KEGG   ORTHOLOGY: K07203Help
Entry
K07203                      KO                                     

Name
MTOR, FRAP, TOR
Definition
serine/threonine-protein kinase mTOR [EC:2.7.11.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04012  ErbB signaling pathway
ko04066  HIF-1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04136  Autophagy - other
ko04138  Autophagy - yeast
ko04139  Mitophagy - yeast
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04371  Apelin signaling pathway
ko04630  JAK-STAT signaling pathway
ko04659  Th17 cell differentiation
ko04714  Thermogenesis
ko04910  Insulin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04920  Adipocytokine signaling pathway
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H01928  Smith-Kingsmore syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04371 Apelin signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04630 Jak-STAT signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04066 HIF-1 signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04072 Phospholipase D signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04151 PI3K-Akt signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04152 AMPK signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04150 mTOR signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04138 Autophagy - yeast
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04136 Autophagy - other
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04139 Mitophagy - yeast
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09143 Cell growth and death
   04218 Cellular senescence
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04920 Adipocytokine signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04919 Thyroid hormone signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09149 Aging
   04211 Longevity regulating pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04212 Longevity regulating pathway - worm
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04213 Longevity regulating pathway - multiple species
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09159 Environmental adaptation
   04714 Thermogenesis
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05230 Central carbon metabolism in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05231 Choline metabolism in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05206 MicroRNAs in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05205 Proteoglycans in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09162 Cancers: Specific types
   05210 Colorectal cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05212 Pancreatic cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05225 Hepatocellular carcinoma
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05226 Gastric cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05214 Glioma
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05221 Acute myeloid leukemia
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05215 Prostate cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05224 Breast cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09167 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04931 Insulin resistance
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09172 Infectious diseases: Viral
