KEGG   ORTHOLOGY: K07198
Entry
K07198                      KO                                     

Symbol
PRKAA, AMPK
Name
5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
Pathway
map04068  FoxO signaling pathway
map04140  Autophagy - animal
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04361  Axon regeneration
map04371  Apelin signaling pathway
map04530  Tight junction
map04710  Circadian rhythm
map04714  Thermogenesis
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04921  Oxytocin signaling pathway
map04922  Glucagon signaling pathway
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04936  Alcoholic liver disease
map05410  Hypertrophic cardiomyopathy
map05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04068 FoxO signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04151 PI3K-Akt signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04152 AMPK signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04150 mTOR signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04922 Glucagon signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04920 Adipocytokine signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04921 Oxytocin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  09158 Development and regeneration
   04361 Axon regeneration
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  09149 Aging
   04211 Longevity regulating pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04213 Longevity regulating pathway - multiple species
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  09159 Environmental adaptation
   04710 Circadian rhythm
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04714 Thermogenesis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   05410 Hypertrophic cardiomyopathy
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04932 Non-alcoholic fatty liver disease
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04931 Insulin resistance
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   03029 Mitochondrial biogenesis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Membrane trafficking [BR:ko04131]
 Autophagy
  Other autophagy associated proteins
   Others
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Mitophagy factors
   Other mitophagy factors
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Genes
HSA: 5562(PRKAA1) 5563(PRKAA2)
PTR: 471564(PRKAA1) 741802(PRKAA2)
PPS: 100975618(PRKAA1) 100991417(PRKAA2)
GGO: 101137882(PRKAA2) 101152987(PRKAA1)
PON: 100172060(PRKAA2) 100174304(PRKAA1)
NLE: 100582042(PRKAA2) 100595096(PRKAA1)
MCC: 695558(PRKAA1) 717703(PRKAA2)
MCF: 102143726(PRKAA2) 102144683(PRKAA1)
CSAB: 103215177(PRKAA1) 103224740(PRKAA2)
