KEGG   ORTHOLOGY: K07205Help
Entry
K07205                      KO                                     

Name
EIF4EBP1
Definition
eukaryotic translation initiation factor 4E binding protein 1
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko03013  RNA transport
ko04012  ErbB signaling pathway
ko04066  HIF-1 signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04218  Cellular senescence
ko04910  Insulin signaling pathway
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05221  Acute myeloid leukemia
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Translation
   03013 RNA transport
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
   04066 HIF-1 signaling pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
   04151 PI3K-Akt signaling pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
   04152 AMPK signaling pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
   04150 mTOR signaling pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
 Cellular Processes
  Cell growth and death
   04218 Cellular senescence
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
  Aging
   04211 Longevity regulating pathway - mammal
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
   05221 Acute myeloid leukemia
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
  Infectious diseases
   05163 Human cytomegalovirus infection
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
   05165 Human papillomavirus infection
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic Type
  mRNA surveillance and transport factors
   Transport factors
    eIF4F and regulatory proteins
     K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
BRITE hierarchy
Other DBs
GO: 0008190
Genes
HSA: 1978(EIF4EBP1)
PTR: 464114(EIF4EBP1)
PPS: 100972246(EIF4EBP1)
GGO: 101145454(EIF4EBP1)
PON: 100455169(EIF4EBP1)
NLE: 105740136(EIF4EBP1)
MCC: 703628(EIF4EBP1)
MCF: 102132583(EIF4EBP1)
CSAB: 103215636(EIF4EBP1)
RRO: 104659123 104679650(EIF4EBP1)
RBB: 108513587(EIF4EBP1)
CJC: 100386453(EIF4EBP1)
SBQ: 101029508(EIF4EBP1) 101030055
MMU: 13685(Eif4ebp1)
RNO: 116636(Eif4ebp1)
CGE: 100769654(Eif4ebp1)
HGL: 101710614(Eif4ebp1)
CCAN: 109688934(Eif4ebp1)
OCU: 100338850(EIF4EBP1)
TUP: 102494657(EIF4EBP1)
CFA: 475590(EIF4EBP1)
AML: 100469745(EIF4EBP1)
UMR: 103659121(EIF4EBP1)
ORO: 101386736(EIF4EBP1)
FCA: 101088571(EIF4EBP1)
PTG: 102961839(EIF4EBP1)
AJU: 106978406(EIF4EBP1)
BTA: 509613(EIF4EBP1)
BOM: 102278368(EIF4EBP1)
BIU: 109553533(EIF4EBP1)
PHD: 102341604(EIF4EBP1)
CHX: 100861234(EIF4EBP1)
OAS: 101111426(EIF4EBP1)
SSC: 100627508(EIF4EBP1)
CFR: 102520195(EIF4EBP1)
CDK: 105089940(EIF4EBP1)
BACU: 103018352(EIF4EBP1)
LVE: 103074746(EIF4EBP1)
OOR: 101277165(EIF4EBP1)
ECB: 100057875(EIF4EBP1)
EPZ: 103543726(EIF4EBP1)
EAI: 106837686(EIF4EBP1)
MYB: 102250463(EIF4EBP1)
MYD: 102758662(EIF4EBP1)
HAI: 109393572(EIF4EBP1)
RSS: 109456095(EIF4EBP1)
PALE: 102881655(EIF4EBP1)
LAV: 100665518(EIF4EBP1)
TMU: 101361891
MDO: 100029774(EIF4EBP1)
SHR: 100918487 111718631(EIF4EBP1)
OAA: 100084037(EIF4EBP1)
GGA: 426773(EIF4EBP1)
MGP: 100546275(EIF4EBP1)
CJO: 107323781(EIF4EBP1)
APLA: 101798286(EIF4EBP1)
ACYG: 106044378(EIF4EBP1)
TGU: 100230789(EIF4EBP1)
PHI: 102105579(EIF4EBP1)
PMAJ: 107213862(EIF4EBP1)
CCW: 104694846(EIF4EBP1)
FCH: 102047520(EIF4EBP1)
CLV: 102083572(EIF4EBP1)
EGZ: 104127858(EIF4EBP1)
AMJ: 102575532(EIF4EBP1)
PSS: 102459901(EIF4EBP1)
CMY: 102944935(EIF4EBP1)
CPIC: 101935335(EIF4EBP1)
ACS: 100553993(eif4ebp1)
PVT: 110075184(EIF4EBP1)
PBI: 103063177(EIF4EBP1)
GJA: 107108168(EIF4EBP1)
DRE: 799566(eif4ebp1)
SRX: 107708518
SANH: 107703566
IPU: 108279290
AMEX: 103026948
NCC: 104941580(eif4ebp1)
OLA: 101162296(eif4ebp1) 101165490
LCF: 108878192(eif4ebp1) 108886048
SASA: 106580340(4EBP2) 106585258(4EBP2)
ELS: 105027007
LCM: 102357265(EIF4EBP1)
CMK: 103190311(eif4ebp1)
CIN: 100183767
SPU: 752411(4e-bp)
CRG: 105341698
OBI: 106879899
EPA: 110249034
ADF: 107332370
SLB: AWJ20_944
DDI: DDB_G0291990(febA)
DFA: DFA_02929(febA)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, Wu Z, Gingras AC, Katsume A, Elchebly M, Spiegelman BM, Harper ME, Tremblay ML, Sonenberg N
  Title
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.
  Journal
Nat Med 7:1128-32 (2001)
DOI:10.1038/nm1001-1128
  Sequence
[mmu:13685]
Reference
  Authors
Yanagiya A, Suyama E, Adachi H, Svitkin YV, Aza-Blanc P, Imataka H, Mikami S, Martineau Y, Ronai ZA, Sonenberg N
  Title
Translational homeostasis via the mRNA cap-binding protein, eIF4E.
  Journal
Mol Cell 46:847-58 (2012)
DOI:10.1016/j.molcel.2012.04.004
  Sequence
[hsa:1978]
Reference
PMID:7629182
  Authors
Lin TA, Kong X, Saltiel AR, Blackshear PJ, Lawrence JC Jr
  Title
Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway.
  Journal
J Biol Chem 270:18531-8 (1995)
DOI:10.1074/jbc.270.31.18531
  Sequence
[mmu:13685]

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