   05170 Human immunodeficiency virus 1 infection
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05163 Human cytomegalovirus infection
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05167 Kaposi sarcoma-associated herpesvirus infection
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05165 Human papillomavirus infection
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09176 Drug resistance: Antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   01522 Endocrine resistance
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PIKK family [OT]
   K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
Membrane trafficking [BR:ko04131]
 Autophagy
  Other autophagy associated proteins
   mTORC1 complex
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
BRITE hierarchy
Other DBs
COG: COG5032
Genes
HSA: 2475(MTOR)
PTR: 457945(MTOR)
PPS: 100980204(MTOR)
GGO: 101138990(MTOR) 109028337
PON: 100456786(MTOR)
NLE: 100594291(MTOR)
MCC: 106992736(MTOR)
MCF: 102128371(MTOR)
CSAB: 103225615(MTOR)
RRO: 104654362(MTOR)
RBB: 108539366(MTOR)
CJC: 100406608(MTOR)
SBQ: 101047083(MTOR)
MMU: 56717(Mtor)
RNO: 56718(Mtor)
CGE: 100755421(Mtor)
NGI: 103732897(Mtor)
HGL: 101725626(Mtor)
CCAN: 109689653 109689656(Mtor)
OCU: 100356164(MTOR)
TUP: 102485262(MTOR)
CFA: 478232(MTOR)
AML: 100471122(MTOR)
UMR: 103666660(MTOR)
ORO: 101363844(MTOR)
FCA: 101098152(MTOR)
PTG: 102967196(MTOR)
AJU: 106984907(MTOR)
BTA: 100139219(MTOR)
BOM: 102281727(MTOR)
BIU: 109570401(MTOR)
PHD: 102332614(MTOR)
CHX: 100860902(MTOR)
OAS: 100271659(MTOR)
SSC: 100127359(MTOR)
CFR: 102510836(MTOR)
CDK: 105107024(MTOR)
BACU: 103004460(MTOR)
LVE: 103083889(MTOR)
OOR: 101284249(MTOR)
ECB: 100051341(MTOR)
EPZ: 103552237(MTOR)
EAI: 106836676(MTOR)
MYB: 102241670(MTOR)
MYD: 102766933(MTOR)
HAI: 109381262(MTOR)
RSS: 109455267(MTOR)
PALE: 102885092(MTOR)
LAV: 100660112(MTOR)
TMU: 101343808
MDO: 100619675(MTOR)
SHR: 100931480(MTOR)
OAA: 100079751(MTOR)
GGA: 419455(MTOR)
MGP: 100547037(MTOR)
CJO: 107323407(MTOR)
APLA: 101802486(MTOR)
ACYG: 106040228(MTOR)
TGU: 100219695(MTOR)
GFR: 102034190(MTOR)
FAB: 101820693(MTOR)
PHI: 102108233(MTOR)
PMAJ: 107213730(MTOR)
CCAE: 111938583(MTOR)
CCW: 104693234(MTOR)
FPG: 101919512(MTOR)
FCH: 102051979(MTOR)
CLV: 102093827(MTOR)
EGZ: 104133077(MTOR)
AAM: 106482444(MTOR)
ASN: 102372197(MTOR)
AMJ: 102574334(MTOR)
PSS: 102451030(MTOR)
CMY: 102947284
CPIC: 101949839(MTOR)
ACS: 100565267(mtor)
PVT: 110073225(MTOR)
PBI: 103053332(MTOR)
GJA: 107108920(MTOR)
XLA: 108696363
XTR: 100491970(mtor)
NPR: 108789092(MTOR) 108796319
DRE: 324254(mtor)
IPU: 108265039(mtor)
AMEX: 103042377(mtor)
TRU: 101074470(mtor)
LCO: 104919512(mtor)
MZE: 101471360(mtor)
OLA: 101156248(mtor)
XMA: 102220301(mtor)
PRET: 103467091(mtor)
NFU: 107391286(mtor)
KMR: 108233102(mtor)
CSEM: 103384900(mtor)
LCF: 108882623(mtor)
SDU: 111227586(mtor)
HCQ: 109511770(mtor)
BPEC: 110157966(mtor)
MALB: 109967123(mtor)
SASA: 100380849(mtor)
ELS: 105013925(mtor)
SFM: 108931071(mtor)
LCM: 102360124(MTOR)
CMK: 103181362(mtor)
CIN: 100178479
SPU: 580879
APLC: 110982650
SKO: 100329005(TOR)
DME: Dmel_CG5092(Tor)
DSI: Dsimw501_GD23862(Dsim_GD23862)
MDE: 101893055
AAG: 5565894
AME: 409393
BIM: 100749875
BTER: 100649664
SOC: 105193564
AEC: 105152845
ACEP: 105624966
PBAR: 105424520
HST: 105190144
DQU: 106747690
CFO: 105256945