CATY: 105583464(PRKAA1) 105595984(PRKAA2)
PANU: 101005652(PRKAA2) 101013448(PRKAA1)
RRO: 104664292(PRKAA2) 104676941(PRKAA1)
RBB: 108532936(PRKAA2) 108544746(PRKAA1)
TFN: 117065053(PRKAA1) 117091972(PRKAA2)
PTEH: 111523274(PRKAA2) 111545491(PRKAA1)
CJC: 100385413(PRKAA1) 100396565(PRKAA2)
SBQ: 101030830(PRKAA1) 101033212(PRKAA2)
MMUR: 105878394(PRKAA1) 105882576(PRKAA2)
MMU: 105787(Prkaa1) 108079(Prkaa2)
MCAL: 110292593(Prkaa2) 110310318(Prkaa1)
MPAH: 110323060(Prkaa2) 110328784(Prkaa1)
RNO: 65248(Prkaa1) 78975(Prkaa2)
MCOC: 116083203(Prkaa1) 116096329(Prkaa2)
MUN: 110556367(Prkaa2) 110563129(Prkaa1)
CGE: 100767909(Prkaa2) 100769574(Prkaa1)
PLEU: 114697339(Prkaa1) 114705848(Prkaa2)
NGI: 103734094(Prkaa2) 103741338(Prkaa1) 108491094
HGL: 101698482(Prkaa2) 101722998(Prkaa1)
CCAN: 109681030 109687258(Prkaa2) 109695664(Prkaa1)
OCU: 100340670(PRKAA2) 100358166(PRKAA1)
TUP: 102491119(PRKAA2) 106735707(PRKAA1)
CFA: 479351(PRKAA1) 489571(PRKAA2)
VVP: 112926098(PRKAA2) 112933502(PRKAA1)
VLG: 121486591(PRKAA1) 121499646(PRKAA2)
AML: 100470115(PRKAA1) 100481376(PRKAA2)
UMR: 103664677(PRKAA1) 103670673(PRKAA2)
UAH: 113254619(PRKAA2) 113260929(PRKAA1)
ORO: 101372712(PRKAA1) 101379000(PRKAA2)
MPUF: 101675498(PRKAA2) 101693231(PRKAA1)
EJU: 114204800(PRKAA1) 114212116(PRKAA2)
FCA: 101095885(PRKAA1) 101096000(PRKAA2)
PYU: 121027198(PRKAA2) 121043998(PRKAA1)
PTG: 102956343(PRKAA1) 102970831(PRKAA2)
PPAD: 109266797(PRKAA2) 109275841(PRKAA1)
AJU: 106970910(PRKAA1) 106974988(PRKAA2)
HHV: 120236224(PRKAA2) 120239782(PRKAA1)
BTA: 538954(PRKAA2) 540404(PRKAA1)
BOM: 102265959(PRKAA1) 102270414(PRKAA2)
BBUB: 102402324(PRKAA2) 102404085(PRKAA1)
CHX: 102171295(PRKAA2) 102181338(PRKAA1)
OAS: 100127210(PRKAA2) 101103425(PRKAA1)
ODA: 120856086(PRKAA2) 120879416(PRKAA1)
CCAD: 122436917(PRKAA2) 122454166(PRKAA1)
SSC: 100145903(PRKAA1) 397504(PRKAA2)
CFR: 102510276(PRKAA1) 102523424(PRKAA2)
CBAI: 105070805(PRKAA1) 105071667(PRKAA2)
CDK: 105092817(PRKAA2) 105106940(PRKAA1)
BACU: 103018222(PRKAA2) 103019090(PRKAA1)
LVE: 103069202(PRKAA2) 103074848(PRKAA1)
OOR: 101287451(PRKAA1) 101290391(PRKAA2)
DLE: 111175861(PRKAA2) 111187179(PRKAA1)
PCAD: 102987031(PRKAA1) 102991456(PRKAA2)
ECB: 100009710(PRKAA1) 100034159(PRKAA2)
EPZ: 103543478 103555108(PRKAA1)
EAI: 106824750(PRKAA1) 106833475(PRKAA2)
MYB: 102241697(PRKAA2) 102248668(PRKAA1)
MYD: 102759339(PRKAA1) 102774877(PRKAA2)
MMYO: 118656158(PRKAA1) 118677140(PRKAA2)
MNA: 107530645(PRKAA2) 107545893(PRKAA1)
HAI: 109374016(PRKAA2) 109376169(PRKAA1)
DRO: 112314641(PRKAA2) 112321079(PRKAA1)
SHON: 118984947(PRKAA2) 118998800(PRKAA1)
MMF: 118626404(PRKAA2) 118641812(PRKAA1)
PALE: 102884524(PRKAA2) 102886520(PRKAA1)
PGIG: 120586161(PRKAA1) 120621730(PRKAA2)
