259478(CDC25A)

SARA:

101550787(CDC25A)

LAV:	100659991(CDC25A)

TMU:

101346532

ETF:	101640269(CDC25A)

DNM:	101423936(CDC25A)

MDO:	100018150(CDC25A)

GAS:	123230824(CDC25A)

SHR:	100924467(CDC25A)

PCW:	110217106(CDC25A)

OAA:	100085311(CDC25A)

GGA:	420375(CDC25A)

PCOC:

116238507(CDC25A)

MGP:	100546502(CDC25A)

CJO:	107308656(CDC25A)

TPAI:

128086415(CDC25A)

LMUT:

125696397(CDC25A)

NMEL:

110390717(CDC25A)

APLA:

101800901(CDC25A)

ACYG:

106046801(CDC25A)

CATA:

118251873(CDC25A)

AFUL:

116486619(CDC25A)

TGU:	100231363(CDC25A)

LSR:	110475093 110476932

SCAN:

103813021(CDC25A)

PMOA:

120510615(CDC25A)

OTC:	121337999(CDC25A)

PRUF:

121357168(CDC25A)

GFR:	102040683(CDC25A)

FAB:	101816817(CDC25A)

OMA:	130250370(CDC25A)

PHI:	102104005(CDC25A)

PMAJ:

107201060(CDC25A)

CCAE:

111925581(CDC25A)

CCW:	104686374(CDC25A)

CBRC:

103617977(CDC25A)

ETL:	114069284(CDC25A)

ZAB:	102067880(CDC25A)

ACHL:

103806323(CDC25A)

SVG:	106862796(CDC25A)

MMEA:

130574572(CDC25A)

HRT:	120763061(CDC25A)

FPG:	101911899(CDC25A)

FCH:	102054923(CDC25A)

CLV:	102084553(CDC25A)

EGZ:	104121808(CDC25A)

NNI:	104019237(CDC25A)

PCRI:

104024426(CDC25A)

PLET:

104614013(CDC25A)

EHS:	104510285(CDC25A)

PCAO:

104048283

ACUN:

113476811(CDC25A)

TALA:

104363385(CDC25A)

PADL:

103916196(CDC25A)

AFOR:

103903477(CDC25A)

ACHC:

115338979(CDC25A)

HALD:

104321484(CDC25A)

HLE:	104828423(CDC25A)

AGEN:

126037607

GCL:

127013312

CCRI:

104160309(CDC25A)

CSTI:

104550080(CDC25A)

CMAC:

104484842(CDC25A)

BREG:

104638872(CDC25A)

FGA:	104069742(CDC25A)

GSTE:

104261162(CDC25A)

LDI:	104349517(CDC25A)

MNB:

103781153

OHA:

104326595

NNT:	104406434(CDC25A)

SHAB:

115610972(CDC25A)

DPUB:

104299212(CDC25A)

PGUU:

104468492(CDC25A)

ACAR:

104517797(CDC25A)

CPEA:

104398438(CDC25A)

AVIT:

104278370

CVF:	104287040(CDC25A)

RTD:	128904788(CDC25A)

CUCA:

104061607(CDC25A)

TEO:	104372529(CDC25A)

BRHI:

104495683

AAM:

106499367

AROW:

112977410(CDC25A)

NPD:	112951558(CDC25A)

TGT:

104579029

DNE:	112993598(CDC25A)

SCAM:

104150100(CDC25A)

ASN:	102384816(CDC25A)

AMJ:	102569214(CDC25A)

CPOO:

109305787(CDC25A)

GGN:	109291133(CDC25A)

PSS:	102458852(CDC25A)

CMY:	102931776(CDC25A)

CCAY:

125632997(CDC25A)

DCC:	119852038(CDC25A)

CPIC:

101944298(CDC25A)

TST:	117871895(CDC25A)

CABI:

116828404(CDC25A)

MRV:	120399640(CDC25A)

ACS:	100558641(cdc25a) 103280245

ASAO:

132779713(CDC25A)

PVT:	110082540(CDC25A)

SUND:

121935243(CDC25A)

PBI:	103059140(CDC25A)

CTIG:

120319681(CDC25A)

TSR:	106549893(CDC25A)

PGUT:

117673238

APRI:

131198945(CDC25A)

PTEX:

113451206(CDC25A)

VKO:	123017889(CDC25A)

PMUA:

114607182(CDC25A)

PRAF:

128423865(CDC25A)

ZVI:

118092194

HCG:	128330758(CDC25A)

GJA:	107124887(CDC25A)

STOW:

125440879(CDC25A)

EMC:	129337525(CDC25A)

XLA:	398141(cdc25a.L) 734734(cdc25a.S)

XTR:	733851(cdc25a)

NPR:

108800705

RTEM:

120941712(CDC25A)

BBUF:

121000768(CDC25A)

BGAR:

122938084(CDC25A)

MUO:	115459789 115465821(CDC25A)

GSH:	117354430(CDC25A)

TPRE:

LBD:

HHAL:

PCLA:

VDE:

VJA:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

128179416 128179421 128180349 128181631

MMER:

123531146 123531152 123533289

RPHI:

132721060

XEN:

124445013

» show all

Reference

PMID:1836978

Authors

Galaktionov K, Beach D

Title

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins.

Journal

Cell 67:1181-94 (1991)
DOI:10.1016/0092-8674(91)90294-9

Sequence

[hsa:993]

Reference

PMID:16682204

Authors

Karlsson-Rosenthal C, Millar JB

Title

Cdc25: mechanisms of checkpoint inhibition and recovery.

Journal

Trends Cell Biol 16:285-92 (2006)
DOI:10.1016/j.tcb.2006.04.002

Reference

PMID:22417828

Authors

Hong HY, Choi J, Cho YW, Kim BC

Title

Cdc25A promotes cell survival by stimulating NF-kappaB activity through IkappaB-alpha phosphorylation and destabilization.

Journal

Biochem Biophys Res Commun 420:293-6 (2012)
DOI:10.1016/j.bbrc.2012.02.152

Sequence

[hsa:993]

All links

Ontology (6)   
   KEGG BRITE (5)   
   GO (1)   
Pathway (10)   
   KEGG PATHWAY (10)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (502)   
   KEGG GENES (287)   
   KEGG MGENES (95)   
   RefGene (117)   
   OC (3)   
Literature (3)   
   PubMed (3)   
All databases (522)   

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