LHU: 105679357
PGC: 109859730
PCF: 106789371
NVI: 100118360(TOR)
MDL: 103576490
TCA: 660499
DPA: 109544499
NVL: 108556975
BMOR: 100431180(TOR2)
PXY: 105390151
API: 100163481
DNX: 107162479
CLEC: 106669228
ZNE: 110840625
FCD: 110851607
TUT: 107359769
CEL: CELE_B0261.2(let-363)
CBR: CBG12850(Cbr-let-363)
BMY: Bm1_48125
TSP: Tsp_04731
CRG: 105331599
MYI: 110448263
OBI: 106870424
SHX: MS3_06813
EGL: EGR_00240
EPA: 110251691
HMG: 100197178
ATH: AT1G50030(TOR)
CRB: 17897805
THJ: 104826500
CIT: 102618367
TCC: 18608126
DZI: 111309034
EGR: 104419800
VRA: 106777509
VAR: 108319939
CCAJ: 109800697
CAM: 101499541
LJA: Lj1g3v0052210.1(Lj1g3v0052210.1) Lj1g3v0052210.2(Lj1g3v0052210.2) Lj1g3v0052210.3(Lj1g3v0052210.3) Lj6g3v1900300.1(Lj6g3v1900300.1) Lj6g3v1900300.2(Lj6g3v1900300.2) Lj6g3v1900300.3(Lj6g3v1900300.3)
ADU: 107488658
AIP: 107643288
FVE: 101310491
PPER: 18766256
PMUM: 103335031
PAVI: 110760196
PXB: 103928072
ZJU: 107427093
CSV: 101212051
CMO: 103495325
MCHA: 111017367
CMAX: 111471047
CMOS: 111454906
CPEP: 111811251
RCU: 8258060
JCU: 105650837
VVI: 100249713
SLY: 101259295
SPEN: 107002769
SOT: 102604383
NSY: 104242814
NTO: 104118002
INI: 109178500
SIND: 105169347
LSV: 111891370
CCAV: 112515141
BVG: 104904834
NNU: 104589114
OSA: 4338174
DOSA: Os05t0235300-01(Os05g0235300)
OBR: 102706940
BDI: 100835842
ATS: 109783936(LOC109783936)
SBI: 8084725
ZMA: 542211(cl3114_1(600))
SITA: 101780377
PDA: 103698521
EGU: 105056261
MUS: 103980358
DCT: 110111565
PEQ: 110022180
AOF: 109833837
ATR: 18423738
PPP: 112284079
CRE: CHLREDRAFT_176480(TOR1)
MIS: MICPUN_88899(TOR)
APRO: F751_1983
SCE: YJR066W(TOR1) YKL203C(TOR2)
ERC: Ecym_3152
KMX: KLMA_30046(TOR2)
NCS: NCAS_0G03440(NCAS0G03440)
NDI: NDAI_0D01470(NDAI0D01470)
TPF: TPHA_0F03570(TPHA0F03570)
TBL: TBLA_0D03670(TBLA0D03670)
TDL: TDEL_0F00460(TDEL0F00460)
KAF: KAFR_0A08100(KAFR0A08100) KAFR_0E00310(KAFR0E00310)
PIC: PICST_33151(TOR2)
CAL: CAALFM_C207330WA(TOR1)
CAUR: QG37_00663
SLB: AWJ20_2811(TOR1)
NCR: NCU05608
NTE: NEUTE1DRAFT148627(NEUTE1DRAFT_148627)
MGR: MGG_15156
SSCK: SPSK_06845
MAW: MAC_01551
MAJ: MAA_02388
CMT: CCM_04900
MBE: MBM_05946
ANI: AN5982.2
ANG: ANI_1_672144(An16g04720)
ABE: ARB_05798
TVE: TRV_04550
PNO: SNOG_08246(SNOG_08245)
PTE: PTT_08717
ZTR: MYCGRDRAFT_67795(TOR1)
PFJ: MYCFIDRAFT_205476(TOR2)
SPO: SPBC216.07c(tor2) SPBC30D10.10c(tor1)
CNE: CNF03740
CNB: CNBF1080
ABP: AGABI1DRAFT126075(AGABI1DRAFT_126075) AGABI1DRAFT35543(AGABI1DRAFT_35543)
ABV: AGABI2DRAFT151451(AGABI2DRAFT_151451) AGABI2DRAFT151460(AGABI2DRAFT_151460)
MGL: MGL_2920
DDI: DDB_G0281569(tor)
DFA: DFA_09983(tor)
EHI: EHI_169320(177.t00028)
SPAR: SPRG_13345
EHX: EMIHUDRAFT_99823(TOR1)
LMA: LMJF_34_3940(TOR3) LMJF_34_4530(TOR2) LMJF_36_6320(TOR1)
LIF: LINJ_34_3750(TOR3) LINJ_34_4160(TOR2) LINJ_36_6580(TOR1)
LBZ: LBRM_20_3550(TOR3) LBRM_20_3990(TOR2) LBRM_35_6620(TOR1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8008069
  Authors
Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, Schreiber SL
  Title
A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
  Journal
Nature 369:756-8 (1994)
DOI:10.1038/369756a0
  Sequence
[hsa:2475]
Reference
  Authors
Jiang Y, Broach JR
  Title
Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.
  Journal
EMBO J 18:2782-92 (1999)
DOI:10.1093/emboj/18.10.2782

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