RAY: 107512438(PRKAA1) 107518350(PRKAA2)
MJV: 108384981(PRKAA2) 108408223(PRKAA1)
TOD: 119235081(PRKAA2) 119260486(PRKAA1)
LAV: 100659413(PRKAA1) 100671280(PRKAA2)
MDO: 100013711(PRKAA1) 100019066(PRKAA2)
SHR: 100926139(PRKAA2) 100928944(PRKAA1)
PCW: 110201331(PRKAA2) 110215066(PRKAA1)
OAA: 100075352(PRKAA1) 100088284(PRKAA2)
GGA: 427185(PRKAA1) 429110(PRKAA2)
PCOC: 116229821(PRKAA1) 116235218(PRKAA2)
MGP: 100034740(PRKAA1) 104916235 780945(PRKAA2)
CJO: 107305860(PRKAA1) 107317703(PRKAA2)
NMEL: 110389430(PRKAA1) 110402720(PRKAA2)
APLA: 101799561(PRKAA2) 101801595(PRKAA1)
ACYG: 106033088(PRKAA2) 106036363(PRKAA1)
TGU: 100217569(PRKAA1) 100224153(PRKAA2) 116806958
LSR: 110476829(PRKAA2) 110482315(PRKAA1)
SCAN: 103815205(PRKAA2) 103821077(PRKAA1) 103824837
PMOA: 120502389(PRKAA1) 120503183(PRKAA2)
GFR: 102031783(PRKAA2) 102038682(PRKAA1) 102044941
FAB: 101809698(PRKAA1) 101811154(PRKAA2)
PHI: 102111333(PRKAA2) 102111653(PRKAA1)
PMAJ: 107208272(PRKAA2) 107216196(PRKAA1)
CCAE: 111933012(PRKAA2) 111941521(PRKAA1)
CCW: 104686759(PRKAA1) 104695510(PRKAA2)
ETL: 114055190(PRKAA2) 114063712(PRKAA1) 114068623
FPG: 101913786(PRKAA1) 101919295(PRKAA2)
FCH: 102049360(PRKAA2) 102050598(PRKAA1)
CLV: 102087954(PRKAA1) 102088108(PRKAA2)
EGZ: 104123889(PRKAA2) 104133929(PRKAA1)
NNI: 104009342(PRKAA2) 104013818 104016188(PRKAA1) 104019864
ACUN: 113482676(PRKAA2) 113489671(PRKAA1)
PADL: 103913361(PRKAA2) 103921472(PRKAA1)
AAM: 106498958(PRKAA2) 106499548(PRKAA1) 106499832
NPD: 112943469(PRKAA2) 112946009(PRKAA1)
ASN: 102374152(PRKAA2) 102375567(PRKAA1)
AMJ: 102570371(PRKAA1) 102576605(PRKAA2)
CPOO: 109307016(PRKAA2) 109307862(PRKAA1)
GGN: 109286603(PRKAA2) 109297866(PRKAA1)
PSS: 102444277(PRKAA1) 102459596(PRKAA2)
CMY: 102940952(PRKAA2) 102944011(PRKAA1)
CPIC: 101941141(PRKAA1) 101948919(PRKAA2)
TST: 117878857(PRKAA1) 117881783(PRKAA2)
CABI: 116837855(PRKAA1) 116838116(PRKAA2)
ACS: 100551935(prkaa2) 100567445(prkaa1)
PVT: 110073913(PRKAA1) 110077130(PRKAA2)
PBI: 103057294(PRKAA1) 103064935(PRKAA2)
PMUR: 107286634(PRKAA2) 107291127(PRKAA1)
TSR: 106540101(PRKAA1) 106554405(PRKAA2)
PGUT: 117664283(PRKAA2) 117679145(PRKAA1)
PMUA: 114598943(PRKAA2) 114606204(PRKAA1)
ZVI: 118077126(PRKAA1) 118088217(PRKAA2)
GJA: 107108814(PRKAA1) 107118038(PRKAA2)
XLA: 108714249 108715541 399172(prkaa2.S) 495290(prkaa1.L)
XTR: 100145520(prkaa1) 100216099(prkaa2)
NPR: 108788157(PRKAA2) 108790816(PRKAA1)
DRE: 100001198(prkaa1) 572074(prkaa2)
CCAR: 109061980 109090650(prkaa1) 109113302 109113825(prkaa2)
IPU: 108258037(prkaa2) 108260283
PHYP: 113531286 113545314(prkaa2)
AMEX: 103022500(prkaa1) 103028619(prkaa2)
EEE: 113570222(prkaa1) 113589709(prkaa2)
TRU: 101065197(prkaa1) 101076074(prkaa2)
