KEGG   ORTHOLOGY: K07360
Entry
K07360                      KO                                     

Name
ZAP70
Definition
tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]
Pathway
ko04014  Ras signaling pathway
ko04064  NF-kappa B signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko05135  Yersinia infection
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05340  Primary immunodeficiency
Disease
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
   04064 NF-kappa B signaling pathway
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
   04660 T cell receptor signaling pathway
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
   04658 Th1 and Th2 cell differentiation
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
   04659 Th17 cell differentiation
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
  09163 Immune disease
   05340 Primary immunodeficiency
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K07360  ZAP70; tyrosine-protein kinase ZAP-70
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SYK family
   K07360  ZAP70; tyrosine-protein kinase ZAP-70
Other DBs
GO: 0004715
Genes
HSA: 7535(ZAP70)
PTR: 459427(ZAP70)
PPS: 100971372(ZAP70)
GGO: 101139136
PON: 100451782
NLE: 100589243
MCC: 707555
MCF: 102135442(ZAP70)
CSAB: 103241092(ZAP70)
RRO: 104661474
RBB: 108529480
CJC: 100390922(ZAP70)
SBQ: 101036932(ZAP70)
MMU: 22637(Zap70)
MCAL: 110297598
MPAH: 110321893
RNO: 301348(Zap70)
MUN: 110545437
CGE: 100767740
NGI: 103738088(Zap70)
HGL: 101716577(Zap70)
CCAN: 109695320
OCU: 100342021(ZAP70)
TUP: 102469719(ZAP70)
CFA: 100271860(ZAP70)
VVP: 112915328
AML: 100473238
UMR: 103671189(ZAP70)
UAH: 113246717
ORO: 101377393(ZAP70)
ELK: 111155922
FCA: 101097059
PTG: 102969244(ZAP70)
PPAD: 109273394
AJU: 106976677
BTA: 504509(ZAP70)
BOM: 102287403(ZAP70)
BIU: 109565800
BBUB: 102408544
CHX: 102176695(ZAP70)
OAS: 101112639
SSC: 100739325
CFR: 102509559
CDK: 105099801
BACU: 103014268(ZAP70)
LVE: 103074297(ZAP70)
OOR: 101286910(ZAP70)
DLE: 111187417
PCAD: 102996375
ECB: 100147296(ZAP70)
EPZ: 103561441(ZAP70)
EAI: 106842544
MYB: 102259670(ZAP70)
MYD: 102775001(ZAP70)
MNA: 107543924
HAI: 109391988
DRO: 112315209
PALE: 102883976
RAY: 107509971
MJV: 108391417
LAV: 100666693
TMU: 101347632
MDO: 100025187(ZAP70)
SHR: 100916187
PCW: 110202117
GGA: 420086(ZAP70)
MGP: 100542877
CJO: 107325684
NMEL: 110388791
APLA: 101798888
ACYG: 106048412(ZAP70)
TGU: 100229988
LSR: 110478014
SCAN: 103821913
GFR: 102034810(ZAP70)
FAB: 101809285(ZAP70)
PHI: 102108601(ZAP70)
PMAJ: 107215340
CCAE: 111940227
CCW: 104697023
ETL: 114070354
FPG: 101916784(ZAP70)
FCH: 102059049
CLV: 102088841
EGZ: 104132036(ZAP70)
NNI: 104018770(ZAP70)
ACUN: 113489494
PADL: 103921148(ZAP70)
AAM: 106486099(ZAP70)
ASN: 102379235
AMJ: 102576066
PSS: 102446767
CMY: 102939519
CPIC: 101946149(ZAP70)
PVT: 110072432
PBI: 103049663
PMUR: 107282189
TSR: 106542969(ZAP70)
PMUA: 114588403
GJA: 107113429
XLA: 108706868 446840(zap70.L)
XTR: 448557(zap70)
NPR: 108798239
DRE: 553615(zap70)
IPU: 108264986(Zap70)
PHYP: 113534995
AMEX: 103044019
EEE: 113575095
TRU: 101069105
LCO: 104921819
NCC: 104944350(zap70)
MZE: 101466346
ONL: 100696446
OLA: 101170171
XMA: 102236845
XCO: 114151578
PRET: 103468233
CVG: 107097723
NFU: 107392881
KMR: 108238465
ALIM: 106516821(zap70)
AOCE: 111580186
CSEM: 103394926
POV: 109636582
LCF: 108896602
SDU: 111225667
SLAL: 111645387
HCQ: 109519137
BPEC: 110167942
MALB: 109961723
ELS: 105011640
SFM: 108919908
PKI: 111860226
LCM: 102357488(ZAP70)
CMK: 103183477(zap70)
RTP: 109915343
DGT: 114515801
 » show all
Reference
  Authors
Kuroyama H, Ikeda T, Kasai M, Yamasaki S, Tatsumi M, Utsuyama M, Saito T, Hirokawa K
  Title
Identification of a novel isoform of ZAP-70, truncated ZAP kinase.
  Journal
Biochem Biophys Res Commun 315:935-41 (2004)
DOI:10.1016/j.bbrc.2004.01.127
  Sequence
[hsa:7535]

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