KEGG   ORTHOLOGY: K07411
Entry
K07411                      KO                                     
Symbol
CYP2A
Name
cytochrome P450 family 2 subfamily A [EC:1.14.14.1]
Pathway
map00830  Retinol metabolism
map01100  Metabolic pathways
Reaction
R08390  
R08391  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07411  CYP2A; cytochrome P450 family 2 subfamily A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07411  CYP2A; cytochrome P450 family 2 subfamily A
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07411  CYP2A; cytochrome P450 family 2 subfamily A
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07411  CYP2A; cytochrome P450 family 2 subfamily A
Genes
MLEU: 105542587
CSYR: 103249340
MMUR: 105876749
LCAT: 123624224 123624296
PCOQ: 105820607
OGA: 100953114
MMU: 13085(Cyp2a12) 13086(Cyp2a4) 13087(Cyp2a5) 233005(Cyp2a22)
MCAL: 110297420
MPAH: 110315448
RNO: 24299(Cyp2a3) 24894(Cyp2a1) 24895(Cyp2a2)
MCOC: 116100315 116100316
ANU: 117714965 117724823
MUN: 110542150 110542622 110542752 110542753 110543049 110543408 110544788 110566204 132647102
CGE: 100689033(Cyp2a14) 100689034(Cyp2a17) 100689035(Cyp2a15) 100772358
MAUA: 101825889 101826326 101826941
PROB: 127238377 127238378 127238675 127238676 127238925
PLEU: 114681552 114681560 114681562 114681563
MORG: 121449318 121449375 121449376 121449417 121449523 121449582 121450179
MFOT: 126491011 126491012 126491013 126491017 126492534 126492562
AAMP: 119820350 119820573 119820576 119820904 119820905
NGI: 103734435 103734436 103734440 103750778
HGL: 101706775 101707867 101708686
CPOC: 100718540 100719371 100727164 100728095 101788175
CCAN: 109674408 109678687
DORD: 106000881 106000893 106001828
DSP: 122097356 122097432 122097569 122097570 122097573
PLOP: 125338612 125338613 125338946 125338990 125338995 125338996 125339000 125339003
NCAR: 124966126 124966677 124967392 124967421 124967497
MMMA: 107151438
OCU: 100328596(CYP2A11)
OPI: 101534346
TUP: 102485364
GVR: 103600499
CFA: 484493(CYP2A7) 484494(CYP2A13)
CLUD: 112645438 112645439
VVP: 112928291 112928355
VLG: 121484617 121484618
NPO: 129499697 129501018
AML: 100464844 100465091
UMR: 103661053 103661107 103680319 103680449
UAH: 113243251
UAR: 123782814 123782854
ELK: 111161434 111161491
LLV: 125088694 125089854
MPUF: 101681178
MNP: 132004910 132006187
MLK: 131818347 131818436
NVS: 122913922 122913923
ORO: 101367426 101386056
ZCA: 113908484 113936362
NSU: 110578340 110590333
LWW: 102726031 102745206
FCA: 101089561(CYP2A25) 101089816(CYP2A13)
PYU: 121011417 121024580
PCOO: 112851420
PBG: 122494015 122494018
PVIV: 125153007 125153442
LRUF: 124511798 124511799
PTG: 102960454 102964639
PPAD: 109256645 109256667
PUC: 125916158 125917829
AJU: 106979615 128313237
HHV: 120239758 120241873
BTA: 540707(CYP2A13)
BOM: 102281503
BIU: 109572736
BBUB: 102401344
BBIS: 104995374
CHX: 102168381
OAS: 100568289(CYP2A6)
BTAX: 128063606
ODA: 120872402
CCAD: 122421546
MBEZ: 129546792
SSC: 403149(CYP2A19)
CFR: 102507471
CBAI: 105062872
CDK: 105093359
VPC: 102541022
BMUS: 118885279
ECB: 100064882(CYP2A13) 100146413 111775200
EPZ: 103543364 103543474 103562350
EAI: 106843256 106843257 106843310
MYB: 102243745 102246236
MYD: 102752404 102758245
MMYO: 118674681 118674840 118674844
MLF: 102424871 102433823
PKL: 118702272 118702273
EFUS: 129147780 129147823
MNA: 107534173
DRO: 112320011