LCO: 104919125(prkaa2) 104924922(prkaa1)
NCC: 104959371(prkaa1) 104959556(prkaa2)
CGOB: 115006880(prkaa2) 115016657
ELY: 117254209(prkaa2) 117269772(prkaa1)
PLEP: 121940022(prkaa2) 121959651 121959685(prkaa1)
SLUC: 116058893(prkaa2) 116063006(prkaa1)
ECRA: 117950155(prkaa2) 117959858(prkaa1)
PFLV: 114561945(prkaa2) 114570939(prkaa1)
GAT: 120814817(prkaa2) 120831523(prkaa1)
MSAM: 119901030(prkaa2) 119914607(prkaa1)
CUD: 121511764(prkaa2) 121525147(prkaa1)
MZE: 101471464(prkaa1) 101487955(prkaa2)
ONL: 100691914(prkaa1) 100706719(prkaa2)
OAU: 116331303(prkaa2) 116331724(prkaa1)
OLA: 101162057(prkaa1) 101173851(prkaa2)
OML: 112155805 112163281(prkaa1)
XMA: 102231393(prkaa2) 102237231(prkaa1)
XCO: 114149149(prkaa1) 114150901(prkaa2)
XHE: 116724400(prkaa1) 116725526(prkaa2)
PRET: 103463785(prkaa2) 103473399(prkaa1)
CVG: 107094060(prkaa2) 107096813(prkaa1)
CTUL: 119772370(prkaa2) 119798995(prkaa1)
NFU: 107374929(prkaa1) 107393439(prkaa2)
KMR: 108230880(prkaa1) 108243401(prkaa2)
ALIM: 106516315(prkaa1) 106530689
AOCE: 111574778(prkaa1) 111579210(prkaa2)
CSEM: 103376655(prkaa2) 103390073(prkaa1)
POV: 109625889(prkaa2) 109626467(prkaa1)
LCF: 108874097(prkaa1) 108879064(prkaa2)
SDU: 111226317(prkaa2) 111237369(prkaa1)
XGL: 120790754(prkaa2) 120806359(prkaa1)
HCQ: 109517709(prkaa1) 109532068(prkaa2)
BPEC: 110154939(prkaa2) 110157325(prkaa1)
MALB: 109962062(prkaa2) 109971334(prkaa1)
SASA: 106560227 106562970(prkaa1) 106568674 106584208(prkaa2)
ELS: 105011784(prkaa2) 105015246(prkaa1)
SFM: 108923517(prkaa2) 108924948(prkaa1)
PKI: 111834803(prkaa2) 111849957(prkaa1)
LOC: 102693561(prkaa2) 102698529(prkaa1)
LCM: 102349521(PRKAA1) 102365637(PRKAA2)
CMK: 103172450(prkaa1) 103185288(prkaa2)
RTP: 109937292
BFO: 118431728
BBEL: 109476113
CIN: 100184788
SCLV: 120340955
SPU: 100888004
APLC: 110977481
SKO: 100313552(Prkaa2)
DME: Dmel_CG3051(AMPKalpha)
DER: 6555730
DSE: 6615977
DSI: Dsimw501_GD16554(Dsim_GD16554)
DAN: 6503702
DSR: 110178854
DPE: 6596737
DMN: 108152076
DWI: 6653054
DGR: 6565234
DAZ: 108618636
DNV: 108656297
DHE: 111605154
DVI: 6634781
CCAT: 101462970
MDE: 101899168
LCQ: 111676734
ACOZ: 120953239
AARA: 120893891
AAG: 5568845
AME: 409577
ACER: 108002261
BIM: 100744469
BBIF: 117217265
BTER: 100643177
CCAL: 108629746
OBB: 114873469
NMEA: 116427125
CGIG: 122396104
SOC: 105201163
MPHA: 105828191
AEC: 105146359
ACEP: 105627819
PBAR: 105426255
VEM: 105561556
HST: 105190214
DQU: 106747619
CFO: 105252990
FEX: 115243937
LHU: 105671278
PGC: 109855776
OBO: 105274617
PCF: 106789443
NVI: 100120450
CSOL: 105361328
MDL: 103568888
CCIN: 107271156
TCA: 663357(Snf1a)
DPA: 109545112
ATD: 109609163
LDC: 111509034
NVL: 108557505
APLN: 108738700
PPYR: 116158812
OTU: 111419862
BMOR: 100101222
BMAN: 114247766
BANY: 112050078
PMAC: 106711118
PPOT: 106109680
PRAP: 110991484
ZCE: 119835105
HAW: 110370867
TNL: 113503039
PXY: 105386201
API: 103309639
DNX: 107165577
AGS: 114126494
RMD: 113551661
BTAB: 109032076
DCI: 103521710
CLEC: 106674381
NLU: 111057138
ZNE: 110828230
CSEC: 111865905
DMK: 116930435
PVM: 113822494
EAF: 111718284
DSV: 119433073
RSAN: 119404532
RMP: 119180770
VDE: 111244523
VJA: 111269469
CSCU: 111634229
PTEP: 107450058
SDM: 118184780
CEL: CELE_PAR2.3(aak-1) CELE_T01C8.1(aak-2)
CBR: CBG06916(Cbr-aak-1) CBG10242 CBG16249(Cbr-aak-2)
BMY: BM_BM5465(Bma-aak-2)
PCAN: 112574032
BGT: 106080129
GAE: 121376464
CRG: 105341321
MYI: 110449031
PMAX: 117324994
OBI: 106875312
EGL: EGR_03655
NVE: 5507582
EPA: 110241483
ATEN: 116291747
ADF: 107338938
AMIL: 114963547
PDAM: 113674454
SPIS: 111336740
DGT: 114526240
HMG: 101238049(prkaa2)
AQU: 100642122
ATH: AT3G01090(KIN10) AT3G17510(CIPK1) AT3G29160(KIN11) AT5G39440(SnRK1.3) AT5G45820(CIPK20)
LJA: Lj0g3v0093489.1(Lj0g3v0093489.1) Lj0g3v0093489.2(Lj0g3v0093489.2) Lj0g3v0267379.1(Lj0g3v0267379.1) Lj0g3v0267379.2(Lj0g3v0267379.2) Lj2g3v1068760.1(Lj2g3v1068760.1) Lj2g3v2413480.2(Lj2g3v2413480.2) Lj3g3v1411750.1(Lj3g3v1411750.1) Lj4g3v2249030.1(Lj4g3v2249030.1) Lj4g3v2249030.2(Lj4g3v2249030.2)
VVI: 100241657(CIPK03) 100241678(CIPK13) 100243133(CIPK07) 100243154 100254223 100258329(CIPK16) 100259621(CIPK19)
DOSA: Os01t0206700-01(Os01g0206700) Os01t0292200-01(Os01g0292200) Os01t0824600-01(Os01g0824600) Os02t0161000-01(Os02g0161000) Os03t0339900-01(Os03g0339900) Os05t0136200-01(Os05g0136200) Os05t0476350-00(Os05g0476350) Os05t0530500-01(Os05g0530500) Os07t0637000-01(Os07g0637000) Os07t0678600-01(Os07g0678600) Os08t0484600-01(Os08g0484600) Os11t0113700-01(Os11g0113700) Os12t0113500-01(Os12g0113500)
APRO: F751_0394
MIS: MICPUN_60554(SNF1-like) MICPUN_68014
PIC: PICST_48613(PPR2)
DDI: DDB_G0277905(snfA)
DFA: DFA_01354(snfA)
TAN: TA09820
TPV: TP04_0818
BBO: BBOV_III009120(17.m07797)
SMIN: v1.2.012456.t2(symbB.v1.2.012456.t2) v1.2.020616.t1(symbB.v1.2.020616.t1) v1.2.020700.t1(symbB.v1.2.020700.t1)
PTI: PHATRDRAFT_8773(MARK3)
FCY: FRACYDRAFT_208334(MARK3)
TPS: THAPSDRAFT_26536(SNF1)
 » show all
Reference
  Authors
Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB
  Title
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.
  Journal
Mol Cell 18:283-93 (2005)
DOI:10.1016/j.molcel.2005.03.027
Reference
PMID:8557660
  Authors
Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE
  Title
Mammalian AMP-activated protein kinase subfamily.
  Journal
J Biol Chem 271:611-4 (1996)
DOI:10.1074/jbc.271.2.611
  Sequence
[hsa:5562]

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