AJM: 119040966
PDIC: 114489773 114511650
PHAS: 123823739 123823893
MMF: 118638478 118638711 118638771 118638868
PPAM: 129066145 129076630
HAI: 109378628 109378629
RFQ: 117035077
MJV: 108397726
TOD: 119250430 119250433 119258431
SARA: 101553388 101553831 101554265
SETR: 126028127
LAV: 100666307 100666783 100667065
ETF: 101647240
DNM: 101416547
MDO: 100015520 100018858
GAS: 123240009 123242994
SHR: 100916556 100916811 100917074
AFZ: 127556214 127556215 127556216 127556217
PCW: 110203005
OAA: 100075646(CYP2A.B) 100089063
AROW: 112961606
CTIG: 120316365
PTEX: 113450319
NSS: 113425563
VKO: 123026164
PRAF: 128420206 128420215 128420236
ZVI: 118086690
RTEM: 120913358
DSV: 119448414 119449663
RSAN: 119382954
RMP: 119162174
ABRU: 129964017
AG: AAA37068(CYP2A8) BAA25259(CYP2A9) BAA85463(CYP2A16)
 » show all
Reference
PMID:3818621 (CYP2A1)
  Authors
Nagata K, Matsunaga T, Gillette J, Gelboin HV, Gonzalez FJ
  Title
Rat testosterone 7 alpha-hydroxylase. Isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene.
  Journal
J Biol Chem 262:2787-93 (1987)
  Sequence
[rno:24894]
Reference
PMID:3192524 (CYP2A2)
  Authors
Matsunaga T, Nagata K, Holsztynska EJ, Lapenson DP, Smith A, Kato R, Gelboin HV, Waxman DJ, Gonzalez FJ
  Title
Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase.
  Journal
J Biol Chem 263:17995-8002 (1988)
  Sequence
[rno:24895]
Reference
PMID:2751996 (CYP2A3)
  Authors
Kimura S, Kozak CA, Gonzalez FJ
  Title
Identification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene.
  Journal
Biochemistry 28:3798-803 (1989)
DOI:10.1021/bi00435a026
  Sequence
[rno:24299]
Reference
PMID:2703500 (CYP2A4)
  Authors
Lindberg R, Burkhart B, Ichikawa T, Negishi M
  Title
The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.
  Journal
J Biol Chem 264:6465-71 (1989)
  Sequence
[mmu:13087]
Reference
PMID:2275554 (CYP2A8)
  Authors
Lai TS, Chiang JY
  Title
Cloning and characterization of two major 3-methylcholanthrene inducible hamster liver cytochrome P450s.
  Journal
Arch Biochem Biophys 283:429-39 (1990)
DOI:10.1016/0003-9861(90)90664-K
  Sequence
[ag:AAA37068]
Reference
PMID:9500848 (CYP2A9)
  Authors
Kurose K, Tohkin M, Ushio F, Fukuhara M
  Title
Cloning and characterization of Syrian hamster testosterone 7 alpha-hydroxylase, CYP2A9.
  Journal
Arch Biochem Biophys 351:60-5 (1998)
DOI:10.1006/abbi.1997.0544
  Sequence
[ag:BAA25259]
Reference
PMID:8349611 (CYP2A10 CYP2A11)
  Authors
Peng HM, Ding X, Coon MJ
  Title
Isolation and heterologous expression of cloned cDNAs for two rabbit nasal microsomal proteins, CYP2A10 and CYP2A11, that are related to nasal microsomal cytochrome P450 form a.
  Journal
J Biol Chem 268:17253-60 (1993)
  Sequence
[ocu:100328596]
Reference
PMID:10524222 (CYP2A16)
  Authors
Tohkin M, Kurose K, Isozaki E, Fukuhara M
  Title
Molecular cloning, heterologous expression, and characterization of a novel member of CYP2A in the Syrian hamster.
  Journal
Biochim Biophys Acta 1446:438-42 (1999)
DOI:10.1016/S0167-4781(99)00109-8
  Sequence
[ag:BAA85463]

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (7)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (3)   
Gene (295)   
   KEGG GENES (261)   
   KEGG MGENES (32)   
   OC (2)   
Literature (8)   
   PubMed (8)   
All databases (317)   

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